IJMS, Vol. 20, Pages 6279: Structural Insights into the Intracellular Region of the Human Magnesium Transport Mediator CNNM4 International Journal of Molecular Sciences doi: 10.3390/ijms20246279 Authors: Paula Giménez-Mascarell Iker Oyenarte Irene González-Recio Carmen Fernández-Rodríguez María Ángeles Corral-Rodríguez Igone Campos-Zarraga Jorge Simón Elie Kostantin Serge Hardy Antonio Díaz Quintana Mara Zubillaga Lizeaga Nekane Merino Tammo Diercks Francisco...
Thu Dec 12, 2019 02:00
IJMS, Vol. 20, Pages 6278: Combined De Novo Transcriptome and Metabolome Analysis of Common Bean Response to Fusarium oxysporum f. sp. phaseoli Infection International Journal of Molecular Sciences doi: 10.3390/ijms20246278 Authors: Limin Chen Quancong Wu Weimin He Tianjun He Qianqian Wu Yeminzi Miao Molecular changes elicited by common bean (Phaseolus vulgaris L.) in response to Fusarium oxysproum f. sp. Phaseoli (FOP) remain elusive. We studied the changes in root metabolism...
Thu Dec 12, 2019 02:00
IJMS, Vol. 20, Pages 6276: A Deep Learning Model for Cell Growth Inhibition IC50 Prediction and Its Application for Gastric Cancer Patients International Journal of Molecular Sciences doi: 10.3390/ijms20246276 Authors: Minjae Joo Aron Park Kyungdoc Kim Won-Joon Son Hyo Sug Lee GyuTae Lim Jinhyuk Lee Dae Ho Lee Jungseok An Jung Ho Kim TaeJin Ahn Seungyoon Nam Heterogeneity in intratumoral cancers leads to discrepancies in drug responsiveness, due to diverse...
Thu Dec 12, 2019 02:00
IJMS, Vol. 20, Pages 6275: NF-κB Signaling Regulates Physiological and Pathological Chondrogenesis International Journal of Molecular Sciences doi: 10.3390/ijms20246275 Authors: Eijiro Jimi Huang Fei Chihiro Nakatomi The nuclear factor-κB (NF-κB) is a transcription factor that regulates the expression of genes that control cell proliferation and apoptosis, as well as genes that respond to inflammation and immune responses. There are two means of NF-κB...
Thu Dec 12, 2019 02:00
IJMS, Vol. 20, Pages 6274: Ataluren for the Treatment of Usher Syndrome 2A Caused by Nonsense Mutations International Journal of Molecular Sciences doi: 10.3390/ijms20246274 Authors: Ananya Samanta Katarina Stingl Susanne Kohl Jessica Ries Joshua Linnert Kerstin Nagel-Wolfrum The identification of genetic defects that underlie inherited retinal diseases (IRDs) paves the way for the development of therapeutic strategies. Nonsense mutations caused approximately 12% of all...
Thu Dec 12, 2019 02:00
IJMS, Vol. 20, Pages 6272: Active Demethylation of Non-CpG Moieties in Animals: A Neglected Research Area International Journal of Molecular Sciences doi: 10.3390/ijms20246272 Authors: Marco Lucarelli Giampiero Ferraguti Andrea Fuso The functional role of cytosine methylation in the CpG moieties of DNA, is well established in several biological functions. The interplay between CpG methylation and hypomethylation is a well-known mechanism of modulation of gene expression. However,...
Thu Dec 12, 2019 02:00
IJMS, Vol. 20, Pages 6277: Optimized Xenograft Protocol for Chronic Lymphocytic Leukemia Results in High Engraftment Efficiency for All CLL Subgroups International Journal of Molecular Sciences doi: 10.3390/ijms20246277 Authors: Sarah Decker Anabel Zwick Shifa Khaja Saleem Sandra Kissel Andres Rettig Konrad Aumann Christine Dierks Preclinical drug development for human chronic lymphocytic leukemia (CLL) requires robust xenograft models recapitulating the entire spectrum...
