Κυριακή 15 Δεκεμβρίου 2019

Spontaneous progression of experimental peri‐implantitis in augmented and pristine bone. A pre‐clinical in vivo study

Spontaneous progression of experimental peri‐implantitis in augmented and pristine bone. A pre‐clinical in vivo study:

Abstract

Objective

To examine progression of experimental peri‐implantitis around different implants placed in augmented and pristine sites.

M&M

6 Labrador dogs were used. 3 months after tooth extraction, 4 implants with different surface modifications were installed on each side of the mandible. A standard osteotomy was applied on one side, while on the contralateral side the osteotomy was modified, resulting in a gap between the implant and the bone wall. The gap was filled with a bone substitute and covered by a resorbable membrane. 3 months after implant installation, implants were exposed and healing abutments were connected. 2 months later, oral hygiene procedures were abandoned and a cotton ligature was placed in a submarginal position around the neck of all implants and kept in place for 4 weeks. Following ligature removal, plaque formation continued for 6 months (spontaneous progression period). Radiographs were obtained throughout the experiment and biopsies were collected and prepared for histological evaluation at the end of the spontaneous progression period.

Results

Differences in bone loss during the spontaneous progression period between pristine and augmented sites were small. The size and vertical dimension of the peri‐implantitis lesion were larger at augmented than at pristine sites. Implants with non‐modified surfaces exhibited smaller amounts of bone loss and smaller dimensions of peri‐implantitis lesions than implants with modified surfaces.

Conclusion

Small differences in spontaneous progression of peri‐implantitis were detected between pristine and augmented sites. Implants with modified surfaces exhibited more bone loss and larger lesions than implants with non‐modified surfaces, irrespective of the type of surrounding bone.

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