Antibiotics, Vol. 9, Pages 687: Pulmonary Sequestration Associated with Actinomycosis: A Case Report
Antibiotics, Vol. 9, Pages 687: Pulmonary Sequestration Associated with Actinomycosis: A Case Report Antibiotics doi: 10.3390/antibiotics9100687 Authors: Juan José Chaves Fernando Polo Nieto María Gómez-Gómez Diana Fierro Rodríguez Daniel García-Concha Rafael Parra-Medina Background: Bronchopulmonary sequestration is a rare congenital malformation of the lower respiratory tract; it consists of a nonfunctioning mass of lung tissue that is irrigated by an anomalous systemic...
Fri Oct 09, 2020 03:00
Antibiotics, Vol. 9, Pages 686: Non-Surgical Periodontal Therapy with Adjunctive Amoxicillin/Metronidazole or Metronidazole When No Aggregatibacter Actinomycetemcomitans Is Detected—A Randomized Clinical Trial Antibiotics doi: 10.3390/antibiotics9100686 Authors: Holger F. R. Jentsch Martin Dietrich Sigrun Eick Background: The aim was to compare two different systemic antibiotics regimens adjunctive to non-surgical periodontal therapy when Aggregatibacter actinomycetemcomitans was...
Fri Oct 09, 2020 03:00
Antibiotics, Vol. 9, Pages 685: Rifabutin-Containing Triple Therapy (RHB-105) for Eradication of Helicobacter pylori: Randomized ERADICATE Hp Trial Antibiotics doi: 10.3390/antibiotics9100685 Authors: Ira N. Kalfus David Y. Graham Dennis S. Riff Raymond M. Panas Due to increasing resistance to commonly used antibiotics, the World Health Organization and Food and Drug Administration have advocated the development of new therapeutic regimens for Helicobacter pylori (H. pylori)....
Fri Oct 09, 2020 03:00
Antibiotics, Vol. 9, Pages 684: The Bactericidal Activity and Spore Inhibition Effect of Manuka Honey against Clostridioides Difficile Antibiotics doi: 10.3390/antibiotics9100684 Authors: Lillian Yu Reynal Palafox-Rosas Brian Luna Rosemary C. She Clostridioides difficile colitis overgrowth occurs when the normal gut microbiome becomes disrupted, often due to antibiotics. Effective treatment remains elusive, due partly to the persistence of its spores in the gut. Natural substances...
Fri Oct 09, 2020 03:00
Antibodies, Vol. 9, Pages 52: Structural Features and PF4 Functions that Occur in Heparin-Induced Thrombocytopenia (HIT) Complicated by COVID-19 Antibodies doi: 10.3390/antib9040052 Authors: Zheng Cai Mark I. Greene Zhiqiang Zhu Hongtao Zhang Platelet factor 4 (PF4, CXCL4) is a small chemokine protein released by activated platelets. Although a major physiological function of PF4 is to promote blood coagulation, this cytokine is involved in innate and adaptive immunity in events...
Sat Oct 10, 2020 03:00
Antioxidants, Vol. 9, Pages 974: Onion Peel Powder as an Antioxidant-Rich Material for Sausages Prepared from Mechanically Separated Fish Meat Antioxidants doi: 10.3390/antiox9100974 Authors: Bedrníček Kadlec Laknerová Mráz Samková Petrášková Hasoňová Vácha Kron Smetana Mechanically separated fish meat (MSFM) can be used for the manufacturing of ready-to-eat products, such as sausages; however, it is highly perishable. Several plant by-products, including...
Sun Oct 11, 2020 03:00
Antioxidants, Vol. 9, Pages 973: Regulation of Nrf2/ARE Pathway by Dietary Flavonoids: A Friend or Foe for Cancer Management? Antioxidants doi: 10.3390/antiox9100973 Authors: Tharindu L. Suraweera H. P. Vasantha Rupasinghe Graham Dellaire Zhaolin Xu The nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway is an important cell signaling mechanism in maintaining redox homeostasis in humans. The role of dietary flavonoids in activating Nrf2/ARE...
Sun Oct 11, 2020 03:00
Antioxidants, Vol. 9, Pages 971: May Mangafodipir or Other SOD Mimetics Contribute to Better Care in COVID-19 Patients? Antioxidants doi: 10.3390/antiox9100971 Authors: Jan Olof G Karlsson Per Jynge Louis J Ignarro Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by massive inflammation of the arterial endothelium accompanied by vasoconstriction and widespread pulmonary micro thrombi. As a result, due to the destruction of nitric oxide (•NO)...
Sat Oct 10, 2020 03:00
Antioxidants, Vol. 9, Pages 972: Antibacterial Activity of Synthetic Cationic Iron Porphyrins Antioxidants doi: 10.3390/antiox9100972 Authors: Artak Tovmasyan Ines Batinic-Haberle Ludmil Benov Widespread antibiotic resistance demands new strategies for fighting infections. Porphyrin-based compounds were long ago introduced as photosensitizers for photodynamic therapy, but light-independent antimicrobial activity of such compounds has not been systematically explored. The results...
Sat Oct 10, 2020 03:00
Antioxidants, Vol. 9, Pages 970: Bioaccessible Raspberry Extracts Enriched in Ellagitannins and Ellagic Acid Derivatives Have Anti-Neuroinflammatory Properties Antioxidants doi: 10.3390/antiox9100970 Authors: Gonçalo Garcia Teresa Faria Pais Paula Pinto Gary Dobson Gordon J. McDougall Derek Stewart Cláudia Nunes Santos Chronic neuroinflammation associated with neurodegenerative disorders has been reported to be prevented by dietary components. Particularly, dietary...
Sat Oct 10, 2020 03:00
Antioxidants, Vol. 9, Pages 968: Circadian Rhythm in Adipose Tissue: Novel Antioxidant Target for Metabolic and Cardiovascular Diseases Antioxidants doi: 10.3390/antiox9100968 Authors: Andy W.C. Man Ning Xia Huige Li Obesity is a major risk factor for most metabolic and cardiovascular disorders. Adipose tissue is an important endocrine organ that modulates metabolic and cardiovascular health by secreting signaling molecules. Oxidative stress is a common mechanism associated with...
Fri Oct 09, 2020 03:00
Antioxidants, Vol. 9, Pages 969: The Industrial Organism Corynebacterium glutamicum Requires Mycothiol as Antioxidant to Resist Against Oxidative Stress in Bioreactor Cultivations Antioxidants doi: 10.3390/antiox9100969 Authors: Fabian Stefan Franz Hartmann Lina Clermont Quach Ngoc Tung Haike Antelmann Gerd Michael Seibold In aerobic environments, bacteria are exposed to reactive oxygen species (ROS). To avoid an excess of ROS, microorganisms are equipped with powerful enzymatic...
Fri Oct 09, 2020 03:00
Antioxidants, Vol. 9, Pages 965: The Late-Stage Protective Effect of Mito-TEMPO against Acetaminophen-Induced Hepatotoxicity in Mouse and Three-Dimensional Cell Culture Models Antioxidants doi: 10.3390/antiox9100965 Authors: Mohammad Abdullah-Al-Shoeb Kenta Sasaki Saori Kikutani Nanami Namba Keiichi Ueno Yuki Kondo Hitoshi Maeda Toru Maruyama Tetsumi Irie Yoichi Ishitsuka An overdose of acetaminophen (APAP), the most common cause of acute liver injury, induces...
Fri Oct 09, 2020 03:00
Antioxidants, Vol. 9, Pages 966: The Universal Soldier: Enzymatic and Non-Enzymatic Antioxidant Functions of Serum Albumin Antioxidants doi: 10.3390/antiox9100966 Authors: Belinskaia Voronina Shmurak Vovk Batalova Jenkins Goncharov As a carrier of many biologically active compounds, blood is exposed to oxidants to a greater extent than the intracellular environment. Serum albumin plays a key role in antioxidant defence under both normal and oxidative stress conditions....
