Life, Vol. 10, Pages 9: A Strategy for Combinatorial Cavity Design in De Novo Proteins Life doi: 10.3390/life10020009 Authors: Karas Hecht Protein sequence space is vast; nature uses only an infinitesimal fraction of possible sequences to sustain life. Are there solutions to biological problems other than those provided by nature? Can we create artificial proteins that sustain life? To investigate these questions, we have created combinatorial collections, or libraries, of novel...
Thu Jan 23, 2020 02:00
Life, Vol. 10, Pages 8: A Theoretical Approach for the Electrochemical Characterization of Ciliary Epithelium Life doi: 10.3390/life10020008 Authors: Riccardo Sacco Giovanna Guidoboni Joseph W. Jerome Giulio Bonifazi Nicholas M. Marazzi Alice C. Verticchio Vercellin Matthew S. Lang Alon Harris The ciliary epithelium (CE) is the primary site of aqueous humor (AH) production, which results from the combined action of ultrafiltration and ionic secretion. Modulation...
Thu Jan 23, 2020 02:00
MPs, Vol. 3, Pages 10: A Rapid and Accurate Bioluminescence-Based Migration Assay Permitting Analysis of Tumor Cell/Stromal Cell Interactions Methods and Protocols doi: 10.3390/mps3010010 Authors: Yoon Parish Coupland Bioluminescent tumor cell lines are used extensively in vivo to monitor tumor growth and metastasis but rarely used in vitro to follow tumor cell behavior. Tumor cell migration is frequently studied in vitro using transwell assays, however, current methods do not...
Thu Jan 23, 2020 02:00
Microorganisms, Vol. 8, Pages 165: Impact of Chronic Obstructive Pulmonary Disease on Incidence, Microbiology and Outcome of Ventilator-Associated Lower Respiratory Tract Infections Microorganisms doi: 10.3390/microorganisms8020165 Authors: Rouzé Boddaert Martin-Loeches Povoa Rodriguez Ramdane Salluh Houard Nseir Objectives: To determine the impact of chronic obstructive pulmonary disease (COPD) on incidence, microbiology, and outcomes of ventilator-associated...
Thu Jan 23, 2020 02:00
Microorganisms, Vol. 8, Pages 164: Mbov_0503 Encodes a Novel Cytoadhesin that Facilitates Mycoplasma bovis Interaction with Tight Junctions Microorganisms doi: 10.3390/microorganisms8020164 Authors: Zhu Dong Baranowski Li Zhao Hao Zhang Chen Hu Chen Citti Guo Molecules contributing to microbial cytoadhesion are important virulence factors. In Mycoplasma bovis, a minimal bacterium but an important cattle pathogen, binding to host cells is emerging...
Thu Jan 23, 2020 02:00
Microorganisms, Vol. 8, Pages 158: CD209 and Not CD28 or STAT6 Polymorphism Mediates Clinical Malaria and Parasitemia among Children from Nigeria Microorganisms doi: 10.3390/microorganisms8020158 Authors: Morenikeji Metelski Hawkes Capria Seamans Falade Ojurongbe Thomas Malaria remains a significant disease, causing epic health problems and challenges all over the world, especially in sub-Saharan Africa. CD209 and CD28 genes act as co-stimulators and regulators...
Thu Jan 23, 2020 02:00
Microorganisms, Vol. 8, Pages 162: Conjugation in Euplotes raikovi (Protista, Ciliophora): New Insights into Nuclear Events and Macronuclear Development from Micronucleate and Amicronucleate Cells Microorganisms doi: 10.3390/microorganisms8020162 Authors: Gong Jiang Vallesi Gao Gao Ciliates form a distinct group of single-celled eukaryotes that host two types of nuclei (micro and macronucleus) in the same cytoplasm and have a special sexual process known as conjugation,...
Thu Jan 23, 2020 02:00
Microorganisms, Vol. 8, Pages 163: Microbial Degradation of Different Hydrocarbon Fuels with Mycoremediation of Volatiles Microorganisms doi: 10.3390/microorganisms8020163 Authors: Horel Schiewer Naturally occurring microorganisms in soil matrices play a significant role in overall hydrocarbon contaminant removal. Bacterial and fungal degradation processes are major contributors to aerobic remediation of surface contaminants. This study investigated degradation of conventional diesel,...
Thu Jan 23, 2020 02:00
Microorganisms, Vol. 8, Pages 161: Salmonella Genomic Island 1 is Broadly Disseminated within Gammaproteobacteriaceae Microorganisms doi: 10.3390/microorganisms8020161 Authors: Cummins Hamidian Djordjevic Salmonella genomic island 1 (SGI1) is an integrative mobilisable element that plays an important role in the capture and spread of multiple drug resistance. To date, SGI1 has been found in clinical isolates of Salmonella enterica serovars, Proteus mirabilis, Morganella morganii,...
Thu Jan 23, 2020 02:00
Microorganisms, Vol. 8, Pages 159: Improvement of Saccharification and Delignification Efficiency of Trichoderma reesei Rut-C30 by Genetic Bioengineering Microorganisms doi: 10.3390/microorganisms8020159 Authors: Gopalakrishnan Manavalan Ramesh Thangavelu Heese Trichoderma reesei produces various saccharification enzymes required for biomass degradation. However, the lack of an effective lignin-degrading enzyme system reduces the species’ efficiency in producing...
