Cancers, Vol. 12, Pages 279: Metabolism of Estrogens: Turnover Differs Between Platinum-Sensitive and -Resistant High-Grade Serous Ovarian Cancer Cells Cancers doi: 10.3390/cancers12020279 Authors: Poschner Wackerlig Castillo-Tong Wolf Decken Rižner Pavlič Meshcheryakova Mechtcheriakova Fritzer-Szekeres Thalhammer Jäger High-grade serous ovarian cancer (HGSOC) is currently treated with cytoreductive surgery and platinum-based chemotherapy....
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Cancers, Vol. 12, Pages 277: Differential Dependency of Human Pancreatic Cancer Cells on Targeting PTEN via PLK 1 Expression Cancers doi: 10.3390/cancers12020277 Authors: Lee Lee Sim Kim Even though the tumour suppressive role of PTEN is well-known, its prognostic implications are ambiguous. The objective of this study was to further explore the function of PTEN expression in human pancreatic cancer. The expression of PTEN has been dominant in various human cancers including...
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Cancers, Vol. 12, Pages 280: Targeting NRF2-Governed Glutathione Synthesis for SDHB-Mutated Pheochromocytoma and Paraganglioma Cancers doi: 10.3390/cancers12020280 Authors: Liu Pang Caisova Ding Yu Zhou Huynh Ghayee Pacak Yang Succinate dehydrogenase subunit B (SDHB) deficiency frequently occurs in cluster I pheochromocytomas and paragangliomas (PCPGs). SDHB-mutated PCPGs are characterized by alterations in the electron transport chain, metabolic...
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Cancers, Vol. 12, Pages 278: CD44 Targeting Mediated by Polymeric Nanoparticles and Combination of Chlorine TPCS2a-PDT and Docetaxel-Chemotherapy for Efficient Killing of Breast Differentiated and Stem Cancer Cells In Vitro Cancers doi: 10.3390/cancers12020278 Authors: Gaio Conte Esposito Reddi Quaglia Moret The presence of rare but highly tumorigenic cancer stem cells (CSCs) within the tumors is recognized as one of the major reasons of failure of conventional chemotherapies,...
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Cancers, Vol. 12, Pages 281: Reply to Comment on “Malfitano, A.M. et al. Virotherapy as a Potential Therapeutic Approach for the Treatment of Aggressive Thyroid Cancer” Cancers 2019, 11, 1532 Cancers doi: 10.3390/cancers12020281 Authors: Malfitano Di Somma Prevete Portella Our work is focused on the future clinical use of oncolytic viruses (OVs) for the treatment of aggressive thyroid carcinomas. Therefore, we provide a brief description of the overall use of OVs in the...
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Cells, Vol. 9, Pages 279: Synthetic 4-Hydroxy Auxarconjugatin B, a Novel Autophagy Inducer, Attenuates Gouty Inflammation by Inhibiting the NLRP3 Inflammasome Cells doi: 10.3390/cells9020279 Authors: Hsieh Li Lam Fang Gan Rao Chiu Wong Ju Chen Chernikov Liu Hsu Hua Gouty arthritis results from the generation of uric acid crystals within the joints. These uric acid crystals activate the NACHT, LRR and PYD domains-containing protein...
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Cells, Vol. 9, Pages 277: Norrin Protects Retinal Ganglion Cells from Excitotoxic Damage via the Induction of Leukemia Inhibitory Factor Cells doi: 10.3390/cells9020277 Authors: Kassumeh Leopold Fuchshofer Thomas Priglinger Tamm Ohlmann Purpose: To investigate whether and how leukemia inhibitory factor (Lif) is involved in mediating the neuroprotective effects of Norrin on retinal ganglion cells (RGC) following excitotoxic damage. Norrin is a secreted protein...
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Cells, Vol. 9, Pages 280: The Role of Bone Morphogenetic Protein 7 (BMP-7) in Inflammation in Heart Diseases Cells doi: 10.3390/cells9020280 Authors: Aluganti Narasimhulu Singla Bone morphogenetic protein-7 is (BMP-7) is a potent anti-inflammatory growth factor belonging to the Transforming Growth Factor Beta (TGF-β) superfamily. It plays an important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. BMP-7...
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Cells, Vol. 9, Pages 278: Regulation of the Extracellular Matrix by Ciliary Machinery Cells doi: 10.3390/cells9020278 Authors: Collins Wann The primary cilium is an organelle involved in cellular signalling. Mutations affecting proteins involved in cilia assembly or function result in diseases known as ciliopathies, which cause a wide variety of phenotypes across multiple tissues. These mutations disrupt various cellular processes, including regulation of the extracellular matrix....
