A rare case of cystic hygroma in neck and extending into thoracic cavity. Int J Surg Case Rep. 2020 Oct 03;76:174-177 Authors: El Sayed M, Touny M, Ibrahim N, Kasb I, Al-Azzawi Z Abstract INTRODUCTION: Cystic hygroma is a benign swelling of the neck among the pediatric population. It is a fluid-filled sac resulting from blockage in the lymphatic system and is commonly located in the cervical region and axilla. CASE PRESENTATION: We...
Sun Oct 11, 2020 14:19
Parasitological association between human leishmaniosis mucosa and paracoccidioidomycosis. Case report. Int J Surg Case Rep. 2020 Sep 23;76:170-173 Authors: de Jesus Oliveira Gonçalves CA, Carneiro JT, de Souza Cruz EL, de Sousa Neves Filho F, Rivadeneira Cárdenas RC, Guimarães DM Abstract INTRODUCTION: Leishmaniasis Mucosa (LM) is a tropical disease that affects the upper respiratory tract and/or oral mucosa. Its etiological agent is Leishmania...
Sat Oct 10, 2020 14:29
Bilateral pulmonary hydatidosis associated with uncommon muscular localization. Int J Surg Case Rep. 2020 Sep 16;76:130-133 Authors: Messaoudi H, Zayène B, Ben Ismail I, Lajmi M, Lahdhili H, Hachicha S, Chenik S Abstract INTRODUCTION: The lung is the second most commonly affected organ by hydatidosis, and the bilateral involvement is rare even in endemic regions. CASE PRESENTATION: We report the case of a 27-year-old patient who presented...
Sat Oct 10, 2020 14:29
An extremely rare combination of choledochocele and bile duct duplication escalating severe acute pancreatitis and cholangitis: A case report. Int J Surg Case Rep. 2020 Sep 23;76:161-165 Authors: Okamoto H, Shiba S, Wakana H, Kawashima K, Fukasawa T Abstract BACKGROUND: Combination of choledochocele and extra-hepatic duct duplication is an extremely rare congenital abnormality. CASE PRESENTATION: The patient was an 81-year-old Japanese...
Fri Oct 09, 2020 14:45
Very delayed liver metastasis from small bowel gastrointestinal stromal tumor (32 years after resection of the small bowel GIST): Report of a case. Int J Surg Case Rep. 2020 Sep 28;76:156-160 Authors: Ishizaki M, Uno F, Yoshida R, Miyauchi S, Honda O Abstract INTRODUCTION: Recurrent forms of gastrointestinal stromal tumor (GIST) include liver metastases and peritoneal dissemination. Recurrence often occurs within 2 years. We report a case of...
Fri Oct 09, 2020 14:45
Gastric bypass with weight regain - Biliary limb distalization plus endoscopic transjejunal A.P.C. pouch therapy in one step: Case report. Int J Surg Case Rep. 2020 Sep 28;76:148-152 Authors: Borjas G, Marruffo M, Sanchez N, Urdaneta A, Gonzalez M, Ramos E, Maldonado A Abstract INTRODUCTION: In recent years there has been a significant growth in the percentage of patients with weight regain after Roux-en-Y gastric bypass (RYGB). Approximately...
Fri Oct 09, 2020 14:45
Agenesis of gall bladder: Diagnosed before it is an unpleasant laparoscopic surprise-clinical case report and review. Int J Surg Case Rep. 2020 Sep 23;76:144-147 Authors: Agarwal PK Abstract INTRODUCTION & BACKGROUND: Agenesis of gall bladder is a rare congenital anomaly and incidence is 0.007-0.0027%. Even though gall bladder is absent, clinical presentation of 50% cases, mimic biliary colic. This combined with inconclusive radiological...
Fri Oct 09, 2020 14:45
Metachronous recurrent pediatric primary spontaneous pneumothorax: A case presentation and literature review. Int J Surg Case Rep. 2020 Sep 24;76:139-143 Authors: Baram A, Othman YN, Muhammed RG, Majeed ZS, Rashid DF, Falah F, Sherzad H, Mahmood ZK, Hama RG Abstract INTRODUCTION: Pediatric primary spontaneous pneumothorax (PSP) is defined as the presence of air in the pleural cavity without underlying lung disease or thoracic trauma. Metachronous...
Fri Oct 09, 2020 14:45
Secondary thoracolumbar deformity and sagittal imbalance due to osteoporosis in a young man with Cushing's disease: A case report. Int J Surg Case Rep. 2020 Sep 29;76:134-138 Authors: Ramírez-Villaescusa J, Ruiz-Picazo D, Oliveira CL, Morillas-Ariño C Abstract INTRODUCTION: To describe an unusual case of Cushing's disease with spontaneous axial pain due to multiple consecutive vertebral fractures which led to secondary deformity that required...
Fri Oct 09, 2020 14:45
Mixed neuroendocrine-non-neuroendocrine neoplasms of ascending colon: A case report. Int J Surg Case Rep. 2020 Sep 23;76:125-129 Authors: Mukai S, Hirata Y, Ishikawa S, Kai A, Kohata A, Okimoto S, Fujisaki S, Fukuda S, Takahashi M, Fukuda T, Nishida T, Egi H, Ohdan H Abstract INTRODUCTION: Neuroendocrine tumor (NET) that develops in the right-sided colon is relatively rare. Coexistence of adenocarcinoma and NET is extremely rare, and such cases...