Thu Jan 23, 2020 02:00
Microorganisms, Vol. 8, Pages 160: Nanoscale Phenotypic Textures of Yersinia pestis Across Environmentally-Relevant Matrices Microorganisms doi: 10.3390/microorganisms8020160 Authors: Iqbal Bertino Shah Ehrhardt Yadavalli The persistence of bacterial pathogens within environmental matrices plays an important role in the epidemiology of diseases, as well as impacts biosurveillance strategies. However, the adaptation potentials, mechanisms for survival, and ecological...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 504: Effectiveness of Different Analytical Methods for the Characterization of Propolis: A Case of Study in Northern Italy Molecules doi: 10.3390/molecules25030504 Authors: Pavlovic Borgonovo Leoni Giupponi Ceciliani Sala Bassoli Giorgi : Propolis is used as folk medicine due to its spectrum of alleged biological and pharmaceutical properties and it is a complex matrix not still totally characterized. Two batches of propolis coming...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 503: White Matter and Neuroprotection in Alzheimer’s Dementia Molecules doi: 10.3390/molecules25030503 Authors: Lorenzini Fernandez Baldassarro Bighinati Giuliani Calzà Giardino Myelin is the main component of the white matter of the central nervous system (CNS), allowing the proper electrical function of the neurons by ensheathing and insulating the axons. The extensive use of magnetic resonance imaging has highlighted the white matter...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 500: Impacts of Chemical-Assisted Thermal Pretreatments on Methane Production from Fruit and Vegetable Harvesting Wastes: Process Optimization Molecules doi: 10.3390/molecules25030500 Authors: Günerhan Us Dumlu Yılmaz Carrère Perendeci The increasing population creates excess pressure on the plantation and production of fruits and vegetables across the world. Consumption demand during the whole year has made production compulsory in the...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 501: The Antiproliferative Activity of Oxypeucedanin via Induction of G2/M Phase Cell Cycle Arrest and p53-Dependent MDM2/p21 Expression in Human Hepatoma Cells Molecules doi: 10.3390/molecules25030501 Authors: Park Hong Park Lee Oxypeucedanin (OPD), a furocoumarin compound from Angelica dahurica (Umbelliferae), exhibits potential antiproliferative activities in human cancer cells. However, the underlying molecular mechanisms of OPD as an anticancer...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 502: A New Method for Determination of Thymol and Carvacrol in Thymi herba by Ultraperformance Convergence Chromatography (UPC2) Molecules doi: 10.3390/molecules25030502 Authors: Chang Sun Ma Han Zhao Bai Zhang Yang Ultraperformance convergence chromatography is an environmentally friendly analytical technique for dramatically reducing the use of organic solvents compared to conventional chromatographic methods. In this study, a...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 499: Non-Volatile Transistor Memory with a Polypeptide Dielectric Molecules doi: 10.3390/molecules25030499 Authors: Lijuan Liang Wenjuan He Rong Cao Xianfu Wei Sei Uemura Toshihide Kamata Kazuki Nakamura Changshuai Ding Xuying Liu Norihisa Kobayashi Organic nonvolatile transistor memory with synthetic polypeptide derivatives as dielectric was fabricated by a solution process. When only poly (γ-benzyl-l-glutamate) (PBLG) was...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 498: Fragaria Genus: Chemical Composition and Biological Activities Molecules doi: 10.3390/molecules25030498 Authors: Fierascu Temocico Fierascu Ortan Babeanu The strawberries represent in our days one of the main fresh fruits consumed globally, inevitably leading to large amounts of by-products and wastes. Usually appreciated because of their specific flavor, the strawberries also possess biological properties, including antioxidant, antimicrobial,...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 496: Abnormal Cannabidiol Affects Production of Pro-Inflammatory Mediators and Astrocyte Wound Closure in Primary Astrocytic-Microglial Cocultures Molecules doi: 10.3390/molecules25030496 Authors: Cardinal von Widdern Hohmann Dehghani Abnormal cannabidiol (abn-CBD) exerts neuroprotective effects in vivo and in vitro. In the present study, we investigated the impact of abn-CBD on the glial production of proinflammatory mediators and scar formation within...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 494: Chicken Heads as a Promising By-Product for Preparation of Food Gelatins Molecules doi: 10.3390/molecules25030494 Authors: Gál Mokrejš Mrázek Pavlačková Janáčová Orsavová Every year, the poultry industry produces a large number of by-products such as chicken heads containing a considerable proportion of proteins, particularly collagen. To prepare gelatin is one of the possibilities to advantageously utilize these by-products as raw...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 497: Simple Syntheses of New Pegylated Trehalose Derivatives as a Chemical Tool for Potential Evaluation of Cryoprotectant Effects on Cell Membrane Molecules doi: 10.3390/molecules25030497 Authors: Pomeisl Richter Golan Kratochvílová In our work, we developed the synthesis of new polyfunctional pegylated trehalose derivatives and evaluated their cryoprotective effect using flow cytometry. We showed that new compounds (modified trehaloses) bound...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 492: Redox-Modulations of Photophysical and Single-molecule Magnet Properties in Ytterbium Complexes Involving Extended-TTF Triads Molecules doi: 10.3390/molecules25030492 Authors: Lefeuvre Flores Gonzalez Gendron Dorcet Riobé Cherkasov Maury Le Guennic Cador Kuropatov Pointillart The reaction between the 2,2’-benzene-1,4-diylbis(6-hydroxy-4,7-di-tert-butyl-1,3-benzodithiol-2-ylium-5-olate triad (H2SQ) and the...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 493: Biological Activities of Gedunin—A Limonoid from the Meliaceae Family
