Abstract Triple-negative breast cancer (TNBC) is defined by a lack of expression of both estrogen (ER) and progesterone (PgR) receptors as well as human epidermal growth factor receptor 2 (HER2) and is associated with poor prognosis. Moreover, the systemic treatment options are limited. However, the TNBC is more likely than other breast cancer subtypes to benefit from immune checkpoint blockade therapy due to its higher immunogenicity, higher enrichment by tumour-infiltrating...
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British Journal of Cancer, Published online: 05 October 2020; doi:10.1038/s41416-020-01099-7A Phase 1 study of gefitinib combined with durvalumab in EGFR TKI-naive patients with EGFR mutation-positive locally advanced/metastatic non-small-cell lung cancer
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British Journal of Cancer, Published online: 05 October 2020; doi:10.1038/s41416-020-01102-1Clinically and biologically relevant subgroups of Wilms tumour defined by genomic and epigenomic analyses
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Publication date: December 2020Source: Cancer Epidemiology, Volume 69Author(s): Carolina Villanueva, Jenny Chang, Argyrios Ziogas, Robert E. Bristow, Verónica M. Vieira
Sun Oct 04, 2020 19:01
Publication date: Available online 3 October 2020Source: European Journal of CancerAuthor(s): Michael K. Fink
Sun Oct 04, 2020 16:56
Publication date: Available online 3 October 2020Source: European Journal of Surgical OncologyAuthor(s): Shanmugam Subbiah, Syed Afroze Hussain, M. Samanth Kumar
Sun Oct 04, 2020 13:38
Publication date: Available online 3 October 2020Source: European Journal of Surgical OncologyAuthor(s): Luigi Pedone Anchora, Nicolò Bizzarri, Ali Kucukmetin, Luigi Carlo Turco, Valerio Gallotta, Vittoria Carbone, Stuart Rundle, Nithya Ratnavelu, Francesco Cosentino, Vito Chiantera, Anna Fagotti, Camilla Fedele, Nana Gomes, Gabriella Ferrandina, Giovanni Scambia
Sun Oct 04, 2020 13:38
Publication date: Available online 3 October 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Zahra Hashemi, Mansoureh Tatari, Haladhara Naik
Sun Oct 04, 2020 13:24
Publication date: Available online 3 October 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Samir Abdallah Hanna, Rodrigo Ramella Munhoz, André Luis de Freitas Perina, Marina Sahade Gonçalves, Fabio Paganini Pereira da Costa, Fabio de Freitas Busnardo, Fabio de Oliveira Ferreira
Sun Oct 04, 2020 13:24
Publication date: Available online 3 October 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Farzaneh Dastan, Ahmad Ameri, Samaneh Dodge, Hadi Hamidi Shishvani, Ali Pirsalehi, Mohammad Abbasinazari
Sun Oct 04, 2020 13:24
Publication date: Available online 3 October 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Lucas Augusto Radicchi, José Carlos de Toledo, Dário Henrique Alliprandini
Sun Oct 04, 2020 13:24
Publication date: Available online 3 October 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Isabel Rodrigues, Tiago Figueiredo, João Gagean, Carolina Ferreira, André Laranja, Tiago Ramos, Sofia Conde, Diana Moreira, Joana Cardia
Sun Oct 04, 2020 13:24
Abstract ObjectiveThis three‐armed randomized controlled feasibility trial tested the acceptability and acute effects of aerobic exercise and technology‐guided mindfulness training (relative to standalone interventions) on cancer‐related fatigue among breast cancer survivors (BCS).MethodsBCS recruited from Central Illinois completed pre‐and post‐testing using established measures and were randomized to one of three groups (combined aerobic exercise with guided‐mindfulness relaxation, aerobic exercise...
Sat Oct 03, 2020 19:53
Abstract ObjectiveRural men affected by cancer are difficult to engage in psychosocial support services. This exploratory study tested whether exposure to printed brochures describing services, distinguished by a focus on rural men affected by cancer, resulted in more positive help‐seeking attitudes than exposure to material focused on rural location only or generic cancer support material.MethodsTargeted versions of a South Australian Cancer Council service brochure were developed to enhance cultural...
Sat Oct 03, 2020 18:59
AbstractThis article is protected by copyright. All rights reserved.