Thu Dec 12, 2019 02:00
IJMS, Vol. 20, Pages 6273: Novel Insights into the Role of HDL-Associated Sphingosine-1-Phosphate in Cardiometabolic Diseases International Journal of Molecular Sciences doi: 10.3390/ijms20246273 Authors: Elena M. G. Diarte-Añazco Karen Alejandra Méndez-Lara Antonio Pérez Núria Alonso Francisco Blanco-Vaca Josep Julve Sphingolipids are key signaling molecules involved in the regulation of cell physiology. These species are found in tissues and in circulation. Although...
Thu Dec 12, 2019 02:00
IJMS, Vol. 20, Pages 6269: Less Cytotoxic Protoflavones as Antiviral Agents: Protoapigenone 1′-O-isopropyl ether Shows Improved Selectivity Against the Epstein–Barr Virus Lytic Cycle International Journal of Molecular Sciences doi: 10.3390/ijms20246269 Authors: Máté Vágvölgyi Gábor Girst Norbert Kúsz Sándor B. Ötvös Ferenc Fülöp Judit Hohmann Jean-Yves Servais Carole Seguin-Devaux Fang-Rong Chang Michael S. Chen Li-Kwan Chang Attila Hunyadi Protoflavones,...
Thu Dec 12, 2019 02:00
IJMS, Vol. 20, Pages 6270: Comparing and Contrasting the Multiple Roles of Butenolide Plant Growth Regulators: Strigolactones and Karrikins in Plant Development and Adaptation to Abiotic Stresses International Journal of Molecular Sciences doi: 10.3390/ijms20246270 Authors: Tao Yang Yuke Lian Chongying Wang Strigolactones (SLs) and karrikins (KARs) are both butenolide molecules that play essential roles in plant growth and development. SLs are phytohormones, with SLs having known...
Thu Dec 12, 2019 02:00
IJMS, Vol. 20, Pages 6268: Loss of p53 Sensitizes Cells to Palmitic Acid-Induced Apoptosis by Reactive Oxygen Species Accumulation International Journal of Molecular Sciences doi: 10.3390/ijms20246268 Authors: Guowu Yu Hongwei Luo Na Zhang Yongbin Wang Yangping Li Huanhuan Huang Yinghong Liu Yufeng Hu Hanmei Liu Junjie Zhang Yi Tang Yubi Huang Palmitic acid, the most common saturated free fatty acid, can lead to lipotoxicity and apoptosis when overloaded...
Thu Dec 12, 2019 02:00
IJMS, Vol. 20, Pages 6271: Biofilms Positively Contribute to Bacillus amyloliquefaciens 54-induced Drought Tolerance in Tomato Plants International Journal of Molecular Sciences doi: 10.3390/ijms20246271 Authors: Da-Cheng Wang Chun-Hao Jiang Li-Na Zhang Lin Chen Xiao-Yun Zhang Jian-Hua Guo Drought stress is a major obstacle to agriculture. Although many studies have reported on plant drought tolerance achieved via genetic modification, application of plant growth-promoting...
Thu Dec 12, 2019 02:00
IJMS, Vol. 20, Pages 6266: Forsythoside A and Forsythoside B Contribute to Shuanghuanglian Injection-Induced Pseudoallergic Reactions through the RhoA/ROCK Signaling Pathway International Journal of Molecular Sciences doi: 10.3390/ijms20246266 Authors: Jiayin Han Yushi Zhang Chen Pan Zhong Xian Chenling Pan Yong Zhao Chunying Li Yan Yi Lianmei Wang Jingzhuo Tian Suyan Liu Dunfang Wang Jing Meng Aihua Liang In recent years, hypersensitivity reactions...