Molecules, Vol. 25, Pages 493: Biological Activities of Gedunin—A Limonoid from the Meliaceae Family Molecules doi: 10.3390/molecules25030493 Authors: Braga Rocha Chung Oliveira Pinho Oliveira Morgado Cruz Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Several biological activities have been attributed to gedunin, including antibacterial, insecticidal, antimalarial, antiallergic, anti-inflammatory, anticancer,...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 488: Towards the Properties of Different Biomass-Derived Proteins via Various Extraction Methods Molecules doi: 10.3390/molecules25030488 Authors: Du Arauzo Meza Zavala Cao Olszewski Kruse This study selected three representative protein-rich biomass—brewer’s spent grain (BSG), pasture grass (PG), and cyanobacteria (Arthrospira platensis; AP) for protein extraction with different extraction methods (alkaline treatment,...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 495: Dapagliflozin Inhibits Cell Adhesion to Collagen I and IV and Increases Ectodomain Proteolytic Cleavage of DDR1 by Increasing ADAM10 Activity Molecules doi: 10.3390/molecules25030495 Authors: Okada Yamada Saito Yokoo Osaki Shimoda Ozawa Nakajima Pessin Okada Yamada Dapagliflozin, empagliflozin, tofogliflozin, selective inhibitors of sodium-glucose cotransporter 2 (SGLT2), is used clinically to reduce circulation...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 490: Nanomedicine and Immunotherapy: A Step Further towards Precision Medicine for Glioblastoma Molecules doi: 10.3390/molecules25030490 Authors: Šamec Zottel Videtič Paska Jovčevska Owing to the advancement of technology combined with our deeper knowledge of human nature and diseases, we are able to move towards precision medicine, where patients are treated at the individual level in concordance with their genetic profiles. Lately, the integration...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 489: Design, Synthesis, and Evaluation of Acetylcholinesterase and Butyrylcholinesterase Dual-Target Inhibitors against Alzheimer’s Diseases Molecules doi: 10.3390/molecules25030489 Authors: Guo Yang Huang Tian Li Du Chen Liu Sun Liu A series of novel compounds 6a–h, 8i–1, 10s–v, and 16a–d were synthesized and evaluated, together with the known analogs 11a–f, for their inhibitory...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 487: Predicting the Blood-Brain Barrier Permeability of New Drug-Like Compounds via HPLC with Various Stationary Phases Molecules doi: 10.3390/molecules25030487 Authors: Janicka Sztanke Sztanke The permeation of the blood-brain barrier is a very important consideration for new drug candidate molecules. In this research, the reversed-phase liquid chromatography with different columns (Purosphere RP-18e, IAM.PC.DD2 and Cosmosil Cholester) was used to...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 491: Innovative Three-Step Microwave-Promoted Synthesis of N-Propargyltetrahydroquinoline and 1,2,3-Triazole Derivatives as a Potential Factor Xa (FXa) Inhibitors: Drug Design, Synthesis, and Biological Evaluation. Molecules doi: 10.3390/molecules25030491 Authors: Santana-Romo Lagos Duarte Castillo Moglie Maestro Charbe Zacconi The coagulation cascade is the process of the conversion of soluble fibrinogen to insoluble fibrin that...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 482: Huntington’s Disease: A Review of the Known PET Imaging Biomarkers and Targeting Radiotracers Molecules doi: 10.3390/molecules25030482 Authors: Klaudia Cybulska Lars Perk Jan Booij Peter Laverman Mark Rijpkema Huntington’s disease (HD) is a fatal neurodegenerative disease caused by a CAG expansion mutation in the huntingtin gene. As a result, intranuclear inclusions of mutant huntingtin protein are formed, which damage striatal medium...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 483: Dissipation of Emamectin Benzoate Residues in Rice and Rice-Growing Environments Molecules doi: 10.3390/molecules25030483 Authors: Deng Chen Guan Liu Liang Li Li The experiment developed the ultra-high-performance liquid chromatography–tandem mass spectrometry (UPLC/MS/MS) method for testing emamectin benzoate, and studied the metabolism of emamectin benzoate in rice plants and rice-growing environments via application...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 481: Hepatotoxicity Modeling Using Counter-Propagation Artificial Neural Networks: Handling an Imbalanced Classification Problem Molecules doi: 10.3390/molecules25030481 Authors: Bajželj Drgan Drug-induced liver injury is a major concern in the drug development process. Expensive and time-consuming in vitro and in vivo studies do not reflect the complexity of the phenomenon. Complementary to wet lab methods are in silico approaches, which present a cost-efficient...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 484: Small Peptide-Doxorubicin Co-Assembly for Synergistic Cancer Therapy Molecules doi: 10.3390/molecules25030484 Authors: Li Chen Chen Peng Yang Design of elaborated nanomaterials to improve the therapeutic efficacy and mitigate the side effects of chemotherapeutic anticancer drugs, such as Doxorubicin (Dox), is significant for cancer treatment. Here, we describe a co-assembled strategy, where amphiphile short peptides are co-assembled with...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 480: Synthesis and Spectral Study of a New Family of 2,5-Diaryltriazoles Having Restricted Rotation of the 5-Aryl Substituent Molecules doi: 10.3390/molecules25030480 Authors: Tsyrenova Nenajdenko Efficient synthesis of 2,5-diaryl substituted 4-azido-1,2,3-triazoles by the reaction of sodium azide with dichlorosubstituted diazadienes was demonstrated. The optical properties of the prepared azidotriazoles were studied to reveal a luminescence maximum in...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 485: Identification and Characterization of pantocin wh-1, a Novel Cyclic Polypeptide Produced by Pantoea dispersa W18 Molecules doi: 10.3390/molecules25030485 Authors: Teng Li Zhang Li Pantoea dispersa W18, isolated from contaminated soil, was found to exert antimicrobial activity against Mycobacterium species, including Mycobacterium tuberculosis, an important human pathogen. Here, the anti-mycobacterial compound produced by Pantoea dispersa...
