Brain Sciences, Vol. 9, Pages 376: A Hybrid Feature Pool-Based Emotional Stress State Detection Algorithm Using EEG Signals Brain Sciences doi: 10.3390/brainsci9120376 Authors: Hasan Kim Human stress analysis using electroencephalogram (EEG) signals requires a detailed and domain-specific information pool to develop an effective machine learning model. In this study, a multi-domain hybrid feature pool is designed to identify most of the important information from the signal. The...
Fri Dec 13, 2019 02:00
Brain Sciences, Vol. 9, Pages 374: Spatial Neglect in Stroke: Identification, Disease Process and Association with Outcome During Inpatient Rehabilitation Brain Sciences doi: 10.3390/brainsci9120374 Authors: Ulrike Hammerbeck Matthew Gittins Andy Vail Lizz Paley Sarah F Tyson Audrey Bowen We established spatial neglect prevalence, disease profile and amount of therapy that inpatient stroke survivors received, and outcomes at discharge using Sentinel Stroke National Audit...
Fri Dec 13, 2019 02:00
Brain Sciences, Vol. 9, Pages 375: Neuroendocrine and Inflammatory Effects of Childhood Trauma Following Psychosocial and Inflammatory Stress in Women with Remitted Major Depressive Disorder Brain Sciences doi: 10.3390/brainsci9120375 Authors: Laura L.M. Cassiers Peter Niemegeers Erik Fransen Manuel Morrens Peter De Boer Luc Van Nueten Stephan Claes Bernard G.C. Sabbe Filip Van Den Eede The dysregulation of the inflammatory and neuroendocrine systems seen in major...
Fri Dec 13, 2019 02:00
Brain Sciences, Vol. 9, Pages 372: A Comprehensive sLORETA Study on the Contribution of Cortical Somatomotor Regions to Motor Imagery Brain Sciences doi: 10.3390/brainsci9120372 Authors: Mustafa Yazici Mustafa Ulutas Mukadder Okuyan Brain–computer interface (BCI) is a technology used to convert brain signals to control external devices. Researchers have designed and built many interfaces and applications in the last couple of decades. BCI is used for prevention, detection,...
Fri Dec 13, 2019 02:00
Brain Sciences, Vol. 9, Pages 373: Cortical Thickness Links Impulsive Personality Traits and Risky Behavior Brain Sciences doi: 10.3390/brainsci9120373 Authors: Rickie Miglin Nadia Bounoua Shelly Goodling Ana Sheehan Jeffrey M. Spielberg Naomi Sadeh Impulsive personality traits are often predictive of risky behavior, but not much is known about the neurobiological basis of this relationship. We investigated whether thickness of the cortical mantle varied as a function...
Fri Dec 13, 2019 02:00
Brain Sciences, Vol. 9, Pages 371: Co-Morbid Insomnia and Sleep Apnea (COMISA): Prevalence, Consequences, Methodological Considerations, and Recent Randomized Controlled Trials Brain Sciences doi: 10.3390/brainsci9120371 Authors: Alexander Sweetman Leon Lack Célyne Bastien Co-morbid insomnia and sleep apnea (COMISA) is a highly prevalent and debilitating disorder, which results in additive impairments to patients’ sleep, daytime functioning, and quality of life, and complex...
Thu Dec 12, 2019 02:00
Brain Sciences, Vol. 9, Pages 370: Helicobacter pylori, Vascular Risk Factors and Cognition in U.S. Older Adults Brain Sciences doi: 10.3390/brainsci9120370 Authors: Cárdenas Boller Román Previous studies suggested that Helicobacter pylori infection could be a risk factor for stroke, dementia, and Alzheimer’s disease (AD). The authors examined data from participants, 60 years old and older in the Third National Health and Nutrition Examination Survey (NHANES-III) to...
Thu Dec 12, 2019 02:00
Brain Sciences, Vol. 9, Pages 369: Protective Effects of Scolopendra Water Extract on Trimethyltin-Induced Hippocampal Neurodegeneration and Seizures in Mice Brain Sciences doi: 10.3390/brainsci9120369 Authors: Yun-Soo Seo Mary Jasmin Ang Byeong Cheol Moon Hyo Seon Kim Goya Choi Hye-Sun Lim Sohi Kang Mijin Jeon Sung-Ho Kim Changjong Moon Joong Sun Kim Trimethyltin (TMT) is an organotin compound with potent neurotoxic action characterized by neuronal degeneration...
Thu Dec 12, 2019 02:00
Cancers, Vol. 11, Pages 2024: Chimeric Antigen Receptor T-Cell Therapy for Multiple Myeloma Cancers doi: 10.3390/cancers11122024 Authors: Naoki Hosen CD19 Chimeric antigen receptor (CAR) T cell therapy has been shown to be effective for B cell leukemia and lymphoma. Many researchers are now trying to develop CAR T cells for various types of cancer. For multiple myeloma (MM), B-cell maturation antigen (BCMA) has been recently proved to be a promising target. However, cure of MM is still...
