IJMS, Vol. 20, Pages 6317: Comparative Proteomic Analysis of Pleurotus ostreatus Reveals Great Metabolic Differences in the Cap and Stipe Development and the Potential Role of Ca2+ in the Primordium Differentiation International Journal of Molecular Sciences doi: 10.3390/ijms20246317 Authors: Weiwei Zhu Jinbo Hu Yang Li Bing Yang Yanli Guan Chong Xu Fei Chen Jingliang Chi Yongming Bao Pleurotus ostreatus is a widely cultivated edible fungus around the world. At...
Sat Dec 14, 2019 02:00
IJMS, Vol. 20, Pages 6315: Cadmium and Lead Decrease Cell–Cell Aggregation and Increase Migration and Invasion in Renca Mouse Renal Cell Carcinoma Cells International Journal of Molecular Sciences doi: 10.3390/ijms20246315 Authors: Ryan Akin David Hannibal Margaret Loida Emily M. Stevens Elizabeth A. Grunz-Borgmann Alan R. Parrish Metastatic renal cell carcinoma (RCC) remains an important clinical issue; the 5-year survival rate of patients with metastasis is approximately...
Sat Dec 14, 2019 02:00
IJMS, Vol. 20, Pages 6314: Salacia chinensis L. Stem Extract Exerts Antifibrotic Effects on Human Hepatic Stellate Cells Through the Inhibition of the TGF-β1-Induced SMAD2/3 Signaling Pathway International Journal of Molecular Sciences doi: 10.3390/ijms20246314 Authors: Phaosri Jantrapirom Takuathung Soonthornchareonnon Sireeratawong Buacheen Pitchakarn Nimlamool Potikanond : Salacia chinensis L. (SC) stems have been used as an ingredient in Thai traditional...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6313: Transthyretin Upregulates Long Non-Coding RNA MEG3 by Affecting PABPC1 in Diabetic Retinopathy International Journal of Molecular Sciences doi: 10.3390/ijms20246313 Authors: Fan Gu Zhang Xin Shao Giampieri Battino The aim of the study was to demonstrate how transthyretin (TTR) could affect long non-coding RNA (lncRNA) of maternally expressed gene 3 (MEG3) and play important roles in diabetic retinopathy (DR). A DR model in C57BL/6 mice...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6312: Applicability of Anti-Human Estrogen Receptor β Antibody PPZ0506 for the Immunodetection of Rodent Estrogen Receptor β Proteins International Journal of Molecular Sciences doi: 10.3390/ijms20246312 Authors: Hirotaka Ishii Mai Otsuka Moeko Kanaya Shimpei Higo Yujiro Hattori Hitoshi Ozawa Several lines of controversial evidence concerning estrogen receptor β (ERβ) remain to be solved because of the unavailability of specific antibodies...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6311: Acupuncture Reduces Apoptosis of Granulosa Cells in Rats with Premature Ovarian Failure Via Restoring the PI3K/Akt Signaling Pathway International Journal of Molecular Sciences doi: 10.3390/ijms20246311 Authors: Shiqi Wang Shujun Lin Mingmin Zhu Chenglu Li Shulian Chen Liu Pu Jihuan Lin Luxi Cao Yimin Zhang Acupuncture is widely recognized as an effective therapy for premature ovarian failure (POF) in clinical, but information about...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6309: ER Stress Induces Cell Cycle Arrest at the G2/M Phase Through eIF2α Phosphorylation and GADD45α International Journal of Molecular Sciences doi: 10.3390/ijms20246309 Authors: Duckgue Lee Daniel Hokinson Soyoung Park Rosalie Elvira Fedho Kusuma Ji-Min Lee Miyong Yun Seok-Geun Lee Jaeseok Han Endoplasmic reticulum (ER) stress is known to influence various cellular functions, including cell cycle progression. Although it is well known how...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6310: Screening of Cellular Stress Responses Induced by Ambient Aerosol Ultrafine Particle Fraction PM0.5 in A549 Cells International Journal of Molecular Sciences doi: 10.3390/ijms20246310 Authors: Pavlína Šimečková Soňa Marvanová Pavel Kulich Lucie Králiková Jiří Neča Jiřina Procházková Miroslav Machala Effects of airborne particles on the expression status of markers of cellular toxic stress and on the release of eicosanoids, linked with inflammation...