Fri Oct 09, 2020 14:45
Diaphragm disease associated with nonsteroidal anti-inflammatory drugs mimicking intestinal tumor: A case report. Int J Surg Case Rep. 2020 Sep 19;76:121-124 Authors: Mori A, Hashida H, Kitamura K, Matsui J, Mizuno R, Tanigawa Y, Izumi A, Ishida S, Yamashita D, Yamaguchi T, Kaihara S Abstract INTRODUCTION: Diaphragm disease is rare and caused by intestinal obstruction due to nonsteroidal anti-inflammatory drugs (NSAIDs). Given the availability...
Fri Oct 09, 2020 14:45
Pancreas angiosarcoma-Case report of a rare cause of abdominal pain. Int J Surg Case Rep. 2020 Sep 23;76:116-120 Authors: Faria A, Lopes F, Figueira A, Miranda C, Coutinho J Abstract INTRODUCTION: Pancreas angiosarcoma is a very aggressive malignant neoplasm. The symptoms are nonspecific and it is usually diagnosed at an advanced stage, which confers a poor prognosis. PRESENTATION OF CASE: We present a 56-year-old woman with abdominal...
Fri Oct 09, 2020 14:45
Prognosis and surgical outcome of soft tissue sarcoma with malignant fungating wounds. Jpn J Clin Oncol. 2020 Oct 10;: Authors: Okajima K, Kobayashi H, Okuma T, Arai S, Zhang L, Hirai T, Ishibashi Y, Ikegami M, Shinoda Y, Akiyama T, Goto T, Tanaka S Abstract OBJECTIVE: Malignant fungating wounds are ulcerating tumors that infiltrate the overlying skin. Little evidence exists regarding the prognosis or treatment of malignant fungating wound...
Sun Oct 11, 2020 13:59
Adjuvant and neoadjuvant therapy for biliary tract cancer: a review of clinical trials. Jpn J Clin Oncol. 2020 Oct 10;: Authors: Nara S, Esaki M, Ban D, Takamoto T, Shimada K, Ioka T, Okusaka T, Ishii H, Furuse J Abstract Cancer originating in the biliary tract can be classified as bile duct cancer (cholangiocarcinoma), gallbladder cancer, or ampullary cancer. Bile duct cancer is further divided to intrahepatic, perihilar and distal bile duct...
Sun Oct 11, 2020 13:59
Retrospective evaluation of risk-reducing salpingo-oophorectomy for BRCA1/2 pathogenic variant carriers among a cohort study in a single institution. Jpn J Clin Oncol. 2020 Oct 10;: Authors: Kobayashi Y, Hirasawa A, Chiyoda T, Ueki A, Masuda K, Misu K, Kawaida M, Hayashi S, Kataoka F, Banno K, Kosaki K, Aoki D Abstract BACKGROUND: Risk-reducing salpingo-oophorectomy is performed for the primary prevention of ovarian cancer in patients with...
Sun Oct 11, 2020 13:59
Feasibility of transrectal and transperineal fiducial marker placement for prostate cancer before proton therapy. Jpn J Clin Oncol. 2020 Oct 08;: Authors: Ohta K, Ogino H, Iwata H, Hashimoto S, Hattori Y, Nakajima K, Yamada M, Shimohira M, Mizoe JE, Shibamoto Y Abstract BACKGROUND: To compare the feasibility of transrectal and transperineal fiducial marker placement for prostate cancer before proton therapy. MATERIALS AND METHODS:...
Fri Oct 09, 2020 13:05
Safety and pharmacokinetics of polatuzumab vedotin in Japanese patients with relapsed/refractory B-cell non-Hodgkin lymphoma: a phase 1 dose-escalation study. Jpn J Clin Oncol. 2020 Oct 08;: Authors: Kinoshita T, Hatake K, Yamamoto K, Higuchi Y, Murakami S, Terui Y, Yokoyama M, Maruyama D, Makita S, Hida Y, Saito T, Tobinai K Abstract OBJECTIVE: A phase 1 dose-escalation study of polatuzumab vedotin (pola) was conducted to assess safety, pharmacokinetics...
Fri Oct 09, 2020 13:05
19 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Med Oral Patol Oral Cir Bucal"[jour] These pubmed results were generated on 2020/10/11PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Concomitant Nephrotic Syndrome with Diffuse Large B-cell Lymphoma: A Case Report. Tohoku J Exp Med. 2020;252(2):153-157 Authors: Kidoguchi K, Katsuya H, Ureshino H, Kizuka-Sano H, Yamaguchi K, Nagata A, Rikitake S, Aikawa K, Naito S, Aoki S, Kubota Y, Ando T, Kimura S Abstract Membranous nephropathy (MN) is a common glomerular disease that is characterized by diffuse thickening of the glomerular basement membrane, and a common cause of nephrotic...
Fri Oct 09, 2020 19:36
Guideline-Based Medications for Older Adults Discharged after Percutaneous Coronary Intervention in a Suburban City of Japan: A Cohort Study Using Claims Data. Tohoku J Exp Med. 2020;252(2):143-152 Authors: Shimada K, Hamada S, Sawano M, Yamamoto H, Yoshie S, Iijima K, Miyata H Abstract Secondary prevention with medications is essential for the better prognosis of patients who have experienced cardiovascular events. We aimed to evaluate the...
Fri Oct 09, 2020 19:36
Multidisciplinary Approach to Prevent de novo Hepatitis B in Patients with Rheumatoid Arthritis. Tohoku J Exp Med. 2020;252(2):133-141 Authors: Watanabe R, Igarashi T, Takahashi T, Kondo H, Okazaki S, Kudo M, Ohyanagi M, Gamoh M Abstract The reactivation of hepatitis B virus (HBV) in patients with rheumatoid arthritis (RA) is currently a social problem. Our hospital has established a project team, which consisted of medical staff including...