Sun Dec 15, 2019 02:00
Cancers, Vol. 11, Pages 2023: Identification of a Subtype of Hepatocellular Carcinoma with Poor Prognosis Based on Expression of Genes within the Glucose Metabolic Pathway Cancers doi: 10.3390/cancers11122023 Authors: Xiaoli Zhang Jin Li Kalpana Ghoshal Soledad Fernandez Lang Li Hepatocellular carcinoma (HCC) is the most prevalent primary cancer and a highly aggressive liver malignancy. Liver cancer cells reprogram their metabolism to meet their needs for rapid proliferation...
Sat Dec 14, 2019 02:00
Cancers, Vol. 11, Pages 2022: Immunotherapy in Pediatric Solid Tumors—A Systematic Review Cancers doi: 10.3390/cancers11122022 Authors: Raoud Marayati Colin H. Quinn Elizabeth A. Beierle Despite advances in the treatment of many pediatric solid tumors, children with aggressive and high-risk disease continue to have a dismal prognosis. For those presenting with metastatic or recurrent disease, multiple rounds of intensified chemotherapy and radiation are the typical course of action,...
Sat Dec 14, 2019 02:00
Cancers, Vol. 11, Pages 2021: Inhibitor of DNA-Binding Protein 4 Suppresses Cancer Metastasis through the Regulation of Epithelial Mesenchymal Transition in Lung Adenocarcinoma Cancers doi: 10.3390/cancers11122021 Authors: Chi-Chung Wang Yuan-Ling Hsu Chi-Jen Chang Chia-Jen Wang Tzu-Hung Hsiao Szu-Hua Pan Metastasis is a predominant cause of cancer death and the major challenge in treating lung adenocarcinoma (LADC). Therefore, exploring new metastasis-related genes and...
Sat Dec 14, 2019 02:00
Cancers, Vol. 11, Pages 2020: Low Systemic Levels of Chemokine C-C Motif Ligand 3 (CCL3) are Associated with a High Risk of Venous Thromboembolism in Patients with Glioma Cancers doi: 10.3390/cancers11122020 Authors: Pegah Mir Seyed Nazari Christine Marosi Florian Moik Julia Riedl Öykü Özer Anna Sophie Berghoff Matthias Preusser Johannes A. Hainfellner Ingrid Pabinger Gerhard J. Zlabinger Cihan Ay A tight interplay between inflammation and hemostasis has...
Sat Dec 14, 2019 02:00
Cancers, Vol. 11, Pages 2019: Tumor Suppressor Function of miR-127-3p and miR-376a-3p in Osteosarcoma Cells Cancers doi: 10.3390/cancers11122019 Authors: Joerg Fellenberg Burkhard Lehner Heiner Saehr Astrid Schenker Pierre Kunz Since the introduction of high-dose chemotherapy about 35 years ago, survival rates of osteosarcoma patients have not been significantly improved. New therapeutic strategies replacing or complementing conventional chemotherapy are therefore urgently...
Sat Dec 14, 2019 02:00
Cancers, Vol. 11, Pages 2017: Aberrant Protein Phosphorylation in Cancer by Using Raman Biomarkers Cancers doi: 10.3390/cancers11122017 Authors: Halina Abramczyk Anna Imiela Beata Brożek-Płuska Monika Kopeć Jakub Surmacki Agnieszka Śliwińska (1) Background: Novel methods are required for analysing post-translational modifications of protein phosphorylation by visualizing biochemical landscapes of proteins in human normal and cancerous tissues and cells. (2) Methods: A...
Fri Dec 13, 2019 02:00
Cancers, Vol. 11, Pages 2018: What Is the Role of Interleukins in Breast Cancer Bone Metastases? A Systematic Review of Preclinical and Clinical Evidence Cancers doi: 10.3390/cancers11122018 Authors: Salamanna Borsari Contartese Costa Giavaresi Fini Breast cancer cells produce stimulators of bone resorption known as interleukins (ILs). However, data on the functional roles of ILs in the homing of metastatic breast cancer to bone are still fragmented. A systematic...
Fri Dec 13, 2019 02:00
Cancers, Vol. 11, Pages 2015: Pursuing a Curative Approach in Multiple Myeloma: A Review of New Therapeutic Strategies Cancers doi: 10.3390/cancers11122015 Authors: Mattia D'Agostino Luca Bertamini Stefania Oliva Mario Boccadoro Francesca Gay Multiple myeloma (MM) is still considered an incurable hematologic cancer and, in the last decades, the treatment goal has been to obtain a long-lasting disease control. However, the recent availability of new effective drugs has led...
