Adult‐onset eosinophilic airway diseases

Adult‐onset eosinophilic airway diseases:

Abstract

Eosinophilic airway inflammation is one of the cardinal features of allergic airway diseases such as atopic asthma and allergic rhinitis. These childhood‐onset conditions are mediated by allergen and allergen‐specific IgE and often accompanied by other allergic diseases including food allergy and eczema. They can develop consecutively in the same patient, which is referred to as an allergic march. In contrast, some phenotypes of asthma, nonsteroidal anti‐inflammatory drugs‐exacerbated airway disease (N‐ERD), chronic rhinosinusitis with nasal polyps (CRSwNP)/eosinophilic CRS, and allergic bronchopulmonary aspergillosis/mycosis (ABPA/ABPM) are adult‐onset airway diseases, which are characterised by prominent peripheral blood eosinophilia. Most of these conditions, except for ABPA/ABPM, are non‐atopic, and the coexistence of multiple diseases, including an adult‐onset eosinophilic systemic disease, eosinophilic granulomatosis with polyangiitis (EGPA), is common. In this review, we focus on eosinophil biology, genetics, and clinical characteristics and the pathophysiology of adult‐onset eosinophilic asthma, N‐ERD, CRSwNP/eosinophilic CRS, ABPA/ABPM, and EGPA, while exploring the common genetic, immunological, and pathological conditions among these adult‐onset eosinophilic diseases.