Chromosomal Abnormalities Associated With Recurrent Miscarriage Emerge from Sequencing Study, Published on Oct 31, 2019  Uganda Genome Resource Sheds Light on Population History, Enables New Association Studies Published on Oct 31, 2019  BillionToOne Taps Eluthia as Exclusive Distributor of NIPT in Certain European Countries Published on Oct 31, 2019

High-Throughput SNP Discovery and Genotyping Using Normalized Genotyping-By-Sequencing This white paper from LGC Group highlights a self-tuning Genotyping-by-Sequencing (GBS) method, called normalized GBS (nGBS), which efficiently reduces the genome complexity of any species to a few hundred thousand loci across the complete genome. Download it from GenomeWeb’s White Paper Channel.

Featured in Depth

Quidel Touts Product Pipeline Despite Revenue Headwinds Published on Oct 31, 2019

S2 Genomics to Commercialize Tissue Sample Prep Platform by Early 2020 Published on Oct 31, 2019

New Early Cancer Detection Alliance to Trial Bevy of New Technologies and Tests Published on Oct 31, 2019

Exact Sciences Preparing to Launch Improved Cologuard, Liver Cancer Test Published on Oct 30, 2019

Live Webinar: Innovations in NGS and CGH for Preimplantation Genetic Testing This webinar on 11/6 will provide an overview of the latest advances in genomics technology for preimplantation genetic testing, with a focus on the advantages of NGS and CGH for specific indications. Register Here

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Ancestry Awards $1M to UpToDate to Support Physician Genetic Testing Published on Oct 30, 2019  Tropical Air Microbiome Analysis Reveals Daily Cycle, Environmental Drivers Published on Oct 25, 2019

GPU-Accelerated Analysis of DNA Sequencing Data In this on-demand webinar, learn how Parabricks has accelerated the secondary analysis of sequencing data to analyze a 30x whole genome in minutes instead of days. Download it from GenomeWeb’s Webinar library

