Title: Actor Jeff Bridges Shares Lymphoma DiagnosisCategory: Health NewsCreated: 10/20/2020 12:00:00 AMLast Editorial Review: 10/21/2020 12:00:00 AM (Source: MedicineNet Cancer General)
Title: What Is Breast Biopsy With Needle Localization?Category: Diseases and ConditionsCreated: 10/21/2020 12:00:00 AMLast Editorial Review: 10/21/2020 12:00:00 AM (Source: MedicineNet Cancer General)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Title: What Does Mediastinal Lymphadenopathy Mean?Category: Diseases and ConditionsCreated: 10/21/2020 12:00:00 AMLast Editorial Review: 10/21/2020 12:00:00 AM (Source: MedicineNet Cancer General)
(European Organisation for Research and Treatment of Cancer) Researchers have found that a class of commonly-used heart drugs may also improve patients' responses to anti-cancer immunotherapies called PD(L)1 inhibitors, according to preliminary findings to be presented at the 32th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, which is taking place online. (Source: EurekAlert! - Cancer)
(European Organisation for Research and Treatment of Cancer) Researchers have developed a way of testing potential drugs for children's cancers so as to take account of the wide genetic diversity of these diseases. instead of conventional testing designs, which use multiple mice as models for rare children's cancers, analysis had revealed that it was possible to evaluate them on a single mouse, which could accelerate the development of better treatments. The research is presented at the 32th EORTC-NCI-AACR...
(European Organisation for Research and Treatment of Cancer) In the largest study of its kind, researchers have found two common genetic variants that can be used to predict whether or not cancer patients might suffer severe adverse side-effects, such as high blood pressure, from the drug bevacizumab. The genome-wide association study is the largest such study in patients being treated with bevacizumab and it is to be presented at the 32th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer...
(Purdue University) A Purdue University scientist and entrepreneur is working to use simple LED light to help determine if certain chemotherapy options will work for specific patients. (Source: EurekAlert! - Biology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
The findings may have implications for radiotherapy, a cancer treatment that can cause damage to salivary glands and leave lasting complications. (Source: The Scientist)
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Researchers at the University of Toronto have found first evidence that neutrophil immune cell activity is the missing link connecting periodontal disease with heart disease, cancer, and other inflammatory conditionsUniversity of Toronto - Faculty of DentistryResearch NewsIMAGE: Neutrophil activation is now believed to be at the root of overactive inflammatory responses, and links conditions such as periodontal disease and heart diseaseviewmore Credit: Noah Fine(TORONTO, ON) Oct. 20, 2020 -- The...
THURSDAY, Oct. 22, 2020 -- If Obamacare, or the Affordable Care Act (ACA), is repealed, pediatric cancer patients could lose critical insurance coverage, a new study warns. Kids with cancer often require intensive treatment and long-term follow-up... (Source: Drugs.com - Daily MedNews)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
WEDNESDAY, Oct. 21, 2020 -- A combination of two " targeted " therapies can beat back a rare form of blood cancer -- without the toxic effects of chemotherapy, a new study has found. In a trial of 63 patients, researchers found that the drug regimen... (Source: Drugs.com - Daily MedNews)
Angiotensin II receptor blockers but not angiotensin converting enzyme inhibitors were associated with better responses and survival for patients receiving immune checkpoint inhibitors for cancer.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
In this guest column, the executive director of the Arizona chapter of the American Cancer Society urges all women to remember to schedule breast cancer screenings, and to help support the organization's efforts statewide. (Source: bizjournals.com Health Care:Physician Practices headlines)
Complete remission, overall survival seen in 98, 95 percent of patients in phase 2 study (Source: The Doctors Lounge - Oncology)
Adherence inversely linked to mortality related to breast cancer, CRC, melanoma in women (Source: The Doctors Lounge - Oncology)
[The Herald] Senior Reporter (Source: AllAfrica News: Health and Medicine)
(American Friends of Tel Aviv University) An international team of researchers has identified a direct molecular link between meat and dairy diets and the development of antibodies in the blood that increase the chances of developing cancer. This connection may explain the high incidence of cancer among those who consume large amounts of dairy products and red meat, similar to the link between high cholesterol and an increased risk of heart disease. (Source: EurekAlert! - Cancer)
(University of Copenhagen The Faculty of Health and Medical Sciences) Researchers from UCPH have discovered how thus far a mysterious function of the so-called MCM proteins protect the human cells against DNA instability, which can cause devastating diseases including cancer. In addition to their known role as molecular motors of genome duplication, MCM proteins control the speed of this process. How cells manage to constrain the speed of DNA replication has puzzled researchers for decades and has...