Fri Dec 13, 2019 02:00
Cancers, Vol. 11, Pages 2016: Dose-Limiting Organs at Risk in Carbon Ion Re-Irradiation of Head and Neck Malignancies: An Individual Risk-Benefit Tradeoff Cancers doi: 10.3390/cancers11122016 Authors: Thomas Held Semi B. Harrabi Kristin Lang Sati Akbaba Paul Windisch Denise Bernhardt Stefan Rieken Klaus Herfarth Jürgen Debus Sebastian Adeberg Background: Carbon ion re-irradiation (CIR) was evaluated to investigate treatment planning and the consequences of...
Fri Dec 13, 2019 02:00
Cancers, Vol. 11, Pages 2014: HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A Cancers doi: 10.3390/cancers11122014 Authors: Daniel Andrade Meghna Mehta James Griffith Sangphil Oh Joshua Corbin Anish Babu Supriyo De Allshine Chen Yan D. Zhao Sanam Husain Sudeshna Roy Liang Xu Jeffrey Aube Ralf Janknecht Myriam Gorospe Terence Herman Rajagopal Ramesh Anupama Munshi Tumor suppressor ARID1A, a subunit of the chromatin...
Fri Dec 13, 2019 02:00
Cancers, Vol. 11, Pages 2011: Cold Atmospheric Plasma Restores Paclitaxel Sensitivity to Paclitaxel-Resistant Breast Cancer Cells by Reversing Expression of Resistance-Related Genes Cancers doi: 10.3390/cancers11122011 Authors: Sungbin Park Heejoo Kim Hwee Won Ji Hyeon Woo Kim Sung Hwan Yun Eun Ha Choi Sun Jung Kim Paclitaxel (Tx) is a widely used therapeutic chemical for breast cancer treatment; however, cancer recurrence remains an obstacle for improved prognosis...
Fri Dec 13, 2019 02:00
Cancers, Vol. 11, Pages 2012: Breast-Associated Adipocytes Secretome Induce Fatty Acid Uptake and Invasiveness in Breast Cancer Cells via CD36 Independently of Body Mass Index, Menopausal Status and Mammary Density Cancers doi: 10.3390/cancers11122012 Authors: Maurice Zaoui Mehdi Morel Nathalie Ferrand Soraya Fellahi Jean-Philippe Bastard Antonin Lamazière Annette Kragh Larsen Véronique Béréziat Michael Atlan Michèle Sabbah Breast adiposity is correlated with...
Fri Dec 13, 2019 02:00
Cancers, Vol. 11, Pages 2013: Impact of ATM and DNA-PK Inhibition on Gene Expression and Individual Response of Human Lymphocytes to Mixed Beams of Alpha Particles and X-Rays Cancers doi: 10.3390/cancers11122013 Authors: Lei Cheng Beata Brzozowska-Wardecka Halina Lisowska Andrzej Wojcik Lovisa Lundholm Accumulating evidence suggests a synergistic effect in cells simultaneously exposed to different types of clustered and dispersed DNA damage. We aimed to analyse the effect...
Fri Dec 13, 2019 02:00
Cancers, Vol. 11, Pages 2010: Targeting the Tumor Microenvironment: An Unexplored Strategy for Mutant KRAS Tumors Cancers doi: 10.3390/cancers11122010 Authors: Patrícia Dias Carvalho Ana Luísa Machado Flávia Martins Raquel Seruca Sérgia Velho Current evidence strongly suggests that cancer cells depend on the microenvironment in order to thrive. In fact, signals from the surrounding tumor microenvironment are crucial for cancer cells´ aggressiveness, altering their...
Fri Dec 13, 2019 02:00
Cancers, Vol. 11, Pages 2006: Somatic Mutation of PIK3CA (H1047R) Is a Common Driver Mutation Hotspot in Canine Mammary Tumors as Well as Human Breast Cancers Cancers doi: 10.3390/cancers11122006 Authors: Kang-Hoon Lee Hyeon-Ji Hwang Hyun Ji Noh Tae-Jin Shin Je-Yoel Cho Breast cancer is one of the most frequently diagnosed cancers in both women and female dogs. Genome-wide association studies in human breast cancer (HBC) have identified hundreds of genetic variations and...
Thu Dec 12, 2019 02:00
Cancers, Vol. 11, Pages 2007: Prediction of Colon Cancer Stages and Survival Period with Machine Learning Approach Cancers doi: 10.3390/cancers11122007 Authors: Gupta Chiang Sahoo Mohapatra You Onthoni Hung Chiang Huang Tsai The prediction of tumor in the TNM staging (tumor, node, and metastasis) stage of colon cancer using the most influential histopathology parameters and to predict the five years disease-free survival (DFS) period using machine...
