Antioxidants, Vol. 9, Pages 98: Improved Tetanic Force and Mitochondrial Calcium Homeostasis by Astaxanthin Treatment in Mouse Skeletal Muscle Antioxidants doi: 10.3390/antiox9020098 Authors: Sztretye Singlár Szabó Angyal Balogh Vakilzadeh Szentesi Dienes Csernoch Background: Astaxanthin (AX) a marine carotenoid is a powerful natural antioxidant which protects against oxidative stress and improves muscle performance. Retinol and its derivatives were described...
Thu Jan 23, 2020 02:00
Atmosphere, Vol. 11, Pages 128: Radial Distributions of Sea Surface Temperature and Their Impacts on the Rapid Intensification of Typhoon Hato (2017) Atmosphere doi: 10.3390/atmos11020128 Authors: Ze Zhang Weimin Zhang Wenjing Zhao Chengwu Zhao As a category-3 typhoon, Hato (2017) experienced the notable rapid intensification (RI) over the hot sea surface before its landfall. The RI process and the influences of local sea surface temperature (SST) patterns on the evolution of...
Thu Jan 23, 2020 02:00
Atmosphere, Vol. 11, Pages 127: A Comparative Study on Cooling Period Thermal Comfort Assessment in Modern Open Office Landscape in Estonia Atmosphere doi: 10.3390/atmos11020127 Authors: Kiil Simson Thalfeldt Kurnitski Local thermal comfort and draught rate has been studied widely. There has been more meaningful research performed in controlled boundary condition situations than in actual work environments involving occupants. Thermal comfort conditions in office buildings...
Thu Jan 23, 2020 02:00
Atmosphere, Vol. 11, Pages 126: The Impact of Indoor Malodor: Historical Perspective, Modern Challenges, Negative Effects, and Approaches for Mitigation Atmosphere doi: 10.3390/atmos11020126 Authors: Dalton Claeson Horenziak Malodors, odors perceived to be unpleasant or offensive, may elicit negative symptoms via the olfactory system’s connections to cognitive and behavioral systems at levels below the known thresholds for direct adverse events. Publications on harm...
Thu Jan 23, 2020 02:00
Biomolecules, Vol. 10, Pages 176: Discrimination of Naturally-Occurring 2-Arylbenzofurans as Cyclooxygenase-2 Inhibitors: Insights into the Binding Mode and Enzymatic Inhibitory Activity Biomolecules doi: 10.3390/biom10020176 Authors: Coy-Barrera 2-arylbenzofuran-containing compounds are chemical entities that can be naturally produced by several organisms. A wide-range of activities is described for several compounds of this kind and they are, therefore, valuable moieties for a lead...
Thu Jan 23, 2020 02:00
Biomolecules, Vol. 10, Pages 177: Multiple Targets Directed Multiple Ligands: An In Silico and In Vitro Approach to Evaluating the Effect of Triphala on Angiogenesis Biomolecules doi: 10.3390/biom10020177 Authors: Abhinand Athira Soumya Sudhakaran Angiogenesis is critical in both physiological and pathological conditions and targeting angiogenesis is a promising strategy for the development of therapies against cancer; however, cells develop resistance to anti-angiogenic...
Thu Jan 23, 2020 02:00
Biomolecules, Vol. 10, Pages 175: New Products Generated from the Transformations of Ferulic Acid Dilactone Biomolecules doi: 10.3390/biom10020175 Authors: He Jia Lu Various ferulic acid (FA) dimers occurring in plant cell walls, such as 8-5-, 8-O-4-, 5-5-, and 8-8- coupled dimers, are effective antioxidants and potential antimicrobials. It is necessary to access these diferulates as reference compounds to validate those isolated from plants. 3,6-bis(4-hydroxy-3-methoxyphenyl)-tetrahydrofuro-[3,4-c]furan-1,4-dione,...
Thu Jan 23, 2020 02:00
Biomolecules, Vol. 10, Pages 173: Dill Extract Induces Elastic Fiber Neosynthesis and Functional Improvement in the Ascending Aorta of Aged Mice with Reversal of Age-Dependent Cardiac Hypertrophy and Involvement of Lysyl Oxidase-Like-1 Biomolecules doi: 10.3390/biom10020173 Authors: Fhayli Boëté Kihal Cenizo Sommer Boyle Jacob Faury Elastic fibers (90% elastin, 10% fibrillin-rich microfibrils) are synthesized only in early life and adolescence mainly by the...
