Related Articles Anti-oral cancer effects of triptolide by downregulation of DcR3 in vitro, in vivo, and in preclinical patient-derived tumor xenograft model. Head Neck. 2019 05;41(5):1260-1269 Authors: Yang CY, Lin CK, Hsieh CC, Tsao CH, Lin CS, Peng B, Chen YT, Ting CC, Chang WC, Lin GJ, Sytwu HK, Chen YW Abstract BACKGROUND: Aberrant expression of decoy receptor 3 (DcR3) is considered to be a diagnostic and therapeutic target for human...
Sat Sep 05, 2020 14:49
Related Articles ASC modulates HIF-1α stability and induces cell mobility in OSCC. Cell Death Dis. 2020 Sep 03;11(9):721 Authors: Wu CS, Chang IY, Hung JL, Liao WC, Lai YR, Chang KP, Li HP, Chang YS Abstract High-level expression of ASC (Apoptosis-associated speck-like protein containing a CARD) leads to lymph node metastasis in OSCC, but the underlying mechanism remains unclear. Here, we show that HIF-1α participates in ASC-induced metastasis....
Sat Sep 05, 2020 14:49
Related Articles tRNA-derived RNA fragments in cancer: current status and future perspectives. J Hematol Oncol. 2020 Sep 04;13(1):121 Authors: Yu M, Lu B, Zhang J, Ding J, Liu P, Lu Y Abstract Non-coding RNAs (ncRNAs) have been the focus of many studies over the last few decades, and their fundamental roles in human diseases have been well established. Transfer RNAs (tRNAs) are housekeeping ncRNAs that deliver amino acids to ribosomes during...
Sun Sep 06, 2020 14:49
Related Articles Correlations and Age-Related Changes of Cervical Sagittal Parameters in Adults Without Symptoms of Cervical Spinal Disease. Spine (Phila Pa 1976). 2020 Sep 01;: Authors: Hu L, Lv Y, Lin Y Abstract STUDY DESIGN: Retrospective study. OBJECTIVE: To determine the correlations and age-related changes of cervical sagittal parameters in adults without obvious cervical spinal disease. SUMMARY OF BACKGROUND DATA: Cervical...
Sun Sep 06, 2020 14:49
Related Articles Endoscopic anatomy of the sellar barrier: From the anatomical model to the operating room. Clin Anat. 2020 Apr;33(3):468-474 Authors: Villalonga JF, Fuchssteiner C, Solari D, Campero A, Cavallo LM, Cappabianca P, Hirtler L Abstract BACKGROUND: The sellar barrier concept reflects the association between the components of the roof of the pituitary fossa and the risk of intraoperative cerebrospinal fluid (CSF) leak in the surgery...
Tue Sep 08, 2020 21:47
Related Articles Investigation on chronic tinnitus efficacy of combination of non-repetitive preferred music and educational counseling: a preliminary study. Eur Arch Otorhinolaryngol. 2020 Sep 05;: Authors: Chen J, Zhong P, Meng Z, Pan F, Qi L, He T, Lu J, He P, Zheng Y Abstract PURPOSE: To improve the efficacy of music therapy on tinnitus relief, specific music that was not repetitively played and satisfies individualized preference was developed....
Tue Sep 08, 2020 21:47
Related Articles Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma. Allergy. 2020 Sep 07;: Authors: Breiteneder H, Peng YQ, Agache I, Diamant Z, Eiwegger T, Fokkens WJ, Traidl-Hoffmann C, Nadeau K, O'Hehir RE, O'Mahony L, Pfaar O, Torres MJ, Wang DY, Zhang L, Akdis CA Abstract Modern healthcare requires a proactive and individualized response to diseases, combining precision diagnosis and personalized...
Tue Sep 08, 2020 21:47
Related Articles Awake fiberoptic intubation in patients with stenosis of the upper airways: Utility of the laryngeal nerve block. Clin Ter. 2020 Jul-Aug;171(4):e335-e339 Authors: Alessandri F, Bellucci R, Tellan G, Pinchera P, Buonopane C, Ralli M, Greco A, de Vincentiis M, Pugliese F, Bilotta F Abstract Awake fiberoptic intubation (AFOI) is mandatory to manage difficult airways. Superior laryngeal nerve block (SLNB) could reduce risks and...
Wed Sep 09, 2020 13:27
Related Articles Overview of Upper Airway Management During COVID-19 Outbreak: Head and Neck Surgeon's Perspective. J Craniofac Surg. 2020 Sep;31(6):e644-e649 Authors: Omari AA, Al-Ashqar R, Nuseir A, Al Balas H, Allan H, Kanaan Y, Alzoubi F Abstract At the end of December, 2019, a new virus was named severe acute respiratory syndrome coronavirus 2 appeared in Wuhan, China, and the disease caused is called as coronavirus disease 2019 (COVID-19)...
Wed Sep 09, 2020 13:27
Related Articles Fluorescence-based method for sensitive and rapid estimation of chlorin e6 in stealth liposomes for photodynamic therapy against cancer. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Aug 12;244:118823 Authors: Jain R, Pradhan R, Hejmady S, Singhvi G, Dubey SK Abstract Chlorin e6 is a chlorine-based porphyrin containing photosensitizer mainly used for the therapy in cancers like neck and head, early-stage lung cancer, and topical...
Wed Sep 09, 2020 13:27
Evaluation of the theranostic properties of gadolinium-based nanoparticles for head and neck cancer.
Related Articles Evaluation of the theranostic properties of gadolinium-based nanoparticles for head and neck cancer. Head Neck. 2019 02;41(2):403-410 Authors: Quatre R, Jacquet T, Atallah I, Tillement O, Lux F, Coll JL, Dufort S, Righini CA Abstract BACKGROUND: The aim of the study was to evaluate the benefits of the combination of Gadolinium-based nanoparticles AGuIX and radiotherapy on the recurrence free survival after tumor resection in...
Thu Sep 10, 2020 16:53
Related Articles Origin site-based staging system of sinonasal inverted papilloma for application to endoscopic sinus surgery. Head Neck. 2019 02;41(2):440-447 Authors: Meng Y, Fang G, Wang X, Song X, Wang K, Lou H, She W, Qin L, Lv M, Zhang T, Yuan T, Tao Y, Meng X, Zhang L, Wang C Abstract BACKGROUND: We aimed to assess the recurrence risk of sinonasal inverted papillomas (SNIPs), based on a staging system developed according to the originating...
