Abstract Background DNA base identification is a proper and high specificity method. However, identification could be challenged in a situation where there is no database or the DNA sequence is almost identical, as in the case of monozygotic (MZ) twins. The aim of this study was to introduce a novel forensic method for distinguishing between almost identical MZ twins by means of an intraoral scanner using the 3D digital pattern...
Fri Oct 02, 2020 03:00
Abstract Introduction Over the last decades, multiple peptide receptors were recognized as potential diagnostic and therapeutic targets in nuclear medicine. 68Ga-NT-20.3 radiopharmaceutical has been developed for diagnosis of neurotensin receptors. High neurotensin receptor expression has been observed in pancreatic ductal adenocarcinoma as well as various malignancies. Until now, 68Ga-labelled NT ligand was successfully applied in...
Fri Oct 02, 2020 03:00
Abstract Objectives Intra‐articular analgesics are increasingly being used after temporomandibular joint (TMJ) arthrocentesis but without clear evidence on its efficacy. The aim of this study was to review the role of intra‐articular analgesic injected after TMJ arthrocentesis in improving postoperative outcomes. Methods PubMed, Embase, Scopus, BioMed Central, CENTRAL, and Google scholar databases were searched from inception up to 15th April 2020. Randomized controlled trials (RCTs) on...
Thu Oct 01, 2020 15:45
Related Articles Sleep Breathing Disorders in the COVID-19 Era: Italian Thoracic Society Organizational Models for a Correct Approach to Diagnosis and Treatment. Respiration. 2020;99(8):690-694 Authors: Insalaco G, Dal Farra F, Braghiroli A, Sacco, Salvaggio A, on behalf of the Italian Thoracic Society (ITS-AIPO) Abstract The attenuation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, at least in Italy, allows a...
Fri Oct 02, 2020 15:01
Optimal Continuous Positive Airway Pressure Treatment of Obstructive Sleep Apnea Reduces Daytime Resting Heart Rate in Prediabetes: A Randomized Controlled Study. J Am Heart Assoc. 2020 Oct 01;:e016871 Authors: Pamidi S, Chapotot F, Wroblewski K, Whitmore H, Polonsky T, Tasali E Abstract Background It has been widely recognized that obstructive sleep apnea (OSA) is linked to cardiovascular disease. Yet, randomized controlled studies failed...
Fri Oct 02, 2020 15:01
Management of sleep apnoea syndrome (SAS) in patients with vasovagal syncope (VVS): a protocol for the VVS-SAS cohort study. BMJ Open. 2020 Sep 30;10(9):e038791 Authors: Puel V, Godard I, Papaioannou G, Gosse P, Pepin JL, Thoin F, Deharo JC, Roche F, Zarqane N, Gagnadoux F, Suehs CM, Molinari N Abstract INTRODUCTION: Recurrent vasovagal syncope (VVS) is associated with decreased quality-of-life and frequent use of emergency services. The evidence...
Fri Oct 02, 2020 15:01
Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers. Sci Rep. 2020 Sep 30;10(1):16156 Authors: Facin AC, Uscategui RAR, Maronezi MC, Pavan L, Menezes MP, Montanhim GL, Camacho AA, Feliciano MAR, Moraes PC Abstract The purpose of this study is to determine whether the brachycephalic obstructive airway syndrome (BOAS) is correlated to alterations in liver and...
Fri Oct 02, 2020 15:01
Obesity, estrogens and adipose tissue dysfunction - implications for pulmonary arterial hypertension. Pulm Circ. 2020 Jul-Sep;10(3):2045894020952019 Authors: Mair KM, Gaw R, MacLean MR Abstract Obesity is a prevalent global public health issue characterized by excess body fat. Adipose tissue is now recognized as an important endocrine organ releasing an abundance of bioactive adipokines including, but not limited to, leptin, adiponectin and...
Fri Oct 02, 2020 15:01
Interrelated atrial fibrillation and leaks triggering and maintaining central sleep apnoea and periodic breathing in a CPAP-treated patient. Respirol Case Rep. 2020 Nov;8(8):e00666 Authors: Prigent A, Serandour AL, Luraine R, Poineuf JS, Bosseau C, Pépin JL Abstract We report the case of a 71-year-old obese continuous positive airway pressure (CPAP)-treated man who developed an acute cardiac failure (ACF) triggered by atrial fibrillation. CPAP...
Fri Oct 02, 2020 15:01
The Importance of Mask Selection on Continuous Positive Airway Pressure Outcomes for Obstructive Sleep Apnea. An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2020 Oct;17(10):1177-1185 Authors: Genta PR, Kaminska M, Edwards BA, Ebben MR, Krieger AC, Tamisier R, Ye L, Weaver TE, Vanderveken OM, Lorenzi-Filho G, DeYoung P, Hevener W, Strollo P Abstract Continuous positive airway pressure (CPAP) remains the major treatment...
Fri Oct 02, 2020 15:01
Diagnostic accuracy of the Berlin questionnaire and therapeutic effect of nasal continuous positive airway pressure in OSAHS patients with glucose metabolic dysfunction. Sleep Breath. 2020 Oct 01;: Authors: Gong LJ, Chang SC, Wu QH, Liu ZL, Wu X, Li SQ Abstract PURPOSE: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is associated with alterations in glucose metabolism. The Berlin questionnaire (BQ) is effective in identifying subjects with...