Fri Oct 09, 2020 19:36
Visualizing the Process of Disaster Mental Health Services in the Joso Flood by Network Analyses of Emails. Tohoku J Exp Med. 2020;252(2):121-131 Authors: Shiratori Y, Tachikawa H, Nemoto K, Ide M, Sodeyama N, Tamura M, Takahashi S, Hori T, Arai T Abstract Joso City, Ibaraki Prefecture, Japan was severely affected by flooding of the River Kinugawa in September 2015. Local psychiatric organizations immediately began providing disaster mental...
Fri Oct 09, 2020 19:36
Differential Diagnosis of COVID-19: Importance of Measuring Blood Lymphocytes, Serum Electrolytes, and Olfactory and Taste Functions. Tohoku J Exp Med. 2020;252(2):109-119 Authors: Nakanishi H, Suzuki M, Maeda H, Nakamura Y, Ikegami Y, Takenaka Y, Mori Y, Hasuo T, Hasegawa C Abstract Coronavirus disease 2019 (COVID-19) is associated with various symptoms and changes in hematological and biochemical variables. However, clinical features, which...
Fri Oct 09, 2020 19:36
Geometry of Sleeve Gastrectomy Measured by 3D CT Versus Weight Loss: Preliminary Analysis. World J Surg. 2020 Oct 09;: Authors: Yamaguchi T, Yamamoto H, Tomozawa Y, Ugi S, Kaida S, Miyake T, Morino K, Watanabe Y, Maegawa H, Tani M Abstract BACKGROUND: The size of the remnant stomach with respect to weight loss failure after laparoscopic sleeve gastrectomy (LSG) remains controversial. This study aimed to evaluate the impact of the actual size...
Sun Oct 11, 2020 14:11
Positive Lymph Nodes in Adrenocortical Carcinoma: What Does It Mean? World J Surg. 2020 Oct 09;: Authors: Sada A, Glasgow AE, Lyden ML, Thompson GB, Dy BM, McKenzie TJ, Habermann EB Abstract BACKGROUND: The role of lymphadenectomy in adrenocortical carcinoma resection is controversial. Therefore, we conducted a population-based study to assess the association between positive lymph nodes (LN) and survival. METHODS: The Surveillance,...
Sat Oct 10, 2020 14:06
A Snapshot of the International Views of the Treatment of Rectal Cancer Patients, a Multi-regional Survey: International Tendencies in Rectal Cancer. World J Surg. 2020 Oct 08;: Authors: Caycedo-Marulanda A, Patel SV, Verschoor CP, Uscategui JP, Chadi SA, Moeslein G, Chand M, Maeda Y, Monson JRT, Wexner SD, Mayol J Abstract BACKGROUND: Management of rectal cancer has a number of potentially appropriate alternatives for each patient. Despite...
Sat Oct 10, 2020 14:06
Understanding the Cause of Chronic Traumatic Encephalopathy and Related Dementias. World Neurosurg. 2020 Sep 28;144:192-193 Authors: Rezaeezadeh Roukerd M, Stump A, Hawryluk GWJ PMID: 33038849 [PubMed - as supplied by publisher]
Sun Oct 11, 2020 14:10
Virtual Residency Training Interviews in the Age of COVID-19 and Beyond. World Neurosurg. 2020 Sep 17;: Authors: Al Saiegh F, Ghosh R, Stefanelli A, Khanna O, Hattar-Medina E, Hoffman M, Hafazalla K, Sabourin V, Farrell C, Tjoumakaris S, Jabbour P, Sharan AD, Rosenwasser RH PMID: 33036950 [PubMed - as supplied by publisher]
Sun Oct 11, 2020 14:10
An Online Calculator for Predicting Academic Career Trajectory in Neurosurgery in the United States.
An Online Calculator for Predicting Academic Career Trajectory in Neurosurgery in the United States. World Neurosurg. 2020 Oct 05;: Authors: Khalafallah AM, Jimenez AE, Horowitz MA, Camp S, Witham TF, Huang J, Mukherjee D Abstract OBJECTIVE: Determining factors that predict a career in academic neurosurgery can help to improve neurosurgical training and faculty mentoring efforts. Though many academic career predictors have been established...
Fri Oct 09, 2020 15:14
Cavernous Sinus Hemangioma: Imaging Diagnosis and Surgical Considerations. World Neurosurg. 2020 Oct 05;: Authors: Montoya F, Vidal A, Sepulveda F, Marileo R, Caro J, Castillo M Abstract Cavernous sinus hemangiomas (CSHs) are extra-axial vascular malformations that tend to bleed during surgery when not correctly identified. We reviewed 12 MRI scans with CSH, 5 of them biopsy-proven. In our review, CSH commonly presented as a lobulated mass...
Fri Oct 09, 2020 15:14
Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation. Eur J Med Chem. 2020 Oct 04;209:112873 Authors: Pecnard S, Provot O, Levaique H, Bignon J, Askenatzis L, Saller F, Borgel D, Michallet S, Laisne MC, Lafanechère L, Alami M, Hamze A Abstract In this work, a series of cyclic bridged analogs of isocombretastatin A-4 (isoCA-4) with phenyl or pyridine linkers were designed and synthesized. The synthesis of the desired...
Sun Oct 11, 2020 13:03
Selective eradication of pluripotent stem cells by inhibiting DHODH activity. Stem Cells. 2020 Oct 10;: Authors: Kondo T Abstract Pluripotent stem cells (PSCs), such as embryonic stem cells and induced pluripotent stem cells, give rise to all kinds of functional cells, making them promising for successful application in regenerative medicine. However, there is concern that a PSC-derived differentiated cell population may form teratomas...
