Relationship between immune parameters during a severe exacerbation in allergic asthmatic children and asthma outcomes in the following year.

Relationship between immune parameters during a severe exacerbation in allergic asthmatic children and asthma outcomes in the following year.:

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Relationship between immune parameters during a severe exacerbation in allergic asthmatic children and asthma outcomes in the following year.

Clin Exp Allergy. 2020 Jan 19;:

Authors: Lejeune S, Mordacq C, Drumez E, Brisset S, Pouessel G, Pichavant M, Engelmann I, Béghin L, Decleyre-Badiu I, Neve V, Thumerelle C, Gosset P, Deschildre A

Abstract

Despite improvement in asthma maintenance treatment, exacerbations remain important issues. They are markers of severe asthma but can also occur in mild asthma (1). Viruses, and mainly Rhinoviruses (RVs), are the main triggers, and they may interact with aeroallergen-specific immunoinflammatory pathways in atopic patients (2,3). Some studies have suggested that these episodes could be related to an alteration of innate immune defenses and particularly a defective production of type I and III interferons (IFN) (4).

PMID: 31955476 [PubMed - as supplied by publisher]