Thu Sep 10, 2020 16:53
Related Articles Evaluation of Artificial Fixation of the Incus and Malleus With Minimally Invasive Intraoperative Laser Vibrometry (MIVIB) in a Temporal Bone Model. Otol Neurotol. 2020 01;41(1):45-51 Authors: Gladiné K, Wales J, Silvola J, Muyshondt PGG, Topsakal V, Van De Heyning P, Dirckx JJJ, von Unge M Abstract BACKGROUND: A significant number of adults suffer from conductive hearing loss due to chronic otitis media, otosclerosis, or other...
Thu Sep 10, 2020 16:53
Related Articles Concurrent cisplatin or cetuximab with radiotherapy in patients with locally advanced head and neck squamous cell carcinoma: A meta-analysis. Medicine (Baltimore). 2020 Sep 04;99(36):e21785 Authors: Tang WH, Sun W, Long GX Abstract BACKGROUND: Concurrent cisplatin with radiotherapy (CRT) or concurrent cetuximab with radiotherapy (BRT) improves outcomes in locally advanced head and neck squamous cell carcinoma (HNSCC) compared...
Fri Sep 25, 2020 14:56
UBE2C is a Potential Biomarker for Tumorigenesis and Prognosis in Tongue Squamous Cell Carcinoma. Diagnostics (Basel). 2020 Sep 04;10(9): Authors: Liu PF, Chen CF, Shu CW, Chang HM, Lee CH, Liou HH, Ger LP, Chen CL, Kang BH Abstract Ubiquitin-conjugating enzyme 2C (UBE2C) involves in numerous cellular processes and the tumor progression in many cancers. However, its role in oral squamous cell carcinoma (OSCC) is unclear. We aimed to investigate...
Thu Sep 10, 2020 16:53
Related Articles Evaluation of the changes of orbital cavity volume and shape after tooth-borne and bone-borne rapid maxillary expansion (RME). Head Face Med. 2020 Sep 08;16(1):21 Authors: Lo Giudice A, Rustico L, Ronsivalle V, Nicotra C, Lagravère M, Grippaudo C Abstract OBJECTIVE: To assess and compare volumetric and shape changes of the orbital cavity in patients treated with tooth-borne (TB) and bone-borne (BB) rapid maxillary expansion...
Tue Sep 15, 2020 15:16
Management of the Disrupted Airway in Children. Laryngoscope. 2020 Sep 09;: Authors: Hsu WC, Schweiger C, Hart CK, Smith M, Varela P, Gutierrez C, Ormaechea M, Cohen AP, Rutter MJ Abstract OBJECTIVE: Our objective was to gather data that would enable us to suggest more specific guidelines for the management of children with airway disruption. STUDY DESIGN: Retrospective case series with data from five tertiary medical centers. ...
Thu Sep 10, 2020 16:53
Improving the Efficacy of Tumor Radiosensitization Through Combined Molecular Targeting. Front Oncol. 2020;10:1260 Authors: Hintelmann K, Kriegs M, Rothkamm K, Rieckmann T Abstract Chemoradiation, either alone or in combination with surgery or induction chemotherapy, is the current standard of care for most locally advanced solid tumors. Though chemoradiation is usually performed at the maximum tolerated doses of both chemotherapy and radiation,...
Thu Sep 10, 2020 16:53
A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling. Cell Rep. 2020 Sep 08;32(10):108118 Authors: Lin Z, Xie R, Guan K, Zhang M Abstract The canonical mammalian Hippo pathway contains a core kinase signaling cascade requiring upstream MST to form a stable complex with SAV1 in order to phosphorylate the downstream LATS/MOB complex. Though SAV1 dimerization is essential for the trans-activation of MST, the molecular mechanism...
Thu Sep 10, 2020 16:53
Deep Brain Stimulation for Facial Pain. Prog Neurol Surg. 2020 Sep 09;35:1-21 Authors: Singleton WGB, Ashida R, Patel NK Abstract Electro-modulation of subcortical deep brain structures by surgically implanted electrodes is now standard evidence-based treatment for movement disorders such as Parkinson's disease and essential tremor and is approved for dystonia and obsessive-compulsive disorder under a humanitarian exemption. Historically, deep...
Thu Sep 10, 2020 16:53
Related Articles Development and Validation of a Novel Surgical Simulation for Parotidectomy and Facial Nerve Dissection. Otolaryngol Head Neck Surg. 2020 08;163(2):344-347 Authors: Gabrysz-Forget F, Rubin S, Nepomnayshy D, Dolan R, Yarlagadda B Abstract We present the development and validation of a low-cost novel model for training of parotid surgery. The model consists of a 3-dimensionally printed skeleton, silicone-based soft tissue, and...
Sat Sep 12, 2020 08:06
Related Articles Home enteral nutrition may prevent myelosuppression of patients with nasopharyngeal carcinoma treated by concurrent chemoradiotherapy. Head Neck. 2019 10;41(10):3525-3534 Authors: Li X, Zhou J, Chu C, You Q, Zhong R, Rao Z, Hu W Abstract BACKGROUND: The aim of this study is to assess the effect of home enteral nutrition (HEN) on the myelosuppression of patients with nasopharyngeal cancer (NPC) during the course of concurrent...
Sat Sep 12, 2020 15:57
Related Articles Recurrence factors in pediatric ameloblastoma: Clinical features and a new classification system. Head Neck. 2019 10;41(10):3491-3498 Authors: Yang R, Tang Y, Zhang X, Liu Z, Gokavarapu S, Lin C, Ren Z, Zhou Y, Cao W, Ji T Abstract BACKGROUND: Ameloblastomas of jaw in the pediatric population are a rare clinical entity and have not been well addressed in the literatures. The present retrospective study analyzed the risk factors...