Fri Oct 09, 2020 03:00
Antioxidants, Vol. 9, Pages 964: The Impact of Mitochondrial Deficiencies in Neuromuscular Diseases Antioxidants doi: 10.3390/antiox9100964 Authors: Judith Cantó-Santos Josep M. Grau-Junyent Glòria Garrabou Neuromuscular diseases (NMDs) are a heterogeneous group of acquired or inherited rare disorders caused by injury or dysfunction of the anterior horn cells of the spinal cord (lower motor neurons), peripheral nerves, neuromuscular junctions, or skeletal muscles leading to muscle...
Fri Oct 09, 2020 03:00
Antioxidants, Vol. 9, Pages 967: Variability in Bulb Organosulfur Compounds, Sugars, Phenolics, and Pyruvate among Greek Garlic Genotypes: Association with Antioxidant Properties Antioxidants doi: 10.3390/antiox9100967 Authors: Ioanna Avgeri Konstantina Zeliou Spyridon A. Petropoulos Penelope J. Bebeli Vasileios Papasotiropoulos Fotini N. Lamari In order to assess the diversity of Greek garlic (Allium sativum L.) landraces, 34 genotypes including commercial ones were grown...
Fri Oct 09, 2020 03:00
Arts, Vol. 9, Pages 103: Film Adaptation as Experimental Game Design Arts doi: 10.3390/arts9040103 Authors: Pippin Barr Film adaptation is a popular approach to game design, but it prioritizes blockbuster films and conventional “game-like” qualities of those films, such as shooting, racing, or spatial exploration. This leads to adaptations that tend to use the aesthetics and narratives of films, but which miss out on potential design explorations of more complex cinematic...
Fri Oct 09, 2020 03:00
Atmosphere, Vol. 11, Pages 1083: Microphysical Processes of a Cold Vortex during Its Movement to the East: A Case Study Atmosphere doi: 10.3390/atmos11101083 Authors: Yanwei Li Weiwei Wang Xin Qin Gerrit de Leeuw A cold vortex is an important weather system that can cause low temperatures and large amounts of rainfall. Many scientific studies have focused on the climatological features of the cold vortex along with its formation, maintenance, structure, circulation features...
Sun Oct 11, 2020 03:00
Atmosphere, Vol. 11, Pages 1082: The Potential of Using Tree-Ring Chronology from the Southern Coast of Korea to Reconstruct the Climate of Subtropical Western North Pacific: A Pilot Study Atmosphere doi: 10.3390/atmos11101082 Authors: Min-Seok Kim Peng Zhang Sung-Ho Woo Youngdae Koh Hans W. Linderholm Jee-Hoon Jeong Tree-ring width (TRW) chronologies have successfully been used as climate proxies to infer climate variabilities over the past hundreds to thousands of years...
Sun Oct 11, 2020 03:00
Atmosphere, Vol. 11, Pages 1080: Changes in the Characteristics of Dry and Wet Periods in Europe (1851–2015) Atmosphere doi: 10.3390/atmos11101080 Authors: Stephanie Hänsel This study spanning the period 1851–2015 explores the spatial and temporal characteristics of dry and wet periods in Europe as well as their variability and changes. It is based on up to 220 stations with monthly precipitation time series that have a varying data availability within the study period. The...
Sat Oct 10, 2020 03:00
Atmosphere, Vol. 11, Pages 1081: Complexity of Forces Driving Trend of Reference Evapotranspiration and Signals of Climate Change Atmosphere doi: 10.3390/atmos11101081 Authors: Mohammad Valipour Sayed M. Bateni Mohammad Ali Gholami Sefidkouhi Mahmoud Raeini-Sarjaz Vijay P. Singh Understanding the trends of reference evapotranspiration (ETo) and its influential meteorological variables due to climate change is required for studying the hydrological cycle, vegetation restoration,...
Sat Oct 10, 2020 03:00
Atmosphere, Vol. 11, Pages 1079: A Comparison of Precipitation Measurements with a PWS100 Laser Sensor and a Geonor T-200B Precipitation Gauge at a Nival Glacial Zone in Eastern Tianshan, Central Asia Atmosphere doi: 10.3390/atmos11101079 Authors: Yufeng Jia Zhongqin Li Chunhai Xu Shuang Jin Haijun Deng Precipitation is a key process in the hydrologic cycle. However, accurate precipitation data are scarce in high mountainous areas, mainly restricted by complex topography,...
Sat Oct 10, 2020 03:00
Atmosphere, Vol. 11, Pages 1078: Combined Eulerian-Lagrangian Hybrid Modelling System for PM2.5 and Elemental Carbon Source Apportionment at the Urban Scale in Milan Atmosphere doi: 10.3390/atmos11101078 Authors: Giovanni Lonati Nicola Pepe Guido Pirovano Alessandra Balzarini Anna Toppetti Giuseppe Maurizio Riva Air quality modeling at the very local scale within an urban area is performed through a hybrid modeling system (HMS) that combines the CAMx Eulerian model the...
Sat Oct 10, 2020 03:00
Atmosphere, Vol. 11, Pages 1073: Determination of Region of Influence Obtained by Aircraft Vertical Profiles Using the Density of Trajectories from the HYSPLIT Model Atmosphere doi: 10.3390/atmos11101073 Authors: Henrique L.G. Cassol Lucas G. Domingues Alber H. Sanchez Luana S. Basso Luciano Marani Graciela P. Tejada Egidio Arai Caio Correia Caroline B. Alden John B. Miller Manuel Gloor Liana O. Anderson Luiz E. O. C. Aragão Luciana V. Gatti Aircraft...
Fri Oct 09, 2020 03:00
Atmosphere, Vol. 11, Pages 1076: Changes in Climate Extremes in Central Asia under 1.5 and 2 ºC Global Warming and their Impacts on Agricultural Productions Atmosphere doi: 10.3390/atmos11101076 Authors: Yang Liu Xiu Geng Zhixin Hao Jingyun Zheng Changes in climate extremes under 1.5 ºC and 2 ºC global warming may impact agricultural production across Central Asia. We used the simulated daily data of average temperature, maximum temperature, minimum temperature,...
Fri Oct 09, 2020 03:00
Atmosphere, Vol. 11, Pages 1074: Predictors of the Indoor-to-Outdoor Ratio of Particle Number Concentrations in Israel Atmosphere doi: 10.3390/atmos11101074 Authors: Siyu Zhang Yuval David M. Broday Raanan Raz Exposure to airborne particles is a risk factor of many short- and long-term health effects. Most epidemiological studies include estimates of exposure to ambient particles, however, people living in developed countries spend most of their time indoors. This work presents...
Fri Oct 09, 2020 03:00
Atmosphere, Vol. 11, Pages 1075: Moisture Variability in the East Pearl River Basin since 1894 CE Inferred from Tree Ring Records Atmosphere doi: 10.3390/atmos11101075 Authors: Teng Li Jinbao Li Tsun Fung Au David D. Zhang Short-term climate change in South China has been extensively studied based on meteorological or hydrological records. However, tree ring-based long-term climate change research is rare, especially in the Pearl River basin, owing to the difficulty in finding...
Fri Oct 09, 2020 03:00
Atmosphere, Vol. 11, Pages 1077: Snow Surface Albedo Sensitivity to Black Carbon: Radiative Transfer Modelling Atmosphere doi: 10.3390/atmos11101077 Authors: Nicholas D. Beres Magín Lapuerta Francisco Cereceda-Balic Hans Moosmüller The broadband surface albedo of snow can greatly be reduced by the deposition of light-absorbing impurities, such as black carbon on or near its surface. Such a reduction increases the absorption of solar radiation and may initiate or accelerate snowmelt...
Fri Oct 09, 2020 03:00
Atmosphere, Vol. 11, Pages 1071: Appraisal of Climate Change and its Impact on Water Resources of Pakistan: A Case Study of Mangla Watershed Atmosphere doi: 10.3390/atmos11101071 Authors: Haroon Haider Muhammad Zaman Shiyin Liu Muhammad Saifullah Muhammad Usman Junaid Nawaz Chauhdary Muhammad Naveed Anjum Muhammad Waseem Water resources are highly dependent on climatic variations. The quantification of climate change impacts on surface water availability is critical...