Sat Oct 03, 2020 18:53
Abstract Anaplastic lymphoma kinase (ALK) inhibition is expected to be a promising therapeutic strategy for ALK‐positive malignancies. We aimed to examine the efficacy and safety of alectinib, a second‐generation ALK inhibitor, in patients with relapsed or refractory ALK‐positive anaplastic large cell lymphoma (ALCL). This open‐label, phase 2 trial included patients (age ≥ 6 years) with relapsed or refractory ALK‐positive ALCL. Alectinib 300 mg was administered orally twice a day (600 mg/day) for...
Sat Oct 03, 2020 17:04
X-inactive-specific transcript (XIST) is a 19 kb noncoding RNA which is oncogenic in many cancers including gastric cancer. It is reported that XIST contributes to gastric cancer cells resistant to cisplatin, but specific mechanisms governing this resistance remain unclear. We firstly examined the XIST level in gastric cancer cells and tumor specimens. We confirmed that XIST is overexpressed in gastric cancer cells and tumors, which further contributed to the poor prognosis of patients with gastric...
Wed Sep 30, 2020 03:00
Tumor cells can activate platelets, which in turn facilitate tumor cell survival and dissemination. Platelets inhibition or blocking platelet–tumor cell interactions has become a strategy to suppress tumor progression. In this study, we investigated the effect of ticagrelor, a new antiplatelet drug, on tumor cell proliferation and metastasis. Our results show that ticagrelor not only inhibits the proliferation, migration, and invasion of B16F10 and Lewis lung carcinoma cells but also induces platelet...
Wed Sep 30, 2020 03:00
Opinion statement The demographics of head and neck cancer (HNC) survivors are changing, contributing to a growing number of survivors and a greater length of survivorship. Curative treatment involves intense multimodal therapy, which contributes to both short-term toxicities and long-term treatment-related effects. Delivering high-quality, relevant cancer survivorship care is a growing national priority. Various survivorship models and tools, such as survivorship care plans,...
Sat Oct 03, 2020 03:00
Publication date: Available online 2 October 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Naohiro Sakashita, Kiyonori Shirai, Yoshihiro Ueda, Ayuka Ono, Teruki Teshima
Sat Oct 03, 2020 18:16
Although the aberrant expression and function of most Ca2+-permeable channels are known to promote gastrointestinal tumors, the association between transient receptor potential vanilloid receptor 1 (TRPV1) channe...
Fri Oct 02, 2020 03:00
Publication date: Available online 3 October 2020Source: European Journal of CancerAuthor(s): Mark Clemons, Michael Ong, Carol Stober, Scott Ernst, Christopher Booth, Christina Canil, Mihaela Mates, Andrew Robinson, Phillip Blanchette, Anil Abraham Joy, John Hilton, Olexiy Aseyev, Gregory Pond, Ahwon Jeong, Brian Hutton, Sasha Mazzarello, Lisa Vandermeer, Igal Kushnir, Dean Fergusson, REaCT investigators
Sat Oct 03, 2020 16:38
Publication date: Available online 3 October 2020Source: European Journal of CancerAuthor(s): Elise Deluche, Alison Antoine, Thomas Bachelot, Mathieu Robain, David Perol, Suzette Delaloge
Sat Oct 03, 2020 16:38
Publication date: Available online 3 October 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Umberto Malapelle, Giulio Rossi, Pasquale Pisapia, Massimo Barberis, Fiamma Buttitta, Francesca Castiglione, Fabiana Letizia Cecere, Antonio Maria Grimaldi, Antonino Iaccarino, Antonio Marchetti, Daniela Massi, Daniela Medicina, Fabio Mele, Roberta Minari, Elisabetta Orlando, Fabio Pagni, Giuseppe Palmieri, Luisella Righi, Alessandro Russo, Stefania Tommasi
Sat Oct 03, 2020 15:01
Publication date: Available online 3 October 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Bulent Cetin, Chiara A. Wabl, Ozge Gumusay
Sat Oct 03, 2020 15:01
ABSTRACT PurposeUnderstanding the end‐of‐life psychosocial needs of cancer patients at home is a knowledge gap. This study describes the trajectory of psychosocial symptoms in the last six months of life among cancer decedents who were receiving home care.MethodsObservational population‐based cohort study of cancer decedents who were receiving home care services between 2007 and 2014. Decedents had to have at least 1 home care assessment in the last six months of life for inclusion. Outcomes were...