Sat Sep 12, 2020 15:57
[The correlation between the degree of anxiety/depression and the improvement of subjective and objective symptoms after functional endoscopic sinus surgery in chronic sinusitis]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Sep 07;55(9):830-836 Authors: Feng DD, Huang JJ, Ke X, Liu J, Shen Y, Yang YC Abstract Objective: To explore whether the improvement of subjective symptoms and objective grades after endoscopic sinus surgery in patients...
Sat Sep 12, 2020 15:57
Probability distribution of copy number alterations along the genome: an algorithm to distinguish different tumour profiles. Sci Rep. 2020 Sep 10;10(1):14868 Authors: Esteves L, Caramelo F, Ribeiro IP, Carreira IM, de Melo JB Abstract Copy number alterations (CNAs) comprise deletions or amplifications of fragments of genomic material that are particularly common in cancer and play a major contribution in its development and progression. High...
Sat Sep 12, 2020 15:57
Transoral robotic OSA surgery. Auris Nasus Larynx. 2020 Sep 08;: Authors: Lin HC, Friedman M Abstract Continuous positive airway pressure (CPAP) is the primary treatment of obstructive sleep apnea/hypopnea syndrome (OSA). Most sleep physicians are in agreement that a certain number of OSA patients cannot or will not use CPAP. Although other conservative therapies such as oral appliance, sleep hygiene and sleep positioning may help some of these...
Mon Sep 14, 2020 07:25
Related Articles The TLR-4/NF-κB signaling pathway activation in cochlear inflammation of rats with noise-induced hearing loss. Hear Res. 2019 08;379:59-68 Authors: Zhang G, Zheng H, Pyykko I, Zou J Abstract The TLR-4/NF-κB signaling pathway is involved in innate immunity and inflammation induced by trauma. The present study aimed to investigate possible TLR-4/NF-κB signaling pathway activation in the cochlea associated with acoustic trauma...
Tue Sep 15, 2020 15:16
Management of Cerebrospinal Fluid Rhinorrhea in the Sphenoid Sinus Lateral Recess Through an Endoscopic Endonasal Transpterygoid Approach With Obliteration of the Lateral Recess. Ear Nose Throat J. 2020 Sep 13;:145561320955140 Authors: He C, Zhen HT Abstract BACKGROUND: Cerebrospinal fluid rhinorrhea in the sphenoid sinus lateral recess is a rare occurrence and poses unique challenges due to limited surgical access for surgical repair. ...
Tue Sep 15, 2020 15:16
Pilomatrix carcinoma of the male breast: a case report. Int J Clin Exp Pathol. 2020;13(8):2153-2157 Authors: Weng G, Li F, Xu M Abstract Pilomatrix carcinoma (PC) is a rare skin adnexal neoplasm derived from piliferous follicles, usually occurring in the head and neck region. An optimal treatment for PC has not yet been established, while surgery with wide margins is recommended, with radiation therapy (RT) and chemotherapy improving the curative...
Tue Sep 15, 2020 15:16
Related Articles COVID-19: Review of a 21st Century Pandemic from Etiology to Neuro-psychiatric Implications. J Alzheimers Dis. 2020;77(2):459-504 Authors: Yamamoto V, Bolanos JF, Fiallos J, Strand SE, Morris K, Shahrokhinia S, Cushing TR, Hopp L, Tiwari A, Hariri R, Sokolov R, Wheeler C, Kaushik A, Elsayegh A, Eliashiv D, Hedrick R, Jafari B, Johnson JP, Khorsandi M, Gonzalez N, Balakhani G, Lahiri S, Ghavidel K, Amaya M, Kloor H, Hussain N, Huang E, Cormier...
Tue Sep 22, 2020 14:53
Pinitol attenuates LPS-induced pneumonia in experimental animals: Possible role via inhibition of the TLR-4 and NF-κB/IκBα signaling cascade pathway. J Biochem Mol Toxicol. 2020 Sep 14;:e22622 Authors: Fan Y, Wang J, Feng Z, Cao K, Xu H, Liu J Abstract Pneumonia is a chronic disorder of the respiratory system associated with worsening quality of life and a significant economic burden. Pinitol, a plant cyclic polyol, has been documented for...
Tue Sep 15, 2020 15:16
Exosomal Delivery of AntagomiRs Targeting Viral and Cellular MicroRNAs Synergistically Inhibits Cancer Angiogenesis. Mol Ther Nucleic Acids. 2020 Aug 19;22:153-165 Authors: Wang J, Jiang Q, Faleti OD, Tsang CM, Zhao M, Wu G, Tsao SW, Fu M, Chen Y, Ding T, Chong T, Long Y, Yang X, Zhang Y, Cai Y, Li H, Peng M, Lyu X, Li X Abstract Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated cancer characterized by a high degree of...
Tue Sep 15, 2020 15:16
Related Articles Activation of PKC induces leukocyte adhesion by the dephosphorylation of ERM. Biochem Biophys Res Commun. 2020 02 26;523(1):177-182 Authors: Tachibana K, Ohnishi H, Ali Haghparast SM, Kihara T, Miyake J Abstract Although circulating leukocytes are non-adherent cells, they also undergo adhesion in response to external stimuli. To elucidate this switch mechanism, we investigated PMA-induced cell adhesion in myelomonocytic KG-1 cells....
Thu Sep 17, 2020 03:09
Related Articles Implantation of a new active bone conduction hearing device with optimized geometry. HNO. 2020 Aug;68(Suppl 2):106-115 Authors: Plontke SK, Götze G, Wenzel C, Rahne T, Mlynski R Abstract Here, we describe the surgical technique for implanting a new, active, transcutaneous bone conduction hearing aid. The implant technology is based on a system that has been in use reliably since 2012. The geometry of the new implant has been...
Thu Sep 17, 2020 03:09
Related Articles Integrative genomic analysis of salivary duct carcinoma. Sci Rep. 2020 Sep 14;10(1):14995 Authors: Kim Y, Song S, Lee M, Swatloski T, Kang JH, Ko YH, Park WY, Jeong HS, Park K Abstract Salivary duct carcinoma (SDC) is one of the most aggressive subtypes of salivary gland cancers. Conventional chemotherapy and/or radiation have shown only limited clinical efficacy in the treatment of recurrent or metastatic SDC. Currently, clinically...