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6308: Reductive Activity and Mechanism of Hypoxia- Targeted AGT Inhibitors: An Experimental and Theoretical Investigation International Journal of Molecular Sciences doi: 10.3390/ijms20246308 Authors: Weinan Xiao Guohui Sun Tengjiao Fan Junjun Liu Na Zhang Lijiao Zhao Rugang Zhong O6-alkylguanine-DNA alkyltransferase (AGT) is the main cause of tumor cell resistance to DNA-alkylating agents, so it is valuable to design tumor-targeted AGT inhibitors...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6306: Conjugates of Gold Nanoparticles and Antitumor Gold(III) Complexes as a Tool for Their AFM and SERS Detection in Biological Tissue International Journal of Molecular Sciences doi: 10.3390/ijms20246306 Authors: Aleksandra M. Bondžić Andreja R. Leskovac Sandra Ž. Petrović Dragana D. Vasić Anićijević Marco Luce Lara Massai Amanda Generosi Barbara Paci Antonio Cricenti Luigi Messori Vesna M. Vasić Citrate-capped gold nanoparticles...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6307: Analysis of EYA3 Phosphorylation by Src Kinase Identifies Residues Involved in Cell Proliferation International Journal of Molecular Sciences doi: 10.3390/ijms20246307 Authors: Aura E. Ionescu Mihaela Mentel Cristian V.A. Munteanu Livia E. Sima Eliza C. Martin Georgiana Necula-Petrareanu Stefan E. Szedlacsek Eyes absent (EYA) are non-thiol-based protein tyrosine phosphatases (PTPs) that also have transcriptional co-activator functions. Their...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6305: The Challenge of Bringing iPSCs to the Patient International Journal of Molecular Sciences doi: 10.3390/ijms20246305 Authors: María del Carmen Ortuño-Costela Victoria Cerrada Marta García-López M. Esther Gallardo The implementation of induced pluripotent stem cells (iPSCs) in biomedical research more than a decade ago, resulted in a huge leap forward in the highly promising area of personalized medicine. Nowadays, we are even closer to the patient...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6303: Mitochondrial Bioenergetics in Brain Following Ozone Exposure in Rats Maintained on Coconut, Fish and Olive Oil-Rich Diets International Journal of Molecular Sciences doi: 10.3390/ijms20246303 Authors: Matthew C. Valdez Danielle Freeborn Joseph M. Valdez Andrew F.M. Johnstone Samantha J. Snow Alan H. Tennant Urmila P. Kodavanti Prasada Rao S. Kodavanti Dietary supplementation with omega-3 and omega-6 fatty acids offer cardioprotection against...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6304: Strategies for Molecular Imprinting and the Evolution of MIP Nanoparticles as Plastic Antibodies—Synthesis and Applications International Journal of Molecular Sciences doi: 10.3390/ijms20246304 Authors: Doaa Refaat Mohamed G. Aggour Ahmed A. Farghali Rashmi Mahajan Jesper G. Wiklander Ian A. Nicholls Sergey A. Piletsky Materials that can mimic the molecular recognition-based functions found in biology are a significant goal for science and...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6301: 4-methylumbelliferone Prevents Liver Fibrosis by Affecting Hyaluronan Deposition, FSTL1 Expression and Cell Localization International Journal of Molecular Sciences doi: 10.3390/ijms20246301 Authors: Irina N. Andreichenko Alexandra A. Tsitrina Alexander V. Fokin Adelya I. Gabdulkhakova Dmitry I. Maltsev Grigorii S. Perelman Elena V. Bulgakova Alexey M. Kulikov Arsen S. Mikaelyan Yuri V. Kotelevtsev 4-methylumbelliferone (4MU) is an...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6298: Epigenetic Modification as a Regulatory Mechanism for Spatiotemporal Dynamics of ANO1 Expression in Salivary Glands International Journal of Molecular Sciences doi: 10.3390/ijms20246298 Authors: Yonghwan Shin Sang-Woo Lee Eun Namkoong Woojin An Jong-Ho Lee Peter D Brown Kyungpyo Park Anoctamin1 (ANO1), a calcium activated chloride channel, is known to play a critical role in salivary secretion. In the salivary gland, ANO1 is expressed exclusively...