Despite the dramatic advancements in pelvic radiotherapy, urinary toxicity remains a significant side-effect. The assessment of clinico-dosimetric predictors of radiation cystitis (RC) based on clinical data has improved substantially over the last decade; however, a thorough understanding of the physiopathogenetic mechanisms underlying the onset of RC, with its variegated acute and late urinary symptoms, is still largely lacking, and data from pre-clinical research is still limited. The aim of this...
We described currently available biomarkers for TAMs that can be measured in patients’ samples (tumor tissue and blood). CD68 is the major biomarker for the quantification of total TAM amounts, while transmembrane receptors (stabilin-1, CD163, CD206, CD204, MARCO) and secreted chitinase-like proteins (YKL-39, YKL-40) are used as biomarkers for the functional TAM polarization. We also considered that specific role of TAMs in tumor progression can depend on the localization in the intratumoral compartments....
Conclusion: A novel nomogram is available as a web-based tool and accurately predicts long-term RFS for GC after radical resection. The tool can also be used to determine the benefit of adjuvant chemotherapy by comparing scores with and without this intervention. (Source: Frontiers in Oncology)
In immune system, B cells are classically positive modulators that regulate inflammation and immune responses. Regulatory B cells (Bregs) are a subset of B cells which play crucial roles in various conditions, including infection, allergies, autoimmune diseases, transplantation, and tumors. Until now, unequivocal surface markers for Bregs still lack consensus, although numerous Breg subsets have been identified. Generally, Bregs exert their immunoregulatory functions mainly through cytokine secretion...
Salivary gland carcinomas (SGCs) account for <5% of head and neck malignant neoplasms, further subcategorized in over 20 histological subtypes. For the most part, treatment for advanced disease is guided by morphology. SGCs in general respond poorly to a wide array of standard chemotherapy, with short durability, and significant toxicity. More recently, next-generation sequencing provided significant input on the molecular characterization of each SGC subtype, not only improving diagnostic differentiation...
Immunotherapy, particularly immune checkpoint blockade and chimeric antigen receptor (CAR)-T cells, holds a great promise against cancer. These treatments have markedly improved survival in solid as well as in hematologic tumors previously considered incurable. However, durable responses occur in a fraction of patients, and existing biomarkers (e.g. PD-L1) have shown limited prediction power. This scenario highlights the need to dissect the complex interplay between immune and tumor cells to identify...
Authors: Masako Shomura Haruka Okabe Emi Sato Kota Fukai Koichi Shiraishi Shunji Hirose Kota Tsuruya Yoshitaka Arase Kazuya Anzai Tatehiro Kagawa Patients with advanced hepatocellular carcinoma (HCC) undergoing molecular targeted therapy often experience non-negligible adverse events (AEs). Paradoxically, certain AEs are reportedly associated with a good prognosis. We aimed to identify factors predictive of treatment duration and overall survival (OS) in patients...
Immune evasion is an important cancer hallmark and the understanding of its mechanisms has generated successful therapeutic approaches. Induction of immunogenic cell death (ICD) is expected to attract immune cell populations that promote innate and adaptive immune responses. Here, we present a critical advance for our adenovirus-mediated gene therapy approach, where the combined p14ARF and human interferon-β (IFNβ) gene transfer to human melanoma cells led to oncolysis, ICD and subsequent activation...
Metabolic alterations play crucial roles in carcinogenesis, tumor progression, and prognosis in clear cell renal cell carcinoma (ccRCC). A risk score (RS) model for ccRCC consisting of disease-associated metabolic genes remains unidentified. Here, we utilized gene set enrichment analysis to analyze expression data from normal and tumor groups from the cancer genome atlas. Out of 70 KEGG metabolic pathways, we found seven and two pathways to be significantly enriched in our normal and tumor groups,...
Authors: Kacem Ben Fradj M, Ouanes Y, Hadj-Taeib S, Mrad Dali K, Bibi M, Khalil J, Sanhaji H, Nouira Y, Feki M Abstract This cohort study aimed to investigate prognostic significance of plasma folate and cobalamin in non-muscle-invasive bladder cancer (NMIBC). A total of 177 NMIBC patients were followed over a period extending to 6 years. Cox regression models were applied to estimate risks for recurrence and progression according to plasma vitamins tertiles. Compared to first tertile,...