Fri Oct 09, 2020 03:00
Atmosphere, Vol. 11, Pages 1072: Increasing Neurons or Deepening Layers in Forecasting Maximum Temperature Time Series? Atmosphere doi: 10.3390/atmos11101072 Authors: Trang Thi Kieu Tran Taesam Lee Jong-Suk Kim Weather forecasting, especially that of extreme climatic events, has gained considerable attention among researchers due to their impacts on natural ecosystems and human life. The applicability of artificial neural networks (ANNs) in non-linear process forecasting has significantly...
Fri Oct 09, 2020 03:00
Bioengineering, Vol. 7, Pages 124: The Extracellular Matrix and Vesicles Modulate the Breast Tumor Microenvironment Bioengineering doi: 10.3390/bioengineering7040124 Authors: Jun Yang Gokhan Bahcecioglu Pinar Zorlutuna Emerging evidence has shown multiple roles of the tumor microenvironment (TME) components, specifically the extracellular matrix (ECM), in breast cancer development, progression, and metastasis. Aside from the biophysical properties and biochemical composition of...
Sun Oct 11, 2020 03:00
Bioengineering, Vol. 7, Pages 123: Degradation of Veterinary Antibiotics in Swine Manure via Anaerobic Digestion Bioengineering doi: 10.3390/bioengineering7040123 Authors: Ali Hosseini Hosseini Taleghani Teng-Teeh Lim Chung-Ho Lin Aaron C. Ericsson Phuc H. Vo Antibiotic-resistant microorganisms are drawing a lot of attention due to their severe and irreversible consequences on human health. The animal industry is considered responsible in part because of the enormous volume...
Fri Oct 09, 2020 03:00
Biology, Vol. 9, Pages 331: Salmonid Antibacterial Immunity: An Aquaculture Perspective Biology doi: 10.3390/biology9100331 Authors: Shawna L. Semple Brian Dixon The aquaculture industry is continuously threatened by infectious diseases, including those of bacterial origin. Regardless of the disease burden, aquaculture is already the main method for producing fish protein, having displaced capture fisheries. One attractive sector within this industry is the culture of salmonids, which...
Sun Oct 11, 2020 03:00
Biology, Vol. 9, Pages 330: Over-Production of Therapeutic Growth Factors for Articular Cartilage Regeneration by Protein Production Platforms and Protein Packaging Cell Lines Biology doi: 10.3390/biology9100330 Authors: Ali Mobasheri Heonsik Choi Pablo Martín-Vasallo This review article focuses on the current state-of-the-art cellular and molecular biotechnology for the over-production of clinically relevant therapeutic and anabolic growth factors. We discuss how the currently...
Fri Oct 09, 2020 03:00
Biology, Vol. 9, Pages 329: Prevalence and Factors Associated with High Concentration of Prostate-Specific Antigen: ELSIA Study Biology doi: 10.3390/biology9100329 Authors: Lucas Lima Galvão Sheilla Tribess Tamara Guimarães Silva Cremilda Garcia Santa Rosa Cristian Gomes Pereira Rizia Rocha Silva Jeffer Eidi Sasaki Jair Sindra Virtuoso Junior Claudio Andre Barbosa de Lira Douglas Assis Teles Santos Background: Prostate cancer (PC) is the second most common...
Fri Oct 09, 2020 03:00
Biomedicines, Vol. 8, Pages 405: Tackling Antibiotic Resistance with Compounds of Natural Origin: A Comprehensive Review Biomedicines doi: 10.3390/biomedicines8100405 Authors: Álvarez-Martínez Barrajón-Catalán Micol Drug-resistant bacteria pose a serious threat to human health worldwide. Current antibiotics are losing efficacy and new antimicrobial agents are urgently needed. Living organisms are an invaluable source of antimicrobial compounds. The antimicrobial activity of...
Sun Oct 11, 2020 03:00
Biomedicines, Vol. 8, Pages 397: Babam2 Regulates Cell Cycle Progression and Pluripotency in Mouse Embryonic Stem Cells as Revealed by Induced DNA Damage Biomedicines doi: 10.3390/biomedicines8100397 Authors: Cheuk Yiu Tenny Chung Paulisally Hau Yi Lo Kenneth Ka Ho Lee BRISC and BRCA1-A complex member 2 (Babam2) plays an essential role in promoting cell cycle progression and preventing cellular senescence. Babam2-deficient fibroblasts show proliferation defect and premature senescence...
Sat Oct 10, 2020 03:00
Biomedicines, Vol. 8, Pages 403: Stearic Acid and TNF-α Co-Operatively Potentiate MIP-1α Production in Monocytic Cells via MyD88 Independent TLR4/TBK/IRF3 Signaling Pathway Biomedicines doi: 10.3390/biomedicines8100403 Authors: Shihab Kochumon Hossein Arefanian Rafaat Azim Steve Shenouda Texy Jacob Nermeen Abu Khalaf Fatema Al-Rashed Amal Hasan Sardar Sindhu Fahd Al-Mulla Rasheed Ahmad Increased circulatory and adipose tissue expression of macrophage inflammatory...
Fri Oct 09, 2020 03:00
Biomedicines, Vol. 8, Pages 404: Identification of Germline Mutations in Melanoma Patients with Early Onset, Double Primary Tumors, or Family Cancer History by NGS Analysis of 217 Genes Biomedicines doi: 10.3390/biomedicines8100404 Authors: Stolarova Jelinkova Storchova Machackova Zemankova Vocka Kodet Kral Cerna Volkova Janatova Soukupova Stranecky Dundr Foretova Macurek Kleiblova Kleibl Cutaneous melanoma is the...
Fri Oct 09, 2020 03:00
Biomedicines, Vol. 8, Pages 402: Endogenous Anti-Cancer Candidates in GPCR, ER Stress, and EMT Biomedicines doi: 10.3390/biomedicines8100402 Authors: Rohit Gundamaraju Wenying Lu Iman Azimi Rajaraman Eri Sukhwinder Singh Sohal The majority of cellular responses to external stimuli are mediated by receptors such as G protein-coupled receptors (GPCRs) and systems including endoplasmic reticulum stress (ER stress). Since GPCR signalling is pivotal in numerous malignancies, they...
Fri Oct 09, 2020 03:00
Biomedicines, Vol. 8, Pages 401: Pancreatic Adenocarcinoma Invasiveness and the Tumor Microenvironment: From Biology to Clinical Trials Biomedicines doi: 10.3390/biomedicines8100401 Authors: Isabel Mejia Sandhya Bodapati Kathryn Chen Begoña Díaz Pancreatic adenocarcinoma (PDAC) originates in the glandular compartment of the exocrine pancreas. Histologically, PDAC tumors are characterized by a parenchyma that is embedded in a particularly prominent stromal component or desmoplastic...
Fri Oct 09, 2020 03:00
Biomedicines, Vol. 8, Pages 400: Tissue-Specific Role of Macrophages in Noninfectious Inflammatory Disorders Biomedicines doi: 10.3390/biomedicines8100400 Authors: Daria Skuratovskaia Maria Vulf Olga Khaziakhmatova Vladimir Malashchenko Aleksandra Komar Egor Shunkin Valeriya Shupletsova Andrei Goncharov Olga Urazova Larisa Litvinova Chronic inflammation may not begin with local tissue disorders, such as hypoxia, but with the accumulation of critically activated...
Fri Oct 09, 2020 03:00
Biomimetics, Vol. 5, Pages 49: Biomimetic Hybrid Systems for Tissue Engineering Biomimetics doi: 10.3390/biomimetics5040049 Authors: Omid Yousefzade Ramaz Katsarava Jordi Puiggalí Tissue engineering approaches appear nowadays highly promising for the regeneration of injured/diseased tissues. Biomimetic scaffolds are continuously been developed to act as structural support for cell growth and proliferation as well as for the delivery of cells able to be differentiated, and also...