(Van Andel Research Institute) Scientists have developed a simple, experimental blood test that distinguishes pancreatic cancers that respond to treatment from those that do not. This critical distinction could one day guide therapeutic decisions and spare patients with resistant cancers from undergoing unnecessary treatments with challenging side effects. The findings were published today inClinical Cancer Research, a journal of the American Association for Cancer Research. (Source: EurekAlert!...
(European Organisation for Research and Treatment of Cancer) Scientists cannot be expected to drop everything they're working on to turn their attention to beating COVID-19, according to the winner of the 2019 Nobel Prize in Physiology or Medicine, Professor Sir Peter Ratcliffe. He delivers the the prestigious Michel Clavel lecture to the 32nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, which is taking place online. (Source: EurekAlert! - Cancer)
(Scripps Research Institute) When it comes to defeating cancer, some immune cells are mightier than others. But even the best-trained eye and today's advanced scientific tools have trouble discerning the most powerful tumor-fighting cells from the rest. A new technique developed by Scripps Research scientist Peng Wu, PhD, aims to change that--offering a new platform that could propel personalized cancer treatments that have been hindered due to the challenges of isolating the most useful immune cells...
(JAMA Network) The financial risks and challenges for independent oncology practices in the COVID-19 era and possible solutions to promote their stability and survival are discussed in this Viewpoint. (Source: EurekAlert! - Cancer)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
(University of California - San Diego) UC San Diego researchers use experimental artificial intelligence system called DrugCell to predict the best approach to treating cancer. (Source: EurekAlert! - Cancer)
(University of California - San Francisco) A new study led by UCSF Benioff Children's Hospitals and the Children's Hospital of Philadelphia (CHOP) has quantified the impact of repealing the 2010 Affordable Care Act (ACA) for 18 to 25-year-old cancer patients, who are covered by their parents' health insurance. (Source: EurekAlert! - Cancer)
(European Organisation for Research and Treatment of Cancer) An experimental vaccine, designed to enlist the body's own immune system to target cancer cells, has shown promise for treating and preventing cancer in mice. The vaccine was created to target a gene called KRAS that is involved in the development of many types of cancer, including lung, bowel and pancreatic cancer. (Source: EurekAlert! - Cancer)
(University of Turku) Cellular optogenetics is a technique that allows researchers to use light to precisely control cell signaling and function in space and time enabling the investigation of mechanisms involved in disease processes. A research team from the University of Turku have developed a novel way to make cellular optogenetic tools much easier to monitor and apply, and showed how they can be used to investigate the cellular side effects of medicines used to treat cancer. (Source: EurekAlert!...
(University of California - Los Angeles Health Sciences) More women could potentially be spared an axillary lymph node dissection -- the surgical removal of 10-20 lymph nodes -- a procedure that causes disabling arm swelling in up to 25% of women, according to a UCLA study. (Source: EurekAlert! - Medicine and Health)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
(Michigan Medicine - University of Michigan) The development and validation of a staging system for non-metastatic prostate cancer could help doctors and patients assess treatment options, as well as improve clinical trials. (Source: EurekAlert! - Medicine and Health)
We report a 3.3-angstrom-resolution cryo–electron microscopy structure of cGAS in complex with the nucleosome core particle. The structure reveals that cGAS uses two conserved arginines to anchor to the nucleosome acidic patch. The nucleosome-binding interface exclusively occupies the strong double-stranded DNA (dsDNA)–binding surface on cGAS and sterically prevents cGAS from oligomerizing into the functionally active 2:2 cGAS-dsDNA state. These findings provide a structural basis for how cGAS maintains...