Thu Dec 12, 2019 02:00
IJMS, Vol. 20, Pages 6267: The Microbiota and Cancer Cachexia International Journal of Molecular Sciences doi: 10.3390/ijms20246267 Authors: Kelly M. Herremans Andrea N. Riner Miles E. Cameron Jose G. Trevino Cancer cachexia is a multifactorial syndrome defined by weight loss, muscle wasting, and systemic inflammation. It affects the majority of patients with advanced cancer and is associated with poor treatment response, early mortality and decreased quality of life. The microbiota...
Thu Dec 12, 2019 02:00
IJMS, Vol. 20, Pages 6265: SLC38A10 (SNAT10) is Located in ER and Golgi Compartments and Has a Role in Regulating Nascent Protein Synthesis International Journal of Molecular Sciences doi: 10.3390/ijms20246265 Authors: Rekha Tripathi Kimia Hosseini Vasiliki Arapi Robert Fredriksson Sonchita Bagchi The solute carrier (SLC) family-38 of transporters has eleven members known to transport amino acids, with glutamine being a common substrate for ten of them, with SLC38A9 being...
Thu Dec 12, 2019 02:00
IJMS, Vol. 20, Pages 6264: Accuracy and Precision of the Receptorial Responsiveness Method (RRM) in the Quantification of A1 Adenosine Receptor Agonists International Journal of Molecular Sciences doi: 10.3390/ijms20246264 Authors: Adrienn Monika Szabo Gabor Viczjan Tamas Erdei Ildiko Simon Rita Kiss Andras Jozsef Szentmiklosi Bela Juhasz Csaba Papp Judit Zsuga Akos Pinter Zoltan Szilvassy Rudolf Gesztelyi The receptorial responsiveness method (RRM) is...
Thu Dec 12, 2019 02:00
JCM, Vol. 8, Pages 2219: Type 2 Diabetes Mellitus and Altered Immune System Leading to Susceptibility to Pathogens, Especially Mycobacterium tuberculosis Journal of Clinical Medicine doi: 10.3390/jcm8122219 Authors: Steve Ferlita Aram Yegiazaryan Navid Noori Gagandeep Lal Timothy Nguyen Kimberly To Vishwanath Venketaraman There has been an alarming increase in the incidence of Type 2 Diabetes Mellitus (T2DM) worldwide. Uncontrolled T2DM can lead to alterations in the...
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JCM, Vol. 8, Pages 2218: Prognostic Significance of Arterial Lactate Levels at Weaning from Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation Journal of Clinical Medicine doi: 10.3390/jcm8122218 Authors: Fausto Biancari Antonio Fiore Kristján Jónsson Giuseppe Gatti Svante Zipfel Vito G. Ruggieri Andrea Perrotti Karl Bounader Antonio Loforte Andrea Lechiancole Diyar Saeed Artur Lichtenberg Marek Pol Cristiano Spadaccio Matteo Pettinari...
Sun Dec 15, 2019 02:00
JCM, Vol. 8, Pages 2217: Identification of Diagnostic and Prognostic microRNAs for Recurrent Vitreous Hemorrhage in Patients with Proliferative Diabetic Retinopathy Journal of Clinical Medicine doi: 10.3390/jcm8122217 Authors: Parviz Mammadzada Juliette Bayle Johann Gudmundsson Anders Kvanta Helder André MicroRNAs (miRNAs) can provide insight into the pathophysiological states of ocular tissues such as proliferative diabetic retinopathy (PDR). In this study, differences in...
Sun Dec 15, 2019 02:00
JCM, Vol. 8, Pages 2216: Circadian Activity Rhythm in Early Relapsing–Remitting Multiple Sclerosis Journal of Clinical Medicine doi: 10.3390/jcm8122216 Authors: Lorenzo Tonetti Federico Camilli Sara Giovagnoli Vincenzo Natale Alessandra Lugaresi While relapsing–remitting is the most prevalent course of multiple sclerosis, the prognostic/predictive markers of the worsening of symptomatology are still debated. With reference to other diseases, the study of the circadian...