CONCLUSION: Overall, our findings provide a valuable source of data about the clinical significance of CYTH4 in ovarian cancer. PMID: 33078956 [PubMed - as supplied by publisher] (Source: Autoimmunity)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
AbstractCalibration is an important measure of the predictive accuracy for a prognostic risk model. A widely used measure of calibration when the outcome is survival time is the expected Brier score. In this paper, methodology is developed to accurately estimate the difference in expected Brier scores derived from nested survival models and to compute an accompanying variance estimate of this difference. The methodology is applicable to time invariant and time-varying coefficient Cox survival models....
Publication date: Available online 21 October 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Dan-Ni Li, Cheng-Cheng Yang, Jin Li, Qiu-Geng Ou Yang, Lv-Tao Zeng, Guo-Qing Fan, Teng-Hui Liu, Xin-Yuan Tian, Jing-Jing Wang, He Zhang, Da-Peng Dai, Ju Cui, Jian-Ping Cai (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100%...
Publication date: Available online 21 October 2020Source: Journal of Molecular BiologyAuthor(s): Motoki Horii, Takashi Matsushita (Source: Journal of Molecular Biology)
Authors: Park JY PMID: 33078601 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
CONCLUSION: The significant differences in survival outcomes between patients with cervical ADC and SCC were only observed in the regional disease subgroup, but not in the localized disease and distant disease subgroups. PMID: 33078590 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
CONCLUSIONS: Imaging and surgical nodal assessment has comparable PFS and OS in patients with cervical cancer stage IB2-IVA. TRIAL REGISTRATION: PROSPERO Identifier: CRD42020155486. PMID: 33078589 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
CONCLUSIONS: KLK5 overexpression is associated with the aggressiveness of cervical cancer and may underlie the diminished response to conventional treatments. Therefore, KLK5 could be a reliable prognostic factor in cervical cancer. PMID: 33078588 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
CONCLUSIONS: Women with stage II EC do not appear to benefit from routine radical hysterectomy though all patients appear to benefit from receipt of radiation therapy (RT), regardless of modality. Additionally, there may be an added survival benefit with the combination of computed tomography and RT in patients with non-endometrioid, high-risk histologies. PMID: 33078593 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
CONCLUSIONS: Our findings revealed that platinum sensitivity and primary stage are clinical factors that significantly affect PPS in patients with recurrent or persistent CCC as well as other histologic subtypes of ovarian cancer. PPS in patients with recurrent CCC should establish the basis for future clinical trials in this population. PMID: 33078599 [PubMed - in process] (Source: Journal of Gynecologic Oncology)MedWorm Message: Have you tried our new medical search engine? More powerful than...
Impact of COVID-19 in gynecologic oncology: a Nationwide Italian Survey of the SIGO and MITO groups.
CONCLUSIONS: National guidelines should be implemented to further promote the safety of patients and health care providers. International cooperation is of paramount importance, as heavily affected nations can serve as an example to find out ways to safely preserve clinical activity during the COVID-19 outbreak. PMID: 33078597 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
CONCLUSIONS: Adjuvant chemoradiation delivered in CRC sequence was associated with improvements in both PFS and OS compared to alternant therapy sequencing. PMID: 33078595 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
CONCLUSIONS: Our data indicated that HMGB3 may serve as an oncoprotein. It could be used as a potential prognostic marker and represent a promising therapeutic strategy for CC treatment. PMID: 33078596 [PubMed - in process] (Source: Journal of Gynecologic Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Authors: Paulino E, de Melo AC PMID: 33078600 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
CONCLUSIONS: Approximately 33.3% (36/108) of the specific BRCA1/2 variants analyzed in this study that were initially classified as VUS over a 13-year period were reclassified. Among these, 5.6% (6/108) were reclassified as pathogenic or likely pathogenic variants. PMID: 33078592 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
CONCLUSION: FSS is feasible and safe in EOC, regardless of the presence of dense adhesions. PMID: 33078594 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Authors: Lim YH, Chay WY, Wong WL PMID: 33078587 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
CONCLUSIONS: Black women are two times more likely to be diagnosed with uterine clear cell carcinoma compared with other races. Asians present at younger ages, with Vietnamese women most likely to be diagnosed at the youngest age. PMID: 33078591 [PubMed - in process] (Source: Journal of Gynecologic Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate...
