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CONCLUSIONS These results indicate that GPX1 is an independent prognostic factor and a novel biomarker for predicting the progression of malignancy in gliomas, which is associated with immune infiltration. PMID: 33085656 [PubMed - in process] (Source: Medical Science Monitor)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
We reported a 31-year-old female who had a history of renal failure and bilateral renal masses. Magnetic resonance imaging of the abdomen revealed bilateral large renal masses replacing renal parenchyma with features suggestive of bilateral renal AML. The patient underwent left nephrectomy, and histopathology examination findings were consistent with the diagnosis of EAML. PMID: 33083036 [PubMed] (Source: Oman Medical Journal)
Publication date: Available online 22 October 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Wenjia Wang, Donglai Chen, Yonghua Sang, Chang Chen, Yongsheng Zhang, Yiming Mao, Yongbing Chen (Source: Clinics and Research in Hepatology and Gastroenterology)
ConclusionsPenile cancer typically occurs as penile squamous cell carcinoma, and its most common metastatic sites are the inguinal lymph nodes. Hemorrhagic transfer of tumor cells is extremely rare, especially to intraocular sites. Intraocular metastatic tumors have a unique presentation on imaging, as observed on magnetic resonance imaging and histopathological analysis. This novel finding of intraocular metastasis in penile squamous cell carcinoma is of great significance to optic surgeons and...
Publication date: Available online 22 October 2020Source: Trends in Pharmacological SciencesAuthor(s): Abigail C. Cornwell, Michael E. Feigin (Source: Trends in Pharmacological Sciences)
Publication date: December 2020Source: Cancer Epidemiology, Volume 69Author(s): Lorraine Fahy, Patricia Fitzpatrick, Caroline Meade, Hilary Coffey Farrell, Diarmuid O'Donoghue, Therese Mooney (Source: Cancer Epidemiology)
Publication date: Available online 2 October 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Zoe Loh, Eliza A. Hawkes, Fiona Chionh, Arun Azad, Geoffrey Chong (Source: Clinical Lymphoma Myeloma and Leukemia)
Publication date: December 2020Source: Cancer Epidemiology, Volume 69Author(s): Lisa A. Cannon-Albright, Jeff Stevens, Craig C. Teerlink, Neeraj Agarwal (Source: Cancer Epidemiology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Publication date: December 2020Source: Cancer Epidemiology, Volume 69Author(s): Karlijn E.P.E. Hermans, Piet A. van den Brandt, Caroline Loef, Rob L.H. Jansen, Leo J. Schouten (Source: Cancer Epidemiology)
Publication date: Available online 22 October 2020Source: Cancer EpidemiologyAuthor(s): Caroline Y. Um, Marjorie L. McCullough, Susan M. Gapstur (Source: Cancer Epidemiology)
Objectives: Radiation is frequently added to chemotherapy for adjuvant treatment of advanced stage endometrial cancer. Multiple adjuvant therapy sequencing options exist, and little data is available to compare these. We compared outcomes and toxicities after “sandwich” chemoradiation (chemotherapy, then radiation, then chemotherapy) and nonsandwich sequences (chemotherapy then radiation, radiation then chemotherapy, or concurrent chemoradiation). Materials and Methods: We recorded baseline...
Conclusions: The study increases knowledge about gender differences in mesothelioma survival and is the first to directly examine this in the United Kingdom. It further disentangles the effects of age, histology, and health status. Increased estrogen may improve survival and could provide a potential target for future therapies. (Source: American Journal of Clinical Oncology)
Conclusions: Available evidence suggests food can be effective at ameliorating cancer treatment-related toxicities and improving prognosis, but more research is needed. (Source: American Journal of Clinical Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Objectives: Survival of patients with locally advanced pancreatic cancer (LAPC) is improved when neoadjuvant chemoradiation enables subsequent surgical resection. Here, the authors assess changes in vessel involvement as a possible indicator of resectability. Methods: Pancreatic gross tumor and all major abdominal vessels were contoured for 49 patients with unresectable LAPC before and after neoadjuvant chemoradiation. Changes were compared by paired t tests. Tumor-vessel relationships were...
Purpose: Radiotherapy (RT) is an effective treatment for localized gastric mucosa-associated lymphoid tissue (MALT) lymphomas unresponsive to antibiotic therapy; however, irradiating the stomach can result in significant radiation to the heart, a risk factor for cardiac disease. We analyzed the Surveillance, Epidemiology, and End Results database to evaluate outcomes related to cardiac disease among patients treated with RT for stage I gastric MALT. Materials and Methods: We identified adult...