Sun Oct 11, 2020 13:03
High-Fluence Light Emitting Diode-Red Light Inhibits Cell Cycle Progression in Human Dermal Fibroblasts. J Biophotonics. 2020 Oct 10;:e202000359 Authors: Masub N, Austin E, Huang A, Jagdeo J Abstract Skin fibrosis is a debilitating feature of several systemic and dermatologic diseases. While current treatment options carry significant risk of side effects and recurrence, high-fluence light emitting diode-generated red light (LED-RL) is...
Sun Oct 11, 2020 13:03
SPATS2, negatively regulated by miR-145-5p, promotes hepatocellular carcinoma progression through regulating cell cycle. Cell Death Dis. 2020 Oct 09;11(10):837 Authors: Dong G, Zhang S, Shen S, Sun L, Wang X, Wang H, Wu J, Liu T, Wang C, Wang H, Lu T, Rao B, Ren Z Abstract Spermatogenesis associated serine rich 2 (SPATS2) has been reported to contribute to the tumorigenesis of multiple malignancies. The molecular function of SPATS2 in...
Sun Oct 11, 2020 13:03
Pterostilbene Sensitizes Cisplatin-Resistant Human Bladder Cancer Cells with Oncogenic HRAS. Cancers (Basel). 2020 Oct 06;12(10): Authors: Chen YT, Huang ZY, Tang HH, Kuo WT, Wu SY, Lan SH, Chang KH, Lin PL, Lee MF, Cheng HC, Liu HS, Huang CF, Huang GC, Su CL Abstract Analysis of various public databases revealed that HRAS gene mutation frequency and mRNA expression are higher in bladder urothelial carcinoma. Further analysis revealed...
Sun Oct 11, 2020 13:03
Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells. Redox Biol. 2020 Sep 29;37:101737 Authors: López-Grueso MJ, Lagal DJ, García-Jiménez ÁF, Tarradas RM, Carmona-Hidalgo B, Peinado J, Requejo-Aguilar R, Bárcena JA, Padilla CA Abstract Peroxiredoxin 6 (PRDX6) has been associated with tumor progression and cancer metastasis. Its acting on phospholipid hydroperoxides and its phospholipase-A2...
Sat Oct 10, 2020 13:09
Sterigmatocystin: occurrence, toxicity and molecular mechanisms of action - a review. Food Chem Toxicol. 2020 Oct 06;:111802 Authors: Zingales V, Fernandéz-Franzón M, Ruiz MJ Abstract The mycotoxin sterigmatocystin (STE) is produced mainly by Aspergillus fungi. It has been reported to occur in grains and grain-based products, cheese, coffee, spices and beer. The STE is a known biogenic precursor of aflatoxin B1, sharing with it several structural...
Sat Oct 10, 2020 13:09
EPZ015666, a selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an antitumour effect in retinoblastoma. Exp Eye Res. 2020 Oct 06;:108286 Authors: Liu X, He J, Mao L, Zhang Y, Cui W, Duan S, Jiang A, Gao Y, Sang Y, Huang G Abstract Retinoblastoma (RB) is the most common intraocular malignant tumour in infants, and chemotherapy has been the primary therapy method in recent years. PRMT5 is an important member of the protein...
Sat Oct 10, 2020 13:09
Light Controlled Cell-Cycle Arrest and Apoptosis. Angew Chem Int Ed Engl. 2020 Oct 09;: Authors: Uhl E, Wolff F, Mangal S, Dube H, Zanin E Abstract Cell-cycle interference by small molecules has widely been used to study fundamental biological mechanisms and to treat a great variety of diseases, most notably cancer. However, at present only limited possibilities exist for spatio-temporal control of the cell cycle. Here we report on a photocaging...
Sat Oct 10, 2020 13:09
Systematic analysis of the transcriptome in small-cell carcinoma of the oesophagus reveals its immune microenvironment. Clin Transl Immunology. 2020;9(10):e1173 Authors: Zhao Q, Chen YX, Wu QN, Zhang C, Liu M, Wang YN, Feng YF, Hu JJ, Fu JH, Yang H, Qi JJ, Wang ZX, Lu YX, Sheng H, Liu ZX, Zuo ZX, Zheng J, Yun JP, Bei JX, Jia WH, Lin DX, Xu RH, Wang F Abstract Objectives: Although the genomic landscape of small-cell carcinoma of the oesophagus...
Sat Oct 10, 2020 13:09
CircDENND2A Promotes Non-small Cell Lung Cancer Progression via Regulating MiR-34a/CCNE1 Signaling. Front Genet. 2020;11:987 Authors: Zhang Y, Shan C, Chen Y, Sun S, Liu D, Zhang X, Zhang S Abstract The mechanism regulating non-small cell lung cancers (NSCLCs) is unclear. In this study, we aimed to determine the roles of DENN domain containing 2A (circDENND2A) in the progression of NSCLC. Circular RNAs (circRNAs) are composited by "head...
Sat Oct 10, 2020 13:09
BRAP: a novel regulator of the cardiomyocyte cell cycle controlling both proliferation and survival?
Related Articles BRAP: a novel regulator of the cardiomyocyte cell cycle controlling both proliferation and survival? Cardiovasc Res. 2020 03 01;116(3):467-469 Authors: Derks W, Bergmann O PMID: 31584619 [PubMed - indexed for MEDLINE]
Sat Oct 10, 2020 13:09
Related Articles Progress in the Discovery of Small Molecule Modulators of DeSUMOylation. Curr Issues Mol Biol. 2020;35:17-34 Authors: Chen S, Dong D, Xin W, Zhou H Abstract SUMOylation and DeSUMOylation are reversible protein post-translational modification (PTM) processes involving small ubiquitin-like modifier (SUMO) proteins. These processes have indispensable roles in various cellular processes, such as subcellular localization, gene...