Thu Jan 23, 2020 02:00
Biomolecules, Vol. 10, Pages 174: The Guanidine Pseudoalkaloids 10-Methoxy-Leonurine and Leonurine Act as Competitive Inhibitors of Tyrosinase Biomolecules doi: 10.3390/biom10020174 Authors: Kim Leem Lee : Tyrosinase plays a key role in the production of melanin. A variety of industrial fields have shown interest in the development of tyrosinase inhibitors from plants. In this study, compounds 1–5 derived from Leonurus japonicas were evaluated to determine their ability...
Thu Jan 23, 2020 02:00
Brain Sciences, Vol. 10, Pages 61: Investigating Age-Related Neural Compensation During Emotion Perception Using Electroencephalography Brain Sciences doi: 10.3390/brainsci10020061 Authors: Yang Di Bernardi Luft Sun Bhattacharya Banissy Previous research suggests declines in emotion perception in older as compared to younger adults, but the underlying neural mechanisms remain unclear. Here, we address this by investigating how “face-age” and “face...
Thu Jan 23, 2020 02:00
Cancers, Vol. 12, Pages 283: The Association of IL-1 and HRAS Gene Polymorphisms with Breast Cancer Susceptibility in a Jordanian Population of Arab Descent: A Genotype–Phenotype Study Cancers doi: 10.3390/cancers12020283 Authors: AL-Eitan Al-Ahmad Almomani Breast cancer (BC) pathogenesis is poorly understood and not yet completely determined. BC susceptibility genes are responsible for 20% to 25% of breast cancer risk. The main objective of this study is to identify the genetic...
Thu Jan 23, 2020 02:00
Cancers, Vol. 12, Pages 282: Autoimmune Complications in Chronic Lymphocytic Leukemia in the Era of Targeted Drugs Cancers doi: 10.3390/cancers12020282 Authors: Vitale Montalbano Salvetti Boccellato Griggio Boccadoro Coscia Autoimmune phenomena are frequently observed in patients with chronic lymphocytic leukemia (CLL) and are mainly attributable to underlying dysfunctions of the immune system. Autoimmune cytopenias (AIC) affect 4–7% of patients with...
Thu Jan 23, 2020 02:00
Cells, Vol. 9, Pages 284: Gold Nanoparticles Modulate BCG-Induced Innate Immune Memory in Human Monocytes by Shifting the Memory Response towards Tolerance Cells doi: 10.3390/cells9020284 Authors: Swartzwelter Barbero Verde Mangini Pirozzi De Luca Puntes Leite Italiani Boraschi Innate immune memory is characterized by a modulation in the magnitude with which innate immune cells such as monocytes and macrophages respond to potential dangers, subsequent...
Thu Jan 23, 2020 02:00
Cells, Vol. 9, Pages 283: Stem Cell Therapy for Diabetes: Beta Cells versus Pancreatic Progenitors Cells doi: 10.3390/cells9020283 Authors: Memon Abdelalim Diabetes mellitus (DM) is one of the most prevalent metabolic disorders. In order to replace the function of the destroyed pancreatic beta cells in diabetes, islet transplantation is the most widely practiced treatment. However, it has several limitations. As an alternative approach, human pluripotent stem cells (hPSCs) can provide...
Thu Jan 23, 2020 02:00
Cells, Vol. 9, Pages 282: Tannic Acid Promotes TRAIL-Induced Extrinsic Apoptosis by Regulating Mitochondrial ROS in Human Embryonic Carcinoma Cells Cells doi: 10.3390/cells9020282 Authors: Sp Kang Jo Rugamba Kim Park Hwang Yoo Liu Jang Yang : Human embryonic carcinoma (EC; NCCIT) cells have self-renewal ability and pluripotency. Cancer stem cell markers are highly expressed in NCCIT cells, imparting them with the pluripotent nature to differentiate...
Thu Jan 23, 2020 02:00
Children, Vol. 7, Pages 9: Bowel Dilatation on Initial Plane Abdominal Radiography May Help to Assess the Severity of Necrotizing Enterocolitis in Preterm Infants Children doi: 10.3390/children7020009 Authors: Zvizdic Sefic Pasic Dzananovic Rustempasic Milisic Jonuzi Vranic Background: Necrotizing enterocolitis (NEC) is the most common life-threatening gastrointestinal emergency associated with prematurity. Timely diagnosis and adequate treatment are crucial...
