Abstract
Objectives
A treatment regimen consisting of bendamustine and brentuximab vedotin (BV) has been described as a highly potent salvage therapy and as an effective induction therapy leading to high response rates before autologous stem cell transplantation (ASCT) in patients with classical Hodgkin lymphoma (cHL). In this retrospective analysis, we aimed to assess this therapy’s efficacy in unselected patients with cHL and CD30+ peripheral T cell lymphoma (PTCL).Patients and methods
Data of 28 patients with cHL and 5 patients with PTCL treated with a combination of bendamustine and BV at three Austrian tertiary cancer centers were analyzed.Results
In patients with cHL, the ORR was 100% (78.6% CR, 21.4% PR). After 17 months median follow‐up, median survival times were not reached; 1‐year‐PFS was 81.9% and 1‐year‐OS was 95.7%. Thirteen eligible patients (46.4%) successfully underwent planned ASCT after salvage therapy with bendamustine and BV and subsequent high dose chemotherapy.Three of the five PTCL patients achieved CR, while two did not respond and died during or shortly after therapy.
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