Daohong Zhou and Aileen Frost explore how they target the proteolysis mechanism and fight cancer using proteolysis targeting chimera (PROTAC) technology. (Source: The Scientist)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
A SPAC sponsored by San Francisco's EcoR1, investments from other biotech investors and a record-shattering Series A round push Nuvation Bio's funding to more than $850 million. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
BOWEL cancer is when abnormal cells continually divide, making more abnormal cells. These lump together to form a tumour. If you'd like to lower your risk of this disease, you're best avoiding a certain breakfast. (Source: Daily Express - Health)
Cancer patients are being targeted by a rogue website selling poor quality wigs which do not match the ones pictured in its adverts. (Source: BBC News | Health | UK Edition)
THE WOODLANDS, Texas, Oct. 22, 2020 — The US Oncology Network (The Network), the largest organization of its kind dedicated to advancing local cancer care and better patient outcomes, continues to expand its reach into local communities by welcoming Alliance Cancer Specialists and Northwest Oncology.... (Source: McKesson News)
WEDNESDAY, Oct. 21, 2020 -- A combination of two " targeted " therapies can beat back a rare form of blood cancer -- without the toxic effects of chemotherapy, a new study has found. In a trial of 63 patients, researchers found that the drug regimen... (Source: Drugs.com - Daily MedNews)
(University of Alberta Faculty of Medicine& Dentistry) University of Alberta scientists have identified the mechanism of action behind a new type of precision cancer drug for blood cancers that is set for human trials, according to research published inNature Communications. (Source: EurekAlert! - Cancer)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
(Impact Journals LLC) Volume 11, Issue 31 from @Oncotarget reported that TQ decreased the expression levels of colorectal stem cell markers CD44 and Epithelial Cell Adhesion Molecule Ep CAM and proliferation marker Ki67 in colonospheres derived from both cell lines and reduced cellular migration and invasion. (Source: EurekAlert! - Cancer)
A SPAC sponsored by San Francisco's EcoR1, investments from other biotech investors and a record-shattering Series A round push Nuvation Bio's funding to more than $850 million. (Source: bizjournals.com Health Care:Biotechnology headlines)
Title: What Happens if Melanoma Gets Into Lymph Nodes?Category: Diseases and ConditionsCreated: 10/21/2020 12:00:00 AMLast Editorial Review: 10/21/2020 12:00:00 AM (Source: MedicineNet Cancer General)
Title: What Is a Simple Mastectomy?Category: Diseases and ConditionsCreated: 10/21/2020 12:00:00 AMLast Editorial Review: 10/21/2020 12:00:00 AM (Source: MedicineNet Cancer General)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Title: Actor Jeff Bridges Shares Lymphoma DiagnosisCategory: Health NewsCreated: 10/20/2020 12:00:00 AMLast Editorial Review: 10/21/2020 12:00:00 AM (Source: MedicineNet Cancer General)
Title: Does Retinoblastoma Cause Blindness?Category: Diseases and ConditionsCreated: 10/21/2020 12:00:00 AMLast Editorial Review: 10/21/2020 12:00:00 AM (Source: MedicineNet Cancer General)
Title: What Is Breast Biopsy With Needle Localization?Category: Diseases and ConditionsCreated: 10/21/2020 12:00:00 AMLast Editorial Review: 10/21/2020 12:00:00 AM (Source: MedicineNet Cancer General)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Title: What Does Mediastinal Lymphadenopathy Mean?Category: Diseases and ConditionsCreated: 10/21/2020 12:00:00 AMLast Editorial Review: 10/21/2020 12:00:00 AM (Source: MedicineNet Cancer General)
(European Organisation for Research and Treatment of Cancer) Researchers have found that a class of commonly-used heart drugs may also improve patients' responses to anti-cancer immunotherapies called PD(L)1 inhibitors, according to preliminary findings to be presented at the 32th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, which is taking place online. (Source: EurekAlert! - Cancer)
(European Organisation for Research and Treatment of Cancer) Researchers have developed a way of testing potential drugs for children's cancers so as to take account of the wide genetic diversity of these diseases. instead of conventional testing designs, which use multiple mice as models for rare children's cancers, analysis had revealed that it was possible to evaluate them on a single mouse, which could accelerate the development of better treatments. The research is presented at the 32th EORTC-NCI-AACR...