Thu Jan 23, 2020 02:00
Climate, Vol. 8, Pages 19: Monitoring Hydrometeorological Droughts Using a Simplified Precipitation Index Climate doi: 10.3390/cli8020019 Authors: Alsumaiei Efficient water management plans should rely on quantitative metrics for assessing water resource shortage scenarios. This study develops a simplified precipitation index (PI) requiring precipitation data only in order to assess hydrometeorological droughts affecting various hydrological systems. The PI index is inspired by the...
Thu Jan 23, 2020 02:00
Diagnostics, Vol. 10, Pages 62: Cardiac Evaluation using Two-Dimensional Speckle-Tracking Echocardiography and Conventional Echocardiography in Taiwanese Patients with Mucopolysaccharidoses Diagnostics doi: 10.3390/diagnostics10020062 Authors: Hsiang-Yu Lin Chih-Kuang Chuang Chung-Lin Lee Ming-Ren Chen Kuo-Tzu Sung Shan-Miao Lin Charles Jia-Yin Hou Dau-Ming Niu Tung-Ming Chang Chung-Lieh Hung Shuan-Pei Lin Background: Mucopolysaccharidoses (MPSs) are a group...
Thu Jan 23, 2020 02:00
Diversity, Vol. 12, Pages 43: Critical Thermal Limits Do Not Vary between Wild-caught and Captive-bred Tadpoles of Agalychnis spurrelli (Anura: Hylidae) Diversity doi: 10.3390/d12020043 Authors: Pintanel Tejedo Almeida-Reinoso Merino-Viteri Gutiérrez-Pesquera Captive-bred organisms are widely used in ecology, evolution and conservation research, especially in scenarios where natural populations are scarce or at risk of extinction. Yet, it is still unclear whether captivity...
Thu Jan 23, 2020 02:00
Foods, Vol. 9, Pages 120: Identification and Characterization of Non-Saccharomyces Species Isolated from Port Wine Spontaneous Fermentations Foods doi: 10.3390/foods9020120 Authors: Mateus Sousa Coimbra S. Rogerson Simões In winemaking, non-Saccharomyces yeast species contribute important organoleptic complexity. Current interest focuses on abundant and dominant strains characteristically present in the early phase of spontaneous alcoholic fermentations. Non-Saccharomyces...
Thu Jan 23, 2020 02:00
Foods, Vol. 9, Pages 123: Improving Stability and Accessibility of Quercetin in Olive Oil-in-Soy Protein Isolate/Pectin Stabilized O/W Emulsion Foods doi: 10.3390/foods9020123 Authors: Wang Wei Deng Xie Huang Zheng Herein we report a soy protein isolate/pectin binary complex particle to stabilize emulsion (olive oil served as dispersed phase) containing quercetin. FTIR was conducted to confirm successful preparation of emulsion before and after embedding quercetin....
Thu Jan 23, 2020 02:00
Foods, Vol. 9, Pages 122: Food Applications and Potential Health Benefits of Pomegranate and its Derivatives Foods doi: 10.3390/foods9020122 Authors: Kandylis Kokkinomagoulos Pomegranate (Punica granatum L.) is an ancient fruit that is particularly cultivated in west Asia, though it is also cultivated in the Mediterranean region and other parts of the world. Since ancient years, its consumption has been associated with numerous health benefits. In recent years, several in vitro...
Thu Jan 23, 2020 02:00
Foods, Vol. 9, Pages 124: Postharvest Fungicide for Avocado Fruits: Antifungal Efficacy and Peel to Pulp Distribution Kinetics Foods doi: 10.3390/foods9020124 Authors: Shimshoni Bommuraj Chen Sperling Barel Feygenberg Maurer Alkan Postharvest application of fungicides is commonly applied in order to reduce food loss. Prochloraz is currently the only postharvest fungicide registered in Israel and Europe in avocado fruits. Due to its unfavorable toxicological...
Thu Jan 23, 2020 02:00
Foods, Vol. 9, Pages 121: Mineral Composition and Antioxidant Potential of Coffee Beverages Depending on the Brewing Method Foods doi: 10.3390/foods9020121 Authors: Janda Jakubczyk Baranowska-Bosiacka Kapczuk Kochman Rębacz-Maron Gutowska Coffee, being one of the world’s most popular beverages, is a rich source of dietary antioxidants. The aim of this study was to determine the mineral content and antioxidant activity as well as acidity of coffee beverages...