Oncology Spandidos

TABLE OF CONTENTS December-2019 Volume 55 Issue 6

CircRNAs: From anonymity to novel regulators of gene expression in cancer (Review) Katherine L. Harper, Euan Mcdonnell, Adrian Whitehouse View Abstract ❯
Assessment of biochemical recurrence of prostate cancer (Review) Xiaozeng Lin, Anil Kapoor, Yan Gu, Mathilda Jing Chow, Hui Xu, Pierre Major, Damu Tang View Abstract ❯
Targeting autophagy is a promising therapeutic strategy to overcome chemoresistance and reduce metastasis in osteosarcoma Yu‑Xin Liao, Hai‑Yang Yu, Ji‑Yang Lv, Yan‑Rong Cai, Fei Liu, Zhi‑Min He, Shi‑Sheng He View Abstract ❯
The long non-coding RNA GHSROS facilitates breast cancer cell migration and orthotopic xenograft tumour growth Patrick B. Thomas, Inge Seim, Penny L. Jeffery, Manuel D. Gahete, Michelle Maugham, Gabrielle J. Crisp, Andrew Stacey, Esha T. Shah, Carina Walpole, Eliza J. Whiteside, Colleen C. Nelson, Adrian C. Herington, Raúl M. Luque, Rakesh N. Veedu, Lisa K. Chopin View Abstract ❯
Population and single‑cell transcriptome analyses reveal diverse transcriptional changes associated with radioresistance in esophageal squamous cell carcinoma Hongjin Wu, Juehua Yu, Deshengyue Kong, Yu Xu, Zunyue Zhang, Jing Shui, Ziwei Li, Huayou Luo, Kunhua Wang View Abstract ❯
UPLC‑MS/MS‑based metabolomic characterization and comparison of pancreatic adenocarcinoma tissues using formalin‑fixed, paraffin‑embedded and optimal cutting temperature‑embedded materials Di Feng, Jing Yuan, Qi Liu, Li Liu, Xu Zhang, Yali Wu, Yifan Qian, Liping Chen, Yan Shi, Mancang Gu View Abstract ❯
Cellular and molecular alterations induced by low‑dose fisetin in human chronic myeloid leukemia cells Anna Klimaszewska‑Wiśniewska, Dariusz Grzanka, Paulina Czajkowska, Marta Hałas‑Wiśniewska, Justyna Durślewicz, Paulina Antosik, Alina Grzanka, Maciej Gagat View Abstract ❯
Ephrin‑B2 inhibits cell proliferation and motility in vitro and predicts longer metastasis‑free survival in breast cancer Zeljana Magic, Josefine Sandström, Gizeh Perez‑Tenorio View Abstract ❯
The HSP90 inhibitor onalespib potentiates 177Lu‑DOTATATE therapy in neuroendocrine tumor cells Sara Lundsten, Diana Spiegelberg, Bo Stenerlöw, Marika Nestor View Abstract ❯
Anisomycin inhibits angiogenesis in ovarian cancer by attenuating the molecular sponge effect of the lncRNA‑Meg3/miR‑421/PDGFRA axis Weiping Ye, Zhentian Ni, Shen Yicheng, Hao Pan, Yongyi Huang, Ying Xiong, Te Liu View Abstract ❯
NELFE promoted pancreatic cancer metastasis and the epithelial‑to‑mesenchymal transition by decreasing the stabilization of NDRG2 mRNA Lili Han, Ying Zan, Chen Huang, Shuqun Zhang View Abstract ❯
Tumor necrosis factor-α triggers opposing signals in head and neck squamous cell carcinoma and induces apoptosis via mitochondrial- and non-mitochondrial-dependent pathways Denis Selimovic, Renate U. Wahl, Emmanuelle Ruiz, Rizwan Aslam, Thomas W. Flanagan, Sofie-Yasmin Hassan, Simeon Santourlidis, Youssef Haikel, Paul Friedlander, Mosaad Megahed, Emad Kandil, Mohamed Hassan View Abstract ❯
Targeting the Hedgehog pathway in combination with X‑ray or carbon ion radiation decreases migration of MCF‑7 breast cancer cells Katrien Konings, Niels Belmans, Randy Vermeesen, Bjorn Baselet, Greta Lamers, Ann Janssen, Sofie Isebaert, Sarah Baatout, Karin Haustermans, Marjan Moreels View Abstract ❯
Minichromosome maintenance protein 10 as a marker for proliferation and prognosis in lung cancer Meng Wang, Songping Xie, Wen Yuan, Tian Xie, Muhammad Jamal, Jie Huang, Qian Yin, Hengya Song, Qiuping Zhang View Abstract ❯
In vitro and in vivo studies on the association of long non‑coding RNAs H19 and urothelial cancer associated 1 with the susceptibility to 5‑fluorouracil in rectal cancer Yasuyuki Yokoyama, Takashi Sakatani, Ryuichi Wada, Kousuke Ishino, Mitsuhiro Kudo, Michihiro Koizumi, Takeshi Yamada, Hiroshi Yoshida, Zenya Naito View Abstract ❯
Analyses of FGFR3 and PIK3CA mutations in neuroblastomas and the effects of the corresponding inhibitors on neuroblastoma cell lines Ourania N. Kostopoulou, Stefan Holzhauser, Birthe K.A. Lange, Anna Ohmayer, Teodora Andonova, Cinzia Bersani, Malin Wickström, Tina Dalianis View Abstract ❯
Upregulated expression of eIF3C is associated with malignant behavior in renal cell carcinoma Min Fan, Kai Wang, Xiaohui Wei, Hongwei Yao, Zhen Chen, Xiaozhou He View Abstract ❯
[Corrigendum] The pterocarpanquinone LQB-118 induces apoptosis in acute myeloid leukemia cells of distinct molecular subtypes and targets FoxO3a and FoxM1 transcription factors Gabriela Nestal De Moraes, Carolina Pereira Castro, Eduardo Jesus Salustiano, Matheus Lourenço Dumas, Fernanda Costas, Eric Wing-Fai Lam, Paulo Roberto Ribeiro Costa, Raquel Ciuvalschi Maia View Abstract ❯
[Corrigendum] CENPE promotes lung adenocarcinoma proliferation and is directly regulated by FOXM1 Lina Shan, Minjie Zhao, Ya Lu, Hongjuan Ning, Shuman Yang, Yonggui Song, Xianbao Shi, Wenshu Chai View Abstract ❯

10-12 October, 2019, Mystras Grand Palace Resort, Sparta, Greece 24nd World Congress on Advances in Oncology & 24th International Symposium on Molecular Medicine 8-9 October 2019, Pre-Congress Workshop: 'SNP genotyping and rare mutation detection in cancer with molecular methods'

7-9 May, 2019, Grand Hotel, Duca D'Este, Rome, Italy 26 th International Symposium on Molecular Medicine

MEDICAL NEWS & PERSPECTIVES, Philanthropists Fund Johns Hopkins Center for Study of Psychedelics Rita Rubin, MA Medical News Audio: Philanthropists Fund Johns Hopkins Center for Study of Psychedelics Quick Uptakes Medical Students Around the World Poorly Trained in Nutrition Jennifer Abbasi Viewpoint: Nutrition Education in Medical School, Residency Training, and Practice; Stephen Devries, MD; Walter Willett, MD, DrPH; Robert O. Bonow, MD, MS Original Investigation: US Burden of Diseases, Injuries, and Disease Risk Factors, 1990-2016; The US Burden of Disease Collaborators Medical News & Perspectives: Stephen Devries, MD: Training Physicians About Nutrition; Jennifer Abbasi AUDIO Medical News Audio Philanthropists Fund Johns Hopkins Center for Study of Psychedelics TRENDING NOW ON JAMA NETWORK OPEN Functional Medicine Model of Care and Patient-Reported Quality of Life Association of Neurocognitive and Physical Function With Gait Speed in Midlife Risk of Oral HPV in Sexually Active Vaccinated Female Adolescents Physical Activity and Fracture Risk Among Postmenopausal Women Association Between Angiotensin-Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, and Suicide