Thu Dec 12, 2019 02:00
Cancers, Vol. 11, Pages 2008: Long Non-Coding RNA MAGI2-AS3 is a New Player with a Tumor Suppressive Role in High Grade Serous Ovarian Carcinoma Cancers doi: 10.3390/cancers11122008 Authors: Priyanka Gokulnath Tiziana de Cristofaro Ichcha Manipur Tina Di Palma Amata Amy Soriano Mario Rosario Guarracino Mariastella Zannini High-Grade Serous Ovarian Carcinoma (HGSC) is the most incidental and lethal subtype of epithelial ovarian cancer (EOC) with a high mortality rate...
Thu Dec 12, 2019 02:00
Cancers, Vol. 11, Pages 2009: Immunotherapy for Multiple Myeloma Cancers doi: 10.3390/cancers11122009 Authors: Hideto Tamura Mariko Ishibashi Mika Sunakawa Koiti Inokuchi Despite therapeutic advances over the past decades, multiple myeloma (MM) remains a largely incurable disease with poor prognosis in high-risk patients, and thus new treatment strategies are needed to achieve treatment breakthroughs. MM represents various forms of impaired immune surveillance characterized...
Thu Dec 12, 2019 02:00
Cancers, Vol. 11, Pages 2005: Implementing Patient-Derived Xenografts to Assess the Effectiveness of Cyclin-Dependent Kinase Inhibitors in Glioblastoma Cancers doi: 10.3390/cancers11122005 Authors: Janis J. Noonan Monika Jarzabek Frank A. Lincoln Brenton L. Cavanagh Arhona R. Pariag Viktorija Juric Leonie S. Young Keith L. Ligon Hanne Jahns Daniella Zheleva Jochen H. M. Prehn Markus Rehm Annette T. Byrne Brona M. Murphy Glioblastoma (GBM) is the...
Thu Dec 12, 2019 02:00
Cancers, Vol. 11, Pages 2004: Higher CCL22+ Cell Infiltration is Associated with Poor Prognosis in Cervical Cancer Patients Cancers doi: 10.3390/cancers11122004 Authors: Wang Schmoeckel Kost Kuhn Vattai Vilsmaier Mahner Mayr Jeschke Heidegger The chemokine CCL22 recruits regulatory T (T-reg) cells into tumor tissues and is expressed in many human tumors. However, the prognostic role of CCL22 in cervical cancer (CC) has not been determined. This study...
Thu Dec 12, 2019 02:00
Cancers, Vol. 11, Pages 2002: JAK-STAT Signaling: A Double-Edged Sword of Immune Regulation and Cancer Progression Cancers doi: 10.3390/cancers11122002 Authors: Katie L. Owen Natasha K. Brockwell Belinda S. Parker Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling mediates almost all immune regulatory processes, including those that are involved in tumor cell recognition and tumor-driven immune escape. Antitumor immune responses are largely driven...
Thu Dec 12, 2019 02:00
Cancers, Vol. 11, Pages 2001: The Genetic Architecture of Gliomagenesis–Genetic Risk Variants Linked to Specific Molecular Subtypes Cancers doi: 10.3390/cancers11122001 Authors: Wendy Yi-Ying Wu Gunnar Johansson Carl Wibom Thomas Brännström Annika Malmström Roger Henriksson Irina Golovleva Melissa L. Bondy Ulrika Andersson Anna M. Dahlin Beatrice Melin Genome-wide association studies have identified 25 germline genetic loci that increase the risk of glioma....
Thu Dec 12, 2019 02:00
Cancers, Vol. 11, Pages 2003: Adjuvant Therapy for High-Risk Stage II or III Colon Adenocarcinoma: A Propensity Score-Matched, Nationwide, Population-Based Cohort Study Cancers doi: 10.3390/cancers11122003 Authors: Chia-Lun Chang Kevin Sheng-Po Yuan Alexander T.H. Wu Szu-Yuan Wu Purpose: To determine the optimal adjuvant chemotherapy regimen for patients with high-risk stage II or III colon adenocarcinoma, we conducted this propensity score-matched, nationwide, population-based...
Thu Dec 12, 2019 02:00
Cancers, Vol. 11, Pages 1997: An Effective Multi-Stage Liposomal DNA Origami Nanosystem for In Vivo Cancer Therapy Cancers doi: 10.3390/cancers11121997 Authors: Stefano Palazzolo Mohamad Hadla Concetta Russo Spena Isabella Caligiuri Rossella Rotondo Muhammad Adeel Vinit Kumar Giuseppe Corona Vincenzo Canzonieri Giuseppe Toffoli Flavio Rizzolio DNA origami systems could be important candidates for clinical applications. Unfortunately, their intrinsic properties...