(European Organisation for Research and Treatment of Cancer) In the largest study of its kind, researchers have found two common genetic variants that can be used to predict whether or not cancer patients might suffer severe adverse side-effects, such as high blood pressure, from the drug bevacizumab. The genome-wide association study is the largest such study in patients being treated with bevacizumab and it is to be presented at the 32th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer...
(Purdue University) A Purdue University scientist and entrepreneur is working to use simple LED light to help determine if certain chemotherapy options will work for specific patients. (Source: EurekAlert! - Biology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
The findings may have implications for radiotherapy, a cancer treatment that can cause damage to salivary glands and leave lasting complications. (Source: The Scientist)
(Impact Journals LLC) The cover for Issue 42 ofOncotarget features Figure 4, " Generation of parametric and texture maps from radiofrequency data, " recently published in " Quantitative ultrasound radiomics using texture derivatives in prediction of treatment response to neo-adjuvant chemotherapy for locally advanced breast cancer " by Dasgupta, et al. which reported that to investigate quantitative ultrasound based higher-order texture derivatives in predicting the response to neoadjuvant chemotherapy...
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Adherence inversely linked to mortality related to breast cancer, CRC, melanoma in women (Source: The Doctors Lounge - Oncology)
Complete remission, overall survival seen in 98, 95 percent of patients in phase 2 study (Source: The Doctors Lounge - Oncology)
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ConclusionIn settings with limited employment protection policies, a cancer diagnosis severely impacts the working experiences of patients, leading to financial loss. Urgent interventions and legislative reforms are needed in these settings to address the unmet employment needs of cancer survivors.Implications for Cancer SurvivorsThis study may facilitate planning of local solutions to fulfill the unmet employment needs following cancer, such as return-to-work navigation services. (Source: Journal...
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ConclusionDespite the use of multi-modal therapeutic regimens, ETMR patients have dismal survival. Understanding the unique biology of these tumors has provided new insights towards novel therapeutic targets. (Source: Journal of Neuro-Oncology)
ConclusionInfiltrating intramedullary astrocytomas WHO II –IV present rare entities with dismal prognosis. Due to the high incidence of surgery-related neurological impairment, the aim of the surgical approach should be limited to obtaining the histological tissue via a biopsy or, tumor debulking in cases with rapidly progressive severe preoperative defi cits. (Source: Journal of Neuro-Oncology)
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Immune checkpoint inhibitor –induced gastroenterocolitis (ICI-GEC) represents one of the common and severe side-effects of immunotherapy, impacting 7–30% of treated patients [1]. Current guidelines recommend systemic corticosteroids for moderate to severe cases of ICI-GEC, but whether these therapies have a dose- or time-d ependent impact on patients' survival outcomes remains unclear [2,3]. Murine data underscore the pleiotropic immunosuppressive effects of corticosteroids, but the clinical implications...
Anal squamous cell carcinoma (SCC) is an infrequent malignancy mainly diagnosed at an early stage, and curative chemoradiotherapy is an effective treatment; therefore, metastatic disease is a rarity with 5% of patients initially metastatic and 10 –17% with distant metastases after standard chemoradiotherapy treatment [1–4]. However, incidence is increasing due to the rise of human papilloma virus (HPV) infections, and we may have to treat metastatic patients more often [4]. Current treatment for...