Thu Jan 23, 2020 02:00
Molecules, Vol. 25, Pages 486: Phase Transition of Ice at High Pressures and Low Temperatures Molecules doi: 10.3390/molecules25030486 Authors: Xu Liu Liu Hu He Li The behavior of ice under extreme conditions undergoes the change of intermolecular binding patterns and leads to the structural phase transitions, which are needed for modeling the convection and internal structure of the giant planets and moons of the solar system as well as H2O-rich exoplanets. Such...
Thu Jan 23, 2020 02:00
Nanomaterials, Vol. 10, Pages 200: The Application of Nano-MoS2 Quantum Dots as Liquid Lubricant Additive for Tribological Behavior Improvement Nanomaterials doi: 10.3390/nano10020200 Authors: Guo Peng Du Shen Li Li Dong Molybdenum disulfide quantum dots (MoS2 QDs) are a promising lubricant additive for enhanced engine efficiency. In this study, MoS2 QDs were used as lubricating oil additives for ball-on-disc contact and had adequate dispersity in paroline oil,...
Thu Jan 23, 2020 02:00
Nanomaterials, Vol. 10, Pages 197: Defect Structure Determination of GaN Films in GaN/AlN/Si Heterostructures by HR-TEM, XRD, and Slow Positrons Experiments Nanomaterials doi: 10.3390/nano10020197 Authors: Ene Dinescu Djourelov Zai Vasile Serban Leca Andronescu The present article evaluates, in qualitative and quantitative manners, the characteristics (i.e., thickness of layers, crystal structures, growth orientation, elemental diffusion depths, edge, and...
Thu Jan 23, 2020 02:00
Nanomaterials, Vol. 10, Pages 198: Almond Shell-Derived, Biochar-Supported, Nano-Zero-Valent Iron Composite for Aqueous Hexavalent Chromium Removal: Performance and Mechanisms Nanomaterials doi: 10.3390/nano10020198 Authors: Shu Ji Cui Shi Wang Hu Luo Guo Nano-zero-valent iron biochar derived from almond shell (nZVI-ASBC) was used for hexavalent chromium (CR) removal. Experiments showed that pH was the main factor (p < 0.01) that affected the experimental...
Thu Jan 23, 2020 02:00
Nanomaterials, Vol. 10, Pages 196: Applications of Nanocellulose/Nanocarbon Composites: Focus on Biotechnology and Medicine Nanomaterials doi: 10.3390/nano10020196 Authors: Bacakova Pajorova Tomkova Matejka Broz Stepanovska Prazak Skogberg Siljander Kallio Nanocellulose/nanocarbon composites are newly emerging smart hybrid materials containing cellulose nanoparticles, such as nanofibrils and nanocrystals, and carbon nanoparticles, such as “classical”...
Thu Jan 23, 2020 02:00
Nanomaterials, Vol. 10, Pages 199: Eu-Doped Citrate-Coated Carbonated Apatite Luminescent Nanoprobes for Drug Delivery Nanomaterials doi: 10.3390/nano10020199 Authors: Jabalera Oltolina Prat Jimenez-Lopez Fernández-Sánchez Choquesillo-Lazarte Gómez-Morales In the field of Nanomedicine, there is an increasing demand for new inorganic nanophosphors with low cytotoxicity and efficient loading-release ability of drugs for applications in bioimaging and drug delivery....
Thu Jan 23, 2020 02:00
ncRNA, Vol. 6, Pages 5: MiRNAs as Novel Adipokines: Obesity-Related Circulating MiRNAs Influence Chemosensitivity in Cancer Patients Non-Coding RNA doi: 10.3390/ncrna6010005 Authors: Withers Dewhurst Hammond Topham Adipose tissue is an endocrine organ, capable of regulating distant physiological processes in other tissues via the release of adipokines into the bloodstream. Recently, circulating adipose-derived microRNAs (miRNAs) have been proposed as a novel class of adipokine,...
Thu Jan 23, 2020 02:00
Nutrients, Vol. 12, Pages 306: Safety and Effectiveness of the Prolonged Treatment of Children with a Ketogenic Diet Nutrients doi: 10.3390/nu12020306 Authors: Jana Ruiz Herrero Elvira Cañedo Villarroya Juan José García Peñas Beatriz García Alcolea Begoña Gómez Fernández Laura Andrea Puerta Macfarland Consuelo Pedrón Giner Background: The ketogenic diet (KD) is an effective treatment against drug-resistant epilepsy in children. The KD is a diet rich in fats that produces...