Thu Sep 17, 2020 03:09
Related Articles Establishment of patient-derived cancer organoids for drug-screening applications. Nat Protoc. 2020 Sep 14;: Authors: Driehuis E, Kretzschmar K, Clevers H Abstract Adult stem cell-based organoid technology is a versatile tool for the generation and long-term maintenance of near-native 3D epithelial tissues in vitro. The generation of cancer organoids from primary patient material enables a range of therapeutic agents to be tested...
Thu Sep 17, 2020 03:09
Related Articles Panel 1: Biotechnology, biomedical engineering and new models of otitis media. Int J Pediatr Otorhinolaryngol. 2020 Mar;130 Suppl 1:109833 Authors: Gisselsson-Solén M, Tähtinen PA, Ryan AF, Mulay A, Kariya S, Schilder AGM, Valdez TA, Brown S, Nolan RM, Hermansson A, van Ingen G, Marom T Abstract OBJECTIVE: To summarize recently published key articles on the topics of biomedical engineering, biotechnology and new models in relation...
Thu Sep 17, 2020 15:07
Related Articles Anti-PD-1 Therapy Does Not Influence Hearing Ability in the Most Sensitive Frequency Range, but Mitigates Outer Hair Cell Loss in the Basal Cochlear Region. Int J Mol Sci. 2020 Sep 13;21(18): Authors: Szepesy J, Miklós G, Farkas J, Kucsera D, Giricz Z, Gáborján A, Polony G, Szirmai Á, Tamás L, Köles L, Varga ZV, Zelles T Abstract The administration of immune checkpoint inhibitors (ICIs) often leads to immune-related adverse...
Thu Sep 17, 2020 15:07
Related Articles Therapeutic applications of the selective high affinity ligand drug SH7139 extend beyond non-Hodgkin's lymphoma to many other types of solid cancers. Oncotarget. 2020 Sep 01;11(35):3315-3349 Authors: Balhorn R, Balhorn MC Abstract SH7139, the first of a series of selective high affinity ligand (SHAL) oncology drug candidates designed to target and bind to the HLA-DR proteins overexpressed by B-cell lymphomas, has demonstrated...
Thu Sep 17, 2020 15:07
Related Articles STRATEGY OF COMPUTED TOMOGRAPHY IMAGE OPTIMISATION IN CERVICAL VERTEBRAE AND NECK SOFT TISSUE IN EMERGENCY PATIENTS. Radiat Prot Dosimetry. 2019 Dec 31;187(1):98-102 Authors: Davoudi M, Khoramian D, Abedi-Firouzjah R, Ataei G Abstract INTRODUCTION: With regards to the use of ionisation radiation in the computed tomography (CT), optimal parameters should be used to reduce the risk of incidence of secondary cancers in patients...
Fri Sep 18, 2020 15:01
Related Articles Novel Geometry of an Extended Length Chimeric Scapular Free Flap for Hemimandibular Reconstruction: Nuances of the Technique Streamlined by In-House Virtual Surgical Planning and 3D Printing for a Severely Vessel-Depleted Neck. J Oral Maxillofac Surg. 2020 May;78(5):823-834 Authors: Ettinger KS, Alexander AE, Morris JM, Arce K Abstract Subscapular-based flaps have historically maintained an unparalleled ability to provide a...
Fri Sep 18, 2020 15:01
Related Articles [The clinic research of septoplasty according to different types of nasal septal deviation]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Aug;34(8):706-709 Authors: He T, Deng G, Huang X, Jiang Y, Shi H Abstract Objective:To divide the deviation parts of nasal septal into different deviation units，and then classify them according to the the deviation units through nasal endoscope, and carry out individual septoplasty...
Fri Sep 18, 2020 15:01
Related Articles The "Segmental SMAS Model": A Didactic Concept of Face and Neck Lift Anatomy. Facial Plast Surg. 2020 Aug;36(4):337-350 Authors: Gassner HG, Magdum AA, Hanga D Abstract Profound understanding of the surgical anatomy of the face and neck is the key to successful face lift surgery. The "Segmental SMAS Model" presented herein is the result of a decade-long effort in teaching fellows a logical and coherent anatomic model of face...
Fri Sep 18, 2020 15:01
Related Articles Smartphone-Based Assessment of Preoperative Decision Conflict and Postoperative Physical Activity Among Patients Undergoing Cancer Surgery: A Prospective Cohort Study. Ann Surg. 2020 Sep 15;: Authors: Panda N, Solsky I, Cauley CE, Lipsitz S, Desai EV, Huang EJ, Benjamin EM, Lubitz CC, Onnela JP, Haynes AB Abstract OBJECTIVE: To determine the prevalence of clinically significant decision conflict (CSDC) among patients undergoing...
Fri Sep 18, 2020 15:01
Related Articles OCCUPATIONAL RADIATION EXPOSURE DOSE OF THE EYE IN DEPARTMENT OF CARDIAC ARRHYTHMIA PHYSICIAN. Radiat Prot Dosimetry. 2019 Dec 31;187(3):361-368 Authors: Kato M, Chida K, Ishida T, Sasaki F, Toyoshima H, Oosaka H, Terata K, Abe Y, Kinoshita T Abstract Interventional radiology (IR) procedures tend to be complex, which delivers high radiation exposure to patient. In the present study, we measured the radiation exposure dose [Hp(3)]...
Sun Sep 20, 2020 06:52
Related Articles Traditional Herbal Medicine Mediated Regulations during Head and Neck Carcinogenesis. Biomolecules. 2020 Sep 15;10(9): Authors: Lan XY, Chung TT, Huang CL, Lee YJ, Li WC Abstract Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent neoplasms worldwide. It is well recognized that environmental challenges such as smoking, viral infection and alcohol consumption are key factors underlying HNSCC pathogenesis....
Sun Sep 20, 2020 06:52
Related Articles Impact of Number of Segmented Tissues on SAR Prediction Accuracy in Deep Pelvic Hyperthermia Treatment Planning. Cancers (Basel). 2020 Sep 16;12(9): Authors: VilasBoas-Ribeiro I, van Rhoon GC, Drizdal T, Franckena M, Paulides MM Abstract In hyperthermia, the general opinion is that pre-treatment optimization of treatment settings requires a patient-specific model. For deep pelvic hyperthermia treatment planning (HTP), tissue...
