Cancers, Vol. 11, Pages 1082: Human Tumor-Infiltrating Dendritic Cells: From in Situ Visualization to High-Dimensional Analyses Cancers doi: 10.3390/cancers11081082 Authors: Hubert Gobbini Bendriss-Vermare Caux Valladeau-Guilemond The interaction between tumor cells and the immune system is considered to be a dynamic process. Dendritic cells (DCs) play a pivotal role in anti-tumor immunity owing to their outstanding T cell activation ability. Their functions and activities...
Tue Jul 30, 2019 03:00
Cancers, Vol. 11, Pages 1081: Early Colorectal Cancers Provide New Evidence for a Lynch Syndrome-to-CMMRD Phenotypic Continuum Cancers doi: 10.3390/cancers11081081 Authors: Fernandez-Rozadilla Alvarez-Barona Schamschula Bodo Lopez-Novo Dacal Calviño-Costas Lancho Amigo Bello Cameselle-Teijeiro Carracedo Colas Muleris Wimmer Ruiz-Ponte Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome, caused...
Tue Jul 30, 2019 03:00
Cancers, Vol. 11, Pages 1083: The Role of Intra-Tumoral Heterogeneity and Its Clinical Relevance in Epithelial Ovarian Cancer Recurrence and Metastasis Cancers doi: 10.3390/cancers11081083 Authors: Roberts Cardenas Tedja Epithelial ovarian cancer is the deadliest gynecologic cancer, due in large part to recurrent tumors. Recurrences tend to have metastasized, mainly in the peritoneal cavity and developed resistance to the first line chemotherapy. Key to the progression and ultimate...
Tue Jul 30, 2019 03:00
Cancers, Vol. 11, Pages 1079: TP53 DNA Binding Domain Mutations Predict Progression-Free Survival of Bevacizumab Therapy in Metastatic Colorectal Cancer Cancers doi: 10.3390/cancers11081079 Authors: Hung-Chih Hsu Jeng-Fu You Shu-Jen Chen Hua-Chien Chen Chien-Yuh Yeh Wen-Sy Tsai Hsin-Yuan Hung Tsai-Sheng Yang Nina Lapke Kien Thiam Tan (1) Background: Bevacizumab-based regimens are a standard treatment for metastatic colorectal cancer (mCRC) patients, however...
Tue Jul 30, 2019 03:00
Cancers, Vol. 11, Pages 1078: Immunotherapy in Hepatocellular Carcinoma: Is There a Light at the End of the Tunnel? Cancers doi: 10.3390/cancers11081078 Authors: Amit Mahipal Sri Harsha Tella Anuhya Kommalapati Alexander Lim Richard Kim Hepatocellular carcinoma (HCC) is the most common primary liver cancer with dismal prognosis when diagnosed at advanced stages. Surgical resection of the primary tumor or orthotropic liver transplantation serves as a potential curative option....
Tue Jul 30, 2019 03:00
Cancers, Vol. 11, Pages 1080: Regulation of Immunity in Breast Cancer Cancers doi: 10.3390/cancers11081080 Authors: Edechi Ikeogu Uzonna Myal Breast cancer affects millions of women worldwide, leading to many deaths and significant economic burden. Although there are numerous treatment options available, the huge potentials of immunotherapy in the management of localized and metastatic breast cancer is currently being explored. However, there are significant gaps in understanding...
Tue Jul 30, 2019 03:00
Cancers, Vol. 11, Pages 1077: Linking Cancer Metabolic Dysfunction and Genetic Instability through the Lens of Iron Metabolism Cancers doi: 10.3390/cancers11081077 Authors: Michael S. Petronek Douglas R. Spitz Garry R. Buettner Bryan G. Allen Iron (Fe) is an essential element that plays a fundamental role in a wide range of cellular functions, including cellular proliferation, DNA synthesis, as well as DNA damage and repair. Because of these connections, iron has been strongly...
Tue Jul 30, 2019 03:00
Cancers, Vol. 11, Pages 1076: PTEN Tumor-Suppressor: The Dam of Stemness in Cancer Cancers doi: 10.3390/cancers11081076 Authors: Francesca Luongo Francesca Colonna Federica Calapà Sara Vitale Micol E. Fiori Ruggero De Maria PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human cancers, while germline PTEN mutations cause inherited syndromes that lead...
Tue Jul 30, 2019 03:00
Cancers, Vol. 11, Pages 1075: Uveal Melanoma Biopsy: A Review Cancers doi: 10.3390/cancers11081075 Authors: Luisa Frizziero Edoardo Midena Sara Trainiti Davide Londei Laura Bonaldi Silvia Bini Raffaele Parrozzani Intraocular tumor diagnosis is based on clinical findings supported by additional imaging tools, such as ultrasound, optical coherence tomography and angiographic techniques, usually without the need for invasive procedures or tissue sampling. Despite improvements...
Tue Jul 30, 2019 03:00
Cancers, Vol. 11, Pages 1074: The Transcriptional Roles of ALK Fusion Proteins in Tumorigenesis Cancers doi: 10.3390/cancers11081074 Authors: Stephen P. Ducray Karthikraj Natarajan Gavin D. Garland Suzanne D. Turner Gerda Egger Anaplastic lymphoma kinase (ALK) is a tyrosine kinase involved in neuronal and gut development. Initially discovered in T cell lymphoma, ALK is frequently affected in diverse cancers by oncogenic translocations. These translocations involve different...
Tue Jul 30, 2019 03:00
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