CONCLUSIONS: We demonstrated MELK as both a prognostic marker and a therapeutic target for ovarian cancer using clinical ovarian cancer samples. MELK inhibition by OTS167 may be an effective approach to treat ovarian cancer patients. PMID: 33078598 [PubMed - in process] (Source: Journal of Gynecologic Oncology)
Authors: Chandana SR, Babiker HM, Mahadevan D Abstract INTRODUCTION: Fibroblast growth factor receptors (FGFR 1-4) are a highly conserved family of receptor tyrosine kinases, involved in several physiological processes. Genetic aberrations of FGFRs and their ligands, fibroblast growth factors (FGFs) are involved in several pathological processes including cancer. The FGF-FGFR axis has emerged as a treatment target in oncology. Because these aberrations drive cancer progression, the development...
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As the use of quercetin for preventing cancer grows in popularity, it may not yet be borne out by the data.Medscape Oncology (Source: Medscape Today Headlines)
Researchers have developed a simple blood test to identify pancreatic cancers that are more likely to respond to treatment than others, according to a paper published Thursday by Clinical Cancer Research. (Source: Health News - UPI.com)
Researchers at the University of Toronto have found first evidence that neutrophil immune cell activity is the missing link connecting periodontal disease with heart disease, cancer, and other inflammatory conditionsUniversity of Toronto - Faculty of DentistryResearch NewsIMAGE: Neutrophil activation is now believed to be at the root of overactive inflammatory responses, and links conditions such as periodontal disease and heart diseaseviewmore Credit: Noah Fine(TORONTO, ON) Oct. 20, 2020 -- The...
THURSDAY, Oct. 22, 2020 -- If Obamacare, or the Affordable Care Act (ACA), is repealed, pediatric cancer patients could lose critical insurance coverage, a new study warns. Kids with cancer often require intensive treatment and long-term follow-up... (Source: Drugs.com - Daily MedNews)
WEDNESDAY, Oct. 21, 2020 -- A combination of two " targeted " therapies can beat back a rare form of blood cancer -- without the toxic effects of chemotherapy, a new study has found. In a trial of 63 patients, researchers found that the drug regimen... (Source: Drugs.com - Daily MedNews)
Angiotensin II receptor blockers but not angiotensin converting enzyme inhibitors were associated with better responses and survival for patients receiving immune checkpoint inhibitors for cancer.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
In this guest column, the executive director of the Arizona chapter of the American Cancer Society urges all women to remember to schedule breast cancer screenings, and to help support the organization's efforts statewide. (Source: bizjournals.com Health Care:Physician Practices headlines)
Complete remission, overall survival seen in 98, 95 percent of patients in phase 2 study (Source: The Doctors Lounge - Oncology)
Adherence inversely linked to mortality related to breast cancer, CRC, melanoma in women (Source: The Doctors Lounge - Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
[The Herald] Senior Reporter (Source: AllAfrica News: Health and Medicine)
(American Friends of Tel Aviv University) An international team of researchers has identified a direct molecular link between meat and dairy diets and the development of antibodies in the blood that increase the chances of developing cancer. This connection may explain the high incidence of cancer among those who consume large amounts of dairy products and red meat, similar to the link between high cholesterol and an increased risk of heart disease. (Source: EurekAlert! - Cancer)
(University of Copenhagen The Faculty of Health and Medical Sciences) Researchers from UCPH have discovered how thus far a mysterious function of the so-called MCM proteins protect the human cells against DNA instability, which can cause devastating diseases including cancer. In addition to their known role as molecular motors of genome duplication, MCM proteins control the speed of this process. How cells manage to constrain the speed of DNA replication has puzzled researchers for decades and has...
(Van Andel Research Institute) Scientists have developed a simple, experimental blood test that distinguishes pancreatic cancers that respond to treatment from those that do not. This critical distinction could one day guide therapeutic decisions and spare patients with resistant cancers from undergoing unnecessary treatments with challenging side effects. The findings were published today inClinical Cancer Research, a journal of the American Association for Cancer Research. (Source: EurekAlert!...