Fri Oct 02, 2020 15:01
Association Analysis Between Common Variants of the TRPM1 Gene and Three Mental Disorders in the Han Chinese Population. Genet Test Mol Biomarkers. 2020 Oct 01;: Authors: Ma C, Li X, Chen J, Li Z, Guan J, Li Y, Yin S, Shi Y Abstract Objective: Our study was designed to determine if the TRPM1 gene is associated with any of three mental disorders. The project included a cross disorder meta analysis and association analysis across 141701 cases...
Fri Oct 02, 2020 15:01
Central Sleep Apnea and Pacing-Induced Cardiomyopathy. Am J Cardiol. 2020 Sep 28;: Authors: Barbieri F, Adukauskaite A, Heidbreder A, Brandauer E, Bergmann M, Stefani A, Holzknecht E, Senoner T, Rubatscher A, Schgör W, Stühlinger M, Pfeifer BE, Bauer A, Hintringer F, Högl B, Dichtl W Abstract The role of central sleep apnea (CSA) in pacing-induced cardiomyopathy (PICM) remains speculative. In a prospective trial entitled UPGRADE, the presence...
Fri Oct 02, 2020 15:01
Renal denervation improves chronic intermittent hypoxia induced hypertension and cardiac fibrosis and balances gut microbiota. Life Sci. 2020 Sep 28;:118500 Authors: Lu D, Wang J, Zhang H, Shan Q, Zhou B Abstract AIMS: Investigate the effect of renal denervation (RDN) on chronic intermittent hypoxia (CIH) induced high blood pressure (BP) and cardiac injury, and explore whether the effect is associated with gut microbiota alteration and its...
Fri Oct 02, 2020 15:01
Inactivated tetanus as an immunological smokescreen: A major step towards harnessing tetanus-based therapeutics. Mol Immunol. 2020 Sep 28;127:164-174 Authors: McLean T, Norbury L, Conduit R, Shepherd N, Coloe P, Sasse A, Smooker P Abstract BACKGROUND AND PURPOSE: Tetanus neurotoxin has many potential therapeutic applications, due to its ability to increase localised muscle tone when injected directly into a muscle. It is a closely related molecule...
Fri Oct 02, 2020 15:01
Predicting Perioperative Respiratory Adverse Events in Children With Sleep-Disordered Breathing. Anesth Analg. 2020 Sep 23;: Authors: Pehora C, Faraoni D, Obara S, Amin R, Igbeyi B, Al-Izzi A, Sayal A, Sayal A, Mc Donnell C Abstract BACKGROUND: No evidence currently exists to quantify the risk and incidence of perioperative respiratory adverse events (PRAEs) in children with sleep-disordered breathing (SDB) undergoing all procedures requiring...
Fri Oct 02, 2020 15:01
Long-Term Clinical Follow-Up of Patients With Chronic Rhinosinusitis. Ann Otol Rhinol Laryngol. 2020 Oct 01;:3489420962822 Authors: Thunberg U, Saber A, Söderquist B, Hugosson S Abstract OBJECTIVE: This study comprised a long-term follow-up of a cohort of patients with chronic rhinosinusitis (CRS) regarding clinical features and symptomatology. METHODS: Data from 42 patients with CRS were available from a previous study. Forty...
Fri Oct 02, 2020 15:01
Early Adverse Events Following Transcervical Hypopharyngeal Diverticulum Surgery. Ann Otol Rhinol Laryngol. 2020 Oct 01;:3489420962136 Authors: Goshtasbi K, Verma SP Abstract OBJECTIVE: To describe rates of short-term morbidity following transcervical surgical treatment of hypopharyngeal diverticulum (HD) and analyze predictors of adverse events. METHODS: The 2005 to 2017 National Surgical Quality Improvement Program database...
Fri Oct 02, 2020 15:01
Publication date: Available online 1 October 2020Source: Pathology - Research and PracticeAuthor(s): Hailang Liu, Kun Tang, Ding Xia, Ejun Peng, Liang Wang, Zhiqiang Chen
Fri Oct 02, 2020 15:07
Publication date: Available online 1 October 2020Source: Pathology - Research and PracticeAuthor(s): Antonio Raffone, Antonio Travaglino, Antonio Angelino, Rosanna Esposito, Martina Pontillo, Antonio Mollo, Angela Santoro, Gian Franco Zannoni, Luigi Insabato, Matilde Sansone, Fulvio Zullo
Fri Oct 02, 2020 15:07
Publication date: Available online 1 October 2020Source: Pathology - Research and PracticeAuthor(s): Qiantao Xiong, Yuwei Jiao, Puyu Yang, Yuxiao Liao, Xiuli Gu, Fuyan Hu, Bifeng Chen
Fri Oct 02, 2020 15:07
Publication date: Available online 2 October 2020Source: Pathology - Research and PracticeAuthor(s): Vladimír Tancoš, Anna Farkašová, Zuzana Kviatkovská, Marián Grendár, Alena Líšková, Zdenko Huťka, Lukáš Plank
Fri Oct 02, 2020 15:07
Publication date: Available online 2 October 2020Source: Pathology - Research and PracticeAuthor(s): Sasha Libbrecht, Joni Van Der Meulen, Veerle Mondelaers, Edward Baert, Caroline Vande Walle, Jo Van Dorpe, David Creytens
Fri Oct 02, 2020 15:07
Publication date: Available online 2 October 2020Source: Pathology - Research and PracticeAuthor(s): Hanxiao Chen, Chong Yu, Lu Shen, Yanqian Wu, Deqi Wu, Zhen Wang, Guangzhong Song, Linjie Chen, Yeting Hong
Fri Oct 02, 2020 15:07
A rise in facial nerve palsies during the coronavirus disease 2019 pandemic. J Laryngol Otol. 2020 Oct 01;:1-9 Authors: Zammit M, Markey A, Webb C PMID: 32998780 [PubMed - as supplied by publisher]
Fri Oct 02, 2020 15:09
Coronavirus disease 2019 and sudden sensorineural hearing loss. J Laryngol Otol. 2020 Oct 01;:1-6 Authors: Lang B, Hintze J, Conlon B PMID: 33000716 [PubMed - as supplied by publisher]
Fri Oct 02, 2020 15:09
Related Articles Diffusion tensor magnetic resonance imaging of the optic nerves in pediatric hydrocephalus. Neurosurg Focus. 2019 12 01;47(6):E16 Authors: Shpanskaya K, Quon JL, Lober RM, Nair S, Johnson E, Cheshier SH, Edwards MSB, Grant GA, Yeom KW Abstract OBJECTIVE: While conventional imaging can readily identify ventricular enlargement in hydrocephalus, structural changes that underlie microscopic tissue injury might be more difficult...