Sat Oct 10, 2020 13:09
Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells. Eur J Pharmacol. 2020 Oct 05;:173609 Authors: Zhang Y, VanHecke GC, Ahn YH, Proby CM, Dinkova-Kostova AT Abstract Cancer cells rely heavily on molecular chaperones, such as heat shock protein 90 (HSP90), and their co-chaperones. The development of HSP90 inhibitors is an attractive therapeutic approach that has the potential to affect multiple hallmarks...
Fri Oct 09, 2020 13:24
Silencing of long non-coding RNA DLX6-AS1 weakens neuroblastoma progression by the miR-513c-5p/PLK4 axis. IUBMB Life. 2020 Oct 08;: Authors: Jia P, Wei E, Liu H, Wu T, Wang H Abstract Emerging evidence has demonstrated the crucial roles of long noncoding RNAs in human cancers, including neuroblastoma (NB). DLX6 antisense RNA 1 (DLX6-AS1) has been identified as an oncogenic driver in NB. However, the mechanisms of DLX6-AS1 in NB progression...
Fri Oct 09, 2020 13:24
Human ABCB1 with an ABCB11-like degenerate nucleotide binding site maintains transport activity by avoiding nucleotide occlusion. PLoS Genet. 2020 Oct;16(10):e1009016 Authors: Goda K, Dönmez-Cakil Y, Tarapcsák S, Szalóki G, Szöllősi D, Parveen Z, Türk D, Szakács G, Chiba P, Stockner T Abstract Several ABC exporters carry a degenerate nucleotide binding site (NBS) that is unable to hydrolyze ATP at a rate sufficient for sustaining transport...
Fri Oct 09, 2020 13:24
The microRNA-17 ~ 92 Family as a Key Regulator of Neurogenesis and Potential Regenerative Therapeutics of Neurological Disorders. Stem Cell Rev Rep. 2020 Oct 08;: Authors: Xia X, Wang Y, Zheng JC Abstract miR-17 ~ 92, an miRNA family containing three paralogous polycistronic clusters, was initially considered as an oncogene and was later demonstrated to trigger various physiological and pathological processes. Emerging evidence has implicated...
Fri Oct 09, 2020 13:24
Andrographolide Induces Apoptosis and Cell Cycle Arrest through Inhibition of Aberrant Hedgehog Signaling Pathway in Colon Cancer Cells. Nutr Cancer. 2020 Oct 08;:1-19 Authors: Khan I, Mahfooz S, Faisal M, Alatar AA, Ansari IA Abstract BACKGROUND: Hedgehog signaling pathway (Hh) is abnormally stimulated in colon cancer. Evidence suggests the therapeutic effectiveness of andrographolide against several cancers. This study attempts to delineate...
Fri Oct 09, 2020 13:24
Cucurbitacin D Induces G2/M Phase Arrest and Apoptosis via the ROS/p38 Pathway in Capan-1 Pancreatic Cancer Cell Line. Evid Based Complement Alternat Med. 2020;2020:6571674 Authors: Kim MS, Lee K, Ku JM, Choi YJ, Mok K, Kim D, Cheon C, Ko SG Abstract Pancreatic cancer has a poor prognosis with a five-year survival rate of less than 10%. Moreover, chemotherapy is mostly rendered ineffective owing to chemotherapy resistance and cytotoxicity....
Fri Oct 09, 2020 13:24
Boswellia dalzielii-Mediated Silver Nanoparticles Inhibited Acute Myeloid Leukemia (AML) Kasumi-1 Cells by Inducing Cell Cycle Arrest. Bioinorg Chem Appl. 2020;2020:8898360 Authors: Adebayo IA, Usman AI, Shittu FB, Ismail NZ, Arsad H, Muftaudeen TK, Samian MR Abstract Background: Acute myeloid leukemia (AML) persists to be a major health problem especially among children as effective chemotherapy to combat the disease is yet to be available....
Fri Oct 09, 2020 13:24
Dysregulation of hsa-miR-34a and hsa-miR-449a leads to overexpression of PACS-1 and loss of DNA damage response (DDR) in cervical cancer. J Biol Chem. 2020 Oct 07;: Authors: Veena MS, Raychaudhuri S, Basak SK, Venkatesan N, Kumar P, Biswas R, Chakrabarti R, Lu J, Su T, Gallagher-Jones M, Morselli M, Fu H, Pellegrini M, Goldstein T, Aladjem MI, Rettig MB, Wilczynski SP, Shin DS, Srivatsan ES Abstract We have observed over expression of...
Fri Oct 09, 2020 13:24
Copper Complexes as Anticancer Agents Targeting Topoisomerases I and II. Cancers (Basel). 2020 Oct 05;12(10): Authors: Molinaro C, Martoriati A, Pelinski L, Cailliau K Abstract Organometallics, such as copper compounds, are cancer chemotherapeutics used alone or in combination with other drugs. One small group of copper complexes exerts an effective inhibitory action on topoisomerases, which participate in the regulation of DNA topology....
Fri Oct 09, 2020 13:24
Related Articles Dissecting the Pol II transcription cycle and derailing cancer with CDK inhibitors. Nat Chem Biol. 2020 07;16(7):716-724 Authors: Parua PK, Fisher RP Abstract Largely non-overlapping sets of cyclin-dependent kinases (CDKs) regulate cell division and RNA polymerase II (Pol II)-dependent transcription. Here we review the molecular mechanisms by which specific CDKs are thought to act at discrete steps in the transcription cycle...