Thu Dec 12, 2019 02:00
Cancers, Vol. 11, Pages 1999: 5-Fluorouracil as a Tumor-Treating Field-Sensitizer in Colon Cancer Therapy Cancers doi: 10.3390/cancers11121999 Authors: Yeon-Joo Lee Jae-Min Cho Sei Sai Ju Yeon Oh Ji-Ae Park Se Jong Oh Misun Park Junhye Kwon Ui Sup Shin Jeong-Hwa Beak Sun Ha Lim Jie-Young Song Sang-Gu Hwang Eun Ho Kim Colorectal cancer (CRC) is a major cause of mortality that can be treated effectively with chemotherapy and radiotherapy, although...
Thu Dec 12, 2019 02:00
Cancers, Vol. 11, Pages 2000: Extracellular Vesicles-Based Biomarkers Represent a Promising Liquid Biopsy in Endometrial Cancer Cancers doi: 10.3390/cancers11122000 Authors: Carolina Herrero Alexandre de la Fuente Carlos Casas-Arozamena Victor Sebastian Martin Prieto Manuel Arruebo Alicia Abalo Eva Colás Gema Moreno-Bueno Antonio Gil-Moreno Ana Vilar Juan Cueva Miguel Abal Laura Muinelo-Romay Tumor-derived extracellular vesicles (EVs) are secreted...
Thu Dec 12, 2019 02:00
Cancers, Vol. 11, Pages 1998: Role of Damage DNA-Binding Protein 1 in Pancreatic Cancer Progression and Chemoresistance Cancers doi: 10.3390/cancers11121998 Authors: Yiyin Zhang Yubin Lei Jin Xu Jie Hua Bo Zhang Jiang Liu Chen Liang Qingcai Meng Xianjun Yu Si Shi Damaged DNA-binding protein 1 (DDB1) recruits nucleotide excision pathway proteins to form the UV-damaged DNA-binding protein complex and is required for DNA repair. DDB1 was reported to participate...
Thu Dec 12, 2019 02:00
Cells, Vol. 8, Pages 1646: Copresentation of BMP-6 and RGD Ligands Enhances Cell Adhesion and BMP-Mediated Signaling Cells doi: 10.3390/cells8121646 Authors: Francesca Posa Anna Luise Grab Volker Martin Dirk Hose Anja Seckinger Giorgio Mori Slobodan Vukicevic Elisabetta Ada Cavalcanti-Adam We report on the covalent immobilization of bone morphogenetic protein 6 (BMP-6) and its co-presentation with integrin ligands on a nanopatterned platform to study cell adhesion...
Sun Dec 15, 2019 02:00
Cells, Vol. 8, Pages 1645: Temporal Dynamics of VEGFA-Induced VEGFR2/FAK Co-Localization Depend on SHB Cells doi: 10.3390/cells8121645 Authors: Ilkka Pietilä Djenolan Van Mourik Andreas Tamelander Vitezslav Kriz Lena Claesson-Welsh Anders Tengholm Michael Welsh Focal adhesion kinase (FAK) is essential for vascular endothelial growth factor-A (VEGFA)/VEGF receptor-2 (VEGFR2)-stimulated angiogenesis and vascular permeability. We have previously noted that presence of...
Sun Dec 15, 2019 02:00
Cells, Vol. 8, Pages 1644: Genetically Engineered Lung Cancer Cells for Analyzing Epithelial–Mesenchymal Transition Cells doi: 10.3390/cells8121644 Authors: Michał Kiełbus Jakub Czapiński Joanna Kałafut Justyna Woś Andrzej Stepulak Adolfo Rivero-Müller Cell plasticity, defined as the ability to undergo phenotypical transformation in a reversible manner, is a physiological process that also exerts important roles in disease progression. Two forms of cellular plasticity...
Sun Dec 15, 2019 02:00
Cells, Vol. 8, Pages 1643: STK3/4 Expression Is Regulated in Uterine Endometrial Cells during the Estrous Cycle Cells doi: 10.3390/cells8121643 Authors: Sohyeon Moon Ok-Hee Lee Sujin Lee Jihyun Lee Haeun Park Miseon Park Eun Mi Chang Keun-Hong Park Youngsok Choi The uterus is dynamically regulated in response to various signaling triggered by hormones during the estrous cycle. The Hippo signaling pathway is known as an important signaling for regulating cellular...
Sun Dec 15, 2019 02:00
Cells, Vol. 8, Pages 1647: Myeloid-Derived Suppressor Cells: Major Figures that Shape the Immunosuppressive and Angiogenic Network in Cancer Cells doi: 10.3390/cells8121647 Authors: Eleni-Kyriaki Vetsika Aristeidis Koukos Athanasios Kotsakis Myeloid-derived suppressor cells (MDSCs) constitute a vast population of immature myeloid cells implicated in various conditions. Most notably, their role in cancer is of great complexity. They exert immunosuppressive functions like hampering...
