Toxic Optic Neuropathy From Quinine Overdose

Toxic Optic Neuropathy From Quinine Overdose: Abstract:

A 45-year-old man presented with longstanding poor vision in both eyes. His medical history was significant for a remote overdose of quinine. After the ingestion, he fell into a coma and on awakening was not able to see light out of both eyes. Several days later, his central vision began to gradually recover and continued to improve over the span of several months. Presently, he had 20/20 visual acuity in both eyes with severely constricted peripheral visual fields. There were bilateral iris transillumination defects, and both optic nerves were diffusely pale with attenuated vasculature and inner retinal thinning on ocular coherence tomography. We present a patient with the stereotypical findings and natural history of quinine toxicity, a rare and not widely known cause of toxic optic neuropathy and retinopathy.

Address correspondence to Paul R. Freund, MD, Department of Ophthalmology and Vision Sciences, University of Toronto, 801 Eglinton Avenue W, Ste 301, Toronto, ON M5N 1E3, Canada; E-mail: pfreund@ualberta.ca

The authors report no conflicts of interest.

© 2019 by North American Neuro-Ophthalmology Society