Τρίτη 30 Ιουλίου 2019

Micheliolide ameliorates renal fibrosis by suppressing the Mtdh/BMP/MAPK pathway

Fenfen Peng, Hongyu Li, Shuting Li, Yuxian Wang, Wenting Liu et al. 
Laboratory Investigation 2019 99 :1092 - 1106; April 11, 2019; 10.1038/s41374-019-0245-6

Lipoprotein modulation of proteinuric renal injury

Yohei Tsuchida, Jianyong Zhong, Tadashi Otsuka, Anna Dikalova, Ira Pastan et al. 
Laboratory Investigation 2019 99 :1107 - 1116; April 24, 2019; 10.1038/s41374-019-0253-6

B7H3 regulates differentiation and serves as a potential biomarker and theranostic target for human glioblastoma

Jingwen Zhang, Jinhua Wang, Diego M. Marzese, Xiaowen Wang, Zixiao Yang et al. 
Laboratory Investigation 2019 99 :1117 - 1129; March 26, 2019; 10.1038/s41374-019-0238-5

miR-146a targeted to splenic macrophages prevents sepsis-induced multiple organ injury

Yoshio Funahashi, Noritoshi Kato, Tomohiro Masuda, Fumitoshi Nishio, Hiroki Kitai et al. 
Laboratory Investigation 2019 99 :1130 - 1142; January 30, 2019; 10.1038/s41374-019-0190-4

Activation of death-associated protein kinase 1 promotes neutrophil apoptosis to accelerate inflammatory resolution in acute respiratory distress syndrome

Shu-Nan Cui, Lin Chen, Yi-Yi Yang, Ya-Xin Wang, Sheng-Nan Li et al. 
Laboratory Investigation 2019 99 :1143 - 1156; March 25, 2019; 10.1038/s41374-019-0242-9

Anti-cancer effect of doxorubicin is mediated by downregulation of HMG-Co A reductase via inhibition of EGFR/Src pathway

Un-Jung Yun, Ji-Hye Lee, Jaegal Shim, Kyungsil Yoon, Sung-Ho Goh et al. 
Laboratory Investigation 2019 99 :1157 - 1172; January 30, 2019; 10.1038/s41374-019-0193-1

Endotoxemia-induced endothelial fibrosis inhibition improves hypotension, tachycardia, multiple organ dysfunction syndrome, cytokine response, oxidative stress, and survival

Alejandro Vallejos, Pedro Olivares, Sebastian Gatica, Vicente Villegas, Cesar Echeverria et al. 
Laboratory Investigation 2019 99 :1173 - 1192; March 25, 2019; 10.1038/s41374-019-0237-6

Reversal of TET-mediated 5-hmC loss in hypoxic fibroblasts by ascorbic acid

Yukun Liu, Shuyun Xu, Tingjian Zu, Feng Li, Shengbo Sang et al. 
Laboratory Investigation 2019 99 :1193 - 1202; March 05, 2019; 10.1038/s41374-019-0235-8

Human relaxin-2 attenuates hepatic steatosis and fibrosis in mice with non-alcoholic fatty liver disease

Kuei-Chuan Lee, Yun-Cheng Hsieh, Che-Chang Chan, Hao-Jhe Sun, Yi-Hsiang Huang et al. 
Laboratory Investigation 2019 99 :1203 - 1216; March 27, 2019; 10.1038/s41374-019-0240-y

Inhibition of prolyl hydroxylase domain (PHD) by JTZ-951 reduces obesity-related diseases in the liver, white adipose tissue, and kidney in mice with a high-fat diet

Hisako Saito, Tetsuhiro Tanaka, Mai Sugahara, Shinji Tanaka, Kenji Fukui et al. 
Laboratory Investigation 2019 99 :1217 - 1232; April 05, 2019; 10.1038/s41374-019-0239-4

TECHNICAL REPORT

A pipeline for rapidly generating genetically engineered mouse models of pancreatic cancer using in vivo CRISPR-Cas9-mediated somatic recombination

Noboru Ideno, Hiroshi Yamaguchi, Takashi Okumura, Jonathon Huang, Mitchell J. Brun et al. 
Laboratory Investigation 2019 99 :1233 - 1244; February 06, 2019; 10.1038/s41374-018-0171-z

Optimized cultivation of porcine choroid plexus epithelial cells, a blood–cerebrospinal fluid barrier model, for studying granulocyte transmigration

Alexa N. Lauer, Martin März, Svenja Meyer, Marita Meurer, Nicole de Buhr et al. 
Laboratory Investigation 2019 99 :1245 - 1255; April 17, 2019; 10.1038/s41374-019-0250-9

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