Objective: Angiosarcoma of the breast is rare and has a poor prognosis. We reviewed our institution’s experience with this disease to characterize presentation, identify management patterns, and report outcomes. Methods: Fifty-eight patients with nonmetastatic angiosarcoma were identified from 1998 to 2019 and retrospectively reviewed. Overall survival (OS) and recurrence-free survival (RFS) were calculated using the Kaplan-Meier analysis and log-rank test. Results: The median follow-up was...
This study was a retrospective analysis of Nationwide Inpatient Sample data collected during 2005 to 2014. This study included critically ill patients, 18 years and above, diagnosed with brain metastasis, identified using International Classification of Diseases-Ninth Revision-Clinical Modification diagnosis and procedure codes. Multivariable logistic regression models were used for predicting factors associated with inpatient palliative care use. Results: Among 18,309 critically ill patients...
Conclusions: Pathologists and neuro-oncologists should be aware of false-positive 1p19q FISH results as they can significantly change treatment and prognosis for glioma patients. Moreover, this issue should be taken into account when designing clinical trials specific to this disease cohort. (Source: American Journal of Clinical Oncology)
The objective of this study was to evaluate the role of a neuro-oncology MDC on patient outcomes. Materials and Methods: Retrospective study was performed on consecutive patients who received radiosurgery for central nervous system (CNS) disease. We evaluated patients 2 years before and 2 years after the implementation of a MDC. Results: A total of 351 patients were analyzed, 163 patients before MDC and 188 after implementation of MDC. Before MDC the median follow-up was dependent on which...
Introduction: With an increasing number of systemic therapy options for hepatocellular carcinoma (HCC), optimal sequencing is an important consideration. There remains limited real-world data about the eligibility of patients for second-line therapies in advanced HCC. We characterized real-world eligibility and use of second-line therapies post sorafenib. Materials and Methods: We identified all patients with advanced HCC who received ≥1 cycle of first-line sorafenib between January 1, 2014...
Conclusions: There was no significant difference in the obstructive jaundice-free survival rate at 24 weeks between the 2 groups. Considering the technical difficulty and invasiveness of covered stent placement, the placement of covered stents may not be needed in patients with a short prognosis of (Source: American Journal of Clinical Oncology)
Objectives: Although cure rates for early stage anal squamous cell cancer (ASCC) are overall high, there may be racial disparities in receipt of treatment and outcome precluding favorable outcomes across all patient demographics. Therefore, the authors aimed to assess the time to treatment initiation and overall survival (OS) in Black and White patients receiving definitive chemoradiation for early stage ASCC. Materials and Methods: The authors identified patients diagnosed with early stage...
Conclusion: Observation of incidental CAC on breast radiation-planning CT scans identified patients who could benefit from cardiac-related preventive strategies. By increasing attention, awareness, and reporting of incidental CAC visible on CT sims, radiation oncologists may fulfill a unique role to bridge a potential gap in cardiovascular preventive medicine. (Source: American Journal of Clinical Oncology)
CONCLUSION: Intrabdominal schwannomas are rare tumors which most commonly exhibit gastrointestinal involvement. Since these tumors are mostly benign, the long-term prognosis of patients is good. Schwannoma should be kept in mind in the differential diagnosis of intrabdominal masses. Radical resections with high morbidity and mortality should be avoided if preoperative diagnosis is made. KEY WORDS: Abdominal tumor, Mesenchymal tumor, Nerve sheath tumor, Schwannoma. PMID: 33085652 [PubMed...
(Source: Indian Journal of Surgical Oncology)
(Source: OncoTargets and Therapy)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
(Source: Cancer Management and Research)
(Source: OncoTargets and Therapy)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
(Source: Cancer Management and Research)
(Source: OncoTargets and Therapy)
(Source: Cancer Management and Research)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
(Source: Cancer Management and Research)
(Source: OncoTargets and Therapy)
(Source: OncoTargets and Therapy)
Authors: Rubert J, Schweiger PJ, Mattivi F, Tuohy K, Jensen KB, Lunardi A Abstract Dietary patterns, microbiome dysbiosis, and gut microbial metabolites (GMMs) have a pivotal role in the homeostasis of intestinal epithelial cells and in disease progression, such as that of colorectal cancer (CRC). Although GMMs and microorganisms have crucial roles in many biological activities, models for deciphering diet-microbiome-host relationships are largely limited to animal models. Thus, intestinal...