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Nutrients, Vol. 12, Pages 302: The Role of Glycemic Index and Glycemic Load in the Development of Real-Time Postprandial Glycemic Response Prediction Models for Patients With Gestational Diabetes Nutrients doi: 10.3390/nu12020302 Authors: Pustozerov Tkachuk Vasukova Dronova Shilova Anopova Piven Pervunina Vasilieva Grineva Popova The incorporation of glycemic index (GI) and glycemic load (GL) is a promising way to improve the accuracy of postprandial...
Thu Jan 23, 2020 02:00
Nutrients, Vol. 12, Pages 304: Frequently Consumed Foods and Energy Contributions among Food Secure and Insecure U.S. Children and Adolescents Nutrients doi: 10.3390/nu12020304 Authors: Eicher-Miller Boushey Bailey Yang Food insecurity is associated with nutritional risk in children. This study identified and compared the most frequently consumed foods, beverages, and food groups and their contributions to energy intake among U.S. children and adolescents (6–11,...
Thu Jan 23, 2020 02:00
Nutrients, Vol. 12, Pages 305: The Impact of Coconut Oil and Epigallocatechin Gallate on the Levels of IL-6, Anxiety and Disability in Multiple Sclerosis Patients Nutrients doi: 10.3390/nu12020305 Authors: Platero Cuerda-Ballester Ibáñez Sancho Lopez-Rodríguez Drehmer Ortí Background: Due to the inflammatory nature of multiple sclerosis (MS), interleukin 6 (IL-6) is high in blood levels, and it also increases the levels of anxiety related to functional disability....
Thu Jan 23, 2020 02:00
Nutrients, Vol. 12, Pages 303: Combined Treatment with Two Water Extracts of Eleutherococcus senticosus Leaf and Rhizome of Drynaria fortunei Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind Study in Healthy Adults Nutrients doi: 10.3390/nu12020303 Authors: Tohda Matsui Inada Yang Kuboyama Kimbara Watari We previously found that the water extract of Eleutherococcus senticosus leaves (ES extract) enhanced cognitive function in normal...
Thu Jan 23, 2020 02:00
Pharmaceuticals, Vol. 13, Pages 21: Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Simple Analysis of Sumatriptan and its Application in Bioequivalence Study Pharmaceuticals doi: 10.3390/ph13020021 Authors: Wisut Wichitnithad Siriwan Nantaphol Petploy Vicheantawatchai Thanyaporn Kiatkumjorn Wachirasak Wangkangwan Pornchai Rojsitthisak This work demonstrated a sensitive, selective, and simple liquid chromatography-tandem mass spectrometry...
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Plants, Vol. 9, Pages 150: Sphingolipid Effects on the Plasma Membrane Produced by Addition of Fumonisin B1 to Maize Embryos Plants doi: 10.3390/plants9020150 Authors: Nora A. Gutiérrez-Nájera Mariana Saucedo-García Liliana Noyola-Martínez Christian Vázquez-Vázquez Silvia Palacios-Bahena Laura Carmona-Salazar Javier Plasencia Mohammed El-Hafidi Marina Gavilanes-Ruiz Fumonisin B1 is a mycotoxin produced by Fusarium verticillioides that modifies the membrane properties...
Thu Jan 23, 2020 02:00
Plants, Vol. 9, Pages 149: Extracts of Common Pesticidal Plants Increase Plant Growth and Yield in Common Bean Plants Plants doi: 10.3390/plants9020149 Authors: Mkindi Tembo Mbega Smith Farrell Ndakidemi Stevenson Belmain Common bean (Phaseolus vulgaris) is an important food and cash crop in many countries. Bean crop yields in sub-Saharan Africa are on average 50% lower than the global average, which is largely due to severe problems with pests and diseases...
Thu Jan 23, 2020 02:00
Plants, Vol. 9, Pages 145: Factors Affecting Organelle Genome Stability in Physcomitrella patens Plants doi: 10.3390/plants9020145 Authors: Odahara Organelle genomes are essential for plants; however, the mechanisms underlying the maintenance of organelle genomes are incompletely understood. Using the basal land plant Physcomitrella patens as a model, nuclear-encoded homologs of bacterial-type homologous recombination repair (HRR) factors have been shown to play an important role in...
Thu Jan 23, 2020 02:00
Plants, Vol. 9, Pages 148: Elucidating the Possible Involvement of Maize Aquaporins and Arbuscular Mycorrhizal Symbiosis in the Plant Ammonium and Urea Transport under Drought Stress Conditions Plants doi: 10.3390/plants9020148 Authors: Quiroga Erice Aroca Delgado-Huertas Ruiz-Lozano This study investigates the possible involvement of maize aquaporins which are regulated by arbuscular mycorrhizae (AM) in the transport in planta of ammonium and/or urea under well-watered...
Thu Jan 23, 2020 02:00
Plants, Vol. 9, Pages 144: Variation in Root and Shoot Growth in Response to Reduced Nitrogen Plants doi: 10.3390/plants9020144 Authors: Tolley Mohammadi Recently, root traits have been suggested to play an important role in developing greater nitrogen uptake and grain yield. However, relatively few breeding programs utilize these root traits. Over a series of experiments at different growth stages with destructive plant biomass measurements, we analyzed above-ground and below-ground...
