Tumor quiescence: elevating SOX2 in diverse tumor cell types downregulates a broad spectrum of the cell cycle machinery and inhibits tumor growth. BMC Cancer. 2020 Oct 01;20(1):941 Authors: Metz EP, Wuebben EL, Wilder PJ, Cox JL, Datta K, Coulter D, Rizzino A Abstract BACKGROUND: Quiescent tumor cells pose a major clinical challenge due to their ability to resist conventional chemotherapies and to drive tumor recurrence. Understanding...
Fri Oct 02, 2020 13:42
Targeting the PI3K/mTOR pathway augments CHK1 inhibitor-induced replication stress and antitumor activity in high-grade serous ovarian cance. Cancer Res. 2020 Sep 30;: Authors: Huang TT, Brill E, Nair JR, Zhang X, Wilson KM, Chen L, Thomas CJ, Lee JM Abstract High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecologic malignancy in industrialized countries and has limited treatment options. Targeting ATR/CHK1-mediated S...
Fri Oct 02, 2020 13:42
Single molecule studies reveal that p53 tetramers dynamically bind response elements containing one or two half sites. Sci Rep. 2020 Sep 30;10(1):16176 Authors: Ly E, Kugel JF, Goodrich JA Abstract The tumor suppressor protein p53 is critical for cell fate decisions, including apoptosis, senescence, and cell cycle arrest. p53 is a tetrameric transcription factor that binds DNA response elements to regulate transcription of target genes....
Fri Oct 02, 2020 13:42
Repeat expansions confer WRN dependence in microsatellite-unstable cancers. Nature. 2020 Sep 30;: Authors: van Wietmarschen N, Sridharan S, Nathan WJ, Tubbs A, Chan EM, Callen E, Wu W, Belinky F, Tripathi V, Wong N, Foster K, Noorbakhsh J, Garimella K, Cruz-Migoni A, Sommers JA, Huang Y, Borah AA, Smith JT, Kalfon J, Kesten N, Fugger K, Walker RL, Dolzhenko E, Eberle MA, Hayward BE, Usdin K, Freudenreich CH, Brosh RM, West SC, McHugh PJ, Meltzer PS, Bass...
Fri Oct 02, 2020 13:42
Charge and Size Dual Switchable Nanocage for Novel Triple-Interlocked Combination Therapy Pattern. Adv Sci (Weinh). 2020 Sep;7(18):2000906 Authors: Yang R, Zhang Z, Fu S, Hou T, Mu W, Liang S, Gao T, Guan L, Fang Y, Liu Y, Zhang N Abstract Combination therapy is a current hot topic in cancer treatment. Multiple synergistic effects elicited by combined drugs are essential in improving antitumor activity. Herein, a pH-triggered charge and...
Fri Oct 02, 2020 13:42
Andrographolide sensitizes human renal carcinoma cells to TRAIL‑induced apoptosis through upregulation of death receptor 4. Oncol Rep. 2020 Nov;44(5):1939-1948 Authors: Bi R, Deng Y, Tang C, Xuan L, Xu B, Du Y, Wang C, Wei W Abstract Tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) selectively induces apoptosis in cancer cells, with minimal toxicity to normal tissues. However, accumulating evidence suggests that certain...
Fri Oct 02, 2020 13:42
Antitumor effects of curcumin on the proliferation, migration and apoptosis of human colorectal carcinoma HCT‑116 cells. Oncol Rep. 2020 Nov;44(5):1997-2008 Authors: Xiang L, He B, Liu Q, Hu D, Liao W, Li R, Peng X, Wang Q, Zhao G Abstract Curcumin is the main component of the Chinese herbal plant turmeric, which has been demonstrated to possess antitumor and other pharmacological properties. The aim of the present study was to investigate...
Fri Oct 02, 2020 13:42
Luteolin, an aryl hydrocarbon receptor ligand, suppresses tumor metastasis in vitro and in vivo. Oncol Rep. 2020 Nov;44(5):2231-2240 Authors: Feng J, Zheng T, Hou Z, Lv C, Xue A, Han T, Han B, Sun X, Wei Y Abstract Estrogen receptor (ER)‑negative breast tumors are associated with low survival rates, which is related to their ability to grow and metastasize into distal organs. The aryl hydrocarbon receptor (AhR), a ligand‑activated transcription...