Fri Oct 09, 2020 13:24
Blood Biomarkers and 6- to 7-Year Childhood Outcomes Following Neonatal Encephalopathy. Am J Perinatol. 2020 Oct 10;: Authors: Pappas A, Shankaran S, McDonald SA, Carlo WA, Laptook AR, Tyson JE, Das A, Skogstrand K, Hougaard DM, Higgins RD Abstract OBJECTIVE: This study aimed to profile the cytokine/chemokine response from day 0 to 7 in infants (≥36 weeks of gestational age) with neonatal encephalopathy (NE) and to explore the association...
Sun Oct 11, 2020 14:18
A unifying mechanism of ketogenic diet action: The multiple roles of nicotinamide adenine dinucleotide. Epilepsy Res. 2020 Sep 14;167:106469 Authors: Elamin M, Ruskin DN, Sacchetti P, Masino SA Abstract The ability of a ketogenic diet to treat seizures and render a neuronal network more resistant to strong electrical activity has been observed for a century in clinics and for decades in research laboratories. Alongside ongoing efforts to understand...
Sun Oct 11, 2020 14:18
Aphasic status epilepticus in a tertiary referral center in Turkey: Clinical features, etiology, and outcome. Epilepsy Res. 2020 Sep 29;167:106479 Authors: Azman F, Tezer FI, Saygi S Abstract OBJECTIVE: Aphasic status epilepticus (ASE), although rare, may often remain underdiagnosed. We aimed to report the patients diagnosed with ASE and describe their clinical presentation, etiology, electrophysiological findings, neuroimaging, treatment options,...
Sun Oct 11, 2020 14:18
Neuromodulation Effects of Deep Brain Stimulation on Beta Rhythm: A Longitudinal Local Field Potential Study. Brain Stimul. 2020 Oct 07;: Authors: Chen Y, Gong C, Tian Y, Orlov N, Zhang J, Guo Y, Xu S, Jiang C, Hao H, Neumann WJ, Kühn AA, Liu H, Li L Abstract BACKGROUND: Deep brain stimulation (DBS) holds great promise in treating various brain diseases but its chronic therapeutic mechanisms are unclear. OBJECTIVE: To explore the immediate...
Sun Oct 11, 2020 14:18
Anesthesia Associated Periodic Discharges. J Clin Neurophysiol. 2020 Oct 07;: Authors: Husari KS, Ritzl EK Abstract PURPOSE: Anesthetic agents have been widely used in the treatment of refractory status epilepticus and the medical management of increased intracranial pressure whenever the goal is therapeutic burst suppression. Periodic patterns typically consisting of generalized periodic discharges (GPDs) following emergence from anesthesia...
Sun Oct 11, 2020 14:18
Coherence between the hippocampus and anterior thalamic nucleus as a tool to improve the effect of neurostimulation in temporal lobe epilepsy: an experimental study. Brain Stimul. 2020 Oct 06;: Authors: Sherdil A, Chabardès S, David O, Piallat B Abstract BACKGROUND: Although the mechanisms by which deep brain stimulation (DBS) modifies the activity of the ictal network are mostly undefined, recent studies have suggested that DBS of the anterior...
Sat Oct 10, 2020 14:14
Efficacy and pharmacokinetics evaluation of 4-(2-chloro-4-fluorobenzyl)-3-(2-thienyl)-1,2,4-oxadiazol-5(4H)-one (GM-90432) as an anti-seizure agent. Neurochem Int. 2020 Oct 06;:104870 Authors: Hwang KS, Kan H, Kim SS, Chae JS, Yang JY, Shin DS, Ahn SH, Ahn JH, Cho JH, Jang IS, Shin J, Joo J, Kim CH, Bae MA Abstract Epilepsy is a common chronic neurological disease characterized by recurrent epileptic seizures. A seizure is an uncontrolled electrical...
Sat Oct 10, 2020 14:14
Neurocysticercosis in Northern Peru: Qualitative Insights from men and women about living with seizures. PLoS Negl Trop Dis. 2020 Oct 09;14(10):e0008715 Authors: Pesantes MA, Moyano LM, Sommerville C, Cysticercosis Working Group in Peru and COHESION Project Abstract BACKGROUND: Neurocysticercosis (NCC) is a helminthic disease of the central nervous system, and it is one of the leading causes of seizures and symptomatic epilepsy in countries...
Sat Oct 10, 2020 14:14
[Epilepsy and vascular risk]. Rev Neurol. 2020 Oct 16;71(8):298-312 Authors: Ramírez-Moreno JM Abstract Epidemiological studies have shown that mortality increases in patients with epilepsy compared to the general population, and this has been associated with an increased risk of cardiovascular or cerebrovascular events. The role played by classic and more speculative vascular risk factors (e.g. oxidative stress) in the development of vascular...
Sat Oct 10, 2020 14:14
Transient hyperammonaemia following epileptic seizures in cats. J Feline Med Surg. 2020 Oct 09;:1098612X20962747 Authors: Nilsson CH, Svensson MB, Säve SJ, Van Meervenne SA Abstract OBJECTIVES: The aim of this study was to determine whether transient postictal hyperammonaemia exists in cats. METHODS: The medical records of all feline patients that presented at a Swedish veterinary hospital between 2008 and 2018 were retrospectively...
Sat Oct 10, 2020 14:14
Related Articles The Return Back to Typical Practice from the "Battle Plan" of the Coronavirus Disease 2019 (COVID-19) Pandemic: A Comparative Study. World Neurosurg. 2020 10;142:e481-e486 Authors: Pressman E, Noureldine MHA, Kumar JI, Krafft PR, Mantei B, Greenberg MS, Agazzi S, van Loveren H, Alikhani P Abstract BACKGROUND: Every aspect of the medical field has been heavily affected by the coronavirus disease 2019 (COVID-19) pandemic, and...