Thu Jan 23, 2020 02:00
Fractal Fract, Vol. 4, Pages 4: Acknowledgement to Reviewers of Fractal Fract in 2019 Fractal and Fractional doi: 10.3390/fractalfract4010004 Authors: Fractal and Fractional Editorial Office The editorial team greatly appreciates the reviewers who have dedicated their considerable time and expertise to the journal’s rigorous editorial process over the past 12 months, regardless of whether the papers are finally published or not [...]
Thu Jan 23, 2020 02:00
IJERPH, Vol. 17, Pages 745: School Ethos and Recurring Sickness Absence: A Multilevel Study of Ninth-Grade Students in Stockholm International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030745 Authors: Brolin Låftman Ramberg Modin School absence has been identified as a severe problem in Sweden, both at the individual level and for society as a whole. Despite the multitude and complexity of reasons behind school absence, health-related problems...
Thu Jan 23, 2020 02:00
IJERPH, Vol. 17, Pages 746: Toxic Effects of the Mixture of Phthalates and Bisphenol A—Subacute Oral Toxicity Study in Wistar Rats International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030746 Authors: Baralić Buha Djordjevic Živančević Antonijević Anđelković Javorac Ćurčić Bulat Antonijević Đukić-Ćosić Phthalates and bisphenol A, classified as endocrine disruptors, have weak estrogenic, anti-androgenic properties,...
Thu Jan 23, 2020 02:00
IJERPH, Vol. 17, Pages 744: A Literature Review and Gap Analysis of Emerging Technologies and New Trends in Gambling International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030744 Authors: Lawn Oster Riley Smith Baigent Rahamathulla There have been significant changes in the gambling landscape particularly relating to gambling in the digital age. As the gambling landscape changes, regulation of gambling also needs to change. In 2018,...
Thu Jan 23, 2020 02:00
IJERPH, Vol. 17, Pages 740: Predicting the Associations between Meridians and Chinese Traditional Medicine Using a Cost-Sensitive Graph Convolutional Neural Network International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030740 Authors: Yeh Chao Lai Chen Natural products are the most important and commonly used in Traditional Chinese Medicine (TCM) for healthcare and disease prevention in East-Asia. Although the Meridian system of TCM was established...
Thu Jan 23, 2020 02:00
IJERPH, Vol. 17, Pages 742: Advanced Technology Use by Care Professionals International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030742 Authors: Brandsma Stoffers Schrijver Advanced technology is a primary solution for the shortage of care professionals and increasing demand for care, and thus acceptance of such technology is paramount. This study investigates factors that increase use of advanced technology during elderly care, focusing on current...
Thu Jan 23, 2020 02:00
IJERPH, Vol. 17, Pages 743: Sex-Based Differences in the Quality of Life of Elderly Koreans with Chronic Musculoskeletal Pain International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030743 Authors: Jeong Lee In this study, we constructed a structural equation model (SEM) for predicting the quality of life (QOL) in elderly Koreans with chronic musculoskeletal pain (CMP) and examined the differences between sexes. Data were earlier collected in a prior...
Thu Jan 23, 2020 02:00
IJERPH, Vol. 17, Pages 741: Burnout Syndrome and Meta-Analyses: Need for Evidence-Based Research in Occupational Health. Comments on Prevalence of Burnout in Medical and Surgical Residents: A Meta-Analysis. Int. J. Environ. Res. Public. Health. 2019, 16, doi:10.3390/ijerph16091479 International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030741 Authors: Chirico Magnavita In their meta-analysis of observational studies, Low et al. showed a high prevalence...