Thu Jan 23, 2020 02:00
Plants, Vol. 9, Pages 147: Plant Aspartic Proteases for Industrial Applications: Thistle Get Better Plants doi: 10.3390/plants9020147 Authors: Folgado Abranches Plant proteases have a number of applications in industrial processes including cheese manufacturing. The flower of the cardoon plant (Cynara cardunculus L.) is traditionally used as a milk-clotting agent in protected designation of origin cheeses made from goat and sheep milk. Plant-derived rennets are of particular importance...
Thu Jan 23, 2020 02:00
Plants, Vol. 9, Pages 146: Genotypic Differences in the Effect of P Fertilization on Phytic Acid Content in Rice Grain Plants doi: 10.3390/plants9020146 Authors: Fukushima Perera Hosoya Akabane Hirotsu Phytic acid (PA) prevents the absorption of minerals in the human intestine, and it is regarded as an antinutrient. Low PA rice is beneficial because of its higher Zn bioavailability and it is suggested that the gene expression level of myo-inositol 3-phosphate synthase...
Thu Jan 23, 2020 02:00
Recycling, Vol. 5, Pages 1: Acknowledgement to Reviewers of Recycling in 2019 Recycling doi: 10.3390/recycling5010001 Authors: Recycling Editorial Office The editorial team greatly appreciates the reviewers who have dedicated their considerable time and expertise to the journal’s rigorous editorial process over the past 12 months, regardless of whether the papers are finally published or not [...]
Wed Jan 22, 2020 02:00
Resources, Vol. 9, Pages 12: The Quality of Rainwater Collected from Roofs and the Possibility of Its Economic Use Resources doi: 10.3390/resources9020012 Authors: Zdeb Zamorska Papciak Słyś The large temporal and spatial variability of rainwater quality, as well as the relatively small number of tests, makes the preliminary assessment of its economic exploitation difficult. Determining the relationship between the conditions and location of rainwater collection and rainwater...
Thu Jan 23, 2020 02:00
Social Sciences, Vol. 9, Pages 8: Social Responsibility Attitudes and Behaviors’ Influence on University Students’ Satisfaction Social Sciences doi: 10.3390/socsci9020008 Authors: Gallardo-Vázquez Folgado-Fernández Hipólito-Ojalvo Valdez-Juárez This study focused on university social responsibility (USR). Corporate social responsibility is currently an extremely common strategy implemented by organizations. Higher education institutions are also introducing this strategy...
Thu Jan 23, 2020 02:00
Technologies, Vol. 8, Pages 11: Accelerometer and Magnetometer Joint Calibration and Axes Alignment Technologies doi: 10.3390/technologies8010011 Authors: Konstantinos Papafotis Paul P. Sotiriadis In this work, we propose an algorithm for joint calibration and axes alignment of a 3-axis accelerometer and a 3-axis magnetometer. The proposed algorithm applies when the two sensors are fixed on the same rigid platform. It achieves accurate calibration without requiring any external piece...
Thu Jan 23, 2020 02:00
Toxics, Vol. 8, Pages 8: Analysis of Cannabinoid-Containing Fluids in Illicit Vaping Cartridges Recovered from Pulmonary Injury Patients: Identification of Vitamin E Acetate as a Major Diluent Toxics doi: 10.3390/toxics8010008 Authors: Bryan Duffy Lingyun Li Shijun Lu Lorie Durocher Mark Dittmar Emily Delaney-Baldwin Deepika Panawennage David LeMaster Kristen Navarette David Spink Beginning in June of 2019, there was a marked increase in reported cases of serious...
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Toxins, Vol. 12, Pages 78: Predominant Mycotoxins, Pathogenesis, Control Measures, and Detection Methods in Fermented Pastes Toxins doi: 10.3390/toxins12020078 Authors: Zhao Wang Chen Yao Fermented pastes are some of the most popular traditional products in China. Many studies reported a strong possibility that fermented pastes promote exposure to mycotoxins, including aflatoxins, ochratoxins, and cereulide, which were proven to be carcinogenic and neurotoxic to humans....
Thu Jan 23, 2020 02:00
Toxins, Vol. 12, Pages 74: Diet Breadth Mediates the Prey Specificity of Venom Potency in Snakes Toxins doi: 10.3390/toxins12020074 Authors: Lyons Dugon Healy Venoms are best known for their ability to incapacitate prey. In predatory groups, venom potency is predicted to reflect ecological and evolutionary drivers relating to diet. While venoms have been found to have preyspecific potencies, the role of diet breadth on venom potencies has yet to be tested at large macroecological...
Thu Jan 23, 2020 02:00
Toxins, Vol. 12, Pages 77: Isolation and Characterization of [DLeu1]microcystin-LY from Microcystis aeruginosa CPCC-464 Toxins doi: 10.3390/toxins12020077 Authors: LeBlanc Merkley Thomas Lewis Békri Renaud Pick McCarron Miles Quilliam [D-Leu1]MC-LY (1) ([M + H]+ m/z 1044.5673, Δ 2.0 ppm), a new microcystin, was isolated from Microcystis aeruginosa strain CPCC464. The compound was characterized by 1H and 13C NMR spectroscopy, liquid chromatography–high...
Thu Jan 23, 2020 02:00
Toxins, Vol. 12, Pages 75: Therapeutic Efficacy of onabotulinumtoxinA Delivered Using Various Approaches in Sensory Bladder Disorder Toxins doi: 10.3390/toxins12020075 Authors: Chen Lee Wang Chuang Cystoscopic onabotulinumtoxinA (onaBoNTA) intradetrusor injection is an efficient and durable modality for treating sensory bladder disorders. However, the inconvenience of using the cystoscopic technique and anesthesia, and the adverse effects of direct needle injection (e.g.,...