Background: To compare the diagnostic performance of Ultrasound Elastography, Ultrasonography (Greyscale& Colour Doppler) and Digital Mammography in the characterisation of breast lesions using Pathological diagnosis as Gold standard. (Source: European Journal of Cancer)
This study analyzes the functional relationship between PAFAH and beta-catenin in breast cancer tissue. (Source: European Journal of Cancer)
Background: Breast cancer is the most common female cancer worldwide. In India it is the number one cancer among women. These women have to undergo extensive form of treatment which results in side effects such as fatigue, sexual dysfunction, shoulder and arm morbidity, which adversely affects women ’s quality of life. To support these women during their survivorship period, appropriate strategies should be taught to these women so that they can manage their problems own. With advancement of technology,...
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Purpose: To evaluate patterns of care in treatment and outcome of ductal carcinoma in situ (DCIS) of the breast in the Netherlands since the introduction of the national screening programme. Treatment trends are interpreted against the background of the ongoing debate considering overdiagnosis and overtreatment. (Source: European Journal of Cancer)
Background: The benefits of multimodal prehabilitation are still in its infant stages – there is emerging evidence to suggest that prehab can reduce the length of hospital stay in colorectal surgery patients. However, there is a lack of published data studying the effects of prehab amongst breast surgery patients. Medway NHS Trust has introduced a pilot prehabilitation programme in October 2018 for their breast cancer patients. The aim of this is to increase patients’ physiological reserve with the...
No conflict of interest. (Source: European Journal of Cancer)
Background: This systematic review investigated the impact of complications on long term outcomes for patients with primary invasive operable breast cancer. (Source: European Journal of Cancer)
We report one of the first analyses of PRO-CTCAE for BC patients with curative intent RT from a large, single-institution prospective registry. (Source: European Journal of Cancer)
Background: Androgen receptor (AR) and AR signaling pathway are thought to play a role in tumour progression and be potentially related to treatment responses and outcomes in invasive breast cancer. In present study, we investigated the clinicopathological significance of AR associated signaling pathway using the large transcriptomic database of early-stage invasive breast cancer. (Source: European Journal of Cancer)
Background: In recent decades, breast cancer (BC) is the most common malignancy in the Russian Federation. The population is descended primarily from newcomers (Slavic ancestors) and indigenous population (Mongoloid race). Currently, nothing is known regarding the molecular factors associated with increased risk of hereditary BC in the indigenous population of Russia. BC prevention models for indigenous population have not been developed yet. Our aim was to evaluate the frequency of hereditary mutations...
Objectives: Intraoperative electron radiotherapy (IOERT) can be used to treat early breast cancer during the conservative surgery. The primary endpoint of this prospective phase II study is the evaluation of this treatment in terms of local control. Early complications and cosmesis will also be analyzed. (Source: European Journal of Cancer)
Introduction: Tumors expressing hormonal receptors (HR) are generally associated with better outcome than Her2 positive and triple negative cancer, but they also include a group of high-risk tumors in terms of survival who would benefit from a more aggressive treatment. Specific genomic tests have been proposed to identify these patients but are not so far universally applied. On the other hand, immunohistochemical bioprofiles, integrated with clinical-pathological data, are commonly used in everyday...
Background: Aim of the study is to evaluate the rate of referrals to the breast unit due to incidental breast findings on thoracic CT. (Source: European Journal of Cancer)
Background: Cytidine deaminase apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like (APOBEC) has been identified as an important mutagenic factor in multiple cancers. APOBEC induces specific mutations, which potentially contributes to tumor progression and/or therapy resistance. To learn how APOBEC mutagenesis impacts tumor evolution in ER+/HER2-breast cancer (BC), we determined which APOBEC-associated amino-acid (AA) changes are more frequently observed than expected in primary and metastatic...