Publication date: February 2021Source: Carbon, Volume 172Author(s): I. Novodchuk, M. Bajcsy, M. Yavuz (Source: Carbon)
Authors: Poudyal BS, Gyawali B, Rondelli D Abstract National lockdown to control the spread of COVID-19 in Nepal started in March 2020. This lockdown mandated closure of private and public transportation. The patients with hematological malignancies were at risk of delayed consultation, admission and missing scheduled chemotherapy. Since there is no official tele-health or e-health system established in hospitals, we decided to use Viber, a free text and call app to trace and provide information...
Conclusion: The study shows that waiting time for radiotherapy in Nigeria was generally longer than what is recommended internationally. This reflects the need to improve access to radiotherapy in order to improve cancer treatment outcomes in resource-limited settings. PMID: 33082847 [PubMed] (Source: Ecancermedicalscience)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained...
Authors: Meyer M, Bindelglas E, Kupferman ME, Eggermont AM Abstract With major parts of the United States in lockdown, parts of Europe and the UK possibly going back on lockdown or expecting a second COVID-19 wave and rapidly rising rates elsewhere other than Asia, many people are forgoing regular cancer screenings and prevention services. More worrisome, some may be experiencing early signs or symptoms, yet they are not seeking evaluation, treatment or surveillance examinations. The long-term...
Authors: Saha A, Anirvan P Abstract The ongoing coronavirus disease 2019 (COVID-19) pandemic has affected millions worldwide and has been found to cause severe disease in patients with underlying comorbidities. In patients with known malignancies, in addition to constraints in routine healthcare, the risk of being susceptible to developing severe forms of the disease is of grave concern. While follow-up studies on survivors of the severe acute respiratory syndrome (SARS) 2003 outbreak revealed...
Authors: Dottorini L, Turati L, Mattei L, Formenti P Abstract The number of oncology, surgery and anaesthesia procedures in older patients has greatly increased in recent years due to ageing populations. Older patients are typically characterised by physical changes such as comorbidities, decline in physiological activities and cognitive impairment. All these factors, together with polypharmacological therapies, may substantially impact perioperative outcome, quality of recovery and, more...
Authors: Selvaraja VK, Gudipudi DK Abstract Cancer immunotherapy has made rapid progress over the past decade leading to high enthusiasm and interest worldwide. Codelivery of immunomodulators with chemotherapeutic agents and radioisotopes has been shown to elicit a strong and sustained immune response in animal models. Despite showing promising results in metastatic and recurrent cancers, the utilisation of immunotherapy in clinical settings has been limited owing to uncertainties in elicited...
Discussion: Our 'real-world' experience shows that unselected older patients represent a significant larger proportion in real life than in RCTs; furthermore, older patients in a real-world setting may experience more side effects possibly affecting the quality of life. The median PFS data suggest that older patients may not derive the same clinical benefit than their fit and younger counterparts.There is a need to enrol vulnerable/frail older patients into RCTs, ensuring that data will also be applicable...
Conclusion: There is a lack of studies which directly address COVID-19 testing of asymptomatic patients before treatment. Our systematic review showed that most of the published data favours routine test for SARS-CoV-2 before initiating systemic treatment but failed to identify a good level of evidence to support these recommendations. Based upon this review, we proposed local recommendations at our centre. Each institution should consider the pros and cons of testing asymptomatic patients, evaluating...
Authors: Gomez-Moreno C, Verduzco-Aguirre H, Soto-Perez-de-Celis E Abstract Mexico is an upper-middle income country located in North America, with an increasing life expectancy and a growing population of older adults. Due to population ageing and lifestyle changes, the number of cancer cases amongst older individuals is expected to increase in the upcoming decades, representing a challenge to the healthcare system. The challenges for implementing geriatric oncology care in Mexico include...
Authors: Astigueta-Pérez J, Abad-Licham M, Chávez-Chirinos C, Beraun-Milla L, Lachos-Dávila A, Diaz-Pérez E, Portugal-Valdivia K, Castañeda PP, Alférez IP, Mezones-Holguín E Abstract Since the COVID-19 pandemic began in China in late 2019, infection from the SARS-CoV-2 virus has spread virtually worldwide. This infection has adversely affected several countries; governments have outlined a series of political measures aimed to preserve the health and safety of their populations. In Peru,...
Authors: Hauchecorne M, Pierro M, Brain E, Bringuier M, Soubeyran P, Chakiba C, Mathoulin-Pelissier S, Paillaud E, Geiss R, Besse B, Mourey L, Vincent H, Baldini C Abstract In France, cancer is the leading cause of death. Its incidence is increasing due to the growing population and longer life expectancy. Although older adults represent most new cases, they remain underrepresented in clinical trials. Their prognosis is often worse due to delayed diagnosis and multimorbidities. Geriatric...