Fri Oct 02, 2020 15:09
Publication date: Available online 2 October 2020Source: Radiotherapy and OncologyAuthor(s): Peter J. Hoskin, Ana M. Rojas, Peter J. Ostler, Linda Bryant, Gerry J. Lowe
Fri Oct 02, 2020 15:14
Publication date: Available online 2 October 2020Source: Radiotherapy and OncologyAuthor(s): Cecile J.A. Wolfs, Richard A.M. Canters, Frank Verhaegen
Fri Oct 02, 2020 15:14
Diagnostic accuracy of the Berlin questionnaire and therapeutic effect of nasal continuous positive airway pressure in OSAHS patients with glucose metabolic dysfunction. Sleep Breath. 2020 Oct 01;: Authors: Gong LJ, Chang SC, Wu QH, Liu ZL, Wu X, Li SQ Abstract PURPOSE: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is associated with alterations in glucose metabolism. The Berlin questionnaire (BQ) is effective in identifying subjects with...
Fri Oct 02, 2020 15:15
Related Articles Patient-specific 3-dimensionally printed models for neurosurgical planning and education. Neurosurg Focus. 2019 12 01;47(6):E12 Authors: Panesar SS, Magnetta M, Mukherjee D, Abhinav K, Branstetter BF, Gardner PA, Iv M, Fernandez-Miranda JC Abstract OBJECTIVE: Advances in 3-dimensional (3D) printing technology permit the rapid creation of detailed anatomical models. Integration of this technology into neurosurgical practice is...
Fri Oct 02, 2020 15:16
Elevated Urine Leukotriene E4 Is Associated With Worse Objective Markers in Nasal Polyposis Patients. Laryngoscope. 2020 Oct 01;: Authors: Choby G, O'Brien EK, Smith A, Barnes J, Hagan J, Stokken JK, Strumpf A, Mattos JL, Payne SC, Divekar R Abstract OBJECTIVES: Urine leukotriene E4 (uLTE4) is a biomarker of leukotriene synthesis and is elevated in patients with aspirin-exacerbated respiratory disease (AERD). It can also be useful to help delineate...
Fri Oct 02, 2020 15:16
Morphometry and morphology of rostral cranial fossa in brachycephalic dogs - CT studies. PLoS One. 2020;15(10):e0240091 Authors: Sokołowski W, Barszcz K, Kupczyńska M, Czopowicz M, Czubaj N, Kinda W, Kiełbowicz Z Abstract Hydrocephalus occurs more often in brachycephalic individuals of different species. Detailed analysis of rostral cranial fossa-region of cerebrospinal fluid outflow-is necessary to understand causes leading to hydrocephalus...
Fri Oct 02, 2020 15:16
Neurofibromatosis type 2: A nationwide population-based study focused on survival after meningioma surgery. Clin Neurol Neurosurg. 2020 Sep 23;198:106236 Authors: Depond CC, Weller J, Resche-Rigon M Abstract BACKGROUND: There is no dedicated study on outcome after meningioma surgery in neurofibromatosis type 2 (NF2) patients. METHODS: We processed the French Système National des Données de Santé (SNDS) database using an algorithm combining...
Fri Oct 02, 2020 15:16
The longitudinal impact of COVID-19 pandemic on neurosurgical practice. Clin Neurol Neurosurg. 2020 Sep 17;198:106237 Authors: Bajunaid K, Alatar A, Alqurashi A, Alkutbi M, Alzahrani AH, Sabbagh AJ, Alobaid A, Barnawi A, Alferayan AA, Alkhani AM, Bin Salamah A, Sheikh BY, Alotaibi FE, Alabbas F, Farrash F, Al-Jehani HM, Alhabib H, Alnaami I, Altweijri I, Khoja I, Taha M, Alzahrani M, Bafaquh MS, Binmahfoodh M, Algahtany MA, Al-Rashed S, Raza SM, Elwatidy S,...
Fri Oct 02, 2020 15:16
Pediatric allergic fungal rhinosinusitis with extensive intracranial extension - Case report and literature review. Int J Surg Case Rep. 2020 Sep 12;75:437-440 Authors: Alenzi HL, Al Momen A, Molani F Abstract INTRODUCTION: Over the last two decades, allergic fungal sinusitis (AFRS) has become increasingly common. It's defined as a noninvasive, benign inflammatory fungal disease of the sinuses which develops in young adults and adolescents....