Fri Oct 02, 2020 20:54
Abstract BackgroundGuidelines recommend systematic evaluation of distress screening and referral for cancer patients. Implementation remains a notable gap for cancer centers serving disadvantaged communities. We present the implementation of a distress screening program within a Veterans Affairs(VA) hospital oncology clinic, serving a majority African American male population of low socioeconomic status(SES).MethodsThe Coleman Foundation funded this program supporting a palliative care physician...
Fri Oct 02, 2020 17:09
ABSTRACT Metastasis is a primary reason related to the mortality of oral squamous cell carcinoma (OSCC) patients. A program called epithelial‐mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium‐derived carcinoma. During EMT, epithelial cancer cells acquire motile mesenchymal phenotypes and detach from primary tumors. Furthermore, recent lines of evidence suggest that EMT confers cancer cells with tumor initiating ability. Thus, selective targeting...
Fri Oct 02, 2020 19:29
Abstract Comprehensive genomic profiling (CGP) testing by next‐generation sequencing has been introduced into clinical practice as part of precision cancer medicine to select effective targeted therapies. However, whether CGP testing at the time of first‐line chemotherapy could be clinically useful is not clear. We conducted this single‐center, prospective, observational study to investigate the feasibility of CGP testing for chemotherapy‐naïve patients with stage III/IV gastrointestinal cancer,...
Fri Oct 02, 2020 19:10
Abstract Stromal invasion is considered an important prognostic factor in patients with lung adenocarcinoma. The mechanisms underlying the formation of tumor stroma and stromal invasion have been studied in the lung; however, they are still unclear. CD109 is a glycosylphosphatidylinositol‐anchored glycoprotein highly expressed in several types of human malignant tumors including lung cancers. In this study, we investigated the in vivo functions of CD109 protein in malignant lung tumors. Initially,...
Fri Oct 02, 2020 19:03
Abstract PD‐1/PD‐L1 immune checkpoint inhibitors are promising cancer immunotherapies, however, responses are still limited, and development of more effective combination immunotherapy is needed. We previously reported that STAT3 activation in cancer cells and immune cells was involved in the immune resistant mechanisms. In this study, we evaluated the effect of highly absorptive forms of curcumin extracts and synthetic curcumin on anti‐tumor T cell responses. The curcumin p.o. administration resulted...
Fri Oct 02, 2020 18:30
Abstract Introduction Recently, the term “Diffuse glioma, BRAF V600E-mutant” has been recommended for IDH-wildtype gliomas with BRAF p.V600E mutation and without CDKN2A/B deletion. However, additional alterations in gliomas that coexist with BRAF-mutations are poorly defined. Methods We analyzed next-generation sequencing results in 315 cancer-associated...
Sat Oct 03, 2020 03:00
Background Patient‐reported outcomes have been used to assess treatment effectiveness and actively engage patients in their disease management. This study was designed to describe the patient‐reported performance status (PS) and the provider‐reported PS. Methods Patients with metastatic genitourinary cancers were recruited from a single cancer center before the initiation of a new line of treatment. PS (Eastern Cooperative Oncology Group [ECOG]), quality of life (Functional Assessment of Chronic...
Fri Oct 02, 2020 19:46
Effective methylation triage of HPV positive women with abnormal cytology in a middle‐income country
Abstract The S5‐methylation test, an alternative to cytology and HPV16/18 genotyping to triage high‐risk HPV‐positive (hrHPV+) women, has not been widely validated in Low‐Middle‐Income countries (LMICs). We compared S5 to HPV16/18 and cytology to detect cervical intraepithelial neoplasia grade 2 or worse (CIN2+) and CIN3+ in hrHPV+ women selected from a randomized pragmatic trial of 2661 Colombian women with an earlier‐borderline abnormal cytology. We included all hrHPV+ CIN2 and CIN3+ cases (n = 183)...
Fri Oct 02, 2020 12:37
Abstract In the context of opportunistic cervical cancer screening settings of low‐and‐middle‐income countries, little is known about the benefits of high‐risk human papillomavirus (hrHPV) testing on high‐grade cervical abnormality detection among women with atypical squamous cells of undetermined significance (ASC‐US) cytology in routine clinical practice. We compared the effectiveness of immediate colposcopy (IC), conventional cytology at 6 and 12 months (colposcopy if ≥ASC‐US) (RC), and hrHPV...