Authors: Nidhamalddin SJ, Hasan RO, Abubakr GO Abstract The announcement of the COVID-19 pandemic by the World Health Organisation in March 2020 and the spread of coronavirus in most parts of the world, including Iraq, have posed severe challenges to the management of cancer patients both psychologically and logistically. Special experts at Hiwa Cancer Hospital, Iraq, took serious action aimed to decrease and prevent the spread of the virus among cancer patients while maintaining standard...
Authors: Gomes F, Lewis A, Morris R, Parks R, Kalsi T, Babic-Illamn G, Baxter M, Colquhoun K, Rodgers L, Smith E, Greystoke A, Bayman N, Cree A, Ng C, de Liguori Carino N, Basile S, Moore J, Merchant Z, Swinson D, Parbhoo A, Jones R, Davies E, Danson SJ, Young R, Morgan J, Wyld L, Corrie PG, Doherty GJ, Crawford K, Wright J, Reed M, Ugolini F, Lind M, Cheung KL, Harari D, Simcock R Abstract The ageing population poses new challenges globally. Cancer care for older patients is one of these...
ConclusionsSurgery and SBRT for MPLC patients are safe and feasible treatments with similar outcomes. However, this finding should be verified by a random controlled trial with a larger study cohort. (Source: General Thoracic and Cardiovascular Surgery)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Prognostic utility of preoperative neutrophil–lymphocyte ratio in cats with malignant mammary tumors
Publication date: Available online 22 October 2020Source: Research in Veterinary ScienceAuthor(s): Eiji Naito, Masashi Yuki, Takashi Hirano, Daiki Kainuma, Reina Aoyama (Source: Research in Veterinary Science)
Publication date: Available online 22 October 2020Source: Artificial Intelligence in MedicineAuthor(s): Laura Macías-García, María Martínez-Ballesteros, José María Luna-Romera, José M. García-Heredia, Jorge García-Gutiérrez, José C. Riquelme-Santos (Source: Artificial Intelligence in Medicine)
This study will provide data on the feasibility of conducting a home-based exercise study and pilot data on the impact of exercise on circulating concentrations of biomarkers reported in the literature to be beneficial for the prognostication of PCa. Methods/design: Thirty male patients, clinically-diagnosed with prostate cancer under active surveillance, will be recruited to participate in a 2-arm, 24-week home-based program. Random allocation to each arm - intervention, and control - will...
CONCLUSIONS: Our study suggests that the LMA Gastro might be a safe alternative for ERCP procedures. There was a high level of practitioner satisfaction. Only minor complications, such as hoarseness, mouth or throat soreness, or minor trauma to the tongue were experienced by patients. Similar incidences of complications may occur with GETA and tubeless anesthesia. The procedure was well tolerated by all patients; all patients maintained adequate oxygenation and required only minimal blood pressure...
Publication date: Available online 22 October 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Jiaojiao Zheng, Chunfeng Zhang, Yuan Li, Yang Jiang, Baocai Xing, Xiaojuan Du (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
CONCLUSIONS: Examination of the UPJ segment of UPJO revealed that Cajal cells and telocytes were scanty or absent, collagen to muscle ratio was high. The low density of Cajal cells and telocytes in the renal pelvis of the obstructed UUT, compared to the normal, points out to the role of the renal pelvis in the pathogenesis of UPJ obstruction. PMID: 33084013 [PubMed - as supplied by publisher] (Source: Folia Morphologica)
Authors: Joiner JB, Pylayeva-Gupta Y, Dayton PA Abstract Focused ultrasound (FUS) has recently emerged as a modulator of the tumor microenvironment, paving the way for FUS to become a safe yet formidable cancer treatment option. Several mechanisms have been proposed for the role of FUS in facilitating immune responses and overcoming drug delivery barriers. However, with the wide variety of FUS parameters used in diverse tumor types, it is challenging to pinpoint FUS specifications that...
Mol Syndromol (Source: Molecular Syndromology)
Authors: Wang D, Li M, Li J, Wan X, Huang Y, Wang C, Zhang P, Xu Y, Kong Z, Lu Y, Wang X, Liu C, Ji C, Li L Abstract The AR signaling pathway plays an important role in initiation and progression of many hormone-related cancers including prostate, bladder, kidney, lung, and breast cancer. However, the potential roles of androgen-responsive long noncoding RNAs (lncRNAs) in hormone-related cancers remained unclear. In the present study, we identified 469 novel androgen-responsive lncRNAs...