Fri Oct 09, 2020 03:00
Biomolecules, Vol. 10, Pages 1433: cAMP Signaling in Pathobiology of Alcohol Associated Liver Disease Biomolecules doi: 10.3390/biom10101433 Authors: Mohamed Elnagdy Shirish Barve Craig McClain Leila Gobejishvili The importance of cyclic adenosine monophosphate (cAMP) in cellular responses to extracellular signals is well established. Many years after discovery, our understanding of the intricacy of cAMP signaling has improved dramatically. Multiple layers of regulation exist...
Sun Oct 11, 2020 03:00
Biomolecules, Vol. 10, Pages 1432: Bullous Pemphigoid: Trigger and Predisposing Factors Biomolecules doi: 10.3390/biom10101432 Authors: Moro Fania Sinagra Salemme Zenzo Bullous pemphigoid (BP) is the most frequent autoimmune subepidermal blistering disease provoked by autoantibodies directed against two hemidesmosomal proteins: BP180 and BP230. Its pathogenesis depends on the interaction between predisposing factors, such as human leukocyte antigen (HLA) genes, comorbidities,...
Sat Oct 10, 2020 03:00
Biomolecules, Vol. 10, Pages 1431: Necroptosis in Intestinal Inflammation and Cancer: New Concepts and Therapeutic Perspectives Biomolecules doi: 10.3390/biom10101431 Authors: Negroni Colantoni Cucchiara Stronati Necroptosis is a caspases-independent programmed cell death displaying intermediate features between necrosis and apoptosis. Albeit some physiological roles during embryonic development such tissue homeostasis and innate immune response are documented, necroptosis...
Sat Oct 10, 2020 03:00
Biomolecules, Vol. 10, Pages 1430: Secretome Analysis of the Banana Fusarium Wilt Fungi Foc R1 and Foc TR4 Reveals a New Effector OASTL Required for Full Pathogenicity of Foc TR4 in Banana Biomolecules doi: 10.3390/biom10101430 Authors: Dan Wang Cunzhi Peng Xingmei Zheng Lili Chang Bingqiang Xu Zheng Tong Banana Fusarium wilt (BFW), which is one of the most important banana diseases worldwide, is mainly caused by Fusarium oxysporum f. sp. cubense tropic race 4 (Foc TR4)....
Fri Oct 09, 2020 03:00
Biomolecules, Vol. 10, Pages 1429: Role of Glutathione in Cancer: From Mechanisms to Therapies Biomolecules doi: 10.3390/biom10101429 Authors: Luke Kennedy Jagdeep K. Sandhu Mary-Ellen Harper Miroslava Cuperlovic-Culf Glutathione (GSH) is the most abundant non-protein thiol present at millimolar concentrations in mammalian tissues. As an important intracellular antioxidant, it acts as a regulator of cellular redox state protecting cells from damage caused by lipid peroxides,...
Fri Oct 09, 2020 03:00
Brain Sciences, Vol. 10, Pages 719: Feasibility and Safety of Transcranial Direct Current Stimulation in an Outpatient Rehabilitation Setting After Stroke Brain Sciences doi: 10.3390/brainsci10100719 Authors: Brice T. Cleland Melissa Galick Amy Huckstep Laura Lenhart Sangeetha Madhavan Transcranial direct current stimulation (tDCS) has strong potential for outpatient clinical use, but feasibility and safety of tDCS has only been evaluated in laboratory and inpatient clinical...
Fri Oct 09, 2020 03:00
Brain Sciences, Vol. 10, Pages 717: Neurophysiological Correlates of Top-Down Phonological and Semantic Influence during the Orthographic Processing of Novel Visual Word-Forms Brain Sciences doi: 10.3390/brainsci10100717 Authors: Beatriz Bermúdez-Margaretto David Beltrán Yury Shtyrov Alberto Dominguez Fernando Cuetos The acquisition of new vocabulary is usually mediated by previous experience with language. In the visual domain, the representation of orthographically unfamiliar...
Fri Oct 09, 2020 03:00
Brain Sciences, Vol. 10, Pages 718: Intervention Using Body Shadow to Evoke Loading Imagery in a Patient with Complex Regional Pain Syndrome in the Foot: A Case Report Brain Sciences doi: 10.3390/brainsci10100718 Authors: Yoshiyuki Hirakawa Ryota Imai Hayato Shigetoh Shu Morioka We present the case of a female patient who developed complex regional pain syndrome (CRPS) after a right-foot injury. The patient had pain from the right knee to the toes and showed severe disgust at...
Fri Oct 09, 2020 03:00
Brain Sciences, Vol. 10, Pages 716: Objective Assessment of Attention-Deficit Hyperactivity Disorder (ADHD) Using an Infinite Runner-Based Computer Game: A Pilot Study Brain Sciences doi: 10.3390/brainsci10100716 Authors: David Delgado-Gómez Aaron Sújar Juan Ardoy-Cuadros Alejandro Bejarano-Gómez David Aguado Carolina Miguelez-Fernandez Hilario Blasco-Fontecilla Inmaculada Peñuelas-Calvo In the last few years, several computerized tasks have been developed to increase...
Fri Oct 09, 2020 03:00
Cancers, Vol. 12, Pages 2918: Time-Resolved Profiling Reveals ATF3 as a Novel Mediator of Endocrine Resistance in Breast Cancer Cancers doi: 10.3390/cancers12102918 Authors: Simone Borgoni Emre Sofyalı Maryam Soleimani Heike Wilhelm Karin Müller-Decker Rainer Will Ashish Noronha Lukas Beumers Pernette J. Verschure Yosef Yarden Luca Magnani Antoine H.C. van Kampen Perry D. Moerland Stefan Wiemann Breast cancer is one of the leading causes of death...
Sun Oct 11, 2020 03:00
Cancers, Vol. 12, Pages 2924: External Validation of the SERC Trial Population: Comparison with the Multicenter French Cohort, the Swedish and SENOMIC Trial Populations for Breast Cancer Patients with Sentinel Node Micro-Metastasis Cancers doi: 10.3390/cancers12102924 Authors: Gilles Houvenaeghel Houssein El Hajj Julien Barrou Monique Cohen Pédro Raro Jérémy De Troyer Pierre Gimbergues Christine Tunon de Lara Vivien Ceccato Véronique Vaini-Cowen Christelle Faure-Virelizier...
Sun Oct 11, 2020 03:00
Cancers, Vol. 12, Pages 2926: The Roles of ceRNAs-Mediated Autophagy in Cancer Chemoresistance and Metastasis Cancers doi: 10.3390/cancers12102926 Authors: Huilin Zhang Bingjian Lu Chemoresistance and metastasis are the main causes of treatment failure and unfavorable outcome in cancers. There is a pressing need to reveal their mechanisms and to discover novel therapy targets. Autophagy is composed of a cascade of steps controlled by different autophagy-related genes (ATGs). Accumulating...
Sun Oct 11, 2020 03:00
Cancers, Vol. 12, Pages 2923: Uveal Melanoma-Derived Extracellular Vesicles Display Transforming Potential and Carry Protein Cargo Involved in Metastatic Niche Preparation Cancers doi: 10.3390/cancers12102923 Authors: Thupten Tsering Alexander Laskaris Mohamed Abdouh Prisca Bustamante Sabrina Parent Eva Jin Sarah Tadhg Ferrier Goffredo Arena Julia V. Burnier Extracellular vesicles (EVs) carry molecules derived from donor cells and are able to alter the properties...
Sun Oct 11, 2020 03:00
Cancers, Vol. 12, Pages 2920: E-Cadherin (CDH1 Gene) Germline Mutations in Gastric Cancer: Evolutions and Innovations Cancers doi: 10.3390/cancers12102920 Authors: Giovanni Corso Bernardo Bonanni Family history has contributed greatly to understanding inherited diseases throughout the centuries, in particular familial and hereditary cancer syndromes [...]
Sun Oct 11, 2020 03:00
Cancers, Vol. 12, Pages 2925: Epigenetic Mechanisms of LncRNAs Binding to Protein in Carcinogenesis Cancers doi: 10.3390/cancers12102925 Authors: Tae-Jin Shin Kang-Hoon Lee Je-Yoel Cho Epigenetic dysregulation is an important feature for cancer initiation and progression. Long non-coding RNAs (lncRNAs) are transcripts that stably present as RNA forms with no translated protein and have lengths larger than 200 nucleotides. LncRNA can epigenetically regulate either oncogenes or tumor...
