Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Κυριακή 11 Οκτωβρίου 2020
Eosinophilic esophagitis with and without airway involvement in children
Eosinophilic esophagitis with and without airway involvement in children – A comparative analysis:
Publication date: December 2020
Source: International Journal of Pediatric Otorhinolaryngology, Volume 139
Author(s): Varun Bora, Anthony Olive, Eric Chiou, Priya Raj, Deepak Mehta
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International Journal of Pediatric Otorhinolaryngology
Volume 139, December 2020, 110422
Eosinophilic esophagitis with and without airway involvement in children – A comparative analysis
Author links open overlay panelVarunBoraaAnthonyOliveabEricChiouabPriyaRajabDeepakMehtaabShow more
https://doi.org/10.1016/j.ijporl.2020.110422Get rights and content
Abstract
Background
Eosinophilic esophagitis (EoE) is an allergic disease characterized by marked eosinophilic infiltration and inflammation of the esophagus eventually leading to esophageal dysfunction. This condition at times may involve the airway leading to breathing difficulties.
Objective
To compare the course of EoE in patients with or without airway involvement.
Methods
A retrospective chart review was done on patients with a diagnosis of Eosinophilic Esophagitis and that were managed in our Aerodigestive clinic from 2012 to 2018. A total of 121 EoE patients were included in the study. Each patient's disease course was examined for pertinent information including – but not limited to – age at presentation, allergies, endoscopic and pathology results, treatments prescribed, and time to resolution. The data was analyzed for any differences between the airway and non-airway groups for each of these variables.
Results
The variables that were analyzed showed no significant difference between patients suffering from EoE with (n = 19) and without (n = 102) airway involvement. However, patients with airway disease trended towards being younger in age at presentation as compared to those without airway symptoms (6.68 years vs. 9.69 years, p = 0.69). Analysis of endoscopic and pathology findings revealed no difference. Similarly, no differences were found between the prescribed treatments. Kaplan-Meier estimates of time to disease remission indicated that 50% of patients had resolution at one year, regardless of airway involvement (p = 0.31).
Conclusions
Our findings indicate that the disease course of patients with EoE does not vary depending on the presence of airway symptoms. Thus, patients with airway symptoms should not be diagnosed or treated any different than those without airway symptoms.
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