Background: Breast cancer is the most frequent cancer in women in the world, however, breast cancer incidence varies substantially world-wide. This disparity can be caused by exposure to reproductive, environmental, lifestyle risk factors, and genetic factors among which is genetic ancestry associated with breast cancer risk. The genetic ancestry is a factor that can influence the risk of many diseases, because of genetic admixture among ancestral source populations from Africa, the Americas and...
We examined what proportion of women with MBC aged 50+yrs received surgery to the primary tumour, and explored what patient and clinical characteristics influence receipt of surgery, as part of the National Audit of Breast Cancer in Older Patients (NABCOP). (Source: European Journal of Cancer)
Background: If endogenous acid –base balance is not well regulated, dietary acid load contributes to metabolic acidosis, which can lead to inflammation and cancer metastasis. However, there is limited epidemiologic evidence on the association between diet-dependent acid load and risk of cancer, particularly for breast cancer (B C). Also increased risk of recurrence among BC survivors was reported for high acid load. We carried out the present study with the aim of exploring its role on BC risk. (Source:...
Background: Early breast cancer (EBC) is not a single disease but consists of several clinically relevant molecular subtypes. Within hormone receptor positive (HR+), HER2 negative (HER2 −) disease, different luminal subtypes (A vs. B) impact on outcome and response to endocrine therapy. Gene expression signatures predicting risk of recurrence are already part of clinical management. Gene profiles correlated with important tumor pathways such as metastasis and progression, immune response or proliferation...
Background: Breast cancer (BC) is the most prevalent female malignancy worldwide. In Russians, who were descended primarily from Slavic ancestors (newcomers), a strong founder effect was observed for the BRCA1 5382insC allele, which account up to 90% of all known BC-associated mutations in this population. To date, despite a significant burden of cancer and limited access to genetic cancer risk assessments there are a limited number of reports on the inherited gene mutations associated with BC among...
Background: Systemic breast cancer therapies interfere with bone turnover and predispose patients to cancer-treatment related bone loss. Breast cancer survivors are at an increased risk for osteoporosis and fracture compared with women in general. (Source: European Journal of Cancer)
Background: Oncoplastic surgery, using plastic surgery ’s metods and techniques, has created a new route in breast surgery and breast cancer therapy with the target of oncologic outcomes comparable to traditional conservative surgery and better aesthetic results. (Source: European Journal of Cancer)
Background: Staging is of great importance for patients with breast cancer in order to make the right therapeutic decisions. The current standard for staging, [18F]FDG PET/CT, might not be the most optimal technique for detection of (distant) metastases in estrogen receptor positive (ER+) breast cancer due to its low metabolic activity rate. The current retrospective study aimed to evaluate the value of [18F]FES PET/CT for (re)staging of patients with clinical (locally) advanced breast cancer or...
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Background: Nowadays the residual tumor after neoadjuvant treatment (NACT) is evaluated by magnetic resonance (MR). Our study has the main objective of estimating MR imaging (MRI) accuracy in finding a complete response to neoadjuvant chemotherapy and estimating the correlation between the size of the residual tumour mass appreciated with MRI after NACT and the size of the residual disease evaluated by post-operative histological examination. (Source: European Journal of Cancer)
Background: Breast cancer molecular subtypes (Luminal A and B, Triple negative, Her2-enriched) together with histology-based parameters (i.e. grading) are pivotal in understanding how tumor response is related to relapse risk and would help clinicians make decisions about additional treatment options after neoadjuvant chemotherapy (NCT). Different methods can be used to assess ER/PR status (Allred score, H score, semiquantitative score). Mitotic index (MI) can be performed on conventional histology...
Background: The 21-gene Recurrence Score ® (RS) assay predicts the likelihood of chemotherapy benefit and 10-year risk of distant recurrence. Thus, this test might be useful to guide adjuvant treatment decisions in HR+/HER2− early breast cancer (EBC). The Oncotype DXÒ Test clinical utility was validated worldwide in major trials includ ing more than 63,000 patients. There are only few studies that investigate the correlation of Ki67 with tumor grade and RS result. The REMAR-Study was designed to...