Thu Jan 23, 2020 02:00
IJERPH, Vol. 17, Pages 735: Role of the Built and Online Social Environments on Expression of Dining on Instagram International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030735 Authors: Vishwali Mhasawade Anas Elghafari Dustin T. Duncan Rumi Chunara Online social communities are becoming windows for learning more about the health of populations, through information about our health-related behaviors and outcomes from daily life. At the same time,...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 762: The SWI/SNF ATP-Dependent Chromatin Remodeling Complex in Arabidopsis Responds to Environmental Changes in Temperature-Dependent Manner International Journal of Molecular Sciences doi: 10.3390/ijms21030762 Authors: Gratkowska-Zmuda Kubala Sarnowska Cwiek Oksinska Steciuk Rolicka Zaborowska Bucior Maassen Franzen Koncz Sarnowski SWI/SNF ATP-dependent chromatin remodeling complexes (CRCs) play important roles in...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 760: Chrysin Modulates Genes Related to Inflammation, Tissue Remodeling, and Cell Proliferation in the Gastric Ulcer Healing International Journal of Molecular Sciences doi: 10.3390/ijms21030760 Authors: Fagundes de Morais Piffer Périco Rodrigues Hiruma-Lima dos Santos Chrysin exhibits anti-inflammatory and antioxidant activities. Here, the gastroprotective effect of chrysin was investigated in mouse models of gastric ulcer induced by absolute...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 761: Subcellular Localization of the TFF Peptides xP1 and xP4 in the Xenopus laevis Gastric/Esophageal Mucosa: Different Secretion Modes Reflecting Diverse Protective Functions International Journal of Molecular Sciences doi: 10.3390/ijms21030761 Authors: Schwarz Hoffmann The TFF peptides xP1 and xP4 from Xenopus laevis are orthologs of TFF1 and TFF2, respectively. xP1 is secreted as a monomer from gastric surface mucous cells and is generally not associated...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 759: Disruption of the Unique ABCG-Family NBD:NBD Interface Impacts Both Drug Transport and ATP Hydrolysis International Journal of Molecular Sciences doi: 10.3390/ijms21030759 Authors: Kapoor Briggs Cox Kerr ABCG2 is one of a triumvirate of human multidrug ATP binding cassette (ABC) transporters that are implicated in the defense of cells and tissues against cytotoxic chemicals, but these transporters can also confer chemotherapy resistance states in...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 757: Immunologic and Non-Immunologic Mechanisms Leading to Airway Remodeling in Asthma International Journal of Molecular Sciences doi: 10.3390/ijms21030757 Authors: Fang Sun Roth Asthma increases worldwide without any definite reason and patient numbers double every 10 years. Drugs used for asthma therapy relax the muscles and reduce inflammation, but none of them inhibited airway wall remodeling in clinical studies. Airway wall remodeling can either be...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 756: Immunomodulatory and Regenerative Effects of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Renal Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21030756 Authors: Tsuji Kitamura Wada Mesenchymal stem cells (MSCs) have immunomodulatory and regenerative effects in many organs, including the kidney. Emerging evidence has shown that the trophic effects from MSCs are mainly mediated by the paracrine mechanism rather than the...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 755: Low Dose of Penfluridol Inhibits VEGF-Induced Angiogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21030755 Authors: Srivastava Zahra Gupta Tullar Srivastava Mikelis : Metastasis is considered a major burden in cancer, being responsible for more than 90% of cancer-related deaths. Tumor angiogenesis is one of the main processes that lead to tumor metastasis. Penfluridol is a classic and commonly used antipsychotic drug,...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 758: Sonic Hedgehog Signaling in Organogenesis, Tumors, and Tumor Microenvironments International Journal of Molecular Sciences doi: 10.3390/ijms21030758 Authors: Kuo-Shyang Jeng Chiung-Fang Chang Shu-Sheng Lin During mammalian embryonic development, primary cilia transduce and regulate several signaling pathways. Among the various pathways, Sonic hedgehog (SHH) is one of the most significant. SHH signaling remains quiescent in adult mammalian tissues. However,...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 753: NTRK Fusions in Central Nervous System Tumors: A Rare, but Worthy Target International Journal of Molecular Sciences doi: 10.3390/ijms21030753 Authors: Gambella Senetta Collemi Vallero Monticelli Cofano Zeppa Garbossa Pellerino Rudà Soffietti Fagioli Papotti Cassoni Bertero The neurotrophic tropomyosin receptor kinase (NTRK) genes (NTRK1, NTRK2, and NTRK3) code for three transmembrane high-affinity tyrosine-kinase...