Sun Sep 20, 2020 14:49
Related Articles Mutation profiling in eight cases of vagal paragangliomas. BMC Med Genomics. 2020 Sep 18;13(Suppl 8):115 Authors: Kudryavtseva AV, Kalinin DV, Pavlov VS, Savvateeva MV, Fedorova MS, Pudova EA, Kobelyatskaya AA, Golovyuk AL, Guvatova ZG, Razmakhaev GS, Demidova TB, Simanovsky SA, Slavnova EN, Poloznikov AА, Polyakov AP, Melnikova NV, Dmitriev AA, Krasnov GS, Snezhkina AV Abstract BACKGROUND: Vagal paragangliomas (VPGLs) belong...
Sun Sep 20, 2020 14:49
Related Articles Association of Autofluorescence-Based Detection of the Parathyroid Glands During Total Thyroidectomy With Postoperative Hypocalcemia Risk: Results of the PARAFLUO Multicenter Randomized Clinical Trial. JAMA Surg. 2020 02 01;155(2):106-112 Authors: Benmiloud F, Godiris-Petit G, Gras R, Gillot JC, Turrin N, Penaranda G, Noullet S, Chéreau N, Gaudart J, Chiche L, Rebaudet S Abstract Importance: Because inadvertent damage of parathyroid...
Tue Sep 22, 2020 14:53
Related Articles Direct Functional Protein Delivery with a Peptide into Neonatal and Adult Mammalian Inner Ear In Vivo. Mol Ther Methods Clin Dev. 2020 Sep 11;18:511-519 Authors: Zhang K, Cheng X, Zhao L, Huang M, Tao Y, Zhang H, Rosenholm JM, Zhuang M, Chen ZY, Chen B, Shu Y Abstract The aim of this study was to study an antimicrobial peptide (AMP), aurein 1.2, which substantially increased protein delivery directly into multiple mammalian...
Tue Sep 22, 2020 14:53
Related Articles Antibody-Based Receptor Targeting Using an Fc-Binding Peptide-Dodecaborate Conjugate and Macropinocytosis Induction for Boron Neutron Capture Therapy. ACS Omega. 2020 Sep 15;5(36):22731-22738 Authors: Nakase I, Aoki A, Sakai Y, Hirase S, Ishimura M, Takatani-Nakase T, Hattori Y, Kirihata M Abstract Boron neutron capture therapy (BNCT) is a radiation method used for cancer therapy. Cellular uptake of boron-10 (10B) atoms induces...
Tue Sep 22, 2020 14:53
Related Articles Synergistic effects of combined treatment with ultrasound-mediated cisplatin-loaded microbubbles and atorvastatin on head and neck cancer. Head Neck. 2020 Sep 21;: Authors: Liao AH, Lin WT, Chen HK, Shih CP, Wang CH, Chu YH Abstract BACKGROUND: Previously, we used ultrasound (US)-mediated cisplatin (CDDP)-loaded microbubbles (CDDP-MBs) to increase intratumoral CDDP level while decreasing systemic cytotoxicity. Statins have shown...
Tue Sep 22, 2020 14:53
Related Articles Continuity of Care Is Associated with Medical Costs and Inpatient Days in Children with Cerebral Palsy. Int J Environ Res Public Health. 2020 04 23;17(8): Authors: Yang KT, Yin CH, Hung YM, Huang SJ, Lee CC, Kuo TJ Abstract Background: Children with cerebral palsy (CP) place a considerable burden on medical costs and add to an increased number of inpatient days in Taiwan. Continuity of care (COC) has not been investigated in...
Wed Sep 23, 2020 14:53
Related Articles Natural Compounds Modulate Drug Transporter Mediated Oral Cancer Treatment. Biomolecules. 2020 Sep 17;10(9): Authors: Yang H, Wei YC, Li WC, Chen HY, Lin HY, Chiang CP, Chen HM Abstract Oral cancer (OC) is a serious health problem. Surgery is the best method to treat the disease but might reduce the quality of life of patients. Photodynamic therapy (PDT) may enhance quality of life but with some limitations. Therefore, the development...
Wed Sep 23, 2020 14:53
Related Articles Nordic results of cochlear implantation in adults: speech perception and patient reported outcomes. Acta Otolaryngol. 2020 Sep 22;:1-9 Authors: West NC, Kressner AA, Baungaard LH, Sandvej MG, Bille M, Cayé-Thomasen P Abstract BACKGROUND: Although cochlear implantation (CI) is widely performed in postlingually hearing-impaired adults in the Nordic countries, the literature on hearing outcomes remains scarce. Aims/objectives:...
Wed Sep 23, 2020 14:53
Related Articles Dynamic hip kinematics before and after periacetabular osteotomy in patients with dysplasia. J Orthop Sci. 2020 Mar;25(2):247-254 Authors: Yoshimoto K, Hamai S, Higaki H, Gondoh H, Shiomoto K, Ikebe S, Hara D, Komiyama K, Nakashima Y Abstract BACKGROUND: We prospectively analyzed the hip kinematics in patients with developmental dysplasia of the hip (DDH) before and after periacetabular osteotomy (PAO) and in healthy subjects...
Thu Sep 24, 2020 14:55
Related Articles Cost-effectiveness of treating head and neck cancer using intensity-modulated radiation therapy: implications for cancer control program in India. Int J Technol Assess Health Care. 2020 Sep 23;:1-8 Authors: Chauhan AS, Prinja S, Ghoshal S, Verma R Abstract BACKGROUND: The newer cancer treatment technologies hold the potential of providing improved health outcomes at an additional cost. So it becomes obligatory to assess the...
Thu Sep 24, 2020 14:55
Related Articles Early fiberoptic endoscopic evaluation of swallow in transoral robotic surgery: Description of swallow function and recovery in the acute postoperative period for oropharyngeal squamous cell carcinoma. Head Neck. 2020 Sep 16;: Authors: Charters EK, Bogaardt H, Freeman-Sanderson AL, Ballard KJ, Davies S, Oates J, Clark J Abstract BACKGROUND: Transoral robotic surgery (TORS) is a minimally invasive approach for the treatment of...