Sun Oct 11, 2020 03:00
Cancers, Vol. 12, Pages 2922: Regulatory Mechanisms of Epigenetic miRNA Relationships in Human Cancer and Potential as Therapeutic Targets Cancers doi: 10.3390/cancers12102922 Authors: Arif Elliot Haupt Griffiths Initiation and progression of cancer are under both genetic and epigenetic regulation. Epigenetic modifications including alterations in DNA methylation, RNA and histone modifications can lead to microRNA (miRNA) gene dysregulation and malignant cellular transformation...
Sun Oct 11, 2020 03:00
Cancers, Vol. 12, Pages 2921: Epidemiology of Cutaneous T-Cell Lymphomas: A Systematic Review and Meta-Analysis of 16,953 Patients Cancers doi: 10.3390/cancers12102921 Authors: Gabor Dobos Anne Pohrt Caroline Ram-Wolff Céleste Lebbé Jean-David Bouaziz Maxime Battistella Martine Bagot Adèle de Masson Cutaneous T-cell lymphomas (CTCL) are a heterogenous group of rare diseases. Many studies have reported on local epidemiology or geographic clustering, however we lack...
Sun Oct 11, 2020 03:00
Cancers, Vol. 12, Pages 2919: Aberrantly Expressed RECQL4 Helicase Supports Proliferation and Drug Resistance of Human Glioma Cells and Glioma Stem Cells Cancers doi: 10.3390/cancers12102919 Authors: Sylwia K. Król Agnieszka Kaczmarczyk Kamil Wojnicki Bartosz Wojtas Bartłomiej Gielniewski Wieslawa Grajkowska Katarzyna Kotulska Cezary Szczylik Ryszard Czepko Mariusz Banach Wojciech Kaspera Wojciech Szopa Andrzej Marchel Tomasz Czernicki Bozena Kaminska...
Sun Oct 11, 2020 03:00
Cancers, Vol. 12, Pages 2917: Microenvironmental Hypoxia Induces Dynamic Changes in Lung Cancer Synthesis and Secretion of Extracellular Vesicles Cancers doi: 10.3390/cancers12102917 Authors: Shun Wilford Tse Chee Fan Tan Jung Eun Park JebaMercy Gnanasekaran Nikhil Gupta Jee Keem Low Kheng Wei Yeoh Wee Joo Chng Chor Yong Tay Neil E. McCarthy Sai Kiang Lim Siu Kwan Sze Extracellular vesicles (EVs) mediate critical intercellular communication within healthy...
Sun Oct 11, 2020 03:00
Cancers, Vol. 12, Pages 2927: Primary Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Kidney: The MD Anderson Cancer Center Experience Cancers doi: 10.3390/cancers12102927 Authors: Nidale Tarek Rabih Said Clark R. Andersen Tina S. Suki Jessica Foglesong Cynthia E. Herzog Nizar M. Tannir Shreyaskumar Patel Ravin Ratan Joseph A. Ludwig Najat C. Daw Limited information exists on the clinical behavior of the Ewing sarcoma family of tumors (ESFT) of the...
Sun Oct 11, 2020 03:00
Cancers, Vol. 12, Pages 2916: Tumor Microenvironment as a Regulator of Radiation Therapy: New Insights into Stromal-Mediated Radioresistance Cancers doi: 10.3390/cancers12102916 Authors: Krisnawan Stanley Schwarz DeNardo : A tumor is a complex “organ” composed of malignant cancer cells harboring genetic aberrations surrounded by a stroma comprised of non-malignant cells and an extracellular matrix. Considerable evidence has demonstrated that components...
Sun Oct 11, 2020 03:00
Cancers, Vol. 12, Pages 2915: Indoxylsulfate, a Metabolite of the Microbiome, Has Cytostatic Effects in Breast Cancer via Activation of AHR and PXR Receptors and Induction of Oxidative Stress Cancers doi: 10.3390/cancers12102915 Authors: Zsanett Sári Edit Mikó Tünde Kovács Anita Boratkó Gyula Ujlaki Laura Jankó Borbála Kiss Karen Uray Péter Bai Changes to bacterial metabolite-elicited signaling, in oncobiosis associated with breast cancer, plays a role in facilitating...
Sat Oct 10, 2020 03:00
Cancers, Vol. 12, Pages 2913: Oncogenic Mutations of MYD88 and CD79B in Diffuse Large B-Cell Lymphoma and Implications for Clinical Practice Cancers doi: 10.3390/cancers12102913 Authors: Carlo Visco Ilaria Tanasi Francesca Maria Quaglia Isacco Ferrarini Costanza Fraenza Mauro Krampera Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin’s lymphoma in adults. Despite the recognition of transcriptional subtypes with distinct functional characteristics,...
Sat Oct 10, 2020 03:00
Cancers, Vol. 12, Pages 2912: The Tumor Microenvironment in Neuroblastoma: New Players, New Mechanisms of Interaction and New Perspectives Cancers doi: 10.3390/cancers12102912 Authors: Laurence Blavier Ren-Ming Yang Yves A. DeClerck The contribution of the tumor microenvironment (TME) to cancer progression has been well recognized in recent decades. As cancer therapeutic strategies are increasingly precise and include immunotherapies, knowledge of the nature and function of the...
Sat Oct 10, 2020 03:00
Cancers, Vol. 12, Pages 2914: Circulating Tumor DNA Testing Opens New Perspectives in Melanoma Management Cancers doi: 10.3390/cancers12102914 Authors: Alessandra Sacco Laura Forgione Marianeve Carotenuto Antonella De Luca Paolo A. Ascierto Gerando Botti Nicola Normanno Malignant melanoma accounts for about 1% of all skin cancers, but it causes most of the skin cancer-related deaths. Circulating tumor DNA (ctDNA) testing is emerging as a relevant tool for the diagnosis...
Sat Oct 10, 2020 03:00
Cancers, Vol. 12, Pages 2911: Cytoreductive Nephrectomy and Overall Survival of Patients with Metastatic Renal Cell Carcinoma Treated with Targeted Therapy—Data from the National Renis Registry Cancers doi: 10.3390/cancers12102911 Authors: Alexandr Poprach Milos Holanek Renata Chloupkova Radek Lakomy Michal Stanik Ondrej Fiala Bohuslav Melichar Katerina Kopeckova Milada Zemanova Igor Kiss Igor Penka Julia Bohosova Tomas Buchler The role of cytoreductive...
Sat Oct 10, 2020 03:00
Cancers, Vol. 12, Pages 2907: PARP1 Deficiency Reduces Tumour Growth by Decreasing E2F1 Hyperactivation: A Novel Mechanism in the Treatment of Cancer Cancers doi: 10.3390/cancers12102907 Authors: Iglesias Seoane Golán Castro-Piedras Fraga Arce Costoya In recent years, poly (ADP-ribose) polymerase (PARP) inhibitors have been evaluated for treating homologous recombination-deficient tumours, taking advantage of synthetic lethality. However, increasing evidence...
Sat Oct 10, 2020 03:00
Cancers, Vol. 12, Pages 2910: Sphingolipid Pathway as a Source of Vulnerability in IDH1mut Glioma Cancers doi: 10.3390/cancers12102910 Authors: Tyrone Dowdy Lumin Zhang Orieta Celiku Sriya Movva Adrian Lita Victor Ruiz-Rodado Mark R. Gilbert Mioara Larion In addition to providing integrity to cellular structure, the various classes of lipids participate in a multitude of functions including secondary messengers, receptor stimulation, lymphocyte trafficking, inflammation,...
Sat Oct 10, 2020 03:00
Cancers, Vol. 12, Pages 2908: Exploring Essential Issues for Improving Therapeutic Cancer Vaccine Trial Design Cancers doi: 10.3390/cancers12102908 Authors: Baxevanis Fortis Ardavanis Perez Therapeutic cancer vaccines have been at the forefront of cancer immunotherapy for more than 20 years, with promising results in phase I and—in some cases—phase II clinical trials, but with failures in large phase III studies. After dozens of clinical studies, only...