Fri Oct 02, 2020 12:34
ABSTRACT We sought to understand the role of stage at diagnosis in observed age disparities in colon cancer survival among people aged 50‐99 using population‐based cancer registry data from seven high‐income countries: Australia, Canada, Denmark, Ireland, New Zealand, Norway and the United Kingdom. We used colon cancer incidence data for the period 2010‐2014. We estimated the three‐year net survival, as well as the three‐year net survival conditional on surviving at least six months and one year...
Fri Oct 02, 2020 12:15
Abstract Germline DNA damage repair (DDR) deficiency has been associated with increased cancer risk, poor prognosis, and therapeutic opportunity for prostate cancer (PCa) patients. However, the landscape of germline mutations in PCa covering comprehensive DNA damage repair genes has not been reported. We performed whole‐exome sequencing in 246 patients who meet the National Cancer Center Network guidelines for genetic testing and analyzed variants in 276 DDR genes, which was from the Cancer Genome...
Fri Oct 02, 2020 12:14
Abstract The risk of developing urothelial carcinoma of the bladder (UCB) in patients treated by radical nephroureterectomy (RNU) for an upper urinary tract urothelial carcinoma (UTUC) is 22‐47% in the two years after surgery. Subject of debate remains whether UTUC and the subsequent UCB are clonally related or represent separate origins. To investigate the clonal relationship between both entities, we performed targeted DNA sequencing of a panel of 41 genes on matched normal and tumor tissue of...
Fri Oct 02, 2020 12:13
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Oct 02, 2020 10:00
Purpose: Patients with estrogen and/or progesterone receptor-positive, early breast cancer benefit from hormonal treatment, yet high global death burdens due to high prevalence and long-term recurrence risk call for biomarkers to guide additional treatment approaches. Experimental Design: From a prospective, observational study of postmenopausal early breast cancer patients treated with tamoxifen or aromatase inhibitors gene expression analyses of 612 tumors was performed using the NanoString® Breast...
Fri Oct 02, 2020 15:33
Background: Rearrangements involving the MYC protooncogene are common in newly diagnosed multiple myeloma (MM), but their prognostic significance is still unclear. The purpose of this study was to assess the impact of MYC rearrangement on clinical characteristics, treatment response, and survival in newly diagnosed MM. Patients and Methods: This is a retrospective study including 1342 patients seen in Mayo Clinic in Rochester, MN, from January 2006 to January 2018, and who had cytogenetic testing...
Fri Oct 02, 2020 15:33
A recent crystal structure of a ribosome complex undergoing partial translocation in the absence of elongation factor EF-G showed disruption of codon-anticodon pairing and slippage of the reading frame by -1, directly implicating EF-G in preservation of the translational reading frame. Among mutations identified in a random screen for dominant-lethal mutations of EF-G were a cluster of 6 that map to the tip of domain IV, which has been shown to contact the codon-anticodon duplex in trapped translocation...
Fri Oct 02, 2020 20:52
Structural Diversity and Phylogenetic Distribution of Valyl tRNA-like Structures in Viruses [Report]
Viruses commonly use specifically folded RNA elements that interact with both host and viral proteins to perform functions important for diverse viral processes. Examples are found at the 3' termini of certain positive-sense ssRNA virus genomes where they partially mimic tRNAs, including being aminoacylated by host cell enzymes. Valine-accepting tRNA-like structures (TLSVal) are an example that share some clear homology to canonical tRNAs but have several important structural differences. Although...
Fri Oct 02, 2020 18:59
Publication date: Available online 2 October 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Fuxing Zhao, Dengfeng Ren, Guoshuang Shen, Raees Ahmad, Li Dong, Feng Du, Jiuda Zhao
Sat Oct 03, 2020 01:13
Publication date: Available online 1 October 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Giuseppe Lamberti, Elisa Andrini, Monia Sisi, Alessandro Rizzo, Claudia Parisi, Alessandro Di Federico, Francesco Gelsomino, Andrea Ardizzoni
Sat Oct 03, 2020 01:13
Publication date: Available online 1 October 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Pierre Loap, Krassen Kirov, Youlia Kirova
Sat Oct 03, 2020 01:13
Publication date: Available online 1 October 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Gabriel Campos Louzeiro, Dieni da Silveira Teixeira, Karen Cherubini, Maria Antonia Zancanaro de Figueiredo, Fernanda Gonçalves Salum
Sat Oct 03, 2020 01:13
Proton pencil beam scanning (PBS) represents an interesting option for the treatment of breast cancer (BC) patients with nodal involvement. Here we compare tangential 3D-CRT and VMAT to PBS proton therapy (PT)...