(European Organisation for Research and Treatment of Cancer) Scientists cannot be expected to drop everything they're working on to turn their attention to beating COVID-19, according to the winner of the 2019 Nobel Prize in Physiology or Medicine, Professor Sir Peter Ratcliffe. He delivers the the prestigious Michel Clavel lecture to the 32nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, which is taking place online. (Source: EurekAlert! - Cancer)MedWorm Message: If you...
(Scripps Research Institute) When it comes to defeating cancer, some immune cells are mightier than others. But even the best-trained eye and today's advanced scientific tools have trouble discerning the most powerful tumor-fighting cells from the rest. A new technique developed by Scripps Research scientist Peng Wu, PhD, aims to change that--offering a new platform that could propel personalized cancer treatments that have been hindered due to the challenges of isolating the most useful immune cells...
(JAMA Network) The financial risks and challenges for independent oncology practices in the COVID-19 era and possible solutions to promote their stability and survival are discussed in this Viewpoint. (Source: EurekAlert! - Cancer)
(University of California - San Diego) UC San Diego researchers use experimental artificial intelligence system called DrugCell to predict the best approach to treating cancer. (Source: EurekAlert! - Cancer)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
(University of California - San Francisco) A new study led by UCSF Benioff Children's Hospitals and the Children's Hospital of Philadelphia (CHOP) has quantified the impact of repealing the 2010 Affordable Care Act (ACA) for 18 to 25-year-old cancer patients, who are covered by their parents' health insurance. (Source: EurekAlert! - Cancer)
(European Organisation for Research and Treatment of Cancer) An experimental vaccine, designed to enlist the body's own immune system to target cancer cells, has shown promise for treating and preventing cancer in mice. The vaccine was created to target a gene called KRAS that is involved in the development of many types of cancer, including lung, bowel and pancreatic cancer. (Source: EurekAlert! - Cancer)
(University of Turku) Cellular optogenetics is a technique that allows researchers to use light to precisely control cell signaling and function in space and time enabling the investigation of mechanisms involved in disease processes. A research team from the University of Turku have developed a novel way to make cellular optogenetic tools much easier to monitor and apply, and showed how they can be used to investigate the cellular side effects of medicines used to treat cancer. (Source: EurekAlert!...
(University of California - Los Angeles Health Sciences) More women could potentially be spared an axillary lymph node dissection -- the surgical removal of 10-20 lymph nodes -- a procedure that causes disabling arm swelling in up to 25% of women, according to a UCLA study. (Source: EurekAlert! - Medicine and Health)
(Michigan Medicine - University of Michigan) The development and validation of a staging system for non-metastatic prostate cancer could help doctors and patients assess treatment options, as well as improve clinical trials. (Source: EurekAlert! - Medicine and Health)
We report a 3.3-angstrom-resolution cryo–electron microscopy structure of cGAS in complex with the nucleosome core particle. The structure reveals that cGAS uses two conserved arginines to anchor to the nucleosome acidic patch. The nucleosome-binding interface exclusively occupies the strong double-stranded DNA (dsDNA)–binding surface on cGAS and sterically prevents cGAS from oligomerizing into the functionally active 2:2 cGAS-dsDNA state. These findings provide a structural basis for how cGAS maintains...
Daohong Zhou and Aileen Frost explore how they target the proteolysis mechanism and fight cancer using proteolysis targeting chimera (PROTAC) technology. (Source: The Scientist)
A SPAC sponsored by San Francisco's EcoR1, investments from other biotech investors and a record-shattering Series A round push Nuvation Bio's funding to more than $850 million. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
BOWEL cancer is when abnormal cells continually divide, making more abnormal cells. These lump together to form a tumour. If you'd like to lower your risk of this disease, you're best avoiding a certain breakfast. (Source: Daily Express - Health)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Cancer patients are being targeted by a rogue website selling poor quality wigs which do not match the ones pictured in its adverts. (Source: BBC News | Health | UK Edition)
THE WOODLANDS, Texas, Oct. 22, 2020 — The US Oncology Network (The Network), the largest organization of its kind dedicated to advancing local cancer care and better patient outcomes, continues to expand its reach into local communities by welcoming Alliance Cancer Specialists and Northwest Oncology.... (Source: McKesson News)
WEDNESDAY, Oct. 21, 2020 -- A combination of two " targeted " therapies can beat back a rare form of blood cancer -- without the toxic effects of chemotherapy, a new study has found. In a trial of 63 patients, researchers found that the drug regimen... (Source: Drugs.com - Daily MedNews)
(University of Alberta Faculty of Medicine& Dentistry) University of Alberta scientists have identified the mechanism of action behind a new type of precision cancer drug for blood cancers that is set for human trials, according to research published inNature Communications. (Source: EurekAlert! - Cancer)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
(Impact Journals LLC) Volume 11, Issue 31 from @Oncotarget reported that TQ decreased the expression levels of colorectal stem cell markers CD44 and Epithelial Cell Adhesion Molecule Ep CAM and proliferation marker Ki67 in colonospheres derived from both cell lines and reduced cellular migration and invasion. (Source: EurekAlert! - Cancer)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any...