Sat Oct 10, 2020 14:14
Related Articles Letter to the Editor Regarding "Deep Brain Stimulation in Intractable Epilepsy: Pedunculopontine Nucleus versus Thalamic Nuclei: A Perspective". World Neurosurg. 2020 07;139:703 Authors: Jaseja H PMID: 32689690 [PubMed - indexed for MEDLINE]
Sat Oct 10, 2020 14:14
Related Articles Tracking the Volume of Neurosurgical Care During the Coronavirus Disease 2019 Pandemic. World Neurosurg. 2020 10;142:e183-e194 Authors: Patel PD, Kelly KA, Reynolds RA, Turer RW, Salwi S, Rosenbloom ST, Bonfield CM, Naftel RP Abstract OBJECTIVE: In the present study, we quantified the effect of the coronavirus disease 2019 (COVID-19) on the volume of adult and pediatric neurosurgical procedures, inpatient consultations, and...
Sat Oct 10, 2020 14:14
Related Articles Antiepileptic Drugs and Accumulation of Hospital Days Among Persons With Alzheimer's Disease. J Am Med Dir Assoc. 2019 06;20(6):751-758 Authors: Lavikainen P, Taipale H, Tanskanen A, Koponen M, Tiihonen J, Hartikainen S, Tolppanen AM Abstract OBJECTIVES: To compare the accumulation of hospital days between initiators and noninitiators of antiepileptic drugs (AEDs) among persons with Alzheimer's disease (AD). DESIGN:...
Sat Oct 10, 2020 14:14
Combination therapy with dipeptidyl peptidase-4 and P2X7 purinoceptor inhibitors gives rise to antiepileptic effects in rats. J Chem Neuroanat. 2020 Oct 05;:101855 Authors: Jamali-Raeufy N, Barati H, Baluchnejadmojarad T, Roghani M, Goudarzi M Abstract OBJECTIVE(S): Although the available therapeutic agents alleviate the symptoms in patients with temporal lobe epilepsy (TLE), these antiepileptic drugs do not provide adequate control of seizures...
Fri Oct 09, 2020 14:10
Biochemical Aspects and Therapeutic Mechanisms of Cannabidiol in Epilepsy. Neurosci Biobehav Rev. 2020 Oct 05;: Authors: Boleti APA, Frihling BEF, E Silva PS, Cardoso PHO, de Moraes LFRN, Rodrigues TAA, Biembengute MEF, Koolen HHF, Migliolo L Abstract Epilepsy is a chronic neurological disease characterized by recurrent epileptic seizures. Studies have shown the complexity of epileptogenesis and ictogenesis, in which immunological processes...
Fri Oct 09, 2020 14:10
Adjunctive cenobamate for the treatment of focal onset seizures in adults with epilepsy: a critical review. Expert Rev Neurother. 2020 Oct 08;: Authors: Wheless JW Abstract INTRODUCTION: Uncontrolled epilepsy has persisted despite the development of numerous antiseizure medications (ASM) over the past 25 years, and a significant need exists for more effective treatments. Cenobamate is a new ASM approved in the US for treatment of adults with...
Fri Oct 09, 2020 14:10
Cerebral pleomorphic xanthoastrocytoma mimicking inflammatory granuloma: Two case reports. Medicine (Baltimore). 2020 Oct 09;99(41):e22478 Authors: Deng SL, Jin RH, Liu YM, Jing Y, Guan Y Abstract RATIONALE: Pleomorphic xanthoastrocytoma (PXA) is a rare low-grade glial neoplasm of the central nervous system, which is difficult to distinguish from other neoplastic and non-neoplastic entities. Herein, we report 2 cases of PXA that had been misdiagnosed...
Fri Oct 09, 2020 14:10
Central Nervous System Infection-Related Isolated Hippocampal Atrophy as Another Subtype of Medial Temporal Lobe Epilepsy with Hippocampal Atrophy: A Comparison to Conventional Medial Temporal Lobe Epilepsy with Hippocampal Atrophy. J Clin Neurol. 2020 Oct;16(4):688-695 Authors: Park S, Kim WJ, Lee SK, Chang JW Abstract BACKGROUND AND PURPOSE: Hippocampal atrophy (HA) resulting from a central nervous system (CNS) infection might be a relevant...
Fri Oct 09, 2020 14:10
Pharmacological Treatment of Epilepsy in Elderly Patients. J Clin Neurol. 2020 Oct;16(4):556-561 Authors: Seo JG, Cho YW, Kim KT, Kim DW, Yang KI, Lee ST, Byun JI, No YJ, Kang KW, Kim D, Drug Committee of Korean Epilepsy Society Abstract The incidence and prevalence of epilepsy are highest in elderly people, and the etiologies of epilepsy in the elderly differ from those in other age groups. Moreover, diagnosing and treating epilepsy in elderly...
Fri Oct 09, 2020 14:10
Clinical Approach to Autoimmune Epilepsy. J Clin Neurol. 2020 Oct;16(4):519-529 Authors: Jang Y, Kim DW, Yang KI, Byun JI, Seo JG, No YJ, Kang KW, Kim D, Kim KT, Cho YW, Lee ST, Drug Committee of Korean Epilepsy Society Abstract Autoimmune epilepsy is a newly emerging area of epilepsy. The concept of "autoimmune" as an etiology has recently been revisited thanks to advances in autoimmune encephalitis and precision medicine with immunotherapies....
Fri Oct 09, 2020 14:10
EEG source localization analysis in epileptic children during a visual working-memory task. Int J Numer Method Biomed Eng. 2020 Oct 08;: Authors: Evangelos G, Ioannis G, Ivan M, Lieven L, Constantinos S Abstract We localize the sources of brain activity of children with epilepsy based on EEG recordings acquired during a visual discrimination working memory task. For the numerical solution of the inverse problem, with the aid of age-specific...