Sat Oct 10, 2020 03:00
Cancers, Vol. 12, Pages 2906: Liver Function Changes in Patients with Hepatocellular Carcinoma Treated with Lenvatinib: Predictive Factors of Progression to Child-Pugh Class B, the Formation of Ascites and the Candidates for the Post-Progression Treatment Cancers doi: 10.3390/cancers12102906 Authors: Takeshi Hatanaka Satoru Kakizaki Tamon Nagashima Masashi Namikawa Takashi Ueno Hiroki Tojima Daichi Takizawa Atsushi Naganuma Hirotaka Arai Ken Sato Norifumi Harimoto...
Sat Oct 10, 2020 03:00
Cancers, Vol. 12, Pages 2903: Efficacy of HDAC Inhibitors Belinostat and Panobinostat against Cisplatin-Sensitive and Cisplatin-Resistant Testicular Germ Cell Tumors Cancers doi: 10.3390/cancers12102903 Authors: Lobo Guimarães-Teixeira Barros-Silva Miranda-Gonçalves Camilo Guimarães Cantante Braga Maurício Oing Honecker Nettersheim Looijenga Henrique Jerónimo Novel treatment options are needed for testicular germ cell tumor (TGCT)...
Sat Oct 10, 2020 03:00
Cancers, Vol. 12, Pages 2909: Female Malignancies and Immunotherapy: What’s New? Cancers doi: 10.3390/cancers12102909 Authors: Silvia Pesce Valerio Gaetano Vellone Emanuela Marcenaro For many years, the therapeutic advances in gynecological neoplasms have remained steady, however, in recent years, the application of the most modern “-omics” sciences has shed light on the pathogenesis and on neoplastic progression, with important implications in the introduction...
Sat Oct 10, 2020 03:00
Cancers, Vol. 12, Pages 2901: Dexamethasone Inhibits TRAIL-Induced Apoptosis through c-FLIP(L) Upregulation and DR5 Downregulation by GSK3β Activation in Cancer Cells Cancers doi: 10.3390/cancers12102901 Authors: Mi-Yeon Jeon Seon Min Woo Seung Un Seo Sang Hyun Kim Ju-Ock Nam Shin Kim Jong-Wook Park Peter Kubatka Kyoung-jin Min Taeg Kyu Kwon Dexamethasone (DEX), a synthetic glucocorticoid, is commonly used as immunosuppressive and chemotherapeutic agent. This...
Fri Oct 09, 2020 03:00
Cancers, Vol. 12, Pages 2902: Immuno-Interface Score to Predict Outcome in Colorectal Cancer Independent of Microsatellite Instability Status Cancers doi: 10.3390/cancers12102902 Authors: Ausrine Nestarenkaite Wakkas Fadhil Allan Rasmusson Susanti Susanti Efthymios Hadjimichael Aida Laurinaviciene Mohammad Ilyas Arvydas Laurinavicius Tumor-associated immune cells have been shown to predict patient outcome in colorectal (CRC) and other cancers. Spatial digital image...
Fri Oct 09, 2020 03:00
Cancers, Vol. 12, Pages 2898: Current Topics in Esophageal Squamous Cell Carcinoma Cancers doi: 10.3390/cancers12102898 Authors: Kurumi Isomoto Approximately 604,000 new cases of esophageal cancers (EC) are expected to be diagnosed in 2020, resulting in 537,000 cancer deaths worldwide. (...)
Fri Oct 09, 2020 03:00
Cancers, Vol. 12, Pages 2900: Aggressive NK Cell Leukemia: Current State of the Art Cancers doi: 10.3390/cancers12102900 Authors: Siba El Hussein L. Jeffrey Medeiros Joseph D. Khoury Aggressive natural killer (NK) cell leukemia (ANKL) is a rare disease with a grave prognosis. Patients commonly present acutely with fever, constitutional symptoms, hepatosplenomegaly, and often disseminated intravascular coagulation or hemophagocytic syndrome. This acute clinical presentation and...
Fri Oct 09, 2020 03:00
Cancers, Vol. 12, Pages 2905: Potential Molecular Players of the Tumor Microenvironment in Extracranial Pediatric Solid Tumors Cancers doi: 10.3390/cancers12102905 Authors: Rosa Noguera Tomás Álvaro Naranjo Pediatric cancers are rare malignancies worldwide and represent around 1% of all new cancer diagnoses. (...)
Fri Oct 09, 2020 03:00
Cancers, Vol. 12, Pages 2897: Positron Emission Tomography in Merkel Cell Carcinoma Cancers doi: 10.3390/cancers12102897 Authors: Christos Sachpekidis Polytimi Sidiropoulou Jessica C. Hassel Nikolaos Drakoulis Antonia Dimitrakopoulou-Strauss Merkel cell carcinoma (MCC) is a rare neuroendocrine skin malignancy usually arising as a nonspecific nodule on sun-exposed areas of the head and neck. Given the poor prognosis of this aggressive tumor, assessment of disease burden in...
Fri Oct 09, 2020 03:00
Cancers, Vol. 12, Pages 2904: Screening for Early Gastric Cancer Using a Noninvasive Urine Metabolomics Approach Cancers doi: 10.3390/cancers12102904 Authors: Hyuk Nam Kwon Hyuk Lee Ji Won Park Young-Ho Kim Sunghyouk Park Jae J. Kim The early detection of gastric cancer (GC) could decrease its incidence and mortality. However, there are currently no accurate noninvasive markers for GC screening. Therefore, we developed a noninvasive diagnostic approach, employing urine...
Fri Oct 09, 2020 03:00
Cancers, Vol. 12, Pages 2899: Senescence-Associated Secretory Phenotype Determines Survival and Therapeutic Response in Cervical Cancer Cancers doi: 10.3390/cancers12102899 Authors: Sharad Purohit Wenbo Zhi Daron G. Ferris Manual Alverez Lynn Kim Hoang Tran Paul Minh Huy Tran Boying Dun Diane Hopkins Bruno dos Santos Sharad Ghamande Jin-Xiong She Molecular biomarkers that can predict survival and therapeutic outcome are still lacking for cervical cancer....
Fri Oct 09, 2020 03:00
Cancers, Vol. 12, Pages 2889: Aptamers: Novel Therapeutics and Potential Role in Neuro-Oncology Cancers doi: 10.3390/cancers12102889 Authors: Paola Amero Soumen Khatua Cristian Rodriguez-Aguayo Gabriel Lopez-Berestein A relatively new paradigm in cancer therapeutics is the use of cancer cell–specific aptamers, both as therapeutic agents and for targeted delivery of anticancer drugs. After the first therapeutic aptamer was described nearly 25 years ago, and the subsequent...
Fri Oct 09, 2020 03:00
Cancers, Vol. 12, Pages 2894: Preoperative Serum Calcitonin and Its Correlation with Extent of Lymph Node Metastasis in Medullary Thyroid Carcinoma Cancers doi: 10.3390/cancers12102894 Authors: Hyunju Park Jun Park Min Sun Choi Jinyoung Kim Hosu Kim Jung Hee Shin Jung-Han Kim Jee Soo Kim Sun Wook Kim Jae Hoon Chung Tae Hyuk Kim The optimal initial surgical extent for medullary thyroid carcinoma (MTC) remains controversial. Previous studies on serum calcitonin...
Fri Oct 09, 2020 03:00
Cancers, Vol. 12, Pages 2891: Novel Concepts of Treatment for Patients with Myelofibrosis and Related Neoplasms Cancers doi: 10.3390/cancers12102891 Authors: Prithviraj Bose Lucia Masarova Srdan Verstovsek Janus kinase (JAK) inhibition forms the cornerstone of the treatment of myelofibrosis (MF), and the JAK inhibitor ruxolitinib is often used as a second-line agent in patients with polycythemia vera (PV) who fail hydroxyurea (HU). In addition, ruxolitinib continues to be studied...
