Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Tue Oct 06, 2020 10:00
Publication date: November 2020Source: Journal of Human Evolution, Volume 148Author(s): Ellis M. Locke, Brenda R. Benefit, Clare M. Kimock, Ellen R. Miller, Isaiah Nengo
Tue Oct 06, 2020 21:19
Breast cancer is the cancer with the highest incidence and mortality worldwide. Its treatment is multidisciplinary with surgery, systemic therapy, and radiotherapy. In Colombia, according to Globocan 2018, the...
Tue Oct 06, 2020 03:00
Publication date: October 2020Source: Journal of Allergy and Clinical Immunology, Volume 146, Issue 4Author(s):
Tue Oct 06, 2020 22:35
Publication date: October 2020Source: Journal of Allergy and Clinical Immunology, Volume 146, Issue 4Author(s):
Tue Oct 06, 2020 22:35
Publication date: October 2020Source: Journal of Allergy and Clinical Immunology, Volume 146, Issue 4Author(s):
Tue Oct 06, 2020 22:35
Publication date: October 2020Source: Journal of Allergy and Clinical Immunology, Volume 146, Issue 4Author(s):
Tue Oct 06, 2020 22:35
Publication date: October 2020Source: Journal of Allergy and Clinical Immunology, Volume 146, Issue 4Author(s):
Tue Oct 06, 2020 22:35
Publication date: October 2020Source: Journal of Allergy and Clinical Immunology, Volume 146, Issue 4Author(s):
Tue Oct 06, 2020 22:35
Publication date: October 2020Source: Journal of Allergy and Clinical Immunology, Volume 146, Issue 4Author(s):
Tue Oct 06, 2020 22:35
Publication date: October 2020Source: Journal of Allergy and Clinical Immunology, Volume 146, Issue 4Author(s): Sarah Miethe, Antonina Karsonova, Alexander Karaulov, Harald Renz
Tue Oct 06, 2020 22:35
Publication date: October 2020Source: Journal of Allergy and Clinical Immunology, Volume 146, Issue 4Author(s): Zuhair K. Ballas, Associate Editors of the JACI
Tue Oct 06, 2020 22:35
Publication date: October 2020Source: Journal of Allergy and Clinical Immunology, Volume 146, Issue 4Author(s): Marc E. Rothenberg, Jean Bousquet
Tue Oct 06, 2020 22:35
Publication date: October 2020Source: Journal of Allergy and Clinical Immunology, Volume 146, Issue 4Author(s):
Tue Oct 06, 2020 22:35
Publication date: Available online 6 October 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Esther Herrera-Luis, Fabian Lorenzo-Diaz, Lesly-Anne Samedy-Bates, Celeste Eng, Jesús Villar, Jose R. Rodriguez-Santana, Esteban G. Burchard, Maria Pino-Yanes
Tue Oct 06, 2020 22:35
Abstract Purpose The purpose of this study was to provide detailed information about the eyebrow approach for the reduction of the frontal bone and its esthetic results with the help of clinical data available. Thus, suggesting this technique is minimally invasive and highly esthetic for frontal bone management. Method In this series, 96 cases were...
Tue Oct 06, 2020 03:00
Objectives Intraoperative placement of neck drains in thyroidectomy patients remains a widespread practice, despite prevailing evidence discouraging this practice. This systematic review and meta‐analysis was conducted to update the currently available evidence base. Methods Two independent investigators performed a comprehensive literature search to identify randomized control trials that evaluated postoperative complications associated with neck drains. This was conducted using four databases:...
Tue Oct 06, 2020 20:52
Objective To evaluate the effect of discharge order sets on prescribing patterns of opioids after pediatric tonsillectomy. Secondary outcomes included encounters for postoperative pain, dehydration, and bleeding. Methods Retrospective chart review of pre‐ and post‐intervention in pediatric post‐tonsillectomy patients, 0–18 years old (n = 1486). Order sets were installed with age‐specific analgesic medication defaults and recommendation of concurrent alternating scheduled ibuprofen and acetaminophen....
Tue Oct 06, 2020 20:55
Objectives/Hypothesis To analyze the use of highly translatable three‐dimensional (3D)–printed auricular scaffolds with and without novel cartilage tissue inserts in a rodent model. Study Design Preclinical rodent animal model. Methods This prospective study assessed a single‐stage 3D‐printed auricular bioscaffold with or without porcine cartilage tissue inserts in an athymic rodent model. Digital Imaging and Communications in Medicine computed tomography images of a human auricle were...