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 743: A Pentapeptide with Tyrosine Moiety as Fluorescent Chemosensor for Selective Nanomolar-Level Detection of Copper(II) Ions International Journal of Molecular Sciences doi: 10.3390/ijms21030743 Authors: Krzysztof Żamojć Dominik Kamrowski Magdalena Zdrowowicz Dariusz Wyrzykowski Wiesław Wiczk Lech Chmurzyński Joanna Makowska Herein, we have investigated principally with the use of UV and fluorescence (steady-state and time-resolved) spectroscopy...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 752: Constitutive Activation of Guanylate Cyclase by the G86R GCAP1 Variant Is Due to “Locking” Cation-π Interactions that Impair the Activator-to-Inhibitor Structural Transition International Journal of Molecular Sciences doi: 10.3390/ijms21030752 Authors: Abbas Marino Bielefeld Koch Dell’Orco Guanylate Cyclase activating protein 1 (GCAP1) mediates the Ca2+-dependent regulation of the retinal Guanylate Cyclase (GC) in photoreceptors, acting as a...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 751: Effect of Bortezomib on Global Gene Expression in PC12-Derived Nerve Cells
IJMS, Vol. 21, Pages 751: Effect of Bortezomib on Global Gene Expression in PC12-Derived Nerve Cells International Journal of Molecular Sciences doi: 10.3390/ijms21030751 Authors: Łuczkowska Rogińska Ulańczyk Machaliński Peripheral neuropathy is one of the main side-effects of novel therapeutics used in oncohematological diseases, but the molecular basis underlying its development and progression as well as neurotoxicity mechanisms induced by the use of these therapeutics...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 746: Revisiting the Interaction of Melittin with Phospholipid Bilayers: The Effects of Concentration and Ionic Strength International Journal of Molecular Sciences doi: 10.3390/ijms21030746 Authors: Thiru Sabapathy Evelyne Deplazes Ricardo L. Mancera Melittin is an anti-microbial peptide (AMP) and one of the most studied membrane-disrupting peptides. There is, however, a lack of accurate measurements of the concentration-dependent kinetics and affinity of binding...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 750: Platelet Adhesion and Thrombus Formation in Microchannels: The Effect of Assay-Dependent Variables International Journal of Molecular Sciences doi: 10.3390/ijms21030750 Authors: Scavone Bozzi Mencarini Podda Cattaneo Redaelli Microfluidic flow chambers (MFCs) allow the study of platelet adhesion and thrombus formation under flow, which may be influenced by several variables. We developed a new MFC, with which we tested the effects of different...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 748: A Computational Approach for the Prediction of Treatment History and the Effectiveness or Failure of Antiretroviral Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21030748 Authors: Tarasova Biziukova Kireev Lagunin Ivanov Filimonov Poroikov Human Immunodeficiency Virus Type 1 (HIV-1) infection is associated with high mortality if no therapy is provided. Currently, the treatment of an HIV-1 positive patient requires...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 749: The Autophagy Regulatory Molecule CSRP3 Interacts with LC3 and Protects Against Muscular Dystrophy International Journal of Molecular Sciences doi: 10.3390/ijms21030749 Authors: Cui Han Tang He Shen Zhao Chen Wei Wang Zhu Li Yin CSRP3/MLP (cysteine-rich protein 3/muscle Lim protein), a member of the cysteine-rich protein family, is a muscle-specific LIM-only factor specifically expressed in skeletal muscle. CSRP3...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 745: Divergent Regulation of Myotube Formation and Gene Expression by E2 and EPA during In-Vitro Differentiation of C2C12 Myoblasts International Journal of Molecular Sciences doi: 10.3390/ijms21030745 Authors: Lacham-Kaplan Camera Hawley Estrogen (E2) and polyunsaturated fatty acids (n-3PUFA) supplements independently support general wellbeing and enhance muscle regeneration in-vivo and myotube formation in-vitro. However, the combined effect of E2 and...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 747: The Endocannabinoid System: A Target for Cancer Treatment International Journal of Molecular Sciences doi: 10.3390/ijms21030747 Authors: Laezza Pagano Navarra Pastorino Proto Fiore Piscopo Gazzerro Bifulco In recent years, the endocannabinoid system has received great interest as a potential therapeutic target in numerous pathological conditions. Cannabinoids have shown an anticancer potential by modulating several pathways involved...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 744: Super-Resolution Imaging of Tight and Adherens Junctions: Challenges and Open Questions International Journal of Molecular Sciences doi: 10.3390/ijms21030744 Authors: Gonschior Haucke Lehmann The tight junction (TJ) and the adherens junction (AJ) bridge the paracellular cleft of epithelial and endothelial cells. In addition to their role as protective barriers against bacteria and their toxins they maintain ion homeostasis, cell polarity, and mechano-sensing....