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6296: Irradiated Human Fibroblasts as a Substitute Feeder Layer to Irradiated Mouse 3T3 for the Culture of Human Corneal Epithelial Cells: Impact on the Stability of the Transcription Factors Sp1 and NFI International Journal of Molecular Sciences doi: 10.3390/ijms20246296 Authors: Gaëtan Le-Bel Sergio Cortez Ghio Louis-Philippe Guérin Francis Bisson Lucie Germain Sylvain L. Guérin Because of the worldwide shortage of graftable corneas, alternatives...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6302: A Novel Hepatic Anti-Fibrotic Strategy Utilizing the Secretome Released from Etanercept-Synthesizing Adipose-Derived Stem Cells International Journal of Molecular Sciences doi: 10.3390/ijms20246302 Authors: Jae Hyun Han Ok-Hee Kim Sang Chul Lee Kee-Hwan Kim Jung Hyun Park Jae Im Lee Kyung Hee Lee Ha-Eun Hong Haeyeon Seo Ho Joong Choi Ji Hyeon Ju Say-June Kim Tumor necrosis factor-α (TNF-α)-driven inflammatory...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6299: O-GlcNAc Transferase Regulates Angiogenesis in Idiopathic Pulmonary Arterial Hypertension International Journal of Molecular Sciences doi: 10.3390/ijms20246299 Authors: Jarrod W. Barnes Liping Tian Stefanie Krick E. Scott Helton Rebecca S. Denson Suzy A. A. Comhair Raed A. Dweik Idiopathic pulmonary arterial hypertension (IPAH) is considered a vasculopathy characterized by elevated pulmonary vascular resistance due to vasoconstriction and/or...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6297: Antibacterial, Antibiofilm, and Antiadhesive Properties of Different Quaternized Chitosan Derivatives International Journal of Molecular Sciences doi: 10.3390/ijms20246297 Authors: Anna Maria Piras Semih Esin Arianna Benedetti Giuseppantonio Maisetta Angela Fabiano Ylenia Zambito Giovanna Batoni In the era of antimicrobial resistance, the identification of new antimicrobials is a research priority at the global level. In this regard, the attention...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6293: Pre-Treatment with Ten-Minute Carbon Dioxide Inhalation Prevents Lipopolysaccharide-Induced Lung Injury in Mice via Down-Regulation of Toll-Like Receptor 4 Expression International Journal of Molecular Sciences doi: 10.3390/ijms20246293 Authors: Shih-En Tang Shu-Yu Wu Shi-Jye Chu Yuan-Sheng Tzeng Chung-Kan Peng Chou-Chin Lan Wann-Cherng Perng Chin-Pyng Wu Kun-Lun Huang Various animal studies have shown beneficial effects of hypercapnia...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6300: The Roles of Indian Hedgehog Signaling in TMJ Formation International Journal of Molecular Sciences doi: 10.3390/ijms20246300 Authors: Till E. Bechtold Naito Kurio Hyun-Duck Nah Cheri Saunders Paul C. Billings Eiki Koyama The temporomandibular joint (TMJ) is an intricate structure composed of the mandibular condyle, articular disc, and glenoid fossa in the temporal bone. Apical condylar cartilage is classified as a secondary cartilage, is fibrocartilaginous...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6294: High Mobility Group Box 1 and TLR4 Signaling Pathway in Gnotobiotic Piglets Colonized/Infected with L. amylovorus, L. mucosae, E. coli Nissle 1917 and S. Typhimurium International Journal of Molecular Sciences doi: 10.3390/ijms20246294 Authors: Igor Splichal Sharon M. Donovan Vera Jenistova Iva Splichalova Hana Salmonova Eva Vlkova Vera Neuzil Bunesova Marek Sinkora Jiri Killer Eva Skrivanova Alla Splichalova High mobility group...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6292: Detection of ALDH3B2 in Human Placenta International Journal of Molecular Sciences doi: 10.3390/ijms20246292 Authors: Sylwia Michorowska Joanna Giebułtowicz Renata Wolinowska Anna Konopka Anna Wilkaniec Paweł Krajewski Ewa Bulska Piotr Wroczyński Aldehyde dehydrogenase 3B2 (ALDH3B2) gene contains a premature termination codon, which can be skipped or suppressed resulting in full-length protein expression. Alternatively, the longest putative...