Thu Jan 23, 2020 02:00
Toxins, Vol. 12, Pages 76: Reduced Expression of a Novel Midgut Trypsin Gene Involved in Protoxin Activation Correlates with Cry1Ac Resistance in a Laboratory-Selected Strain of Plutella xylostella (L.) Toxins doi: 10.3390/toxins12020076 Authors: Gong Kang Zhou Sun Guo Qin Zhu Bai Ye Akami Wu Wang Xu Yang Bravo Soberón Guo Wen Zhang Bacillus thuringiensis (Bt) produce diverse insecticidal proteins to kill insect...
Thu Jan 23, 2020 02:00
Toxins, Vol. 12, Pages 79: Factor XII-Deficient Chicken Plasma as a Useful Target for Screening of Pro- and Anticoagulant Animal Venom Toxins Toxins doi: 10.3390/toxins12020079 Authors: Prezoto Oguiura The sensitivity of vertebrate citrated plasma to pro- and anticoagulant venom or toxins occurs on a microscale level (micrograms). Although it improves responses to agonists, recalcification triggers a relatively fast thrombin formation process in mammalian plasma. As it has a natural...
Thu Jan 23, 2020 02:00
Toxins, Vol. 12, Pages 73: Bioprospecting Sponge-Associated Marine Cyanobacteria to Produce Bioactive Compounds Toxins doi: 10.3390/toxins12020073 Authors: Konstantinou Mavrogonatou Zervou Giannogonas Gkelis Marine cyanobacteria are considered a prolific source of bioactive natural products with a range of biotechnological and pharmacological applications. However, data on the production of natural compounds from sponge-associated cyanobacteria are scarce. This study...
Thu Jan 23, 2020 02:00
Toxins, Vol. 12, Pages 72: Reply to Comment on Re-Visiting Immunogenicity Associated with Botulinum Toxin Treatment. Toxins 2019, 11, 491 Toxins doi: 10.3390/toxins12020072 Authors: Bellows Jankovic We appreciate the commentary on our article by Foster and Beard, both employees of Ipsen [...]
Thu Jan 23, 2020 02:00
Toxins, Vol. 12, Pages 71: Comments on Immunogenicity Associated with Botulinum Toxin Treatment. Toxins 2019, 11, 491 Toxins doi: 10.3390/toxins12020071 Authors: Foster Beard In contrast to the prevailing arguments presented in the current review, the incidence of neutralising antibody (NAb) formation is not a significant issue for any of the present type A therapeutic botulinum neurotoxin (BoNT) products. Furthermore, clinical non-responsiveness is poorly correlated with the presence...
Thu Jan 23, 2020 02:00
Urban Science, Vol. 4, Pages 6: Toponymy, Pioneership, and the Politics of Ethnic Hierarchies in the Spatial Organization of British Colonial Nairobi Urban Science doi: 10.3390/urbansci4010006 Authors: Wanjiru-Mwita Giraut Toponyms, along with other urban symbols, were used as a tool of control over space in many African countries during the colonial period. This strategy was epitomized by the British, who applied it in Nairobi and other parts of Kenya from the late 1800s. This...
Thu Jan 23, 2020 02:00
Vaccines, Vol. 8, Pages 40: Hydrostatic Filtration Enables Large-Scale Production of Outer Membrane Vesicles That Effectively Protect Chickens against Gallibacterium anatis Vaccines doi: 10.3390/vaccines8010040 Authors: Antenucci Arak Gao Allahgadry Thøfner Bojesen Gallibacterium anatis is a Gram-negative opportunistic avian pathogen representing an emerging threat to poultry meat and egg production worldwide. To date, no vaccine able to effectively prevent the morbidity...
Thu Jan 23, 2020 02:00
Veterinary Sciences, Vol. 7, Pages 13: Diversity of Diptera Species in Estonian Pig Farms Veterinary Sciences doi: 10.3390/vetsci7010013 Authors: Tummeleht Jürison Kurina Kirik Jeremejeva Viltrop In light of the African swine fever outbreaks in Estonian pig farms during the past few years, the question of the vector potential of Diptera in the pig farm environment has risen. However, the arthropod fauna of the pig farm environment is currently not well established....
Thu Jan 23, 2020 02:00
Veterinary Sciences, Vol. 7, Pages 12: In Vitro Antibacterial Activity of Biological-Derived Silver Nanoparticles: Preliminary Data Veterinary Sciences doi: 10.3390/vetsci7010012 Authors: Meroni Soares Filipe Martino Silver nanoparticles (AgNPs) are promising alternatives to antibiotics. The aims of this study were to produce AgNPs using two biological methods and determine their antibacterial activity against Pseudomonas aeruginosa and Staphylococcus pseudintermedius. AgNPs...
Thu Jan 23, 2020 02:00
Viruses, Vol. 12, Pages 134: Molecular Detection of Rabies Lyssaviruses from Dogs in Southeastern Nigeria: Evidence of TransboundaryTransmission of Rabies in West Africa Viruses doi: 10.3390/v12020134 Authors: Eze Ngoepe Anene Ezeokonkwo Nwosuh Sabeta Despite being the first country to register confirmed cases of Mokola and Lagos bat lyssaviruses (two very distant lyssaviruses), knowledge gaps, particularly on the molecular epidemiology of lyssaviruses, still exist...