Sun Dec 15, 2019 02:00
JCM, Vol. 8, Pages 2210: Erastin Inhibits Septic Shock and Inflammatory Gene Expression via Suppression of the NF-κB Pathway Journal of Clinical Medicine doi: 10.3390/jcm8122210 Authors: Byung Moo Oh Seon-Jin Lee Gyoung Lim Park Yo Sep Hwang Jeewon Lim Eun Sun Park Kyung Ho Lee Bo Yeon Kim Yong Tae Kwon Hee Jun Cho Hee Gu Lee Sepsis is a life-threatening condition that is caused by an abnormal immune response to infection and can lead to tissue damage, organ...
Sat Dec 14, 2019 02:00
JCM, Vol. 8, Pages 2211: 1,25(OH)2D3 Differently Affects Immunomodulatory Activities of Mesenchymal Stem Cells Depending on the Presence of TNF-α, IL-1β and IFN-γ Journal of Clinical Medicine doi: 10.3390/jcm8122211 Authors: Christian Behm Alice Blufstein Johannes Gahn Barbara Kubin Michael Nemec Andreas Moritz Xiaohui Rausch-Fan Oleh Andrukhov Periodontal ligament-derived mesenchymal stem cells (hPDLSCs) possess immunomodulatory abilities which are strongly enhanced...
Sat Dec 14, 2019 02:00
JCM, Vol. 8, Pages 2214: Liposomal Lapatinib in Combination with Low-Dose Photodynamic Therapy for the Treatment of Glioma Journal of Clinical Medicine doi: 10.3390/jcm8122214 Authors: Carl Fisher Girgis Obaid Carolyn Niu Warren Foltz Alyssa Goldstein Tayyaba Hasan Lothar Lilge Background: Malignant gliomas are highly invasive and extremely difficult to treat tumours with poor prognosis and outcomes. Photodynamic therapy (PDT), mediated by Gleolan®, has been...
Sat Dec 14, 2019 02:00
JCM, Vol. 8, Pages 2212: Impact of Positive Airway Pressure on International Restless Legs Syndrome Score in Sleep Disordered Breathing Journal of Clinical Medicine doi: 10.3390/jcm8122212 Authors: Seetha Lakshmanan Nicolas R. Thompson Maeve Pascoe Reena Mehra Nancy Foldvary-Schaefer Irene L. Katzan Harneet K. Walia Study Objective: Studies have shown increased prevalence of restless legs syndrome (RLS) in sleep disordered breathing (SDB), however limited data have...
Sat Dec 14, 2019 02:00
JCM, Vol. 8, Pages 2213: Leptin Modulates the Expression of miRNAs-Targeting POMC mRNA by the JAK2-STAT3 and PI3K-Akt Pathways Journal of Clinical Medicine doi: 10.3390/jcm8122213 Authors: Adel Derghal Julien Astier Flavie Sicard Charlène Couturier Jean-François Landrier Lourdes Mounien The central control of energy balance involves a strongly regulated neuronal network within the hypothalamus and the brainstem. In these structures, pro-opiomelanocortin (POMC) neurons...
Sat Dec 14, 2019 02:00
JCM, Vol. 8, Pages 2215: The Incidence of Chronic Kidney Disease Three Years after Non-Severe Acute Kidney Injury in Critically Ill Patients: A Single-Center Cohort Study Journal of Clinical Medicine doi: 10.3390/jcm8122215 Authors: Sébastien Rubin Arthur Orieux Benjamin Clouzeau Claire Rigothier Christian Combe Didier Gruson Alexandre Boyer The risk of chronic kidney disease (CKD) following severe acute kidney injury (AKI) in critically ill patients is well documented,...