Sun Dec 15, 2019 02:00
Cells, Vol. 8, Pages 1641: Critical Impact of Human Amniotic Membrane Tension on Mitochondrial Function and Cell Viability In Vitro Cells doi: 10.3390/cells8121641 Authors: Laura Poženel Andrea Lindenmair Katy Schmidt Andrey V. Kozlov Johannes Grillari Susanne Wolbank Asmita Banerjee Adelheid Weidinger Amniotic cells show exciting stem cell features, which has led to the idea of using living cells of human amniotic membranes (hAMs) in toto for clinical applications....
Sun Dec 15, 2019 02:00
Cells, Vol. 8, Pages 1642: The Microbiome–Estrogen Connection and Breast Cancer Risk Cells doi: 10.3390/cells8121642 Authors: Sheetal Parida Dipali Sharma The microbiome is undoubtedly the second genome of the human body and has diverse roles in health and disease. However, translational progress is limited due to the vastness of the microbiome, which accounts for over 3.3 million genes, whose functions are still unclear. Numerous studies in the past decade have demonstrated how microbiome...
Sun Dec 15, 2019 02:00
Cells, Vol. 8, Pages 1639: Knock Down of Plakophillin 2 Dysregulates Adhesion Pathway through Upregulation of miR200b and Alters the Mechanical Properties in Cardiac Cells Cells doi: 10.3390/cells8121639 Authors: Luca Puzzi Daniele Borin Priyatansh Gurha Raffaella Lombardi Valentina Martinelli Marek Weiss Laura Andolfi Marco Lazzarino Luisa Mestroni Ali J. Marian Orfeo Sbaizero Background: Mutations in genes encoding intercalated disk/desmosome proteins,...
Sat Dec 14, 2019 02:00
Cells, Vol. 8, Pages 1640: The Effect of Fibroblast Growth Factor 15 Signaling in Non-Steatotic and Steatotic Liver Transplantation from Cardiocirculatory Death Cells doi: 10.3390/cells8121640 Authors: Cindy G. Avalos-de León Mónica B. Jiménez-Castro María Eugenia Cornide-Petronio José Gulfo Floriana Rotondo Jordi Gracia-Sancho Araní Casillas-Ramírez Carmen Peralta We elucidate the relevance of fibroblast growth factor 15 (FGF15) in liver transplantation (LT) using...
Sat Dec 14, 2019 02:00
Cells, Vol. 8, Pages 1637: Identification and Validation Model for Informative Liquid Biopsy-Based microRNA Biomarkers: Insights from Germ Cell Tumor In Vitro, In Vivo and Patient-Derived Data Cells doi: 10.3390/cells8121637 Authors: João Lobo Ad J.M. Gillis Annette van den Berg Lambert C.J. Dorssers Gafanzer Belge Klaus-Peter Dieckmann Henk P. Roest Luc J.W. van der Laan Jourik Gietema Robert J. Hamilton Carmen Jerónimo Rui Henrique Daniela Salvatori Leendert...
Sat Dec 14, 2019 02:00
Cells, Vol. 8, Pages 1638: Non-Coding RNAs in IGF-1R Signaling Regulation: The Underlying Pathophysiological Link between Diabetes and Cancer Cells doi: 10.3390/cells8121638 Authors: Baoqing Chen Junyan Li Dongmei Chi Iman Sahnoune Steliana Calin Leonard Girnita George A. Calin The intricate molecular network shared between diabetes mellitus (DM) and cancer has been broadly understood. DM has been associated with several hormone-dependent malignancies, including breast,...
Sat Dec 14, 2019 02:00
Cells, Vol. 8, Pages 1636: The Role of NF-κB in Physiological Bone Development and Inflammatory Bone Diseases: Is NF-κB Inhibition “Killing Two Birds with One Stone”? Cells doi: 10.3390/cells8121636 Authors: Eijiro Jimi Nana Takakura Fumitaka Hiura Ichiro Nakamura Shizu Hirata-Tsuchiya Nuclear factor-κB (NF-κB) is a transcription factor that regulates the expression of various genes involved in inflammation and the immune response. The activation of NF-κB...
Sat Dec 14, 2019 02:00
Cells, Vol. 8, Pages 1635: Improving the Quantification of DNA Sequences Using Evolutionary Information Based on Deep Learning Cells doi: 10.3390/cells8121635 Authors: Hilal Tayara Kil To Chong It is known that over 98% of the human genome is non-coding, and 93% of disease associated variants are located in these regions. Therefore, understanding the function of these regions is important. However, this task is challenging as most of these regions are not well understood in terms...
Sat Dec 14, 2019 02:00
Cells, Vol. 8, Pages 1634: The Butterfly Effect of RNA Alterations on Transcriptomic Equilibrium Cells doi: 10.3390/cells8121634 Authors: Desi Tay : Post-transcriptional regulation plays a key role in modulating gene expression, and the perturbation of transcriptomic equilibrium has been shown to drive the development of multiple diseases including cancer. Recent studies have revealed the existence of multiple post-transcriptional processes that coordinatively regulate the expression...
