Chemo-radiation outcomes for esophageal cancer: A reflection from a tertiary cancer center on selection of patients for more aggressive therapy

Chemo-radiation outcomes for esophageal cancer: A reflection from a tertiary cancer center on selection of patients for more aggressive therapy:



Janaki Gururajachar Manur, M G John Sebastian, Savitha Mary David



Indian Journal of Cancer 2020 57(1):84-88



Introduction: Most esophageal cancer patients present with poor nutritional status and may not tolerate radical treatment.

Aim: We aim to identify patients who are good candidates for chemo-radiation (CTRT).

Materials and Methods: Fifty-four patients treated with CTRT were followed up for a mean period of 28 months and factors affecting the outcome were analyzed along with the recurrence pattern.

Results:Forty-eight patients (88%) received CTRT and all completed treatment as scheduled. Eighteen (32%), 15 (27%) patients were alive with and without disease, respectively, at 28 months while 20 (37%) were dead. There was no statistically significant correlation between local failure and any of the factors like length, grade of the tumor, and chemotherapy received.

Conclusion: Esophageal cancer patients present at an advanced stage and hence careful selection of patients for radical CTRT is very important for providing relatively longer disease-free interval. Equally important is the close monitoring of patients during treatment which helps in completing the planned treatment which translates into a better long-term outcome.