Conclusions: Our study suggests that AA levels are associated with the stage of disease and prognosis in patients with HNC. More study is necessary to evaluate if serum AA levels may be considered a hallmark of HNC and prove to be clinically useful markers of disease status and prognosis in HNC patients. PMID: 33082883 [PubMed - in process] (Source: Disease Markers)
Chronic jet lag creates favorable cancer conditions in experimental models More at https://www.nsf.gov/discoveries/disc_summ.jsp?cntn_id=301480&WT.mc_id=USNSF_1 This is a Research News item. (Source: NSF Discoveries)
Publication date: January 2021Source: Urology Case Reports, Volume 34Author(s): Matheus Nister, Pablo A. Melo, Jairo A.G. Galvis, Diego D.W. e Sousa, Glaysson T. Tavares, Carlos V.M. Maciel (Source: Urology Case Reports)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Publication date: Available online 21 October 2020Source: European UrologyAuthor(s): Di Maria Jiang, Nazanin Fallah-Rad, Roy Lee, Pamela Ng, Alan D. Smith, Aaron R. Hansen, Anthony M. Joshua, Jaclyn Beca, Srikala S. Sridhar (Source: European Urology)
CONCLUSIONS: Various endpoints confirmed an augmented response of cells in the valley dose region of the Grid block significantly (compared with the cells irradiated by identical dose of uniform beam), suggesting the role of high-dose bystander effect which was more pronounced in resistant carcinoma cell lines. These findings could provide a partial explanation for the Grid beneficial response seen in a number of pre-clinical and clinical studies. PMID: 33074047 [PubMed - as supplied by publisher]...
CONCLUSION: These results suggest that combined treatment with TTF and RT may be a good alternative treatment for patients with pancreatic cancer. PMID: 33074042 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
Conclusions: DNA-PK inhibitor NU7441 radiosensitized 2D cultured NT2.5 monolayer cells but not cells obtained from 3D cultured spheroids. The combination, NU7441 and radiation led to an increase in spheroid fragmentation compared to spheroids treated only with radiation. PMID: 33074046 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)
CONCLUSION: This review focuses on potentially novel mechanisms of TTFields anti-tumor action and their implications in completed and ongoing clinical trials and pre-clinical studies. Moreover, the review discusses advantages and strategies using chemotherapy agents and radiation therapy in combination with TTFields for future clinical use. PMID: 33086019 [PubMed - as supplied by publisher] (Source: International Journal of Radiation Biology)MedWorm Message: If you are looking to buy something...
Conclusion: Molecular methods should be utilized in the differential diagnosis of CL to eliminate false diagnoses of granulomatous diseases and skin cancers. PMID: 33082794 [PubMed] (Source: Iranian Journal of Parasitology)
Authors: Nourian A, Hekmatimoghaddam S, Sazmand A PMID: 33082814 [PubMed] (Source: Iranian Journal of Parasitology)
Authors: Vidula N, Ellisen LW, Bardia A Abstract Metastatic triple-negative breast cancer (TNBC) is associated with a poor prognosis, and the development of better therapeutics represents a major unmet clinical need. Although the mainstay of treatment of metastatic TNBC is chemotherapy, advances in genomics and molecular profiling have helped better define subtypes of TNBC with distinct biologic drivers to guide the therapeutic development of targeted therapies, including AKT inhibitors...
Publication date: November 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 11Author(s): Clare Schilling, Gopinath Gnanasegaran, Selvam Thavaraj, Boris Vojnovic, Rose Ngu, Mark McGurk (Source: European Journal of Surgical Oncology (EJSO))
Publication date: November 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 11Author(s): (Source: European Journal of Surgical Oncology (EJSO))
Publication date: November 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 11Author(s): (Source: European Journal of Surgical Oncology (EJSO))
Publication date: November 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 11Author(s): (Source: European Journal of Surgical Oncology (EJSO))
In the recent Journal article by Obitsu and colleagues,1 80% of the participants were patients with colorectal cancer. All cases of venous thromboembolism (VTE) developing were in patients treated surgically for colorectal cancer. (Source: Journal of the American College of Surgeons)
In the article, “Practice Patterns and Guideline Non-Adherence in Surgical Management of Appendiceal Carcinoid Tumors,” which appeared in the June 2019 issue of the Journal of the American College of Surgeons, Volume 228, Number 6, pages 839-851, the variables for ‘Tumor size’ were printed incorrectly. The correct Table 1 is presented below. The editors apologize for this error. (Source: Journal of the American College of Surgeons)
Conclusions: It is important to focus increased attention on how the daily practical and psychosocial life of patients with chronic cancer, including metastatic GIST, is affected by their disease. Doing so might provide health-care workers with clues regarding how best to guide and support such patients throughout their emotional journey and, therefore, to improve their quality of life. As new medical treatments can also prolong survival and induce long-term clinical remission in relation to several...
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