Fri Oct 02, 2020 13:42
Herbal formula Renshenwuweizi decoction induces p53-mediated cell cycle arrest and apoptosis in A549 cells. J Tradit Chin Med. 2020 Oct;40(5):766-773 Authors: Yu S, Zhang W, Yang J, Zhao W, Liu M, Zhao D, Bai X, Wang S Abstract OBJECTIVE: To investigate the effect of Renshenwuweizi decoction (RSWWZ decoction) on the growth of non-small cell lung cancer cells in vitro. METHODS: A549 non-small cell lung cancer cells were divided...
Fri Oct 02, 2020 13:42
Curcumin from Jianghuang (Rhizoma Curcumae Longae) protects against exposure to ultraviolet B by antioxidation and attenuating mitochondrion-dependent apoptosis. J Tradit Chin Med. 2020 Oct;40(5):782-791 Authors: Hou J, Fang F, Kang S, Wang Z, Yang Y Abstract OBJECTIVE: To investigate the protective effect of curcumin extracted from Jianghuang (Rhizoma Curcumae Longae) against ultraviolet B (UVB) and the possible mechanism. METHODS:...
Fri Oct 02, 2020 13:42
Hsa_circRNA_0000518 facilitates breast cancer development via regulation of the miR-326/FGFR1 axis. Thorac Cancer. 2020 Oct 01;: Authors: Jiang J, Lin H, Shi S, Hong Y, Bai X, Cao X Abstract BACKGROUND: Breast cancer (BC) is a heterogeneous malignant tumor that threatens the health of women worldwide. Hsa_circRNA_0000518 (circ_0000518) has been revealed to be upregulated in BC tissues. However, the role and mechanism of circ_0000518 in...
Fri Oct 02, 2020 13:42
A spirostanol saponin isolated from Tupistra chinensis Baker simultaneously induces apoptosis and autophagy by regulating the JNK pathway in human gastric cancer cells. Steroids. 2020 Sep 28;:108737 Authors: Xu J, Wang Z, Huang Y, Wang Y, Xiang L, He X Abstract T-17, a bioactive spirostanol saponin extracted from Tupistra chinensis Baker, was previously reported with anti-inflammatory and cytotoxic activities. However, the mechanism underlying...
Fri Oct 02, 2020 13:42
The HDAC Inhibitor Domatinostat Promotes Cell Cycle Arrest, Induces Apoptosis and Increases Immunogenicity of Merkel Cell Carcinoma Cells. J Invest Dermatol. 2020 Sep 28;: Authors: Song L, Bretz AC, Gravemeyer J, Spassova I, Muminova S, Gambichler T, Sriram A, Ferrone S, Becker JC Abstract Merkel cell carcinoma (MCC) is a rare, highly aggressive skin cancer for which immune modulation by immune checkpoint inhibitors show remarkable response...
Fri Oct 02, 2020 13:42
The secretome of senescent preadipocytes influences the phenotype and function of cells of the vascular wall. Biochim Biophys Acta Mol Basis Dis. 2020 Sep 28;:165983 Authors: Parvizi M, Ryan ZC, Ebtehaj S, Arendt BK, Lanza IR Abstract Senescent cells accumulate in numerous tissues in several chronic conditions such as aging, obesity, and diabetes. These cells are in a state of irreversible cell-cycle arrest and secrete inflammatory cytokines,...
Fri Oct 02, 2020 13:42
Related Articles An artificial nucleoside that simultaneously detects and combats drug resistance to doxorubicin. Eur J Haematol. 2020 Feb;104(2):97-109 Authors: Choi JS, Berdis A Abstract OBJECTIVES: Doxorubicin is a DNA-damaging agent used to treat hematological cancers. Unfortunately, drug resistance can occur by defective DNA repair activity coupled with the ability of DNA polymerases to misreplicate unrepaired DNA lesions. This study demonstrates...
Sat Oct 03, 2020 13:34
CDK4/6 inhibition enhances antitumor efficacy of chemotherapy and immune checkpoint inhibitor combinations in preclinical models and enhances T-cell activation in patients with SCLC receiving chemotherapy. J Immunother Cancer. 2020 Oct;8(2): Authors: Lai AY, Sorrentino JA, Dragnev KH, Weiss JM, Owonikoko TK, Rytlewski JA, Hood J, Yang Z, Malik RK, Strum JC, Roberts PJ Abstract BACKGROUND: Combination treatment with chemotherapy and immune...
Sat Oct 03, 2020 13:34
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors. Bioorg Med Chem. 2020 Sep 04;28(22):115739 Authors: Bouzriba C, Larcher L, Gagné-Boulet M, Fortin S Abstract N-phenyl ureidobenzenesulfonates (PUB-SOs) is a new class of promising anticancer agents inducing replication stresses and cell cycle arrest in S-phase. However, the pharmacological target of PUB-SOs was still unidentified. Consequently,...