A SPAC sponsored by San Francisco's EcoR1, investments from other biotech investors and a record-shattering Series A round push Nuvation Bio's funding to more than $850 million. (Source: bizjournals.com Health Care:Biotechnology headlines)
Title: What Happens if Melanoma Gets Into Lymph Nodes?Category: Diseases and ConditionsCreated: 10/21/2020 12:00:00 AMLast Editorial Review: 10/21/2020 12:00:00 AM (Source: MedicineNet Cancer General)
Title: What Is a Simple Mastectomy?Category: Diseases and ConditionsCreated: 10/21/2020 12:00:00 AMLast Editorial Review: 10/21/2020 12:00:00 AM (Source: MedicineNet Cancer General)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Title: Actor Jeff Bridges Shares Lymphoma DiagnosisCategory: Health NewsCreated: 10/20/2020 12:00:00 AMLast Editorial Review: 10/21/2020 12:00:00 AM (Source: MedicineNet Cancer General)
Title: Does Retinoblastoma Cause Blindness?Category: Diseases and ConditionsCreated: 10/21/2020 12:00:00 AMLast Editorial Review: 10/21/2020 12:00:00 AM (Source: MedicineNet Cancer General)
Title: What Is Breast Biopsy With Needle Localization?Category: Diseases and ConditionsCreated: 10/21/2020 12:00:00 AMLast Editorial Review: 10/21/2020 12:00:00 AM (Source: MedicineNet Cancer General)
Title: What Does Mediastinal Lymphadenopathy Mean?Category: Diseases and ConditionsCreated: 10/21/2020 12:00:00 AMLast Editorial Review: 10/21/2020 12:00:00 AM (Source: MedicineNet Cancer General)
(European Organisation for Research and Treatment of Cancer) Researchers have found that a class of commonly-used heart drugs may also improve patients' responses to anti-cancer immunotherapies called PD(L)1 inhibitors, according to preliminary findings to be presented at the 32th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, which is taking place online. (Source: EurekAlert! - Cancer)
(European Organisation for Research and Treatment of Cancer) Researchers have developed a way of testing potential drugs for children's cancers so as to take account of the wide genetic diversity of these diseases. instead of conventional testing designs, which use multiple mice as models for rare children's cancers, analysis had revealed that it was possible to evaluate them on a single mouse, which could accelerate the development of better treatments. The research is presented at the 32th EORTC-NCI-AACR...
(European Organisation for Research and Treatment of Cancer) In the largest study of its kind, researchers have found two common genetic variants that can be used to predict whether or not cancer patients might suffer severe adverse side-effects, such as high blood pressure, from the drug bevacizumab. The genome-wide association study is the largest such study in patients being treated with bevacizumab and it is to be presented at the 32th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer...
(Purdue University) A Purdue University scientist and entrepreneur is working to use simple LED light to help determine if certain chemotherapy options will work for specific patients. (Source: EurekAlert! - Biology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
The findings may have implications for radiotherapy, a cancer treatment that can cause damage to salivary glands and leave lasting complications. (Source: The Scientist)
Mark above section as read
Researchers at the University of Toronto have found first evidence that neutrophil immune cell activity is the missing link connecting periodontal disease with heart disease, cancer, and other inflammatory conditionsUniversity of Toronto - Faculty of DentistryResearch NewsIMAGE: Neutrophil activation is now believed to be at the root of overactive inflammatory responses, and links conditions such as periodontal disease and heart diseaseviewmore Credit: Noah Fine(TORONTO, ON) Oct. 20, 2020 -- The...