Fri Oct 02, 2020 03:00
This study aimed to assess the effectiveness and cost-effectiveness of nimotuzumab in patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC).
Fri Oct 02, 2020 03:00
There is an increasing application of moderately hypofractionated radiotherapy for prostate cancer. We presented our outcomes and treatment-related toxicities with moderately hypofractionated (67.5 Gy in 25 fr...
Fri Oct 02, 2020 03:00
Conservative surgery followed by breast and nodal irradiation is the standard loco-regional early breast cancer (BC) treatment for patients with four or more involved lymph nodes. However, the treatment strate...
Fri Oct 02, 2020 03:00
Screening for lung cancer has become a reality in certain countries, most notably the United States, but its implementation currently is under discussion and not established in many nations, including France. Screening for lung cancer currently is proposed using a low‐dose computed tomography scanner. However, this approach lacks sensitivity and specificity, and could be improved when combined with a blood test (so‐called “liquid biopsy”). Such tests attempt to detect biomarker (s) of early cancer...
Fri Oct 02, 2020 19:50
Publication date: Available online 2 October 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Liliana DeMiglio, Victoria Murdoch, Jessica Ivison, Samarth Fageria, Ioannis A. Voutsadakis
Fri Oct 02, 2020 18:00
Publication date: Available online 2 October 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Roman O. Kowalchuk, Michael R. Waters, K. Martin Richardson, Kelly M. Spencer, James M. Larner, C.R. Kersh
Fri Oct 02, 2020 18:00
Publication date: Available online 1 October 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Radovan Vojtíšek, Emília Sukovská, Marika Kylarová, Denisa Kacerovská, Jan Baxa, Barbora Divišová, Jindřich Fínek
Fri Oct 02, 2020 18:00
Publication date: Available online 1 October 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Giorgia Lo Presti, Marco Roncador, Maira Biggiogero, Chiara Soloni, Alessandra Franzetti-Pellanda
Fri Oct 02, 2020 18:00
Publication date: Available online 1 October 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Lucas Coelho Casimiro, Geovanne Pedro Mauro, Carolina Trindade Mello Medici, Eduardo Weltman
Fri Oct 02, 2020 18:00
Publication date: December 2020Source: Cancer Epidemiology, Volume 69Author(s): Liang Qiao, Peng Zhou, Bo Li, Xiao-xia Liu, Li-na Li, Ying-yi Chen, Jing Ma, Yu-qian Zhao, Ting-yuan Li, Qiang Li
Fri Oct 02, 2020 17:39
Microwave ablation enhances tumor-specific immune response in patients with hepatocellular carcinoma
Abstract Thermal ablative therapies are standard treatments for localized hepatocellular carcinoma (HCC). In addition to local tumor destruction, ablation leads to abscopal effects in distant lesions most likely mediated by an anti-tumor immune response. Although microwave ablation (MWA) is increasingly substituting other ablative techniques, its systemic immunostimulatory effects are poorly studied. We analyzed tumor-specific immune responses in peripheral blood of HCC patients...
Fri Oct 02, 2020 03:00
Publication date: November 2020Source: European Journal of Cancer, Volume 139Author(s): Anissa Moktefi, Carolina Saldana, Thomas Stehlé, Aude Guillemin, Dil Sahali, Mario Ollero, Carole Henique, Christophe Tournigand
Fri Oct 02, 2020 16:20
Imaging biomarkers are important in oncology as they non-invasively provide information about the tumor and can be used for treatment response monitoring [1]. Quantitative imaging biomarkers (QIBs), are of particular interest because they provide quantitative information about tissue characteristics [2]. Ideally, they facilitate the comparison across different vendors and centers. However, differences in system hardware, acquisition parameters, and image analysis techniques introduce variability...
Fri Oct 02, 2020 03:00
Publication date: Available online 2 October 2020Source: European Journal of Surgical OncologyAuthor(s): Yasmin Jauhari, David Dodwell, Melissa Ruth Gannon, Kieran Horgan, Karen Clements, Jibby Medina, David Alan Cromwell
Fri Oct 02, 2020 15:38
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