Sat Oct 03, 2020 13:34
Non-cytotoxic 1,2,3-triazole tethered fused heterocyclic ring derivatives display Tax protein inhibition and impair HTLV-1 infected cells. Bioorg Med Chem. 2020 Sep 08;28(22):115746 Authors: Dos Santos DF, de Pilger DRB, Vandermeulen C, Khouri R, Mantoani SP, Nunes PSG, de Andrade P, Carvalho I, Casseb J, Twizere JC, Willems L, Freitas-Junior L, Kashima S Abstract Human T cell lymphotropic virus type 1 (HTLV-1) is a human retrovirus that...
Sat Oct 03, 2020 13:34
Citrus hystrix Extracts Protect Human Neuronal Cells against High Glucose-Induced Senescence. Pharmaceuticals (Basel). 2020 Sep 30;13(10): Authors: Pattarachotanant N, Tencomnao T Abstract Citrus hystrix (CH) is a beneficial plant utilized in traditional folk medicine to relieve various health ailments. The antisenescent mechanisms of CH extracts were investigated using human neuroblastoma cells (SH-SY5Y). Phytochemical contents and antioxidant...
Sun Oct 04, 2020 13:39
Caffeine Stabilises Fission Yeast Wee1 in a Rad24-Dependent Manner but Attenuates Its Expression in Response to DNA Damage. Microorganisms. 2020 Sep 30;8(10): Authors: Alao JP, Johansson-Sjölander J, Rallis C, Sunnerhagen P Abstract The widely consumed neuroactive compound caffeine has generated much interest due to its ability to override the DNA damage and replication checkpoints. Previously Rad3 and its homologues was thought to be...
Sun Oct 04, 2020 13:39
Urinary cell cycle arrest proteins urinary tissue inhibitor of metalloprotease 2 and insulin-like growth factor binding protein 7 predict acute kidney injury after severe trauma: A prospective observational study. J Trauma Acute Care Surg. 2020 Oct;89(4):761-767 Authors: Hatton GE, Wang YW, Isbell KD, Finkel KW, Kao LS, Wade CE Abstract BACKGROUND: Recognition and clinical diagnosis of acute kidney injury (AKI) after trauma is difficult....
Sun Oct 04, 2020 13:39
A form of secondary ovarian insufficiency (SOI) due to adrenal hypoandrogenism as new infertility diagnosis. Endocrine. 2020 Oct 02;: Authors: Gleicher N, Darmon S, Molinari E, Zhang L, Hu J, Albertini DF, Barad DH Abstract BACKGROUND: Mediated via the androgen receptor on granulosa cells, models of small growing follicle stages demonstrate dependence on testosterone. Androgen deficiency reduces ovarian response to follicle stimulation...
Sun Oct 04, 2020 13:39
Curcumin promotes cancer-associated fibroblasts apoptosis via ROS-mediated endoplasmic reticulum stress. Arch Biochem Biophys. 2020 Sep 30;:108613 Authors: Zeng Y, Du Q, Zhang Z, Ma J, Han L, Wang Y, Yang L, Tao N, Qin Z Abstract Cancer-associated fibroblasts (CAFs) play an important role in tumorigenesis, development, and migration. Eliminating CAFs or reducing their tumor-promoting activity is beneficial for tumor immunotherapy. Curcumin...
Sun Oct 04, 2020 13:39
Nanoformulation design and therapeutic potential of a novel tubulin inhibitor in pancreatic cancer. J Control Release. 2020 Sep 30;: Authors: Bhattarai RS, Kumar V, Romanova S, Bariwal J, Chen H, Deng S, Bhatt VR, Bronich T, Li W, Mahato RI Abstract Successful treatment of pancreatic cancer remains a challenge due to desmoplasia, development of chemoresistance, and systemic toxicity. Herein, we synthesized (6-(3-hydroxy-4-methoxylphenyl)pyridin-2-yl)...
Sun Oct 04, 2020 13:39
9-cis-UAB30, a novel rexinoid agonist, decreases tumorigenicity and cancer cell stemness of human neuroblastoma patient-derived xenografts. Transl Oncol. 2020 Sep 30;14(1):100893 Authors: Marayati R, Bownes LV, Stafman LL, Williams AP, Quinn CH, Atigadda V, Aye JM, Stewart JE, Yoon KJ, Beierle EA Abstract Retinoic acid (RA) therapy has been utilized as maintenance therapy for high-risk neuroblastoma, but over half of patients treated with...
Sun Oct 04, 2020 13:39
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