Fri Oct 09, 2020 03:00
Cancers, Vol. 12, Pages 2895: CD99–PTPN12 Axis Suppresses Actin Cytoskeleton-Mediated Dimerization of Epidermal Growth Factor Receptor Cancers doi: 10.3390/cancers12102895 Authors: Kyoung-Jin Lee Yuri Kim Min Seo Kim Hyun-Mi Ju Boyoung Choi Hansoo Lee Dooil Jeoung Ki-Won Moon Dongmin Kang Jiwon Choi Jong In Yook Jang-Hee Hahn The epidermal growth factor receptor (EGFR), a member of ErbB receptor tyrosine kinase (RTK) family, is activated through growth...
Fri Oct 09, 2020 03:00
Cancers, Vol. 12, Pages 2892: Direct Transfer of Mesoporous Silica Nanoparticles between Macrophages and Cancer Cells Cancers doi: 10.3390/cancers12102892 Authors: Stefan Franco Achraf Noureddine Jimin Guo Jane Keth Michael L. Paffett C. Jeffrey Brinker Rita E. Serda Macrophages line the walls of microvasculature, extending processes into the blood flow to capture foreign invaders, including nano-scale materials. Using mesoporous silica nanoparticles (MSNs) as a model...
Fri Oct 09, 2020 03:00
Cancers, Vol. 12, Pages 2893: Advances in Natural or Synthetic Nanoparticles for Metastatic Melanoma Therapy and Diagnosis Cancers doi: 10.3390/cancers12102893 Authors: Maria Beatrice Arasi Francesca Pedini Sonia Valentini Nadia Felli Federica Felicetti Advanced melanoma is still a major challenge in oncology. In the early stages, melanoma can be treated successfully with surgery and the survival rate is high, nevertheless the survival rate drops drastically after metastasis...
Fri Oct 09, 2020 03:00
Cancers, Vol. 12, Pages 2896: Emergence of Cancer-Associated Fibroblasts as an Indispensable Cellular Player in Bone Metastasis Process Cancers doi: 10.3390/cancers12102896 Authors: Mukaida Zhang Sasaki Bone metastasis is frequently complicated in patients with advanced solid cancers such as breast, prostate and lung cancers, and impairs patients’ quality of life and prognosis. At the first step of bone metastasis, cancer cells adhere to the endothelium in bone marrow...
Fri Oct 09, 2020 03:00
Cancers, Vol. 12, Pages 2890: Non-Coding and Regulatory RNAs as Epigenetic Remodelers of Fatty Acid Homeostasis in Cancer Cancers doi: 10.3390/cancers12102890 Authors: Silvia Cruz-Gil Lara P. Fernández Ruth Sánchez-Martínez Marta Gómez de Cedrón Ana Ramírez de Molina Cancer cells commonly display metabolic fluctuations. Together with the Warburg effect and the increased glutaminolysis, alterations in lipid metabolism homeostasis have been recognized as a hallmark of cancer....
Fri Oct 09, 2020 03:00
Cells, Vol. 9, Pages 2272: Small-Molecule Chemical Knockdown of MuRF1 in Melanoma Bearing Mice Attenuates Tumor Cachexia Associated Myopathy Cells doi: 10.3390/cells9102272 Authors: Adams Gußen Zozulya Cruz Moriscot Linke Labeit : Patients with malignant tumors frequently suffer during disease progression from a syndrome referred to as cancer cachexia (CaCax): CaCax includes skeletal muscle atrophy and weakness, loss of bodyweight, and fat tissues. Currently,...
Sun Oct 11, 2020 03:00
Cells, Vol. 9, Pages 2270: Cell Mechanics in Embryoid Bodies Cells doi: 10.3390/cells9102270 Authors: Kira Zeevaert Mohamed H. Elsafi Mabrouk Wolfgang Wagner Roman Goetzke Embryoid bodies (EBs) resemble self-organizing aggregates of pluripotent stem cells that recapitulate some aspects of early embryogenesis. Within few days, the cells undergo a transition from rather homogeneous epithelial-like pluripotent stem cell colonies into a three-dimensional organization of various...
Sun Oct 11, 2020 03:00
Cells, Vol. 9, Pages 2271: Therapeutic miRNA-Enriched Extracellular Vesicles: Current Approaches and Future Prospects Cells doi: 10.3390/cells9102271 Authors: Javaria Munir Jeong Kyo Yoon Seongho Ryu Extracellular vesicles (EVs) are 50–300 nm vesicles secreted by eukaryotic cells. They can carry cargo (including miRNA) from the donor cell to the recipient cell. miRNAs in EVs can change the translational profile of the recipient cell and modulate cellular morphology. This...
Sun Oct 11, 2020 03:00
Cells, Vol. 9, Pages 2269: Breast Cancer-Derived Microparticles Reduce Cancer Cell Adhesion, an Effect Augmented by Chemotherapy Cells doi: 10.3390/cells9102269 Authors: Dvir Shechter Michal Harel Abhishek Mukherjee Leonel M. Sagredo David Loven Elad Prinz Shimrit Avraham Veronique Orian-Rousseau Tamar Geiger Yuval Shaked Haguy Wolfenson Tumor cell heterogeneity is primarily dictated by mutational changes, sometimes leading to clones that undergo a metastatic...
Sat Oct 10, 2020 03:00
Cells, Vol. 9, Pages 2267: Learning from Fifteen Years of Genome-Wide Association Studies in Age-Related Macular Degeneration Cells doi: 10.3390/cells9102267 Authors: Strunz Kiel Sauerbeck Weber : Over the last 15 years, genome-wide association studies (GWAS) have greatly advanced our understanding of the genetic landscape of complex phenotypes. Nevertheless, causal interpretations of GWAS data are challenging but crucial to understand underlying mechanisms and pathologies....
Sat Oct 10, 2020 03:00
Cells, Vol. 9, Pages 2266: Production of ROS by Gallic Acid Activates KDM2A to Reduce rRNA Transcription Cells doi: 10.3390/cells9102266 Authors: Tanaka Obinata Konishi Yamagiwa Tsuneoka Metformin, which is suggested to have anti-cancer effects, activates KDM2A to reduce rRNA transcription and proliferation of cancer cells. Thus, the specific activation of KDM2A may be applicable to the treatment of cancers. In this study, we screened a food-additive compound library...
Sat Oct 10, 2020 03:00
Cells, Vol. 9, Pages 2268: Revisiting the Karyotype Evolution of Neotropical Boid Snakes: A Puzzle Mediated by Chromosomal Fissions Cells doi: 10.3390/cells9102268 Authors: Viana Ezaz Cioffi Liehr Al-Rikabi Tavares-Pinheiro Bertollo Feldberg The Boidae family is an ancient group of snakes widely distributed across the Neotropical region, where several biogeographic events contributed towards shaping their evolution and diversification. Most species of this...
Sat Oct 10, 2020 03:00
Cells, Vol. 9, Pages 2264: Cell Signaling Pathway Reporters in Adult Hematopoietic Stem Cells Cells doi: 10.3390/cells9102264 Authors: Jolanda. J.D. de Roo Frank. J.T. Staal Hematopoietic stem cells (HSCs) develop at several anatomical locations and are thought to undergo different niche regulatory cues originating from highly conserved cell signaling pathways, such as Wnt, Notch, TGF-β family, and Hedgehog signaling. Most insight into these pathways has been obtained by...
Fri Oct 09, 2020 03:00
Cells, Vol. 9, Pages 2265: The Multimodal Serotonergic Agent Vilazodone Inhibits L-DOPA-Induced Gene Regulation in Striatal Projection Neurons and Associated Dyskinesia in an Animal Model of Parkinson’s Disease Cells doi: 10.3390/cells9102265 Authors: Feras Altwal Connor Moon Anthony R. West Heinz Steiner Levodopa (L-DOPA) treatment in Parkinson’s disease is limited by the emergence of L-DOPA-induced dyskinesia. Such dyskinesia is associated with aberrant gene regulation...