Tue Oct 06, 2020 20:56
In the original publication of the article, the left panel of Fig. 3 was published incorrectly.
Tue Oct 06, 2020 03:00
Abstract Background As the member of erbium laser family, Erbium, Chromium: Yttrium Scandium Gallium Garnet (Er,Cr:YSGG) has obtained the approval for caries removal and cavity preparation by Food and Drug Administration (FDA). However, there is still controversy over the beneficial effects of Er,Cr:YSGG preparations on microleakage. The present study is the first systematic review and meta-analysis to compare the microleakage...
Tue Oct 06, 2020 03:00
Five dimensions of voice assessment are considered as visual evaluation, videostroboscopy, acoustic, aerodynamic, patient-based, and auditory-perceptual. Auditory-perceptual voice assessment scales are the standard scales for clinicians to document voice therapy outcomes in dysphonic patients. The primary objective of the present study was to investigate the construct and discriminant validities of the Persian Version of the CAPE-V (ATSHA). A secondary objective was to determine the differences between...
Tue Oct 06, 2020 03:00
Despite being widely used by professional sopranos, the emission of upper high range notes is still a subject of considerable controversy both to those who use them and those who study them.
Tue Oct 06, 2020 03:00
Serum amylase elevation (SAE) may be a surrogate indicator of post‐operative acute pancreatitis (PAP) and predict clinically relevant post‐operative pancreatic fistula. SAE was defined as serum amylase more than three times the normal concentration at post‐operative day 1. Post‐operative abdominal computed tomography scan was routinely performed and retrospectively and blindly re‐assessed for findings consistent with PAP. SAE can be considered a valid surrogate of PAP and is strongly associated...
Mon Oct 05, 2020 20:53
Our research demonstrates a high rate of immediate breast reconstruction following mastectomy that includes a wide range of autologous and alloplastic reconstructions within a diverse patient population. Our study represents a unique opportunity to identify barriers and facilitate patient choice reconstruction rates, particularly in tertiary services with a strong multicultural and multi‐linguistic population. Abstract Background In Australia, the rate of immediate breast reconstruction...
Mon Oct 05, 2020 20:57
This retrospective study determined the rate of breast reconstruction in women who had mastectomy as treatment for breast cancer at public hospitals in South Western Sydney Local Health District – a culturally diverse health district in New South Wales, Australia – and compared the rate of reconstruction in the culturally and linguistically diverse (CALD) and non‐CALD populations. The study found a low breast reconstruction rate in public hospitals in South Western Sydney Local Health District....
Mon Oct 05, 2020 20:58
The management of an open abdomen in critically ill patients remains an evolving field because of its relative rarity. We describe our experience with the Abdominal Re‐approximation Anchor device in the emergency and elective setting at a tertiary hospital in Queensland, Australia. Primary fascial closure was achieved in 100% of patients demonstrating that the Abdominal Re‐approximation Anchor device is an important tool for the general surgeon in managing these complex cases. Abstract ...
Mon Oct 05, 2020 20:59
This observational study investigated consent for spine surgery using video recording of surgeons obtaining consent. Transcripts from the video recordings were analysed blindly using quantitative and linguistic ethnography. There were wide disparities in provision of informed consent, particularly in risk counselling; providing insight into the limitations of our current practice. Abstract Background The tension between the ideal of informed consent and the reality of the process is...
Mon Oct 05, 2020 21:00
The consent process is complex and somewhat of an artform for procedural specialties. Readability of consent forms was objectively examined. The objective readability of the texts exceeds local and international recommendations. Abstract Background The aim of this study was to conduct a readability analysis on both patient take‐home information and consent forms for common foot and ankle procedures. Our hypothesis was that the objective reading skills required to read and comprehend...
Mon Oct 05, 2020 21:01
We assess the available evidence for the use of intra‐operative flexible sigmoidoscopy to prevent complications following colorectal resection. Intra‐operative flexible sigmoidoscopy increases the likelihood of identifying an anastomotic defect or bleeding intra‐operatively. This allows for an immediate intervention that decreases the rate of anastomotic leak and anastomotic bleeding. Abstract Background Anastomotic leak (AL) after colorectal resection leads to increased oncological...