Listen and Subscribe to JAMA’s Medical News Podcast

Research Articles,

Disinfection of Cariogenic Pathogens in Planktonic Lifestyle, Biofilm and Carious Dentine with Antimicrobial Photodynamic Therapy,

Minjing Wu, Li Xu, Zhiyu Cai, Shan Huang, Yijun Li, Lishan Lei, Xiaojing Huang

Version of Record online: 22 October 2019

We compared the antibacterial effects of antimicrobial photodynamic therapy (aPDT) and 0.12% chlorhexidine (CHX) on Streptococcus mutans and Lactobacillus acidophilus in planktonic lifestyle, biofilm and carious dentine. Samples were treated with 0.1 mg mL⁻¹ toluidine blue O followed by irradiation with a light emission diode (λ − 635 ± 10 nm; 500 mW; 31.5 J cm⁻²; 60 s) and 0.12% CHX (60 s), respectively. Microbial culture analysis showed that aPDT achieved comparable antibacterial effects with 0.12% CHX against Lactobacillus acidophilus and showed greater bactericidal potential against Streptococcus mutans biofilm. Photosensitizer and light parameters need further optimization to eradicate Streptococcus mutans in dentine caries.

Research Articles

Photoinactivation Sensitivity of Staphylococcus carnosus to Visible‐light Irradiation as a Function of Wavelength

Katharina Hoenes, Ulla Wenzel, Barbara Spellerberg, Martin Hessling

Version of Record online: 22 October 2019

Approach of applying LEDs in a broad range but spectrally resolved (left) on a bacterial strain, to get knowledge about its endogenous photosensitizers (middle). Absorption spectra of possibly involved photosensitizers are measured and variably combined, while the mathematical calculation of a fit with the measured action spectrum of bacterial inactivation carves out the best match (right). The calculated factors indicate to which extent a certain photosensitizer contributes to the measured bactericidal effect. In this investigation, we derived flavins and zinc protoporphyrin IX most relevant for the photosensitizer composition of S. carnosus between 405 and 500 nm.

Special Issue Research Articles

Evaluation of Light Fluence Distribution Using an IR Navigation System for HPPH‐mediated Pleural Photodynamic Therapy (pPDT)

Timothy C. Zhu, Yihong Ong, Michele M. Kim, Xing Liang, Jarod C. Finlay, Andreea Dimofte, Charles B. Simone 2nd, Joseph S. Friedberg, Theresa M. Busch, Eli Glatstein, Keith A. Cengel

Version of Record online: 22 October 2019

 

Uniform light fluence distribution for patients undergoing photodynamic therapy (PDT) is critical to ensure predictable PDT outcomes. We have developed a real‐time infrared (IR) tracking camera to follow the movement of the light point source and to determine the surface contour of the treatment area. We conclude that it is feasible to use an IR camera‐based system to track the motion of the light source during PDT and demonstrate its use to quantify the uniformity of light distribution, which deviated by a standard deviation of 18% from the prescribed light dose.

Special Issue Research Articles

Weather‐informed Light–tissue Model–Based Dose Planning for Indoor Daylight Photodynamic Therapy

Ethan P. M. LaRochelle, Michael Shane Chapman, Edward V. Maytin, Tayyaba Hasan, Brian W. Pogue

Version of Record online: 21 October 2019

 

A one‐time site assessment can be used to determine appropriate sites for daylight‐PDT treatments throughout the year. Spectral measurements taken during this site assessment can then be correlated with real‐time weather data to improve light dose estimates.

Research Articles

Analyzing the Synergistic Effects of Antioxidants in Combating Photoaging Using Model Nematode, Caenorhabditis elegans

Mani Iyer Prasanth, Subramanyam Gayathri, James Prabhanand Bhaskar, Venkateswaran Krishnan, Krishnaswamy Balamurugan

Version of Record online: 21 October 2019

Schematic representation showing the initiation of aging and photoaging process inside the cells exposed to UV‐A. Treating the cells with antioxidants has reduced the level of aging and photoaging. Further, the combination of selective antioxidants could reduce the level of aging and photoaging in a greater manner than that of the individual effects.

Research Articles

A Dual Emissive Coumarin–urea Derivative with an Electron‐withdrawing Substituent in the Presence of Acetate Anion

Tomoyuki Shinoda, Yoshinobu Nishimura, Tatsuo Arai

Version of Record online: 20 October 2019

 

Coumarin–urea derivatives showed significant differences in tautomer formation depending on the positions of a urea moiety substituted on the coumarin ring in the presence of acetate ion. Furthermore, the substitution of a CF₃ group resulted in a remarkable improvement of its fluorescence quantum yield. These findings will contribute to new molecular design of highly fluorescent anion sensors.