Fri Oct 02, 2020 15:16
Minimally invasive surgical treatment of intracranial meningiomas in elderly patients (≥ 65 years): outcomes, readmissions, and tumor control. Neurosurg Focus. 2020 Oct;49(4):E17 Authors: Thakur JD, Mallari RJ, Corlin A, Yawitz S, Huang W, Eisenberg A, Sivakumar W, Krauss HR, Griffiths C, Barkhoudarian G, Kelly DF Abstract OBJECTIVE: Increased lifespan has led to more elderly patients being diagnosed with meningiomas. In this study, the authors...
Fri Oct 02, 2020 15:16
Aberrant AICA Injury During Translabyrinthine Approach. Otol Neurotol. 2020 Sep 28;: Authors: Bauer AM, Angster K, Schuman AD, Thompson BG, Telian SA Abstract OBJECTIVE: To define a complication of the translabyrinthine surgical approach to the posterior fossa related to a rare variant of the anterior inferior cerebellar artery (AICA) that penetrated into the petrous temporal bone. PATIENT: A healthy 59-year-old male with a unilateral...
Fri Oct 02, 2020 15:16
Publication date: December 2020Source: Biomedicine & Pharmacotherapy, Volume 132Author(s): Lin Li, Jingjian Yang, Baoe Liu, Yuting Zou, Minghao Sun, Zijing Li, Runan Yang, Xiumei Xu, Lifang Zou, Guilin Li, Shuangmei Liu, Guodong Li, Shangdong Liang
Fri Oct 02, 2020 15:18
Publication date: December 2020Source: Biomedicine & Pharmacotherapy, Volume 132Author(s): Peng Ge, Yalan Luo, Chukwuemeka Samuel Okoye, Haiyang Chen, Jiayue Liu, Guixin Zhang, Caiming Xu, Hailong Chen
Fri Oct 02, 2020 15:18
Publication date: December 2020Source: Biomedicine & Pharmacotherapy, Volume 132Author(s): Yanping Wang, Bangjie Zuo, Nannan Wang, Shulin Li, Caixia Liu, Dong Sun
Fri Oct 02, 2020 15:18
Transforming Clinical Pathways. Arch Pathol Lab Med. 2020 Oct 01;144(10):1164-1165 Authors: Khan AI PMID: 33002150 [PubMed - as supplied by publisher]
Fri Oct 02, 2020 15:24
Point-of-Care Testing and Equity. Arch Pathol Lab Med. 2020 Oct 01;144(10):1191-1192 Authors: Musaad SMA PMID: 33002151 [PubMed - as supplied by publisher]
Fri Oct 02, 2020 15:24
Results From 16 Years of Quality Surveillance of Urine Albumin to Creatinine Ratio Testing for a National Indigenous Point-of-Care Testing Program. Arch Pathol Lab Med. 2020 Oct 01;144(10):1199-1203 Authors: Regnier T, Shephard M, Shephard A, Graham P, DeLeon R, Shepherd S Abstract CONTEXT.—: The burden of chronic kidney disease in Indigenous Australians is 7.3 times higher than that of non-Indigenous Australians. If chronic kidney disease...
Fri Oct 02, 2020 15:24
Estimated Risk for Insulin Dose Error Among Hospital Patients Due to Glucose Meter Hematocrit Bias in 2020. Arch Pathol Lab Med. 2020 Oct 01;144(10):1204-1208 Authors: Inman M, Lyon AW, Lyon OAS, Lyon ME Abstract CONTEXT.—: Glycemic control requires accurate blood glucose testing. The extent of hematocrit interference is difficult to assess to assure quality patient care. OBJECTIVE.—: To predict the effect of patient hematocrit on...
Fri Oct 02, 2020 15:24
Benefits and Risks of Direct-to-Consumer Testing. Arch Pathol Lab Med. 2020 Oct 01;144(10):1193-1198 Authors: Ayala-Lopez N, Nichols JH Abstract CONTEXT.—: Convenience, avoidance of doctor's appointments, curiosity, and the desire to take control of one's health are driving interest toward direct-to-consumer (DTC) testing. DTC is laboratory testing that is initiated by the consumer without a physician order. The results are reported back directly...
Fri Oct 02, 2020 15:24
Amyloid Deposition in the Brain. Arch Pathol Lab Med. 2020 Oct 01;144(10):1162-1163 Authors: Gokden M PMID: 33002155 [PubMed - as supplied by publisher]
Fri Oct 02, 2020 15:24
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08352
Thu Oct 01, 2020 07:00
Abstract Franco Andrea Bonelli, a disciple of Lamarck, was one of the few naturalists who taught and disseminated transformism in Italy in the early nineteenth century. The explanation of the history of life on Earth offered by Lamarck’s theory was at odds with the Genesis narrative, while the issue of man’s place in nature raised heated debates. Bonelli sought to reconcile science and religion through his original interpretation of the variability of species, but he also focused...
Fri Oct 02, 2020 03:00
Related Articles Intranasal midazolam as first-line inhospital treatment for status epilepticus: a pharmaco-EEG cohort study. Ann Clin Transl Neurol. 2019 12;6(12):2413-2425 Authors: Kay L, Merkel N, von Blomberg A, Willems LM, Bauer S, Reif PS, Schubert-Bast S, Rosenow F, Strzelczyk A Abstract OBJECTIVE: We sought to evaluate the efficacy and tolerability of intranasal midazolam (in-MDZ) as first-line inhospital therapy in patients with status...
Fri Oct 02, 2020 15:30
Related Articles Application of Cannabinoids in Neurosciences: Considerations and Implications. Crit Care Nurs Q. 2020 Apr/Jun;43(2):216-231 Authors: Owusu KA, Saliba L, Ammar AA, Ammar MA, Mucksavage J Abstract Medicinal cannabinoid use continues to evolve across the United States, although legitimate federal recognition for medicinal purpose is lacking. Variability exists across states within the United States with respect to legislation,...