Sat Dec 14, 2019 02:00
JCM, Vol. 8, Pages 2207: Mesenchymal Stem/Stromal Cell Production Compliant with Good Manufacturing Practice: Comparison between Bone Marrow, the Gold Standard Adult Source, and Wharton’s Jelly, an Extraembryonic Source Journal of Clinical Medicine doi: 10.3390/jcm8122207 Authors: Caroline Laroye Mélanie Gauthier Hélène Antonot Véronique Decot Loïc Reppel Danièle Bensoussan Many clinical trials report mesenchymal stem/stromal cells (MSCs) efficacy in various indications....
Sat Dec 14, 2019 02:00
JCM, Vol. 8, Pages 2209: Aortic Valvular Disease in Elderly Subjects with Heterozygous Familial Hypercholesterolemia: Impact of Lipid-Lowering Therapy Journal of Clinical Medicine doi: 10.3390/jcm8122209 Authors: Victoria Marco-Benedí Martin Laclaustra Juan M. Casado-Dominguez Rosa Villa-Pobo Rocío Mateo-Gallego Rosa M. Sánchez-Hernández Marta Blanco Nuez Emilio Ortega-Martínez de Victoria Marta Sitges Juan Pedro-Botet Jose Puzo Teresa Villarroel Fernando...
Sat Dec 14, 2019 02:00
JCM, Vol. 8, Pages 2208: Near-Infrared Spectroscopy Monitoring in Cardiac and Noncardiac Surgery: Pairwise and Network Meta-Analyses Journal of Clinical Medicine doi: 10.3390/jcm8122208 Authors: Christian Ortega-Loubon Francisco Herrera-Gómez Coralina Bernuy-Guevara Pablo Jorge-Monjas Carlos Ochoa-Sangrador Juan Bustamante-Munguira Eduardo Tamayo F. Javier Álvarez Goal-directed therapy based on brain-oxygen saturation (bSo2) is controversial and hotly debated. While...
Sat Dec 14, 2019 02:00
JCM, Vol. 8, Pages 2206: The Level of FGF 21 as a New Risk Factor for the Occurrence of Cardiometabolic Disorders amongst the Psoriatic Patients Journal of Clinical Medicine doi: 10.3390/jcm8122206 Authors: Kiluk Baran Kaminski Maciaszek Flisiak Fibroblast growth factors 21 and 23 are used as markers of cardiometabolic disorders which are common comorbidities in psoriasis. The study aimed to evaluate the serum level of these factors in psoriatic patients and elucidate...
Fri Dec 13, 2019 02:00
JCM, Vol. 8, Pages 2204: Testicular Function of Childhood Cancer Survivors: Who Is Worse? Journal of Clinical Medicine doi: 10.3390/jcm8122204 Authors: Ylenia Duca Andrea Di Cataldo Giovanna Russo Emanuela Cannata Giovanni Burgio Michele Compagnone Angela Alamo Rosita A. Condorelli Sandro La Vignera Aldo E. Calogero Background: A multi-disciplinary approach has led to an improvement in prognosis of childhood cancers. However, in parallel with the increase in...
Fri Dec 13, 2019 02:00
JCM, Vol. 8, Pages 2205: New Targeted Gold Nanorods for the Treatment of Glioblastoma by Photodynamic Therapy Journal of Clinical Medicine doi: 10.3390/jcm8122205 Authors: Youssef Yesmurzayeva Larue Jouan-Hureaux Colombeau Arnoux Acherar Vanderesse Frochot This study describes the employment of gold nanorods (AuNRs), known for their good reputation in hyperthermia-based cancer therapy, in a hybrid combination of photosensitizers (PS) and peptides (PP)....
Fri Dec 13, 2019 02:00
JCM, Vol. 8, Pages 2201: Altered Bioenergetics of Blood Cell Sub-Populations in Acute Pancreatitis Patients Journal of Clinical Medicine doi: 10.3390/jcm8122201 Authors: Jack C. Morton Jane A. Armstrong Ajay Sud Alexei V. Tepikin Robert Sutton David N. Criddle Acute pancreatitis (AP) is a debilitating, sometimes fatal disease, marked by local injury and systemic inflammation. Mitochondrial dysfunction is a central feature of pancreatic damage in AP, however, its involvement...