Background: Clinical prediction models provide insight in the probability of an event based on the combination of multiple predictor variables. Predicted probabilities may support clinical decision making. It is currently uncertain how many prediction models exist to support decision making in breast cancer care, which outcomes can be predicted, and which predictor variables are necessary to predict these outcomes. We aimed to systematically review prediction models that may be used to guide clinical...
This study focuses on patients’ experience with mammography and on their opinion on performing a breast ultrasound only for the assessment of their complaints. (Source: European Journal of Cancer)
This study aims to systematically review current literature with data on the prevalence of depression symptoms in metastatic and recurrent breast cancer patients, examine the pooled mean prevalence of depression symptoms and potential sources of heterogeneity. (Source: European Journal of Cancer)
Background: In the UK there are trends for centralising complex surgery in high-volume centres. Evidence to support this trend are perceived benefits for patients, staff& health economy. In 2012, 5 hospitals in Northeast London were merged as a single NHS trust, serving 2 million people. A new surgical strategy was approved to establish several Surgical Centres of Excellence across the 5 sites. This resulted in patients being required to travel further to have their surgery at the relevant centre....
Background: Radiotherapy enables good long-term local control and survival in early breast cancer patients. However, some patients experience acute or late adverse events that may decrease their quality of life. Cardiotoxicity of radiotherapy represents one of the important late adverse events. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is one of the biomarkers for the evaluation of suspected heart failure. Genetic factors can also contribute to the interindividual variability in the occurrence...
Background: There is a spectrum of lesions that fall into the category of ‘uncertain malignant potential’ (B3). These lesions are often associated with atypia, insitu or invasive carcinoma. Therefore, once these lesions are discovered on biopsy, it necessitates the need to ensure adequate sampling to exclude focal carcinoma. Vacuum Assisted Excision (VAE) has become t he management of choice of B3 lesions (Source: European Journal of Cancer)
Introduction: The surveillance for postoperative metastasis in asymptomatic breast cancer patients has been a debate. The purpose of this study is to analysis survival benefit of surveillance for postoperative metastasis in breast cancer patient. (Source: European Journal of Cancer)
Sentinel lymph node biopsy in early breast cancer: Experience from a tertiary care facility in India
Background: Sentinel lymph node biopsy (SLNBx) is a standard of care in early breast cancer. In India, SLNBx has been slow in uptake. Only in recent years, centres in big cities have adopted it. A retrospective analysis of a prospectively maintained database of SLNBx procedures at Max Superspecialty Hospital, Vaishali, India has been carried out. (Source: European Journal of Cancer)
Background: The new localisation technique of Hologic LOCalizer Radio-Frequency Identification (RFID) Tags for impalpable breast cancers has several advantages over current methods, including the option to be placed anytime prior to surgery and no radioactivity-related protocols. Our unit is the first in the UK to begin using this new technology. (Source: European Journal of Cancer)
Background: The new respiratory illness commonly referred to as “corona virus” and officially called COVID-19 has changed life and delivery of health care worldwide. In UK it has resulted in major changes as not only halted the breast screening but also forced the breast unit to undergo reconfiguration for safety of patients and staff. The risk of becoming s eriously ill from COVID-19 is low for most people. However, it’s very important to know that people being treated for breast cancer may have...
Background: Pertuzumab combined with trastuzumab and chemotherapy is now the standard neoadjuvant treatment for non-metastatic HER2-positive early breast cancer (HER2+ BC). However, information on the efficacy of this combination in Asian population is sparse. This retrospective study aims to assess the clinical outcome of adding pertuzumab to trastuzumab and chemotherapy (PH/CTX) for stage II to III HER2+ BC in an Asian cohort. (Source: European Journal of Cancer)
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