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6295: Thermo-Responsive Polymer Brushes with Side Graft Chains: Relationship Between Molecular Architecture and Underwater Adherence International Journal of Molecular Sciences doi: 10.3390/ijms20246295 Authors: Ugo Sidoli Hisaschi T. Tee Ivan Raguzin Jakob Mühldorfer Frederik R. Wurm Alla Synytska During the last few decades, wet adhesives have been developed for applications in various fields. Nonetheless, key questions such as the most suitable...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6291: High-Energy Diet and Shorter Light Exposure Drives Markers of Adipocyte Dysfunction in Visceral and Subcutaneous Adipose Depots of Psammomys obesus International Journal of Molecular Sciences doi: 10.3390/ijms20246291 Authors: Joanne T.M. Tan Victoria A. Nankivell Carmel Bilu Tomer Shemesh Stephen J. Nicholls Paul Zimmet Noga Kronfeld-Schor Alex Brown Christina A. Bursill Dysfunctional adipose tissue phenotype underpins type 2 diabetes...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6290: Genome-Wide Analysis of Whole Human Glycoside Hydrolases by Data-Driven Analysis in Silico International Journal of Molecular Sciences doi: 10.3390/ijms20246290 Authors: Takahiro Nakamura Muhamad Fahmi Jun Tanaka Kaito Seki Yukihiro Kubota Masahiro Ito Glycans are involved in various metabolic processes via the functions of glycosyltransferases and glycoside hydrolases. Analysing the evolution of these enzymes is essential for improving the understanding...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6288: Alteration of GABAergic Input Precedes Neurodegeneration of Cerebellar Purkinje Cells of NPC1-Deficient Mice International Journal of Molecular Sciences doi: 10.3390/ijms20246288 Authors: Michael Rabenstein Nico Murr Andreas Hermann Arndt Rolfs Moritz J. Frech Niemann-Pick Disease Type C1 (NPC1) is a rare hereditary neurodegenerative disease belonging to the family of lysosomal storage disorders. NPC1-patients suffer from, amongst other symptoms,...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6287: The Zebrafish (Danio rerio) Is a Relevant Model for Studying Sex-Specific Effects of 17β-Estradiol in the Adult Heart International Journal of Molecular Sciences doi: 10.3390/ijms20246287 Authors: Selina Hein David Hassel Georgios Kararigas Cardiovascular diseases are a major cause of morbidity and mortality, and there are significant sex differences therein. However, the underlying mechanisms are poorly understood. The steroid hormone 17β-estradiol...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6289: Peptides, Antibodies, Peptide Antibodies and More International Journal of Molecular Sciences doi: 10.3390/ijms20246289 Authors: Nicole Trier Paul Hansen Gunnar Houen The applications of peptides and antibodies to multiple targets have emerged as powerful tools in research, diagnostics, vaccine development, and therapeutics. Antibodies are unique since they, in theory, can be directed to any desired target, which illustrates their versatile nature and...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6285: Expression Profile of the Chromosome 14 MicroRNA Cluster (C14MC) Ortholog in Equine Maternal Circulation throughout Pregnancy and Its Potential Implications International Journal of Molecular Sciences doi: 10.3390/ijms20246285 Authors: Pouya Dini Hossam El-Sheikh Ali Mariano Carossino Shavahn C. Loux A. Esteller-Vico Kirsten E. Scoggin Peter Daels Barry A. Ball Equine chromosome 24 microRNA cluster (C24MC), the ortholog of human C14MC,...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6286: Usefulness of Mesenchymal Cell Lines for Bone and Cartilage Regeneration Research International Journal of Molecular Sciences doi: 10.3390/ijms20246286 Authors: M. Piñeiro-Ramil C. Sanjurjo-Rodríguez R. Castro-Viñuelas S. Rodríguez-Fernández I.M. Fuentes-Boquete F.J. Blanco S.M. Díaz-Prado The unavailability of sufficient numbers of human primary cells is a major roadblock for in vitro repair of bone and/or cartilage, and for performing disease...