Fri Dec 13, 2019 02:00
JCM, Vol. 8, Pages 2202: Management of Refeeding Syndrome in Medical Inpatients Journal of Clinical Medicine doi: 10.3390/jcm8122202 Authors: Emilie Reber Natalie Friedli Maria F. Vasiloglou Philipp Schuetz Zeno Stanga Refeeding syndrome (RFS) is the metabolic response to the switch from starvation to a fed state in the initial phase of nutritional therapy in patients who are severely malnourished or metabolically stressed due to severe illness. It is characterized by increased...
Fri Dec 13, 2019 02:00
JCM, Vol. 8, Pages 2203: Hyperprolactinaemia Journal of Clinical Medicine doi: 10.3390/jcm8122203 Authors: Irene Samperi Kirstie Lithgow Niki Karavitaki Hyperprolactinaemia is one of the most common problems in clinical endocrinology. It relates with various aetiologies (physiological, pharmacological, pathological), the clarification of which requires careful history taking and clinical assessment. Analytical issues (presence of macroprolactin or of the hook effect) need to be...
Fri Dec 13, 2019 02:00
JCM, Vol. 8, Pages 2200: Paraoxonase-1 Serum Concentration and PON1 Gene Polymorphisms: Relationship with Non-Alcoholic Fatty Liver Disease Journal of Clinical Medicine doi: 10.3390/jcm8122200 Authors: Mircea Vasile Milaciu Ștefan Cristian Vesa Ioana Corina Bocșan Lorena Ciumărnean Dorel Sâmpelean Vasile Negrean Raluca Maria Pop Daniela Maria Matei Sergiu Pașca Andreea Liana Răchișan Anca Dana Buzoianu Monica Acalovschi Background: Non-alcoholic fatty...
Fri Dec 13, 2019 02:00
JCM, Vol. 8, Pages 2199: MicroRNAs as Therapeutic Targets and Clinical Biomarkers in Atherosclerosis
JCM, Vol. 8, Pages 2199: MicroRNAs as Therapeutic Targets and Clinical Biomarkers in Atherosclerosis Journal of Clinical Medicine doi: 10.3390/jcm8122199 Authors: Emma L. Solly Catherine G. Dimasi Christina A. Bursill Peter J. Psaltis Joanne T. M. Tan Atherosclerotic cardiovascular disease remains the leading cause of morbidity and mortality worldwide. Atherosclerosis develops over several decades and is mediated by a complex interplay of cellular mechanisms that drive a...
Fri Dec 13, 2019 02:00
JCM, Vol. 8, Pages 2198: Development of Prodrugs for PDT-Based Combination Therapy Using a Singlet-Oxygen-Sensitive Linker and Quantitative Systems Pharmacology Journal of Clinical Medicine doi: 10.3390/jcm8122198 Authors: Luong Nguyen Mengjie Li Sukyung Woo Youngjae You Photodynamic therapy (PDT) has become an effective treatment for certain types of solid tumors. The combination of PDT with other therapies has been extensively investigated in recent years to improve its effectiveness...
Fri Dec 13, 2019 02:00
JCM, Vol. 8, Pages 2197: Ceramide Content in Liver Increases Along with Insulin Resistance in Obese Patients Journal of Clinical Medicine doi: 10.3390/jcm8122197 Authors: Razak Hady Błachnio-Zabielska Szczerbiński Zabielski Imierska Dadan Krętowski The liver plays a central role in the glucose and lipid metabolism. Studies performed on animal models have shown an important role of lipid accumulation in the induction of insulin resistance. We sought to explain...
Thu Dec 12, 2019 02:00
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