Fri Oct 02, 2020 15:30
Inherited Disorders of Lysine Metabolism: A Review. J Nutr. 2020 Oct 01;150(Supplement_1):2556S-2560S Authors: Bouchereau J, Schiff M Abstract Lysine is an essential amino acid, and inherited diseases of its metabolism therefore represent defects of lysine catabolism. Although some of these enzyme defects are not well described yet, glutaric aciduria type I (GA1) and antiquitin (2-aminoadipic-6-semialdehyde dehydrogenase) deficiency represent...
Fri Oct 02, 2020 15:30
Osthole inhibits proliferation of kainic acid‑activated BV‑2 cells by modulating the Notch signaling pathway. Mol Med Rep. 2020 Nov;22(5):3759-3766 Authors: Li YZ, Sun Z, Xu HR, Zhang QG, Zeng CQ Abstract Epilepsy is a syndrome involving chronic recurrent transient brain dysfunction. Activation and proliferation of microglia serve important roles in epilepsy pathogenesis and may be targets for treatment. Although osthole, an active constituent...
Fri Oct 02, 2020 15:30
Response to lacosamide monotherapy in a patient with medically refractory Jeavons syndrome: a case report and review of the literature. Epileptic Disord. 2020 Sep 30;: Authors: Zawar I, Franic L, Knight EP Abstract Jeavons syndrome is a childhood genetic generalized epilepsy characterized by eyelid myoclonia with or without absences, eyelid closure-induced epileptiform discharges and/or seizures and photoparoxysmal response. This syndrome accounts...
Fri Oct 02, 2020 15:30
The phenotype and treatment of SCN2A-related developmental and epileptic encephalopathy. Epileptic Disord. 2020 Sep 30;: Authors: Kim HJ, Yang D, Kim SH, Kim B, Kim HD, Lee JS, Choi JR, Lee ST, Kang HC Abstract AIMS: We aimed to delineate the phenotypic spectrum of SCN2A-related developmental and epileptic encephalopathy (DEE) and determine the effectiveness of various treatment modalities, including sodium channel blockers and the ketogenic...
Fri Oct 02, 2020 15:30
CircHivep2 contributes to microglia activation and inflammation via miR-181a-5p/SOCS2 signalling in mice with kainic acid-induced epileptic seizures. J Cell Mol Med. 2020 Oct 01;: Authors: Xiaoying G, Guo M, Jie L, Yanmei Z, Ying C, Shengjie S, Haiyan G, Feixiang S, Sihua Q, Jiahang S Abstract Epilepsy is a chronic brain disease characterized by recurrent seizures. Circular RNA (circRNA) is a novel family of endogenous non-coding RNAs that...
Fri Oct 02, 2020 15:30
Epilepsy surgery for pediatric patients with mild malformation of cortical development. Seizure. 2020 Sep 23;82:50-55 Authors: Kwon HE, Kim SH, Kang HC, Lee JS, Kim HD Abstract PURPOSE: The observation of mild malformation of cortical development (mMCD) has yet to have a major clinical impact due to the lack of clinical and research data. We characterized the clinical features, surgical outcomes, and postoperative seizure control patterns in...
Fri Oct 02, 2020 15:30
Risk factors, comorbidities, quality of life, and complications after surgery in idiopathic normal pressure hydrocephalus: review of the INPH-CRasH study. Neurosurg Focus. 2020 Oct;49(4):E8 Authors: Israelsson H, Larsson J, Eklund A, Malm J Abstract OBJECTIVE: Idiopathic normal pressure hydrocephalus (INPH) is a dementia treatable by insertion of a shunt that drains CSF. The cause of the disease is unknown, but a vascular pathway has been suggested....
Fri Oct 02, 2020 15:30
Key points Time restricted eating produces spontaneous energy restriction and significant weight loss. Time restricted eating decreases diastolic blood pressure independent of weight loss. Time restricted eating may improve insulin resistance and glucose regulation. Abstract Intermittent fasting has grown in popularity as a weight loss strategy in recent years. In particular, time restricted eating (TRE), has been popularized in the diet industry with dozens of books touting its ability...
Thu Oct 01, 2020 18:52
Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology
Abstract Under conditions of hypoxia, most eukaryotic cells can shift their primary metabolic strategy from predominantly mitochondrial respiration towards increased glycolysis to maintain ATP levels. This hypoxia‐induced reprogramming of metabolism is key to satisfying cellular energetic requirements during acute hypoxic stress. At a transcriptional level, this metabolic switch can be regulated by several pathways including the hypoxia inducible factor‐1α (HIF‐1α) which induces an increased expression...
Fri Oct 02, 2020 15:48
Key points Masters athletes maintain high levels of activity into older age and allow an examination of the effects of ageing dissociated from the effects of increased sedentary behaviour. Evidence suggests masters athletes are more successful at motor unit remodelling; the reinnervation of denervated fibres acting to preserve muscle fibre number, however little data are available in females. Here we used intramuscular electromyography to demonstrate motor units sampled from the tibialis anterior...
Fri Oct 02, 2020 15:48
Key points Chemogenetic activation of MVN‐projecting 5‐HT neurons resulted in deficits in vestibular‐mediated tasks, including negative geotaxis, balance beam and rota‐rod tests 5‐HT1AR mediates the vestibular‐related behavioural effects of 5‐HT in the VN 5‐HT1AR activation attenuated eEPSC and eIPSC via a presynaptic mechanism in the VN Abstract While the anxiolytic effects of serotonergic neuromodulation are well studied, its role in sensorimotor coordination and postural control is...
