A Zebrafish JAK1-A634D Gain-of-Function Model Provides New Insights into the Pathogenesis of Familial Hypereosinophilia

GSE142599 A Zebrafish JAK1-A634D Gain-of-Function Model Provides New Insights into the Pathogenesis of Familial Hypereosinophilia: Contributors : Anna Cordeiro-Santanach ; Sergey V Prykhozhij ; Adam P Deveau ; Gabriel Wajnberg ; Nicolas Crapoulet ; Stuart E Turvey ; Jason N Berman

Series Type : Expression profiling by high throughput sequencing

Organism : Danio rerio

JAK1 plays an important role during zebrafish development as hematopoietic regulator with a specific impact in the myeloid lineage, from where the eosinophils arise. Several genes in the JAK-STAT pathway are elevated in the transgenic mutants (STAT1B, SOCS3A, SOCS3B, PIAS2) as well as patways involved in hematopoiesis, immunity, response to interferon and response to biotic stimuli.