Thu Sep 24, 2020 14:55
Related Articles Effects of a wireless frequency modulation system on learning ability and emotional and behaviour problem improvement in 11 children with cochlear implant. Clin Otolaryngol. 2019 09;44(5):820-825 Authors: Cho YS, Ahn JH, Seol HY, Hong SH, Moon IJ PMID: 31095874 [PubMed - indexed for MEDLINE]
Fri Sep 25, 2020 14:56
Related Articles Gene editing based hearing impairment research and therapeutics. Neurosci Lett. 2019 09 14;709:134326 Authors: Kang W, Sun Z, Zhao X, Wang X, Tao Y, Wu H Abstract Hearing impairment affects 1 in 500 newborns worldwide and nearly one out of three people over the age of 65 (WHO, 2019). Hereditary hearing loss is the most common type of congenital deafness; genetic factors also affect deafness susceptibility. Gene therapies may...
Fri Sep 25, 2020 14:56
Related Articles Safety and Efficacy of MRI Scans in Patients With Implanted Microvascular Coupling Devices. Laryngoscope. 2020 06;130(6):1428-1430 Authors: Phalke N, Thomas WW, Azzi J, Li RJ, Petrisor D, Wax MK Abstract OBJECTIVE: To demonstrate the safety and compatibility of microvascular couplers in patients undergoing postoperative magnetic resonance imaging (MRI) scans. STUDY DESIGN: Retrospective case series. METHODS:...
Fri Sep 25, 2020 14:56
Related Articles Transoral neck surgery prevents attentional bias towards the neck compared to open neck surgery. Laryngoscope. 2020 06;130(6):1603-1608 Authors: Liao D, Ishii LE, Chen LW, Chen J, Juarez M, Darrach HM, Kumar AR, Russell JO, Tufano RP, Ishii M Abstract OBJECTIVE: Measure attentional distraction of neck scars after open neck surgery compared to transoral endoscopic thyroidectomy via a vestibular approach (TOETVA) or transoral...
Fri Sep 25, 2020 14:56
Related Articles Initial displacement as a risk factor for avascular necrosis of the femoral head in pediatric femoral neck fractures: a review of one hundred eight cases. Int Orthop. 2020 01;44(1):129-139 Authors: Wang W, Li Y, Guo Y, Li M, Mei H, Shao J, Xiong Z, Li J, Canavese F, Chen S, Chinese Multicenter Pediatric Orthopedic Study Group (CMPOS) Abstract PURPOSE: To evaluate the correlation between avascular necrosis (AVN) and the amount...
Sat Sep 26, 2020 14:56
Related Articles Pediatric tracheotomy in infants: Based on 10 years of experience at a pediatric tertiary center in South Korea. Asian J Surg. 2020 Apr;43(4):567-568 Authors: Sung ES, Lee IW, Roh HJ, Lee JC PMID: 31952878 [PubMed - indexed for MEDLINE]
Sat Sep 26, 2020 14:56
Related Articles Development of a Tongue Immobilization Device Using a 3D Printer for IMRT of Nasopharyngeal Cancer Patients. Cancer Res Treat. 2020 Sep 15;: Authors: Ju SG, Ahn YC, Kim YB, Park SG, Choi YM, Na CH, Hong CS, Oh D, Kwon DY, Kim CC, Kim DH Abstract Purpose: This study aimed to reduce radiation doses to the tongue, a patient-specific semi-customized tongue immobilization device (SCTID) was developed using a 3D printer for helical...
Sat Sep 26, 2020 14:56
Related Articles Sumatriptan alleviates radiation-induced oral mucositis in rats by inhibition of NF-kB and ERK activation, prevention of TNF-α and ROS release. Arch Oral Biol. 2020 Sep 16;119:104919 Authors: Ala M, Mohammad Jafari R, Ala M, Agbele AT, Hejazi SM, Tavangar SM, Mahdavi SRM, Dehpour AR Abstract OBJECTIVES: Oral mucositis caused by radiation therapy is a common problem in cancer patients, especially those with head and neck cancer....
Sat Sep 26, 2020 14:56
Related Articles Intra-Operative Detection of a Left-Sided Non-Recurrent Laryngeal Nerve during Vagus Nerve Stimulator Implantation. Medicina (Kaunas). 2020 Sep 23;56(10): Authors: Labuschagne JJ, Hammer N Abstract Left sided non-recurrent laryngeal nerves (NRLN) are very rarely observed during surgery in the head and neck region. Arising directly from the cervical aspect of the vagus nerve, the NRLN lies in a vulnerable position distant from...
Mon Sep 28, 2020 14:49
Related Articles A unique radioprotective effect of resolvin E1 reduces irradiation-induced damage to the inner ear by inhibiting the inflammatory response. Radiat Oncol. 2020 Sep 25;15(1):223 Authors: Zhang J, Xu A, Niu T, Liu C, Zhang Y, Li T, Wang J, Wang Y, Sun D Abstract BACKGROUND: In addition to the direct effects of irradiation, the induced inflammatory response may play an important role in the damage to the inner ear caused by radiotherapy...
Mon Sep 28, 2020 14:49
Related Articles Prediction Model Combining Clinical and MR Data for Diagnosis of Lymph Node Metastasis in Patients With Rectal Cancer. J Magn Reson Imaging. 2020 Sep 26;: Authors: Xu H, Zhao W, Guo W, Cao S, Gao C, Song T, Yang L, Liu Y, Han Y, Zhang L, Wang K Abstract BACKGROUND: Determining the status of lymph node (LN) metastasis in rectal cancer patients preoperatively is crucial for the treatment option. However, the diagnostic accuracy...
Mon Sep 28, 2020 14:49
Related Articles Robot-assisted epiglottopexy as a method for managing adult obstructive sleep apnea. Am J Otolaryngol. 2020 Sep 18;41(6):102742 Authors: Shehan JN, Du E, Cohen MB Abstract INTRODUCTION: Patients who do not tolerate continuous positive airway pressure (CPAP) for treatment of obstructive sleep apnea (OSA) often seek surgical management. A variety of procedures exist to address the nasal passages, oropharynx, hypopharynx, and larynx....