Fri Oct 09, 2020 14:10
Related Articles Folding a neuroscience center into streamlined COVID-19 response teams: Lessons in origami. Neurology. 2020 09 29;95(13):583-592 Authors: Correa DJ, Labovitz DL, Milstein MJ, Monderer R, Haut SR Abstract In response to the COVID-19 pandemic epicenter in Bronx, NY, the Montefiore Neuroscience Center required rapid and drastic changes when considering the delivery of neurologic care, health and safety of staff, and continued...
Fri Oct 09, 2020 14:10
Related Articles Breath analysis in detecting epilepsy. J Breath Res. 2020 04 15;14(3):031001 Authors: van Dartel D, Schelhaas HJ, Colon AJ, Kho KH, de Vos CC Abstract The aim of this proof of concept study is to investigate if an electronic nose (eNose) is able to make a distinction between breath profiles of diagnosed epilepsy patients and epilepsy-free control subjects. An eNose is a non-invasive device, with a working mechanism that is...
Fri Oct 09, 2020 14:10
Inferior Divisional Oculomotor Nerve Palsy Due to Orbital Lymphoma. J Clin Neurol. 2020 Oct;16(4):711-713 Authors: Lee JY, Kim HJ, Kwon E, Choi JY, Oh HJ, Kim JS PMID: 33029984 [PubMed]
Fri Oct 09, 2020 13:59
Tacrolimus for Treating Orbital and Cranial Form of Idiopathic Inflammatory Pseudotumors. J Clin Neurol. 2020 Oct;16(4):674-680 Authors: Kim HJ, Lee S, Koo YJ, Kwon E, Kim HJ, Choi JY, Kim JS Abstract BACKGROUND AND PURPOSE: Orbital and cranial form of idiopathic inflammatory pseudotumors (IIPs) are rare disorders with heterogeneous clinical presentations. Corticosteroids have been the first-line treatment for IIPs, but they are not always...
Fri Oct 09, 2020 13:59
A new hybrid immunocapture bioassay with improved reproducibility to measure tissue factor-dependent procoagulant activity of microvesicles from body fluids. Thromb Res. 2020 Sep 21;196:414-424 Authors: Franco C, Lacroix R, Vallier L, Judicone C, Bouriche T, Laroumagne S, Astoul P, Dignat-George F, Poncelet P Abstract BACKGROUND: The procoagulant activity of tissue factor-bearing microvesicles (MV-TF) has been associated with the risk...
Sun Oct 11, 2020 13:46
Focal adhesion kinase: Insight into its roles and therapeutic potential in oesophageal cancer. Cancer Lett. 2020 Oct 07;: Authors: Zhang Y, Liu S, Zhou S, Yu D, Gu J, Qin Q, Cheng Y, Sun X Abstract Oesophageal cancer is associated with high morbidity and mortality rates because it is highly invasive and prone to recurrence and metastasis, with a five-year survival rate of <20%. Therefore, there is an urgent need for new methods aimed...
Sun Oct 11, 2020 13:46
Older adult perspectives on medical decision making and emergency general surgery: "It had to be done." J Pain Symptom Manage. 2020 Oct 07;: Authors: Sokas C, Yeh IM, Coogan K, Bernacki R, Mitchell S, Bader A, Ladin K, Palmer JA, Tulsky JA, Cooper Z Abstract CONTEXT: Optimal surgical care for older adults with life-threatening conditions, with high risk of poor perioperative outcomes and morality in the months after surgery, should incorporate...
Sun Oct 11, 2020 13:46
Prophylaxis of thromboembolism during therapy with asparaginase in adults with acute lymphoblastic leukaemia. Cochrane Database Syst Rev. 2020 Oct 10;10:CD013399 Authors: Rank CU, Lynggaard LS, Als-Nielsen B, Stock W, Toft N, Nielsen OJ, Frandsen TL, Tuckuviene R, Schmiegelow K Abstract BACKGROUND: The risk of venous thromboembolism is increased in adults and enhanced by asparaginase-based chemotherapy, and venous thromboembolism introduces...
Sun Oct 11, 2020 13:46
Clinical impact of hypothalamic-pituitary disorders after conformal radiation therapy for pediatric low-grade glioma or ependymoma. Pediatr Blood Cancer. 2020 Oct 10;:e28723 Authors: van Iersel L, van Santen HM, Potter B, Li Z, Conklin HM, Zhang H, Chemaitilly W, Merchant TE Abstract BACKGROUND: To determine the impact of hypothalamic-pituitary (HP) disorders on health outcomes in children and adolescents who received conformal radiation...
Sun Oct 11, 2020 13:46
The role of psychosocial support in the experiences of people living with advanced cancer: a qualitative exploration of patients' perspectives. Psychooncology. 2020 Oct 10;: Authors: Newton JC, O'Connor M, Saunders C, Moorin R, Ali S, Nowak AK, Halkett GK Abstract BACKGROUND: People living with advanced cancer experience significant distress and reduced quality of life due to their symptom burden and life-limiting prognosis. Limited qualitative...
Sun Oct 11, 2020 13:46
Robotic interval debulking surgery for advanced epithelial ovarian cancer: current challenge or future direction? A systematic review. J Robot Surg. 2020 Oct 09;: Authors: Psomiadou V, Prodromidou A, Fotiou A, Lekka S, Iavazzo C Abstract We evaluated the effectiveness, safety and efficacy of robotic interval debulking surgery (IDS) in advanced epithelial ovarian cancer (EOC) treated with neoadjuvant chemotherapy (NACT). We conducted a...
Sun Oct 11, 2020 13:46
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