Fri Oct 02, 2020 15:48
Publication date: Available online 2 October 2020Source: CortexAuthor(s): Elvio Blini, Caroline Tilikete, Leonardo Chelazzi, Alessandro Farnè, Fadila Hadj-Bouziane
Fri Oct 02, 2020 16:02
Publication date: Available online 2 October 2020Source: CortexAuthor(s): Bruno Rossion
Fri Oct 02, 2020 16:02
Characteristics and Clinical Outcome of Breast Cancer Patients with Asymptomatic Brain Metastases. Cancers (Basel). 2020 Sep 28;12(10): Authors: Laakmann E, Witzel I, Neunhöffer T, Weide R, Schmidt M, Park-Simon TW, Möbus V, Mundhenke C, Polasik A, Lübbe K, Hesse T, Riecke K, Thill M, Fasching PA, Denkert C, Fehm T, Nekljudova V, Rey J, Loibl S, Müller V Abstract Background: Brain metastases (BM) have become a major challenge in patients with...
Fri Oct 02, 2020 16:04
Neoadjuvant Pyrotinib plus Trastuzumab and Chemotherapy for Stage I-III HER2-Positive Breast Cancer: A Phase II Clinical Trial. Oncologist. 2020 Sep 30;: Authors: Xuhong J, Qi X, Tang P, Fan L, Chen L, Zhang F, Tan X, Yan W, Zhong L, He C, Liang Y, Ren L, Wang M, Zhang Y, Jiang J Abstract LESSONS LEARNED: This is the first trial to explore the neoadjuvant therapy of pyrotinib in HER2-positive operable and locally advanced breast cancer, in...
Fri Oct 02, 2020 16:04
Leveraging the increased rates of pathologic complete response after neoadjuvant treatment in breast cancer to de-escalate surgical treatments. J Surg Oncol. 2020 Oct 01;: Authors: Esgueva A, Siso C, Espinosa-Bravo M, Sobrido C, Miranda I, Salazar JP, Rubio IT Abstract INTRODUCTION: Breast conservative surgery (BCS) and sentinel lymph node biopsy (SLNB) after neoadjuvant treatment (NAT) is safe and effective for selected patients. This aim...
Fri Oct 02, 2020 16:04
Trastuzumab emtansine plus atezolizumab versus trastuzumab emtansine plus placebo in previously treated, HER2-positive advanced breast cancer (KATE2): a phase 2, multicentre, randomised, double-blind trial. Lancet Oncol. 2020 Oct;21(10):1283-1295 Authors: Emens LA, Esteva FJ, Beresford M, Saura C, De Laurentiis M, Kim SB, Im SA, Wang Y, Salgado R, Mani A, Shah J, Lambertini C, Liu H, de Haas SL, Patre M, Loi S Abstract BACKGROUND: HER2-positive...
Fri Oct 02, 2020 16:04
Regulation of inflammatory cytokines for spinal cord injury recovery. Histol Histopathol. 2020 Oct 01;:18262 Authors: Lin S, Xu C, Lin J, Hu H, Zhang C, Mei X Abstract Spinal cord injury (SCI) is one of the most destructive traumatic diseases in human beings. The balance of inflammation in the microenvironment is crucial to the repair process of spinal cord injury. Inflammatory cytokines are direct mediators of local lesion inflammation and...
Fri Oct 02, 2020 16:07
Quantitative analysis of metal artifacts of dental implant in CBCT image by correlation analysis to micro-CT: A microstructural study. Dentomaxillofac Radiol. 2020 Oct 01;:20200365 Authors: Min CK, Kim KA Abstract OBJECTIVES: Quantification of dental implant metal artifacts in CBCT images using correlation analysis of trabecular microstructural parameters from CBCT and micro-CT, and analysis of the effect of varying the angular position...
Fri Oct 02, 2020 16:11
Ultrasound in the diagnosis of parotid duct obstruction not caused by sialolithiasis: Diagnostic value in reference to direct visualization with sialendoscopy. Dentomaxillofac Radiol. 2020 Oct 01;:20200261 Authors: Goncalves M, Mantsopoulos K, Schapher M, Iro H, Koch M Abstract OBJECTIVES: The aim of this study was toevaluate the diagnostic value of ultrasound in the obstructive pathology of the parotic gland not caused by sialolithiasis...
Fri Oct 02, 2020 16:11
Corrigendum to: The Patterns and Associated Cost of Serologic Testing for Helicobacter pylori in the US Military Health System. Mil Med. 2020 Sep 30;: Authors: Pak K, Junga Z, Mertz A, Singla M PMID: 33000121 [PubMed - as supplied by publisher]
Fri Oct 02, 2020 16:14
Improving Readiness: Preventive Maintenance of the Human Operating System that Drives Readiness and Lethality. Mil Med. 2020 Oct 01;185(Supplement_3):12-16 Authors: Howell G Abstract Improving the readiness and lethality of the U.S. fighting forces has always been a key priority, and it received renewed emphasis in the National Defense Authorization Act of 2017. A major rearrangement of the Defense Health Agency and the Military Health System...
Fri Oct 02, 2020 16:14
Leading the Military Health System Transformation: From Military Treatment Facility to Market Construct. Mil Med. 2020 Oct 01;185(Supplement_3):3-11 Authors: Melton JJ, Quick JW Abstract The transition of authority to manage and administer all DoD Medical Treatment Facilities from the Military Department Services to the Defense Health Agency is an extremely complex challenge involving multiple stakeholders and systems in an effort to achieve...