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Cells, Vol. 9, Pages 276: miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis Cells doi: 10.3390/cells9020276 Authors: Condrat Thompson Barbu Bugnar Boboc Cretoiu Suciu Cretoiu Voinea MicroRNAs (miRNAs) represent a class of small, non-coding RNAs with the main roles of regulating mRNA through its degradation and adjusting protein levels. In recent years, extraordinary progress has been made in terms of identifying...
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Cells, Vol. 9, Pages 281: Glycochenodeoxycholate Promotes Liver Fibrosis in Mice with Hepatocellular Cholestasis Cells doi: 10.3390/cells9020281 Authors: Hohenester Kanitz Kremer Paulusma Wimmer Kuehn Denk Horst Elferink Beuers Hydrophobic bile salts are considered to promote liver fibrosis in cholestasis. However, evidence for this widely accepted hypothesis remains scarce. In established animal models of cholestasis, e.g., by Mdr2 knockout, cholestasis...
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IJERPH, Vol. 17, Pages 737: Establishment of an Automatic Real-Time Monitoring System for Irrigation Water Quality Management International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030737 Authors: Syu Chang Pan In order to provide the real-time monitoring for identifying the sources of pollution and improving the irrigation water quality management, the integration of continuous automatic sampling techniques and cloud technologies is essential....
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IJERPH, Vol. 17, Pages 739: Study of the Differential Consequences of Neglect and Poverty on Adaptive and Maladaptive Behavior in Children International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030739 Authors: Herruzo Raya Trenas Pino Herruzo The consequences of physical neglect on retardation in the development of adaptive behaviors and the increased risk of poor physical and mental health are well documented. As physical neglect is a phenomenon...
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IJERPH, Vol. 17, Pages 733: Effects of a Fundamental Motor Skill-Based Afterschool Program on Children’s Physical and Cognitive Health Outcomes International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030733 Authors: Lee Zhang Chu Gu Zhu Globally, more than half of school-aged children do not engage in the recommended 60 minutes of daily moderate to vigorous physical activity (MVPA). Given that developing sufficient fundamental motor skills...
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IJERPH, Vol. 17, Pages 730: Netizens’ Food Safety Knowledge, Attitude, Behaviors, and Demand for Science Popularization by WeMedia International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030730 Authors: Zhao Yu Xiao Cai Luo Zhang This study aimed to investigate netizens’ food safety knowledge, attitudes and behavior, status, and their demand for science popularization by WeMedia. Firstly, participants were recruited by WeMedia,...
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IJERPH, Vol. 17, Pages 732: Spatial Variation and Source of Dissolved Heavy Metals in the Lancangjiang River, Southwest China International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030732 Authors: Liang Han Zeng Qu Liu Liu Dissolved heavy metals are not only the essential micronutrients, but also the toxic elements for human bodies. To investigate the heavy metal sources and assess the water quality of the Lancangjiang River, dissolved...
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IJERPH, Vol. 17, Pages 731: Coronary Artery Disease Diagnosis; Ranking the Significant Features Using a Random Trees Model International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030731 Authors: Joloudari Joloudari Saadatfar GhasemiGol Razavi Mosavi Nabipour Shamshirband Nadai Heart disease is one of the most common diseases in middle-aged citizens. Among the vast number of heart diseases, coronary artery disease (CAD) is...
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IJERPH, Vol. 17, Pages 736: Unravelling Teacher Job Satisfaction: The Contribution of Collective Efficacy and Emotions Towards Professional Role International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030736 Authors: Buonomo Fiorilli Benevene Purpose: The purpose of this paper is to explore whether, and to what extent, collective beliefs and emotions towards professional role could predict job satisfaction, above and beyond the role of self-efficacy...
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IJERPH, Vol. 17, Pages 738: Oral Health Problems and Utilization of Dental Services Among Spanish and Immigrant Children and Adolescents International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030738 Authors: Portero de la Cruz Cebrino Spanish and immigrant children and adolescents vary widely in their frequency of dental visits and occurrence of dental problems. The aims of this study were to discover the prevalence of dental problems and utilization...
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IJERPH, Vol. 17, Pages 734: Predicting Water Cycle Characteristics from Percolation Theory and Observational Data International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030734 Authors: Hunt Faybishenko Ghanbarian Egli Yu The fate of water and water-soluble toxic wastes in the subsurface is of high importance for many scientific and practical applications. Although solute transport is proportional to water flow rates, theoretical and experimental...
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Technologies, Vol. 8, Pages 10: Application-Specific SoC Design Using Core Mapping to 3D Mesh NoCs with Nonlinear Area Optimization and Simulated Annealing Technologies doi: 10.3390/technologies8010010 Authors: Jan Moritz Joseph Dominik Ermel Lennart Bamberg Alberto García-Oritz Thilo Pionteck Core mapping, in which a core graph is mapped to a network graph to minimize communication, is a common design problem for Systems-on-Chip interconnected by a Network-on-Chip. In conventional...
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