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 754: Analysis of Aldo–Keto Reductase Gene Family and Their Responses to Salt, Drought, and Abscisic Acid Stresses in Medicago truncatula International Journal of Molecular Sciences doi: 10.3390/ijms21030754 Authors: Jie Yu Hao Sun Jiaju Zhang Yiyao Hou Tiejun Zhang Junmei Kang Zhen Wang Qingchuan Yang Ruicai Long Salt and drought stresses are two primary abiotic stresses that inhibit growth and reduce the activity of photosynthetic apparatus...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 740: Interplay of Heme with Macrophages in Homeostasis and Inflammation International Journal of Molecular Sciences doi: 10.3390/ijms21030740 Authors: Pradhan Vijayan Gueler Immenschuh Macrophages are an integral part of the mononuclear phagocyte system that is critical for maintaining immune homeostasis. They play a key role for initiation and modulation of immunological responses in inflammation and infection. Moreover, macrophages exhibit a wide spectrum...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 742: Computational Modeling of Claudin Structure and Function International Journal of Molecular Sciences doi: 10.3390/ijms21030742 Authors: Shadi Fuladi Ridaka-Wal Jannat Le Shen Christopher R. Weber Fatemeh Khalili-Araghi Tight junctions form a barrier to control passive transport of ions and small molecules across epithelia and endothelia. In addition to forming a barrier, some of claudins control transport properties of tight junctions by forming...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 739: Roles of Reconstituted High-Density Lipoprotein Nanoparticles in Cardiovascular Disease: A New Paradigm for Drug Discovery International Journal of Molecular Sciences doi: 10.3390/ijms21030739 Authors: Huang Wang Huang Huang Epidemiological results revealed that there is an inverse correlation between high-density lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease (ASCVD). Mounting evidence supports that HDLs...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 741: Omega-3 Versus Omega-6 Polyunsaturated Fatty Acids in the Prevention and Treatment of Inflammatory Skin Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21030741 Authors: Balić Vlašić Žužul Marinović Bukvić Mokos Omega-3 (ω-3) and omega-6 (ω-6) polyunsaturated fatty acids (PUFAs) are nowadays desirable components of oils with special dietary and functional properties. Their therapeutic and health-promoting...
Thu Jan 23, 2020 02:00
IJMS, Vol. 21, Pages 738: Tuning of Titanium Microfiber Scaffold with UV-Photofunctionalization for Enhanced Osteoblast Affinity and Function International Journal of Molecular Sciences doi: 10.3390/ijms21030738 Authors: Iwasaki Hirota Tanaka Kitajima Tabuchi Ishijima Park Sugita Miyazawa Goto Ikeda Ogawa Titanium (Ti) is an osteoconductive material that is routinely used as a bulk implant to fix and restore bones and teeth. This study explored...
Thu Jan 23, 2020 02:00
JCM, Vol. 9, Pages 329: Proteomic Analysis of Iodinated Contrast Agent-Induced Perturbation of Thyroid Iodide Uptake Journal of Clinical Medicine doi: 10.3390/jcm9020329 Authors: Maha Hichri Georges Vassaux Jean-Marie Guigonis Thierry Juhel Fanny Graslin Julien Guglielmi Thierry Pourcher Béatrice Cambien (1) Background: We recently showed that iodinated contrast media (ICM) reduced thyroid uptake of iodide independently of free iodide through a mechanism different...
Thu Jan 23, 2020 02:00
JCM, Vol. 9, Pages 327: Male Infertility: Shining a Light on Lipids and Lipid-Modulating Enzymes in the Male Germline Journal of Clinical Medicine doi: 10.3390/jcm9020327 Authors: Walters Gadella Sutherland Nixon Bromfield Despite the prevalence of male factor infertility, most cases are defined as idiopathic, thus limiting treatment options and driving increased rates of recourse to assisted reproductive technologies (ARTs). Regrettably, our current armory of ARTs...
Thu Jan 23, 2020 02:00
JCM, Vol. 9, Pages 322: Experienced Burden of and Adherence to Smartphone-Based Ecological Momentary Assessment in Persons with Affective Disorders Journal of Clinical Medicine doi: 10.3390/jcm9020322 Authors: van Genugten Schuurmans Lamers Riese Penninx Schoevers Riper Smit (1) Background: The use of smartphone-based ecological momentary assessment (EMA) questionnaires in affective disorder research has rapidly increased. Though, a thorough understanding...
Thu Jan 23, 2020 02:00
JCM, Vol. 9, Pages 325: Impact of Using Different Levels of Threshold-Based Artefact Correction on the Quantification of Heart Rate Variability in Three Independent Human Cohorts Journal of Clinical Medicine doi: 10.3390/jcm9020325 Authors: Alcantara Plaza-Florido Amaro-Gahete Acosta Migueles Molina-Garcia Sacha Sanchez-Delgado Martinez-Tellez Heart rate variability (HRV) is a non-invasive indicator of autonomic nervous system function. HRV recordings...