Fri Dec 13, 2019 02:00
Cells, Vol. 8, Pages 1633: Shaping of Innate Immune Response by Fatty Acid Metabolite Palmitate Cells doi: 10.3390/cells8121633 Authors: Hong-Tai Tzeng I-Tsu Chyuan Wei-Yu Chen Innate immune cells monitor invading pathogens and pose the first-line inflammatory response to coordinate with adaptive immunity for infection removal. Innate immunity also plays pivotal roles in injury-induced tissue remodeling and the maintenance of tissue homeostasis in physiological and pathological...
Fri Dec 13, 2019 02:00
Cells, Vol. 8, Pages 1632: CD38 Expression by Myeloma Cells and Its Role in the Context of Bone Marrow Microenvironment: Modulation by Therapeutic Agents Cells doi: 10.3390/cells8121632 Authors: Federica Costa Benedetta Dalla Palma Nicola Giuliani In the last decades CD38 has emerged as an attractive target for multiple myeloma (MM). CD38 is a novel multifunctional glycoprotein that acts as a receptor, adhesion molecule interacting with CD31 and as an ectoenzyme. As an ectoenzyme,...
Fri Dec 13, 2019 02:00
Cells, Vol. 8, Pages 1630: Adenosine A1-A2A Receptor-Receptor Interaction: Contribution to Guanosine-Mediated Effects Cells doi: 10.3390/cells8121630 Authors: Débora Lanznaster Caio M. Massari Vendula Marková Tereza Šimková Romain Duroux Kenneth A. Jacobson Víctor Fernández-Dueñas Carla I. Tasca Francisco Ciruela Guanosine, a guanine-based purine nucleoside, has been described as a neuromodulator that exerts neuroprotective effects in animal and cellular ischemia...
Fri Dec 13, 2019 02:00
Cells, Vol. 8, Pages 1631: Post-ER Stress Biogenesis of Golgi Is Governed by Giantin Cells doi: 10.3390/cells8121631 Authors: Cole P. Frisbie Alexander Y. Lushnikov Alexey V. Krasnoslobodtsev Jean-Jack M. Riethoven Jennifer L. Clarke Elena I. Stepchenkova Armen Petrosyan Background: The Golgi apparatus undergoes disorganization in response to stress, but it is able to restore compact and perinuclear structure under recovery. This self-organization mechanism is significant...
Fri Dec 13, 2019 02:00
Cells, Vol. 8, Pages 1629: The Anti-CD38 Antibody Therapy in Multiple Myeloma Cells doi: 10.3390/cells8121629 Authors: Maria Teresa Petrucci Federico Vozella Multiple myeloma (MM) is the second-most common hematologic malignancy after diffuse large B-cell lymphoma. Despite the improvement in response and survival rates following the introduction of novel therapies, only a few patients are cured, and the majority of MM patients experience several relapses and receive multiple lines...
Thu Dec 12, 2019 02:00
Cells, Vol. 8, Pages 1627: Structural Biology and Electron Microscopy of the Autophagy Molecular Machinery Cells doi: 10.3390/cells8121627 Authors: Lai Ye Zhang Jiang Lau Autophagy is a highly regulated bulk degradation process that plays a key role in the maintenance of cellular homeostasis. During autophagy, a double membrane-bound compartment termed the autophagosome is formed through de novo nucleation and assembly of membrane sources to engulf unwanted cytoplasmic...
Thu Dec 12, 2019 02:00
Cells, Vol. 8, Pages 1628: Traditional and Advanced Cell Cultures in Hematopoietic Stem Cell Studies
Cells, Vol. 8, Pages 1628: Traditional and Advanced Cell Cultures in Hematopoietic Stem Cell Studies Cells doi: 10.3390/cells8121628 Authors: Ribeiro-Filho Levy Ruiz Mantovani Bydlowski Hematopoiesis is the main function of bone marrow. Human hematopoietic stem and progenitor cells reside in the bone marrow microenvironment, making it a hotspot for the development of hematopoietic diseases. Numerous alterations that correspond to disease progression have been identified...
Thu Dec 12, 2019 02:00
Cells, Vol. 8, Pages 1625: The Enigmatic Function of PARP1: From PARylation Activity to PAR Readers Cells doi: 10.3390/cells8121625 Authors: Tatiana Kamaletdinova Zahra Fanaei-Kahrani Zhao-Qi Wang Poly(ADP-ribosyl)ation (PARylation) is catalysed by poly(ADP-ribose) polymerases (PARPs, also known as ARTDs) and then rapidly removed by degrading enzymes. Poly(ADP-ribose) (PAR) is produced from PARylation and provides a delicate and spatiotemporal interaction scaffold for numerous...