Mon Oct 05, 2020 21:05
Patients diagnosed with frailty had significantly higher 90‐day mortality and long‐term hospitalization (LTH) regardless of which criteria were used. The CFS and FI were better predictors of 90‐day mortality, and the CFS was a better predictor of LTH. Abstract Background To compare the predictive power of three different evaluation methods of frailty for 90‐day outcomes of elderly patients undergoing elective abdominal surgery. Methods A prospective cohort study was conducted with...
Mon Oct 05, 2020 21:06
Ten patients received rapid 3D print‐formed cranioplasty implants, formed intraoperatively using polymethylmethacrylate between 2013 and 2019. The functional results and stability of the implants were deemed to be favourable by participating surgeons. 3D print‐formed implants are an effective method of patient‐specific implant formation. Abstract Background To clinically evaluate 3D print‐formed implant process, using cranioplasty as a proof of concept, to examine its effectiveness and...
Mon Oct 05, 2020 21:08
Mon Oct 05, 2020 22:15
From ants to primates, 'Napoleonic' intelligence has evolved to help animals contend with the myriad cognitive challenges arising from interactions with rival outsiders, suggest researchers.
Tue Oct 06, 2020 16:12
A new plant species named Cardamine insueta appeared in the region of Urnerboden in the Swiss alps, after the land has changed from forest to grassland over the last 150 years. The inheritance of two key traits from its parent plants enabled the newly emerged species to grow in a distinct environmental niche, as researchers now show.
Tue Oct 06, 2020 16:12
Researchers have found that Rtl1, which is a mouse ortholog of the human RTL1 gene, appears to be the major gene responsible for muscle and placental defects in models of Temple and Kagami-Ogata syndromes, which are serious genetic conditions. Theirs is the first study to demonstrate that a domesticated gene that is specific to placental mammals plays an important role in fetal and neonatal muscle development.
Tue Oct 06, 2020 18:42
In their efforts to identify the genetic basis for differences in mate choice that keep two co-existing species of butterfly separate, evolutionary biologists have identified five candidate genes that are associated with divergence in visual mating preferences.
Tue Oct 06, 2020 18:43
New analysis of the DNA sequence of the male-specific Y chromosomes from all living species of the great ape family helps to clarify our understanding of how this enigmatic chromosome evolved.
Tue Oct 06, 2020 22:35
From ants to primates, 'Napoleonic' intelligence has evolved to help animals contend with the myriad cognitive challenges arising from interactions with rival outsiders, suggest researchers.
Tue Oct 06, 2020 16:12
New analysis of the DNA sequence of the male-specific Y chromosomes from all living species of the great ape family helps to clarify our understanding of how this enigmatic chromosome evolved.
Tue Oct 06, 2020 22:35
Human tumors of the same or different histology, stage and site exhibit a broad range of heterogeneity in radiation dose response [1–3]. The potential advantages to have optimal dose distribution for eradication of heterogeneous tumors have been creatively proposed long time ago [4–6]. In the past, the “gold standard” to measure tumor intrinsic radiosensitivity was a soft agar clonogenic assay using cells derived from primary tumor biopsies to calculate a surviving fraction at 2 Gy (SF2) [7–9]. However,...
Tue Oct 06, 2020 03:00
Stereotactic body radiation therapy (SBRT) is an effective, convenient, and cost-effective definitive radiotherapy option for localized prostate cancer and is supported by the National Comprehensive Cancer Network (NCCN) for low-, intermediate-, and high-risk disease.[1–3] This technique exploits the estimated low α/β ratio for prostate cancer of approximately 1.5-3.0 Gy, which denotes a greater sensitivity to hypofractionation.[4–7] The use of SBRT for definitive treatment of prostate cancer is...
Tue Oct 06, 2020 03:00
Wilms’ tumour (WT) and neuroblastoma (NBL) are two of the most common abdominal solid tumours diagnosed in children. Depending on the risk stratification, the treatment involves a combination of surgery, chemotherapy and radiotherapy [1,2]. During radiotherapy treatment planning (RTP), magnetic resonance imaging (MRI) scans are commonly acquired to define the target volume thanks to their superior soft-tissue contrast [3]. In addition, computed tomography (CT) images are used for the computation...