Fri Oct 02, 2020 16:14
Just Culture Is Not "Just" Culture-It's Shifting Mindset. Mil Med. 2020 Oct 01;185(Supplement_3):52-57 Authors: Foslien-Nash C, Reed B Abstract Health care and the Veterans Health Administration have adopted many initiatives to improve patient care, including efforts to create a "Just Culture" environment for patient safety and quality outcomes. Despite significant resources and efforts on these initiatives and some temporary improvements,...
Fri Oct 02, 2020 16:14
Resolving Conflict in Real Time: Operationalizing Culture Transformation in Deployments. Mil Med. 2020 Oct 01;185(Supplement_3):41-45 Authors: Weber ED Abstract Preparation is the key to performance. The Army invests substantially in team and unit preparation prior to deployments. However, despite the time and training to build camaraderie and confidence in one another, conflict still arises within units. Most training does not address the...
Fri Oct 02, 2020 16:14
Mindset First, Strategy Second: Finding the Savings and Performance in Changing Culture. Mil Med. 2020 Oct 01;185(Supplement_3):17-24 Authors: Gibson DR Abstract Resolving major challenges for health care organizations is a constant challenge. Each military service provides its leaders with superb education and training to lead the constant needs and changes of the mission requirements. The primary trap we leaders may fall into, though, is...
Fri Oct 02, 2020 16:14
New Findings What is the topic of this review? We review sex differences within physiological systems implicated in exercise performance. Specifically, how they integrate to determine metabolic thresholds and fatigability. Thereafter, we discuss the implications these sex differences might have for long‐term adaptation to exercise. What advances does it highlight? The review collates evidence from recent physiological studies that have investigated sex as a biological variable demonstrating...
Thu Oct 01, 2020 18:51
New Findings What is the central question of this study? Whether and how hsa_circ_001653 influences the development of GC? What is the main finding and its importance? 1. Bioinformatics analysis revealed differentially expressed hsa_circ_001653 is in GC and adjacent normal tissues, and is strongly related to the pathology of patients with GC. 2. Knockdown of hsa_circ_001653 suppresses the proliferation, invasion and migration of GC cells, while inducing cell apoptosis via miR‐377‐mediated...
Fri Oct 02, 2020 16:19
New Findings What is the central question of this study? Does blockade of the IL‐6 receptor by tocilizumab inhibit immune cell mobilization to the blood stream in humans during an acute bout of exercise? What is the main finding and its importance? Blockade of IL‐6 receptor signaling by tocilizumab attenuates mobilization of NK cells and dendritic cells to the blood stream during exercise. This implies an inhibitory effect of tocilizumab on the innate immune response to physical...
Fri Oct 02, 2020 16:19
New Findings What is the central question to this study? Do the sweat glands maximum ion reabsorption rates increase following heat acclimation in healthy older individuals and is this associated with elevated aldosterone concentrations? What is the main finding and its importance? Sweat glands maximum ion reabsorption rates improved heterogeneously across body sites, which occurred without any changes in aldosterone concentration following a controlled hyperthermic heat acclimation...
Fri Oct 02, 2020 16:19
Related Articles The nasopharyngeal airway: Estimation of the nares-to-mandible and nares-to-tragus distance in young children to assess current clinical practice. Resuscitation. 2019 07;140:50-54 Authors: Johnson M, Miskovic A, Ray S, Chong K, Hickson M, Bingham B, Skellett S Abstract BACKGROUND: Nasopharygeal airways are used in urgent situations to alleviate airway obstruction. Guidelines for measuring the length of the NPA differ between...
Fri Oct 02, 2020 16:22
Related Articles Clinical Application of Two-Dimensional Scanning Digital Kymography in Discrimination of Diplophonia. J Speech Lang Hear Res. 2019 10 25;62(10):3643-3654 Authors: Bae IH, Wang SG, Kwon SB, Kim ST, Sung ES, Lee JC Abstract Purpose The purpose of this study was to investigate the characteristics of diplophonia using an auditory perception and multimodal simultaneous examination, which included sound waveform analysis, electroglottography...
Fri Oct 02, 2020 16:22
Related Articles Objective Acoustic Quantification of Perceived Voice Tremor Severity. J Speech Lang Hear Res. 2019 10 25;62(10):3689-3705 Authors: Maryn Y, Leblans M, Zarowski A, Barkmeier-Kraemer J Abstract Purpose This study compared auditory-perceptual measures of presence/absence and severity of vocal tremor to acoustic markers of vocal tremor. The validity (both concurrent and diagnostic) of various acoustic markers of vocal tremor was...
Fri Oct 02, 2020 16:22
Related Articles Effect of an aerosol box on tracheal intubation difficulty. J Anesth. 2020 10;34(5):790-793 Authors: Wakabayashi R, Ishida T, Yamada T, Kawamata M Abstract The aim of this study was to determine the effect of an aerosol box on tracheal intubation difficulty. Eighteen experienced anesthetists intubated the trachea of a manikin with a normal airway 6 times using a direct laryngoscope, a McGRATH™ MAC videolaryngoscope, or an...
Fri Oct 02, 2020 16:22
Surgical Management in Tracheobronchopathia Osteochondroplastica: A Case Study. Laryngoscope. 2020 Oct 01;: Authors: Dharia I, Bielamowicz S Abstract Tracheobronchopathia Osteochondroplastica is a benign condition characterized by osseous and cartilaginous submucosal growths of the tracheobronchial tree. This is a case report of an individual that was to undergo elective surgery using general anesthesia with endotracheal tube intubation. However,...