Mon Sep 28, 2020 14:49
Related Articles Augmented reality for image guidance in transoral robotic surgery. J Robot Surg. 2020 Aug;14(4):579-583 Authors: Chan JYK, Holsinger FC, Liu S, Sorger JM, Azizian M, Tsang RKY Abstract With the advent of precision surgery, there have been attempts to integrate imaging with robotic systems to guide sound oncologic surgical resections while preserving critical structures. In the confined space of transoral robotic surgery (TORS),...
Tue Sep 29, 2020 18:35
Related Articles Planning mass eradication of Helicobacter pylori infection for indigenous Taiwanese peoples to reduce gastric cancer. J Gastroenterol Hepatol. 2020 Apr;35(4):609-616 Authors: Bair MJ, Chuang SL, Lei WY, Chen CL, Tian HW, Chiang TH, Su WW, Lin CC, Chung Lo YT, Jou YY, Wu CY, Chia SL, Wu MS, Chen HH, Chu CH, Lee YC, Wang YW Abstract BACKGROUND AND AIM: The aim of this study is to identify gastric cancer burden in Indigenous Taiwanese...
Tue Sep 29, 2020 18:35
Related Articles Superiority of NBI endoscopy to PET/CT scan in detecting esophageal cancer among head and neck cancer patients: a retrospective cohort analysis. BMC Cancer. 2020 Jan 29;20(1):69 Authors: Su HA, Hsiao SW, Hsu YC, Wang LY, Yen HH Abstract BACKGROUND: Second primary cancer of the esophagus is frequent in head and neck patients, especially in high-risk populations, and has a great impact on the prognosis. Although Positron emission...
Tue Sep 29, 2020 18:35
Related Articles Construction of a convolutional neural network classifier developed by computed tomography images for pancreatic cancer diagnosis. World J Gastroenterol. 2020 Sep 14;26(34):5156-5168 Authors: Ma H, Liu ZX, Zhang JJ, Wu FT, Xu CF, Shen Z, Yu CH, Li YM Abstract BACKGROUND: Efforts should be made to develop a deep-learning diagnosis system to distinguish pancreatic cancer from benign tissue due to the high morbidity of pancreatic...
Tue Sep 29, 2020 18:35
Related Articles CircRNAs: A New Chapter in Oral Squamous Cell Carcinoma Biology. Onco Targets Ther. 2020;13:9071-9083 Authors: Fan HY, Jiang J, Tang YJ, Liang XH, Tang YL Abstract With the rapid development of bioinformatics and gene sequencing technologies, understanding of circular RNAs (circRNAs) has been extended, and numerous studies have identified the key regulator role of circRNAs in a variety of diseases, especially in cancer. Recently,...
Tue Sep 29, 2020 18:35
Related Articles Bridging the Gap Between Fluid Biomarkers for Alzheimer's Disease, Model Systems, and Patients. Front Aging Neurosci. 2020;12:272 Authors: Bjorkli C, Sandvig A, Sandvig I Abstract Alzheimer's disease (AD) is a debilitating neurodegenerative disease characterized by the accumulation of two proteins in fibrillar form: amyloid-β (Aβ) and tau. Despite decades of intensive research, we cannot yet pinpoint the exact cause of the disease...
Tue Sep 29, 2020 18:35
Related Articles Functional Integrity of the Inferior Vestibular Nerve and Posterior Canal BPPV. Front Neurol. 2020;11:894 Authors: Shupak A, Falah R, Kaminer M Abstract The functional integrity of the inferior vestibular nerve (IVN) may be evaluated by the cervical vestibular evoked myogenic potential (cVEMP) response, which requires signal transmission via the nerve. As functional integrity of the IVN innervating the posterior semicircular...
Tue Sep 29, 2020 18:35
Related Articles An Integrated Analysis of mRNAs and miRNAs Microarray Profiles to Screen miRNA Signatures Involved in Nasopharyngeal Carcinoma. Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820956998 Authors: Liu L, Wang H, Yan C, Tao S Abstract OBJECTIVE: We aim to identify several microRNAs (miRNAs/miRs)-messenger RNAs (mRNAs) biomarkers correlated to nasopharyngeal carcinoma (NPC) based on an integrated analysis of miRNA and mRNAs microarray...
Tue Sep 29, 2020 18:35
Related Articles Transcervical endoscopic retropharyngeal lymph node (RPLN) dissection in nasopharyngeal carcinoma with RPLN recurrence. Head Neck. 2020 Sep 28;: Authors: Liu YP, Wang SL, Zou X, You R, Yang Q, Zhang MX, Wang ZQ, Lin M, Xie YL, Chen SY, Ouyang YF, Yu ZK, Liu XK, Sun R, Hua YJ, Huang PY, Li H, Chen MY Abstract BACKGROUND: Surgical access for retropharyngeal lymph node (RPLN) dissection is difficult. We aimed to examine the efficacy...
Tue Sep 29, 2020 18:35
Related Articles Intranasal delivery of SDF-1α-preconditioned bone marrow mesenchymal cells improves remyelination in the cuprizone-induced mouse model of multiple sclerosis. Cell Biol Int. 2020 Feb;44(2):499-511 Authors: Beigi Boroujeni F, Pasbakhsh P, Mortezaee K, Pirhajati V, Alizadeh R, Aryanpour R, Madadi S, Ragerdi Kashani I Abstract Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS)...
Wed Sep 30, 2020 14:29
Targeting Liver Cancer Stem Cells: An Alternative Therapeutic Approach for Liver Cancer. Cancers (Basel). 2020 Sep 24;12(10): Authors: Lee HY, Hong IS Abstract The first report of cancer stem cell (CSC) from Bruce et al. has demonstrated the relatively rare population of stem-like cells in acute myeloid leukemia (AML). The discovery of leukemic CSCs prompted further identification of CSCs in multiple types of solid tumor. Recently, extensive...
Wed Sep 30, 2020 14:29
EUFOREA treatment algorithm for allergic rhinitis. Rhinology. 2020 Sep 29;: Authors: Hellings PW, Scadding G, Bachert C, Bjermer L, Canonica GW, Cardell LO, Carney AS, Constantinidis J, Deneyer L, Diamant Z, Durham S, Gevaert P, Harvey R, Hopkins C, Kjeldsen A, Klimek L, Lund VJ, Price D, Rimmer J, Ryan D, Roberts G, Sahlstrand-Johnson P, Salmi S, Samji M, Scadding G, Smith P, Steinsvik A, Wagenmann M, Seys S, Wahn U, Fokkens WJ Abstract Allergic...