THURSDAY, Oct. 22, 2020 -- If Obamacare, or the Affordable Care Act (ACA), is repealed, pediatric cancer patients could lose critical insurance coverage, a new study warns. Kids with cancer often require intensive treatment and long-term follow-up... (Source: Drugs.com - Daily MedNews)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
WEDNESDAY, Oct. 21, 2020 -- A combination of two " targeted " therapies can beat back a rare form of blood cancer -- without the toxic effects of chemotherapy, a new study has found. In a trial of 63 patients, researchers found that the drug regimen... (Source: Drugs.com - Daily MedNews)
Angiotensin II receptor blockers but not angiotensin converting enzyme inhibitors were associated with better responses and survival for patients receiving immune checkpoint inhibitors for cancer.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
In this guest column, the executive director of the Arizona chapter of the American Cancer Society urges all women to remember to schedule breast cancer screenings, and to help support the organization's efforts statewide. (Source: bizjournals.com Health Care:Physician Practices headlines)
Complete remission, overall survival seen in 98, 95 percent of patients in phase 2 study (Source: The Doctors Lounge - Oncology)
Adherence inversely linked to mortality related to breast cancer, CRC, melanoma in women (Source: The Doctors Lounge - Oncology)
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[The Herald] Senior Reporter (Source: AllAfrica News: Health and Medicine)
(American Friends of Tel Aviv University) An international team of researchers has identified a direct molecular link between meat and dairy diets and the development of antibodies in the blood that increase the chances of developing cancer. This connection may explain the high incidence of cancer among those who consume large amounts of dairy products and red meat, similar to the link between high cholesterol and an increased risk of heart disease. (Source: EurekAlert! - Cancer)
(University of Copenhagen The Faculty of Health and Medical Sciences) Researchers from UCPH have discovered how thus far a mysterious function of the so-called MCM proteins protect the human cells against DNA instability, which can cause devastating diseases including cancer. In addition to their known role as molecular motors of genome duplication, MCM proteins control the speed of this process. How cells manage to constrain the speed of DNA replication has puzzled researchers for decades and has...
(Van Andel Research Institute) Scientists have developed a simple, experimental blood test that distinguishes pancreatic cancers that respond to treatment from those that do not. This critical distinction could one day guide therapeutic decisions and spare patients with resistant cancers from undergoing unnecessary treatments with challenging side effects. The findings were published today inClinical Cancer Research, a journal of the American Association for Cancer Research. (Source: EurekAlert!...
(European Organisation for Research and Treatment of Cancer) Scientists cannot be expected to drop everything they're working on to turn their attention to beating COVID-19, according to the winner of the 2019 Nobel Prize in Physiology or Medicine, Professor Sir Peter Ratcliffe. He delivers the the prestigious Michel Clavel lecture to the 32nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, which is taking place online. (Source: EurekAlert! - Cancer)
(Scripps Research Institute) When it comes to defeating cancer, some immune cells are mightier than others. But even the best-trained eye and today's advanced scientific tools have trouble discerning the most powerful tumor-fighting cells from the rest. A new technique developed by Scripps Research scientist Peng Wu, PhD, aims to change that--offering a new platform that could propel personalized cancer treatments that have been hindered due to the challenges of isolating the most useful immune cells...
(JAMA Network) The financial risks and challenges for independent oncology practices in the COVID-19 era and possible solutions to promote their stability and survival are discussed in this Viewpoint. (Source: EurekAlert! - Cancer)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
(University of California - San Diego) UC San Diego researchers use experimental artificial intelligence system called DrugCell to predict the best approach to treating cancer. (Source: EurekAlert! - Cancer)
(University of California - San Francisco) A new study led by UCSF Benioff Children's Hospitals and the Children's Hospital of Philadelphia (CHOP) has quantified the impact of repealing the 2010 Affordable Care Act (ACA) for 18 to 25-year-old cancer patients, who are covered by their parents' health insurance. (Source: EurekAlert! - Cancer)
(European Organisation for Research and Treatment of Cancer) An experimental vaccine, designed to enlist the body's own immune system to target cancer cells, has shown promise for treating and preventing cancer in mice. The vaccine was created to target a gene called KRAS that is involved in the development of many types of cancer, including lung, bowel and pancreatic cancer. (Source: EurekAlert! - Cancer)
(University of Turku) Cellular optogenetics is a technique that allows researchers to use light to precisely control cell signaling and function in space and time enabling the investigation of mechanisms involved in disease processes. A research team from the University of Turku have developed a novel way to make cellular optogenetic tools much easier to monitor and apply, and showed how they can be used to investigate the cellular side effects of medicines used to treat cancer. (Source: EurekAlert!...