Fri Oct 02, 2020 16:22
Immunohistochemical analysis of laryngeal muscle of horses clinically affected with recurrent laryngeal neuropathy. Equine Vet J. 2020 Oct 01;: Authors: Steel CM, Walmsley EA, Anderson GA, Coles CA, Ahern B, White JD Abstract BACKGROUND: As myosin heavy chain (MyHC) profile of muscle fibres is heavily influenced by neural input, changes in MyHC expression are expected in horses clinically affected with recurrent laryngeal neuropathy (RLN) yet...
Fri Oct 02, 2020 16:22
Publication date: Available online 1 October 2020Source: Academic RadiologyAuthor(s): Vahid Eslami, Alireza Abrishami, Ehsan Zarei, Nastaran Khalili, Zahra Baharvand, Morteza Sanei-Taheri
Fri Oct 02, 2020 16:27
Publication date: Available online 1 October 2020Source: Academic RadiologyAuthor(s): Neo Poyiadji, Chad Klochko, Jeff LaForce, Manuel L. Brown, Brent Griffith
Fri Oct 02, 2020 16:27
Duodenal gangliocytic paraganglioma: A very rare cause for upper gastrointestinal bleeding: Case report with review of literature. Int J Surg Case Rep. 2020 Sep 23;75:408-412 Authors: Arif SH, Mohammed AA, Yaqo RT Abstract INTRODUCTION: Gangliocytic paraganglioma is a rare tumors mainly arises from the second part of the duodenum. The tumor is generally benign, but some cases are associated with lymph node or distant metastasis. It must be...
Fri Oct 02, 2020 16:44
Case report: Tension pneumoperitoneum after diagnostic colonoscopy in an 11 y/o boy with Crohns disease. Int J Surg Case Rep. 2020 Sep 23;75:413-417 Authors: Seitz ST, Rückel A, Siebenlist G, Besendörfer M, Schellerer VS Abstract INTRODUCTION: Endoscopy is an established diagnostic and therapeutic tool in paediatric gastroenterology and a save method with rare complications. PRESENTATION OF CASE: We present the case of an 11-year-old...
Fri Oct 02, 2020 16:44
Introduction of VISIONSENSE® for indocyanine green fluorescence-guided parathyroidectomy: Report of a case. Int J Surg Case Rep. 2020 Sep 23;75:418-421 Authors: Kamada T, Yoshida M, Suzuki N, Takeuchi H, Takahashi J, Marukuchi R, Narihiro S, Ohdaira H, Suzuki Y Abstract INTRODUCTION: VISIONSENSE® is a new near-infrared (NIR) fluorescence laparoscope and has an NIR overlay threshold function that allows us to set a floor for the NIR signal to...
Fri Oct 02, 2020 16:44
Spontaneous bacterial peritonitis caused by Edwardsiella tarda: A case report. Int J Surg Case Rep. 2020 Sep 23;75:422-425 Authors: Hayashi H, Murase Y, Sano H, Nishio K, Kumazawa I Abstract INTRODUCTION: Edwardsiella tarda is a member of the Enterobacteriaceae family of gram-negative bacilli isolated from animals. Gastroenteritis is the most common manifestation of E. tarda infection. However, extraintestinal infections can occur in immunocompromised...
Fri Oct 02, 2020 16:44
Gossypiboma during orthognathic surgery: A case report. Int J Surg Case Rep. 2020 Sep 23;75:429-432 Authors: Alshehri SZ, Alkindi MG, Ibraheim OA, Ababtain RA, Alfotawi R Abstract INTRODUCTION: Dislodgment of nasopharyngeal temperature probes and/or unretrieved device fragments (UDFs) or gossypibome at a patient's hypopharynx is rare complication after orthognathic surgery that may occur as a result of surgical manipulation or may be a consequence...
Fri Oct 02, 2020 16:44
Pediatric allergic fungal rhinosinusitis with extensive intracranial extension - Case report and literature review. Int J Surg Case Rep. 2020 Sep 12;75:437-440 Authors: Alenzi HL, Al Momen A, Molani F Abstract INTRODUCTION: Over the last two decades, allergic fungal sinusitis (AFRS) has become increasingly common. It's defined as a noninvasive, benign inflammatory fungal disease of the sinuses which develops in young adults and adolescents....
Fri Oct 02, 2020 16:44
Robot-assisted laparoscopic total gastrectomy for Epstein-Barr virus-associated multiple gastric cancer: A case report. Int J Surg Case Rep. 2020 Sep 24;75:446-450 Authors: Kimura K, Ebihara Y, Tanaka K, Nakanishi Y, Asano T, Noji T, Kurashima Y, Murakami S, Nakamura T, Tsuchikawa T, Okamura K, Shichinohe T, Kanno-Okada H, Hirano S Abstract INTRODUCTION: Epstein-Barr virus-associated gastric cancer (EBVaGC) sometimes appears as multiple gastric...
Fri Oct 02, 2020 16:44
Hyperkinetic manifestations in superficial siderosis: evidence for pathogenic network disruption. Neurol Sci. 2020 Oct 01;: Authors: De Mase A, Saracino D, Andreone V Abstract Superficial siderosis (SS) of central nervous system is a rare condition characterized by hemosiderin deposition diffusely involving supratentorial and infratentorial compartments. SS usually manifests with ataxia and sensorineural hearing loss. Basal ganglia are almost...
Fri Oct 02, 2020 16:45
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