Thu Dec 12, 2019 02:00
Cells, Vol. 8, Pages 1623: Vascular PPARβ/δ Promotes Tumor Angiogenesis and Progression Cells doi: 10.3390/cells8121623 Authors: Kay-Dietrich Wagner Siyue Du Luc Martin Nathalie Leccia Jean-François Michiels Nicole Wagner Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors, which function as transcription factors. Among them, PPARβ/δ is highly expressed in endothelial cells. Pharmacological activation with PPARβ/δ...
Thu Dec 12, 2019 02:00
Cells, Vol. 8, Pages 1624: Battling Glioblastoma: A Novel Tyrosine Kinase Inhibitor with Multi-Dimensional Anti-Tumor Effect (Running Title: Cancer Cells Death Signalling Activation) Cells doi: 10.3390/cells8121624 Authors: Anisha Viswanathan Aliyu Musa Akshaya Murugesan João R. Vale Carlos A. M. Afonso Saravanan Konda Mani Olli Yli-Harja Nuno R. Candeias Meenakshisundaram Kandhavelu Glioblastoma (GB), a grade IV glioma, with high heterogeneity and chemoresistance,...
Thu Dec 12, 2019 02:00
Cells, Vol. 8, Pages 1626: LPS Inhibits Fatty Acid Absorption in Enterocytes through TNF-α Secreted by Macrophages Cells doi: 10.3390/cells8121626 Authors: Heyuan Liu Lixia Kai Huahua Du Xinxia Wang Yizhen Wang Diarrhea, such as steatorrhea, could result from fat absorption disorders, which could be caused by many factors, including Escherichia coli infection. However, it is not clear how E. coli affects fatty acid absorption in animals. Lipopolysaccharide (LPS), as one of...
Thu Dec 12, 2019 02:00
Cells, Vol. 8, Pages 1620: Spheroid Culture System Methods and Applications for Mesenchymal Stem Cells Cells doi: 10.3390/cells8121620 Authors: Na-Eun Ryu Soo-Hong Lee Hansoo Park Owing to the importance of stem cell culture systems in clinical applications, researchers have extensively studied them to optimize the culture conditions and increase efficiency of cell culture. A spheroid culture system provides a similar physicochemical environment in vivo by facilitating cell–cell...
Thu Dec 12, 2019 02:00
Cells, Vol. 8, Pages 1621: SWR1 Chromatin Remodeling Complex: A Key Transcriptional Regulator in Plants Cells doi: 10.3390/cells8121621 Authors: Mohammad Aslam Beenish Fakher Bello Hassan Jakada Shijiang Cao Yuan Qin The nucleosome is the structural and fundamental unit of eukaryotic chromatin. The chromatin remodeling complexes change nucleosome composition, packaging and positioning to regulate DNA accessibility for cellular machinery. SWI2/SNF2-Related 1 Chromatin Remodeling...
Thu Dec 12, 2019 02:00
Cells, Vol. 8, Pages 1619: TGF-β and microRNA Interplay in Genitourinary Cancers Cells doi: 10.3390/cells8121619 Authors: Joanna Boguslawska Piotr Kryst Slawomir Poletajew Agnieszka Piekielko-Witkowska Genitourinary cancers (GCs) include a large group of different types of tumors localizing to the kidney, bladder, prostate, testis, and penis. Despite highly divergent molecular patterns, most GCs share commonly disturbed signaling pathways that involve the activity of TGF-β...
Thu Dec 12, 2019 02:00
Cells, Vol. 8, Pages 1622: Identification of TRIM25 as a Negative Regulator of Caspase-2 Expression Reveals a Novel Target for Sensitizing Colon Carcinoma Cells to Intrinsic Apoptosis Cells doi: 10.3390/cells8121622 Authors: Usman Nasrullah Kristina Haeussler Abhiruchi Biyanee Ilka Wittig Josef Pfeilschifter Wolfgang Eberhardt Colorectal cancer (CRC) is one of the most common cancers that is characterized by a high mortality due to the strong metastatic potential of the...
Thu Dec 12, 2019 02:00
Cells, Vol. 8, Pages 1618: Molecular and Cellular Mechanisms of Melatonin in Osteosarcoma Cells doi: 10.3390/cells8121618 Authors: Ko-Hsiu Lu Renn-Chia Lin Jia-Sin Yang Wei-En Yang Russel J. Reiter Shun-Fa Yang Osteosarcoma, the most common primary bone malignancy, occurs most frequently in adolescents with a peak of incidence at 11–15 years. Melatonin, an indole amine hormone, shows a wide range of anticancer activities. The decrease in melatonin levels simultaneously...
Thu Dec 12, 2019 02:00
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