Wed Sep 30, 2020 14:29
Post-approval upper airway stimulation predictors of treatment effectiveness in the ADHERE registry.
Related Articles Post-approval upper airway stimulation predictors of treatment effectiveness in the ADHERE registry. Eur Respir J. 2019 01;53(1): Authors: Heiser C, Steffen A, Boon M, Hofauer B, Doghramji K, Maurer JT, Sommer JU, Soose R, Strollo PJ, Schwab R, Thaler E, Withrow K, Kominsky A, Larsen C, Kezirian EJ, Hsia J, Chia S, Harwick J, Strohl K, Mehra R, ADHERE registry investigators Abstract Upper airway stimulation (UAS) has been...
Thu Oct 01, 2020 18:27
Related Articles How do we teach surgical residents in the COVID-19 era? J Surg Educ. 2020 Sep - Oct;77(5):1005-1007 Authors: Okland TS, Pepper JP, Valdez TA Abstract OBJECTIVE: In response to ongoing concerns regarding transmission of the novel coronavirus (COVID-19), surgical practice has changed for the foreseeable future. Practice guidelines recommend only urgent or emergent surgical procedures be performed to minimize viral transmission....
Thu Oct 01, 2020 18:27
Biofilm Growth Causes Damage to Silicone Voice Prostheses in Patients after Surgical Treatment of Locally Advanced Laryngeal Cancer. Pathogens. 2020 Sep 26;9(10): Authors: Spałek J, Deptuła P, Cieśluk M, Strzelecka A, Łysik D, Mystkowska J, Daniluk T, Król G, Góźdź S, Bucki R, Durnaś B, Okła S Abstract Voice prosthesis implantation with the creation of a tracheoesophageal fistula is the gold standard procedure for voice rehabilitation in patients...
Thu Oct 01, 2020 18:27
Neutrophils mediated multistage nanoparticle delivery for prompting tumor photothermal therapy. J Nanobiotechnology. 2020 Sep 29;18(1):138 Authors: Ye B, Zhao B, Wang K, Guo Y, Lu Q, Zheng L, Li A, Qiao J Abstract BACKGROUND: Neutrophil-based drug delivery system possesses excellent advantages in targeting at tumour because neutrophils are easily recruited by chemotactic factor in tumor microenvironment. Herein, we developed a novel tactic...
Thu Oct 01, 2020 18:27
Childhood Exposure to Low-Moderate Doses of Ionizing Radiation and the Risk of Vascular Diseases -The Tinea Capitis Study. Am J Epidemiol. 2020 Sep 30;: Authors: Sadetzki S, Chetrit A, Boursi B, Luxenburg O, Novikov I, Cohen A Abstract The Tinea Capitis Study, Israel, 1966-2011 We assessed the association between childhood exposure to low-moderate doses of ionizing radiation (IR) to the head and neck and the development of vascular diseases...
Thu Oct 01, 2020 18:27
Related Articles Targeting EZH2 Enhances Antigen Presentation, Antitumor Immunity, and Circumvents Anti-PD-1 Resistance in Head and Neck Cancer. Clin Cancer Res. 2020 01 01;26(1):290-300 Authors: Zhou L, Mudianto T, Ma X, Riley R, Uppaluri R Abstract PURPOSE: Anti-programmed death-1 (PD-1) receptor-based therapeutics improve survival in patients with recurrent head and neck squamous cell carcinoma (HNSCC), but many do not benefit due to a...
Fri Oct 02, 2020 14:18
Effectiveness of the No action level protocol for head & neck patients - Time considerations. Rep Pract Oncol Radiother. 2020 Sep-Oct;25(5):828-831 Authors: Kukolowicz P, Mietelska M, Kiprian D Abstract Background: The No Action Protocol (NAL) was used to diminish the systematic set-up error. Recently, owing to the development of image registration technologies, the on-line positioning control is more often used. This method significantly...
Fri Oct 02, 2020 14:18
Cross verification of independent dose recalculation, log files based, and phantom measurement-based pretreatment quality assurance for volumetric modulated arc therapy. J Appl Clin Med Phys. 2020 Oct 01;: Authors: Han C, Yi J, Zhu K, Zhou Y, Ai Y, Zheng X, Xie C, Jin X Abstract Independent treatment planning system (TPS) check with Mobius3D software, log files based quality assurance (QA) with MobiusFX, and phantom measurement-based QA with...
Fri Oct 02, 2020 14:18
Altered expression of genes regulating inflammation and synaptogenesis during regrowth of afferent neurons to cochlear hair cells. PLoS One. 2020;15(10):e0238578 Authors: Wu CC, Brugeaud A, Seist R, Lin HC, Yeh WH, Petrillo M, Coppola G, Edge ASB, Stankovic KM Abstract The spiral ganglion neurons constitute the primary connection between auditory hair cells and the brain. The spiral ganglion afferent fibers and their synapse with hair cells...
Fri Oct 02, 2020 14:18
Treatment after progression in the era of immunotherapy. Lancet Oncol. 2020 Oct;21(10):e463-e476 Authors: Billan S, Kaidar-Person O, Gil Z Abstract Immunotherapy represents a paradigm shift in oncology treatment. The goal of immunotherapy is to overcome immunosuppression induced by a tumour and its microenvironment, thereby allowing the immune system to target and kill cancer cells. The immunotherapy era began when the first immune checkpoint...
Fri Oct 02, 2020 14:18
Prognostic value of immune-related genes and immune cell infiltration analysis in the tumor microenvironment of head and neck squamous cell carcinoma. Head Neck. 2020 Oct 03;: Authors: Wang Z, Yuan H, Huang J, Hu D, Qin X, Sun C, Chen G, Wang B Abstract BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is one of the few malignant tumors that respond well to immunotherapy. We aimed to investigate the immune-related genes and immune cell...
Sun Oct 04, 2020 13:58
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