Cyclooxygenase activity in bradykinin-induced dermal extravasation

Cyclooxygenase activity in bradykinin-induced dermal extravasation. A study in mice and humans: ConclusionThese data suggest that COX activity contributes to bradykinin-induced dermal extravasation in mice and humans. In addition, our findings may open new treatment options and point to a potential activity of drugs interfering with the release of the COX substrate arachidonic acid, e.g. glucocorticoids.Graphical abstractGraphical illustration of the potential role of prostaglandin formation for dermal extravasation induced by activation of bradykinin type 2 receptors (B2). B2 translates the bradykinin signal via the Gq transduction pathway including generation of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) resulting in an increase of the intracellular concentration of Ca2+. This ion binds and activates a variety of intracellular proteins. Among those, binding to calm...

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