Fri Oct 09, 2020 03:00
Cells, Vol. 9, Pages 2261: Astrogliosis in an Experimental Model of Hypovitaminosis B12: A Cellular Basis of Neurological Disorders due to Cobalamin Deficiency Cells doi: 10.3390/cells9102261 Authors: Zuzanna Rzepka Jakub Rok Justyna Kowalska Klaudia Banach Justyna Magdalena Hermanowicz Artur Beberok Beata Sieklucka Dorota Gryko Dorota Wrześniok Cobalamin deficiency affects human physiology with sequelae ranging from mild fatigue to severe neuropsychiatric abnormalities....
Fri Oct 09, 2020 03:00
Cells, Vol. 9, Pages 2259: Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration Cells doi: 10.3390/cells9102259 Authors: Laura Prieto Clemente Malena Rabenau Stephan Tang Josefina Stanka Eileen Cors Jenny Stroh Carsten Culmsee Silvia von Karstedt Ferroptosis is a form of regulated necrosis characterized by a chain-reaction of detrimental membrane lipid peroxidation following collapse of glutathione peroxidase...
Fri Oct 09, 2020 03:00
Cells, Vol. 9, Pages 2262: The Functional Role of microRNAs in the Pathogenesis of Tauopathy Cells doi: 10.3390/cells9102262 Authors: Domenico Praticò Tauopathies are neurodegenerative disorders which include Alzheimer’s disease, Pick’s disease, corticobasal degeneration, and progressive supranuclear palsy among others. Pathologically, they are characterized by the accumulation of highly phosphorylated and aggregated tau protein in different brain regions. Currently,...
Fri Oct 09, 2020 03:00
Cells, Vol. 9, Pages 2260: Pseudomonas aeruginosa Planktonic- and Biofilm-Conditioned Media Elicit Discrete Metabolic Responses in Human Macrophages Cells doi: 10.3390/cells9102260 Authors: Amanda L. Fuchs Isaac R. Miller Sage M. Schiller Mary Cloud B. Ammons Brian Eilers Brian Tripet Valérie Copié Macrophages (MΦs) are prevalent innate immune cells, present throughout human bodily tissues where they orchestrate innate and adaptive immune responses to maintain...
Fri Oct 09, 2020 03:00
Cells, Vol. 9, Pages 2263: Neuropathic Itch Cells doi: 10.3390/cells9102263 Authors: James Meixiong Xinzhong Dong Hao-Jui Weng Neurologic insults as varied as inflammation, stroke, and fibromyalgia elicit neuropathic pain and itch. Noxious sensation results when aberrantly increased afferent signaling reaches percept-forming cortical neurons and can occur due to increased sensory signaling, decreased inhibitory signaling, or a combination of both processes. To treat these symptoms,...
Fri Oct 09, 2020 03:00
Chemosensors, Vol. 8, Pages 98: A Critical Factor for Quantifying Proteins in Unmodified Gold Nanoparticles-Based Aptasensing: The Effect of pH Chemosensors doi: 10.3390/chemosensors8040098 Authors: Dai Lu Dong Zhang Qian Zhao Xiangyang Lu Xingbo Shi Unmodified gold nanoparticles (AuNPs)-based aptasensing (uGA) assay has been widely implemented in the determination of many different targets, but there are few reports on protein detection using uGA. Here, we designed a uGA...
Fri Oct 09, 2020 03:00
Chemosensors, Vol. 8, Pages 97: Dual-Modal Assay Kit for the Qualitative and Quantitative Determination of the Total Water Hardness Using a Permanent Marker Fabricated Microfluidic Paper-Based Analytical Device Chemosensors doi: 10.3390/chemosensors8040097 Authors: Oyejide Damilola Oyewunmi Seyed Hamid Safiabadi-Tali Sana Jahanshahi-Anbuhi A dip-and-read microfluidic paper-based analytical device (µPAD) was developed for the qualitative and quantitative detection of the...
Fri Oct 09, 2020 03:00
Children, Vol. 7, Pages 176: Making a Decision between Acute Appendicitis and Acute Gastroenteritis Children doi: 10.3390/children7100176 Authors: Yi-Ting Lu Po-Cheng Chen Ying-Hsien Huang Fu-Chen Huang Acute appendicitis is one of the most common pediatric abdominal emergencies. Early diagnosis is vital for a positive outcome. However, it may initially present with diarrhea and vomiting, mimicking acute gastroenteritis, thus delaying prompt surgery. Differentiating appendicitis...
Sun Oct 11, 2020 03:00
Children, Vol. 7, Pages 173: Good Subjective Outcomes, Stable Knee and High Return to Sport after Tibial Eminence Avulsion Fracture in Children Children doi: 10.3390/children7100173 Authors: Stefano Stallone Filippo Selleri Giovanni Trisolino Alberto Grassi Luca Macchiarola Marina Magnani Eleonora Olivotto Stefano Zaffagnini Stefano Stilli Fabio Catani Avulsion fracture of the tibial spine (TSA) is uncommon in children, although its incidence is increasing...
Fri Oct 09, 2020 03:00
Children, Vol. 7, Pages 174: Dietary Diversity and Nutritional Status of Preschool Children in North West Province, South Africa: A Cross Sectional Study Children doi: 10.3390/children7100174 Authors: Perpetua Modjadji Dineo Molokwane Patricia Ogechi Ukegbu Preschool children consume diets inadequate to meet their macro and micronutrient requirements, which ultimately affect their nutritional status due to lack of dietary diversity. A cross sectional study was conducted to investigate...
Fri Oct 09, 2020 03:00
Children, Vol. 7, Pages 175: Psychometric Analyses of the Indian (Hindi) Version of the Child Perception Questionnaire (CPQ11–14) Children doi: 10.3390/children7100175 Authors: Santosh Kumar Tadakamadla Garima Mangal Mir Faeq Ali Quadri Maryam Nayeem Jyothi Tadakamadla The current research aims to evaluate the reliability and validity of the Hindi Child Perception Questionnaire (CPQ11–14) in a child population of India. A randomly selected sample of children aged...
Fri Oct 09, 2020 03:00
Children, Vol. 7, Pages 172: Trunk Lateral Flexor Endurance and Body Fat: Predictive Risk Factors for Low Back Pain in Child Equestrian Athletes Children doi: 10.3390/children7100172 Authors: Antonio Cejudo Angélica Ginés-Díaz Olga Rodríguez-Ferrán Fernando Santonja-Medina Pilar Sainz de Baranda Low back pain (LBP) is the most common overuse musculoskeletal injury suffered by child equestrian athletes (CEA). Despite this, little is known about the risk factors related to...
Fri Oct 09, 2020 03:00
Climate, Vol. 8, Pages 114: Impact of Climate Change on Vegetation Cover at South Port Sudan Area Climate doi: 10.3390/cli8100114 Authors: Pei Sun Loh Hussien Ibrahim Mohammed Alnoor Shuangyan He Arid regions worldwide, for example, Sudan, are affected by climate change and susceptible to environmental deterioration. In this study, temperature and rainfall data from 1985 to 2015 obtained from the Sudan Meteorological Authority were compared with satellite images of vegetation coverage...
Sat Oct 10, 2020 03:00
Climate, Vol. 8, Pages 115: Characteristics of Climate Change in the Lancang–Mekong Sub-Region Climate doi: 10.3390/cli8100115 Authors: Li Song The Lancang–Mekong River is an important international river in Southeastern Asia. In recent years, due to climate change, natural disasters, such as drought and flooding, have frequently occurred in the region, which has a negative effect on the sustainable development of the social economy. Due to the lack of meteorological monitoring...
Sat Oct 10, 2020 03:00
Dentistry Journal, Vol. 8, Pages 116: Comparison in Four Different Implant Systems of Mechanical Resistance to Maximal Stress in Prosthetic Screws—An In Vitro Study Dentistry Journal doi: 10.3390/dj8040116 Authors: Pedro Barreiros Luís Neves Carlos Aroso José M. Mendes António Sérgio Silva Micromovements of the implant–abutment connection influence peri-implant bone preservation. This study evaluates and quantifies the maximal torque after a cycle of implant prosthetic...
Fri Oct 09, 2020 03:00
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