Thu Jan 23, 2020 02:00
JCM, Vol. 9, Pages 326: Statin and Cancer Mortality and Survival: An Umbrella Systematic Review and Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9020326 Authors: Jeong Lee Kim Eisenhut Kronbichler van der Vliet Shin Gamerith The aim of this study is to provide an overview and understand the strength of evidence and the extent of potential biases and the validity of claimed associations between the use of statins and cancer mortality or survival....
Thu Jan 23, 2020 02:00
JCM, Vol. 9, Pages 323: Multiplexed Proteomic Approach for Identification of Serum Biomarkers in Hepatocellular Carcinoma Patients with Normal AFP Journal of Clinical Medicine doi: 10.3390/jcm9020323 Authors: Lee Ko Yoon Jung Kim Seo Yim Kim Kwon Yeon Um Byun Alpha fetoprotein (AFP) has been used as a serologic indicator of hepatocellular carcinoma (HCC). We aimed to identify an HCC-specific serum biomarker for diagnosis using a multiplexed...
Thu Jan 23, 2020 02:00
JCM, Vol. 9, Pages 324: Eighteen Months Follow-Up with Patient-Centered Outcomes Assessment of Complete Dentures Manufactured Using a Hybrid Nanocomposite and Additive CAD/CAM Protocol Journal of Clinical Medicine doi: 10.3390/jcm9020324 Authors: Cristache Totu Iorgulescu Pantazi Dorobantu Nechifor Isildak Burlibasa Nechifor Enachescu Abstract: The present study aimed to assess the eighteen month follow-up patient-centered outcomes of a simple and...
Thu Jan 23, 2020 02:00
JCM, Vol. 9, Pages 328: Conversion to Everolimus was Beneficial and Safe for Fast and Slow Tacrolimus Metabolizers After Renal Transplantation Journal of Clinical Medicine doi: 10.3390/jcm9020328 Authors: Thölking Gillhaus Schütte-Nütgen Pavenstädt Koch Suwelack Reuter Fast tacrolimus (TAC) metabolism (concentration/dose (C/D) ratio < 1.05 ng/ml/mg) is a risk factor for inferior outcomes after renal transplantation (RTx) as it fosters, e.g., TAC-related...
Thu Jan 23, 2020 02:00
JCM, Vol. 9, Pages 320: Adult Migraine Hospital Admission Trends in Finland: A Nationwide Registry Study Journal of Clinical Medicine doi: 10.3390/jcm9020320 Authors: Sipilä Ruuskanen Rautava Kytö Abstract：Population-level data on migraine hospital admission trends are unavailable. Changes in stroke care may have influenced these, since migraine is one of the most common stroke mimics. In this study, all hospital admissions on neurological, internal medicine, and pediatric...
Thu Jan 23, 2020 02:00
JCM, Vol. 9, Pages 321: Ketone Bodies Are Mildly Elevated in Subjects with Type 2 Diabetes Mellitus and Are Inversely Associated with Insulin Resistance as Measured by the Lipoprotein Insulin Resistance Index Journal of Clinical Medicine doi: 10.3390/jcm9020321 Authors: Garcia Shalaurova Matyus Oskardmay Otvos Dullaart Connelly Background: Quantifying mildly elevated ketone bodies is clinically and pathophysiologically relevant, especially in the context of...
Thu Jan 23, 2020 02:00
JCM, Vol. 9, Pages 319: Mortality on the UNOS Waitlist for Patients with Autoimmune Liver Disease Journal of Clinical Medicine doi: 10.3390/jcm9020319 Authors: Suri Danford Patwardhan Bonder Background: Outcomes on the liver transplant waitlist can vary by etiology. Our aim is to investigate differences in waitlist mortality of autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) using the United Network for Organ Sharing...
Thu Jan 23, 2020 02:00
JCM, Vol. 9, Pages 318: Nanosystems for Improved Targeted Therapies in Melanoma Journal of Clinical Medicine doi: 10.3390/jcm9020318 Authors: Beiu Giurcaneanu Grumezescu Holban Popa Mihai Melanoma is one of the most aggressive forms of skin cancer, with limited therapeutic options. Since its incidence has been rapidly rising in recent years, the study of new targeted therapeutic strategies has increased. The implication of nanoscience in the development of alternative...
Thu Jan 23, 2020 02:00
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