(University of California - Los Angeles Health Sciences) More women could potentially be spared an axillary lymph node dissection -- the surgical removal of 10-20 lymph nodes -- a procedure that causes disabling arm swelling in up to 25% of women, according to a UCLA study. (Source: EurekAlert! - Medicine and Health)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
(Michigan Medicine - University of Michigan) The development and validation of a staging system for non-metastatic prostate cancer could help doctors and patients assess treatment options, as well as improve clinical trials. (Source: EurekAlert! - Medicine and Health)
We report a 3.3-angstrom-resolution cryo–electron microscopy structure of cGAS in complex with the nucleosome core particle. The structure reveals that cGAS uses two conserved arginines to anchor to the nucleosome acidic patch. The nucleosome-binding interface exclusively occupies the strong double-stranded DNA (dsDNA)–binding surface on cGAS and sterically prevents cGAS from oligomerizing into the functionally active 2:2 cGAS-dsDNA state. These findings provide a structural basis for how cGAS maintains...
Daohong Zhou and Aileen Frost explore how they target the proteolysis mechanism and fight cancer using proteolysis targeting chimera (PROTAC) technology. (Source: The Scientist)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
A SPAC sponsored by San Francisco's EcoR1, investments from other biotech investors and a record-shattering Series A round push Nuvation Bio's funding to more than $850 million. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
BOWEL cancer is when abnormal cells continually divide, making more abnormal cells. These lump together to form a tumour. If you'd like to lower your risk of this disease, you're best avoiding a certain breakfast. (Source: Daily Express - Health)
Cancer patients are being targeted by a rogue website selling poor quality wigs which do not match the ones pictured in its adverts. (Source: BBC News | Health | UK Edition)
THE WOODLANDS, Texas, Oct. 22, 2020 — The US Oncology Network (The Network), the largest organization of its kind dedicated to advancing local cancer care and better patient outcomes, continues to expand its reach into local communities by welcoming Alliance Cancer Specialists and Northwest Oncology.... (Source: McKesson News)
WEDNESDAY, Oct. 21, 2020 -- A combination of two " targeted " therapies can beat back a rare form of blood cancer -- without the toxic effects of chemotherapy, a new study has found. In a trial of 63 patients, researchers found that the drug regimen... (Source: Drugs.com - Daily MedNews)
(University of Alberta Faculty of Medicine& Dentistry) University of Alberta scientists have identified the mechanism of action behind a new type of precision cancer drug for blood cancers that is set for human trials, according to research published inNature Communications. (Source: EurekAlert! - Cancer)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
(Impact Journals LLC) Volume 11, Issue 31 from @Oncotarget reported that TQ decreased the expression levels of colorectal stem cell markers CD44 and Epithelial Cell Adhesion Molecule Ep CAM and proliferation marker Ki67 in colonospheres derived from both cell lines and reduced cellular migration and invasion. (Source: EurekAlert! - Cancer)
A SPAC sponsored by San Francisco's EcoR1, investments from other biotech investors and a record-shattering Series A round push Nuvation Bio's funding to more than $850 million. (Source: bizjournals.com Health Care:Biotechnology headlines)
Title: What Happens if Melanoma Gets Into Lymph Nodes?Category: Diseases and ConditionsCreated: 10/21/2020 12:00:00 AMLast Editorial Review: 10/21/2020 12:00:00 AM (Source: MedicineNet Cancer General)
Title: What Is a Simple Mastectomy?Category: Diseases and ConditionsCreated: 10/21/2020 12:00:00 AMLast Editorial Review: 10/21/2020 12:00:00 AM (Source: MedicineNet Cancer General)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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