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J Clin Endocrinol Metab. 2019 Dec 13;:
Authors: Jarvie EM, Stewart FM, Ramsay JE, Brown EA, Meyer BJ, Olivecrona G, Griffin BA, Freeman DJ
Abstract
CONTEXT: Maternal body mass index (BMI) is associated with increased birth weight but does not explain all the variance in fetal adiposity.
OBJECTIVE: To assess the contribution of maternal body fat distribution to offspring birth weight and adiposity.
DESIGN: Longitudinal study throughout gestation and at delivery.
SETTING: Women recruited at 12 weeks of gestation and followed up at 26 and 36 weeks. Cord blood was collected at delivery.
PATIENTS: Pregnant women (n=45) with BMI 18.0-46.3 kg/m2 and healthy pregnancy outcome.
METHODS: Maternal first trimester abdominal subcutaneous and visceral adipose tissue thickness (SAT and VAT) was assessed by ultrasound.
RESULTS: VAT was the only anthropometric measure independently associated with birth weight centile (r2 adjusted 15.8%, P=0.002). BMI was associated with trimester 2 and trimester 1 - 3 area under the curve (AUC) glucose and insulin resistance (HOMA). SAT alone predicted trimester 2 lipoprotein lipase (LPL) mass (a marker of adipocyte insulin sensitivity) (11.3%, P=0.017). VAT was associated with fetal triglyceride (9.3%, P=0.047). Placental weight was the only independent predictor of fetal adiposity (48%, P<0.001). Maternal trimester 2 and AUC LPL were inversely associated with fetal adiposity (r=-0.69, P=0.001 and r=-0.58, P=0.006 respectively).
CONCLUSIONS: Maternal VAT provides additional information to BMI for prediction of birth weight. VAT may be a marker of reduced SAT expansion and increased availability of maternal fatty acids for placental transport.
PMID: 31832635 [PubMed - as supplied by publisher]
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