High-sensitive and multiplex biosensing assay of NSCLC-derived exosomes via different recognition sites based on SPRi array

High-sensitive and multiplex biosensing assay of NSCLC-derived exosomes via different recognition sites based on SPRi array: Publication date: Available online 28 January 2020Source: Biosensors and BioelectronicsAuthor(s): Yunpeng Fan, Xiaolei Duan, Min Zhao, Xiaotong Wei, Jiangling Wu, Wenqin Chen, Ping Liu, Wei Cheng, Quan Cheng, Shijia DingAbstractNon-small cell lung cancer (NSCLC) have been reported to secret a high concentration of exosomes into blood circulatory system, which is one of sensitive and non-invasive biomarkers for NSCLC's early-stage diagnosis. But it is still lack of feasible and accurate methods to analyze the different NSCLC cells-derived exosomes. Herein, we built a SPRi biosensing assay for high-sensitive and multiplex characterization of NSCLC-derived exosomes by bioaffinity interactions of antibodies and different recognition sites. By this way, the exosomes derived from normal lung and...