Tue Oct 06, 2020 03:00
Therapeutic Hypothermia and Temperature Management, Ahead of Print.
Tue Oct 06, 2020 10:00
Abstract Objectives Substance misuse during pregnancy can be harmful to the health of both mothers and infants. Existing recovery services or prenatal care for pregnant women with substance use disorders (SUD) in the U.S. and other countries typically fall short in providing the necessary specialized care women with SUDs need. Disclosure of substance misuse is one key factor in gaining access to specialized prenatal care; yet, barriers...
Tue Oct 06, 2020 03:00
Horm Metab ResDOI: 10.1055/a-1250-8221The chemokine (C-C motif) ligand 2 (CCL2) and its receptor CCR2 are involved in gestational diabetes mellitus (GDM). The present study aims to explore the effects of CCL2 blocking on GDM. Serum CCL2, interleukin (IL)-6, and tumor necrosis factor (TNF)-α were determined in GDM patients and healthy volunteers. C57BL/KsJdb/+mouse was used as the GDM model and CCL2 antibody (αCCL2) was applied. Flow cytometry was applied to determine the frequency of macrophages....
Tue Oct 06, 2020 02:00
Abstract Our goal was to undertake a genome‐wide epigenomic liquid biopsy of cerebrospinal fluid for the comprehensive analysis of cell‐free DNA (cfDNA) methylation signatures in the human central nervous system (CNS). Solution‐phase hybridization and massively parallel sequencing of bisulfite converted human DNA was employed to compare methylation signatures of cfDNA obtained from cerebrospinal fluid (CSF) with plasma. Recovery of cfDNA from CSF was relatively low (68 to 840 pg/mL) compared to...
Tue Oct 06, 2020 15:11
Abstract We analyze unidirectional and reciprocally connected pairs of neurons in the chemical connectomes of the male and hermaphrodite C. elegans, using recently published data. Our analysis reveals that reciprocal connections provide communication between most neurons with chemical synapses, and comprise on average more synapses than both unidirectional connections and the entire connectome. We further reveal that the C. elegans connectome is wired so that afferent connections onto neurons with...
Tue Oct 06, 2020 12:46
Abstract Peripheral nerve injury (PNI) is a common and incurable disease in the clinic, but the effects of available treatments are still not satisfactory. Therefore, it is necessary to explore new treatment methods. To explore the effect and mechanism of melatonin in peripheral nerve regeneration, we administered melatonin to mice with PNI by intraperitoneal injection. We applied microarray analysis to detect differentially expressed genes of mice with sciatic nerve injury after melatonin application....
Tue Oct 06, 2020 13:13
LaryngorhinootologieDOI: 10.1055/a-1250-8639 Hintergrund Patienten mit Gaumenspalte haben sehr häufig im Kindesalter einen binauralen Paukenerguss. Die konsekutive Schallleitungsschwerhörigkeit gilt als Risikofaktor für die Entwicklung einer auditiven Verarbeitungs- und Wahrnehmungsstörung. In der internationalen Literatur finden sich nur wenige Studien über die auditive Verarbeitung und Wahrnehmung bei dieser Population. Daher hatte diese Untersuchung das Ziel, ein eigenes Patientenklientel...
Tue Oct 06, 2020 02:00
Abstract Introduction Atypical teratoid rhabdoid tumor (ATRT) is a rare, often lethal brain tumor of childhood characterized by a complex epigenetic landscape amongst a simple genetic background. Recent molecular studies have defined key biologic events that contribute to tumorigenesis and molecular subtypes of ATRT. Methods Seminal studies on ATRT...
Tue Oct 06, 2020 03:00
Abstract Purpose Despite the large clinical interest in mindfulness, little is known about its effects in patients with brain tumours. Novel delivery methods such as App based Mindfulness training (AMT) may assist in the delivery of mindfulness treatment to this group of patients. Methods We aimed to determine the feasibility...
Tue Oct 06, 2020 03:00
Abstract Neuroblastoma is the most common neoplasm associated with pediatric Horner syndrome. The laboratory and imaging evaluation of isolated pediatric Horner syndrome is controversial. We review the literature published in the last several decades and present the rationale for the imaging work-up in this patient cohort.