Fri Dec 13, 2019 02:00
IJMS, Vol. 20, Pages 6284: Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms International Journal of Molecular Sciences doi: 10.3390/ijms20246284 Authors: Dae Yun Seo Jeong Rim Ko Jung Eun Jang Tae Nyun Kim Jae Boum Youm Hyo-Bum Kwak Jun Hyun Bae Amy Hyein Kim Kyung Soo Ko Byoung Doo Rhee Jin Han Diabetes mellitus is associated with cardiovascular, ophthalmic, and renal comorbidities. Among these,...
Thu Dec 12, 2019 02:00
IJMS, Vol. 20, Pages 6283: Genetic Programs Driving Oncogenic Transformation: Lessons from in Vitro Models International Journal of Molecular Sciences doi: 10.3390/ijms20246283 Authors: Giorgio Paluvai Picco Brancolini Cancer complexity relies on the intracellular pleiotropy of oncogenes/tumor suppressors and in the strong interplay between tumors and micro- and macro-environments. Here we followed a reductionist approach, by analyzing the transcriptional adaptations induced...
Thu Dec 12, 2019 02:00
IJMS, Vol. 20, Pages 6281: The Mechanism of Bisphenol A Atherogenicity Involves Apolipoprotein A-I Downregulation through NF-κB Activation International Journal of Molecular Sciences doi: 10.3390/ijms20246281 Authors: Trusca Dumitrescu Fenyo Tudorache Simionescu Gafencu Apolipoprotein A-I (apoA-I) is the major protein component of high-density lipoproteins (HDL), mediating many of its atheroprotective properties. Increasing data reveal the pro-atherogenic effects...
Thu Dec 12, 2019 02:00
IJMS, Vol. 20, Pages 6280: Effects of Farnesiferol B on Ischemia-Reperfusion-Induced Renal Damage, Inflammation, and NF-κB Signaling International Journal of Molecular Sciences doi: 10.3390/ijms20246280 Authors: Lu Zhang Xianjun Fu Ting Gui Tianqi Wang Zhenguo Wang Gerd A. Kullak-Ublick Zhibo Gai Background: G-protein-coupled bile acid receptor (TGR5), a membrane bile acid receptor, regulates macrophage reactivity, and attenuates inflammation in different disease models....
Thu Dec 12, 2019 02:00
IJMS, Vol. 20, Pages 6282: Resveratrol Treatment Enhances the Cellular Response to Leptin by Increasing OBRb Content in Palmitate-Induced Steatotic HepG2 Cells International Journal of Molecular Sciences doi: 10.3390/ijms20246282 Authors: Andrea Ardid-Ruiz Maria Ibars Pedro Mena Daniele Del Rio Begoña Muguerza Lluís Arola Gerard Aragonès Manuel Suárez The interaction of leptin with its hepatic longest receptor (OBRb) promotes the phosphorylation of signal transducer...
Thu Dec 12, 2019 02:00
IJMS, Vol. 20, Pages 6279: Structural Insights into the Intracellular Region of the Human Magnesium Transport Mediator CNNM4 International Journal of Molecular Sciences doi: 10.3390/ijms20246279 Authors: Paula Giménez-Mascarell Iker Oyenarte Irene González-Recio Carmen Fernández-Rodríguez María Ángeles Corral-Rodríguez Igone Campos-Zarraga Jorge Simón Elie Kostantin Serge Hardy Antonio Díaz Quintana Mara Zubillaga Lizeaga Nekane Merino Tammo Diercks Francisco...
Thu Dec 12, 2019 02:00
IJMS, Vol. 20, Pages 6278: Combined De Novo Transcriptome and Metabolome Analysis of Common Bean Response to Fusarium oxysporum f. sp. phaseoli Infection International Journal of Molecular Sciences doi: 10.3390/ijms20246278 Authors: Limin Chen Quancong Wu Weimin He Tianjun He Qianqian Wu Yeminzi Miao Molecular changes elicited by common bean (Phaseolus vulgaris L.) in response to Fusarium oxysproum f. sp. Phaseoli (FOP) remain elusive. We studied the changes in root metabolism...
Thu Dec 12, 2019 02:00
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