Thu Jan 23, 2020 02:00
Viruses, Vol. 12, Pages 133: Bioprospecting Staphylococcus Phages with Therapeutic and Bio-Control Potential Viruses doi: 10.3390/v12020133 Authors: Oduor Kadija Nyachieo Mureithi Skurnik Emergence of antibiotic-resistant bacteria is a serious threat to the public health. This is also true for Staphylococcus aureus and other staphylococci. Staphylococcus phages Stab20, Stab21, Stab22, and Stab23, were isolated in Albania. Based on genomic and phylogenetic analysis, they...
Thu Jan 23, 2020 02:00
Water, Vol. 12, Pages 335: Numerical Simulation of Frost Heave of Concrete Lining Trapezoidal Channel Under an Open System Water doi: 10.3390/w12020335 Authors: Mo Lou To study the distribution law of frost heave in base soil with a concrete lining structure and compound geomembrane, the coupled heat–moisture–stress, capillary action, and membrane water migration were considered, and multi-field coupling software was used to simulate the frost heaving of the...
Thu Jan 23, 2020 02:00
Water, Vol. 12, Pages 334: A Screening Model to Predict Entrapped LNAPL Depletion Water doi: 10.3390/w12020334 Authors: Teramoto Chang Accidental leakage of hydrocarbons is a common subsurface contamination scenario. Once released, the hydrocarbons migrate until they reach the vicinity of the uppermost portion of the saturated zone, where it accumulates. Whenever the amplitude of the water table fluctuation is high, the light non-aqueous phase liquid (LNAPL) may be completely entrapped...
Thu Jan 23, 2020 02:00
Water, Vol. 12, Pages 333: Modelling the 2012 Lahar in a Sector of Jamapa Gorge (Pico de Orizaba Volcano, Mexico) Using RAMMS and Tree-Ring Evidence Water doi: 10.3390/w12020333 Authors: Franco-Ramos Ballesteros-Cánovas Figueroa-García Vázquez-Selem Stoffel Caballero A good understanding of the frequency and magnitude of lahars is essential for the assessment of torrential hazards in volcanic terrains. In many instances, however, data on past events is scarce or...
Thu Jan 23, 2020 02:00
Water, Vol. 12, Pages 332: Roof-Harvested Rainwater Use in Household Agriculture: Contributions to the Sustainable Development Goals Water doi: 10.3390/w12020332 Authors: Amos Rahman Gathenya Friedler Karim Renzaho Food and water are at the heart of sustainable development. Roof-harvested rainwater kept in rainwater storage systems (RSS) and used in household agriculture (HA) has the potential to increase yields and supplement household nutrition. Combined systems...
Thu Jan 23, 2020 02:00
Water, Vol. 12, Pages 329: A Framework Proposal for Regional-Scale Flood-Risk Assessment of Cultural Heritage Sites and Application to the Castile and León Region (Central Spain) Water doi: 10.3390/w12020329 Authors: Garrote Díez-Herrero Escudero García Floods, at present, may constitute the natural phenomenon with the greatest impact on the deterioration of cultural heritage, which is the reason why the study of flood risk becomes essential in any attempt to manage cultural...
Thu Jan 23, 2020 02:00
Water, Vol. 12, Pages 330: A Bi-Objective Approach for Optimizing the Installation of PATs in Systems of Transmission Mains Water doi: 10.3390/w12020330 Authors: Creaco Galuppini Campisano Ciaponi Pezzinga This paper proposes the bi-objective optimization for the installation of pumps operating as turbines (PATs) in systems of transmission mains, which typically operate at steady flow conditions to cater to tanks in the service of water distribution networks. The methodology...
Thu Jan 23, 2020 02:00
Water, Vol. 12, Pages 331: Photochemically Induced Changes of Dissolved Organic Matter in a Humic-Rich and Forested Stream Water doi: 10.3390/w12020331 Authors: Wilske Herzsprung Lechtenfeld Kamjunke von Tümpling Photochemical processing is an important way to transform terrestrial dissolved organic matter (DOM) but was rarely investigated by ultra-high resolution mass spectrometry. We performed an irradiation experiment with water from a shaded forest stream flowing...
Thu Jan 23, 2020 02:00
Water, Vol. 12, Pages 327: Human Health Risks Associated with Recreational Waters: Preliminary Approach of Integrating Quantitative Microbial Risk Assessment with Microbial Source Tracking Water doi: 10.3390/w12020327 Authors: Gitter Mena Wagner Boellstorff Borel Gregory Gentry Karthikeyan Gastrointestinal (GI) illness risks associated with exposure to waters impacted by human and nonhuman fecal sources were estimated using quantitative microbial risk assessment...
Thu Jan 23, 2020 02:00
Water, Vol. 12, Pages 328: Impacts of Tile Drainage on Phosphorus Losses from Edge-of-Field Plots in the Lake Champlain Basin of New York Water doi: 10.3390/w12020328 Authors: Klaiber Kramer Young Quantifying the influence of tile drainage on phosphorus (P) transport risk is important where eutrophication is a concern. The objective of this study was to compare P exports from tile-drained (TD) and undrained (UD) edge-of-field plots in northern New York. Four plots (46 by 23...
Thu Jan 23, 2020 02:00
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