Tue Oct 06, 2020 03:00
Abstract Background Ligamentum arteriosum calcification may be a normal finding in some children, although the frequency has not been well described. Objective To estimate the frequency of ligamentum arteriosum calcification in children at postmortem imaging. Materials and methods ...
Tue Oct 06, 2020 03:00
Abstract Intervention-induced neuroplastic changes within the motor or cognitive system have been shown in the human brain. While cognitive and motor brain areas are densely interconnected, it is unclear whether this interconnectivity allows for a shared susceptibility to neuroplastic changes. Using the preparation for a theoretical exam as training intervention that primarily engages the cognitive system, we tested the hypothesis whether neuroplasticity acts across interconnected...
Tue Oct 06, 2020 03:00
Abstract Glomus tumors (GTs) are uncommon benign tumors, accounting for <2% of all soft tissue tumors and usually occur within the dermis or subcutis of distal extremities. Primary tracheal GT is rare, and to date less than 40 tracheal GTs have been reported. Tracheal GT usually present as a polypoidal mass. They express smooth muscle markers, and are negative for cytokeratin (CK) and neuroendocrine markers on immunohistochemistry (IHC). We here report a case of tracheal GT...
Tue Oct 06, 2020 03:00
Abstract We report a 2-year-old child with congenital hydrocephalus who presented with a frontal meningocoele due to ventriculo-subgaleal fistula secondary to hydrocephalus (internal rupture), which gradually ruptured spontaneously through the skin. This case is unique given its association with occipital encephalocele and is only the second case to present with external rupture beyond the age of 1 year. Further, the ventricles have ruptured through the skull, after the closure...
Tue Oct 06, 2020 03:00
The authors have noted an error in Fig. 1B and Fig. 1C.
Tue Oct 06, 2020 03:00
The AR signaling pathway plays an important role in initiation and progression of many hormone-related cancers including prostate, bladder, kidney, lung, and breast cancer. However, the potential roles of androgen-responsive long noncoding RNAs (lncRNAs) in hormone-related cancers remained unclear. In the present study, we identified 469 novel androgen-responsive lncRNAs using microarray data. After validating the accuracy of the array data, we constructed a transcriptional network which contained...
Tue Oct 06, 2020 19:50
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07862
Mon Oct 05, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07841
Tue Oct 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c09185
Tue Oct 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04955
Tue Oct 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c09520
Tue Oct 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08980
Tue Oct 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08928
Tue Oct 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c09914
Tue Oct 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02389
Tue Oct 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08688
Tue Oct 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06109
Tue Oct 06, 2020 07:00
Limited data are available regarding antiviral therapy efficacy in most severe patients under mechanical ventilation for Covid-19-related acute respiratory distress syndrome (ARDS).
Tue Oct 06, 2020 03:00
Opinion statement Oncoplastic surgery (OPS) expands the indications and possibilities of breast-conserving surgery (BCS) by allowing for a wider cancer resection than lumpectomy. Ongoing investigation and reporting of OPS outcomes along with improvements in comprehensive training in breast surgical oncology will impact on awareness and lead to increased adoption of these techniques. Indications for OPS include concern about clear margins, poor tumor location (upper inner pole...
Tue Oct 06, 2020 03:00
Opinion statement Cervical cancer (CC) is most often caused by the human papillomavirus (HPV). In principle, these ties to the virus should make HPV tumors a relatively easy target for clearance by the immune system. However, these HPV-associated tumors have evolved strategies to escape immune attack. Checkpoint inhibition immunotherapy, which has had remarkable success in cancer treatment, has the potential to overcome the immune escape in CC by harnessing the patient’s own...
Tue Oct 06, 2020 03:00
Opinion statement Head and neck cancer of unknown primary (HNCUP) is increasingly encountered in both community otolaryngology practice and the academic head and neck cancer program. A stepwise diagnostic evaluation will identify many primary sites. However, true HNCUP remains common in high-volume practices after appropriate examination, imaging, and biopsies. The prognosis for the majority of the patients is good, owing to the common association with high-risk HPV, and putative...
Tue Oct 06, 2020 03:00
Abstract Purpose Peripheral gangrene (PG) is a known complication requiring limb amputation among sepsis survivors; however, its incidence and associated risk factors remain controversial. We aimed to examine the incidence of limb amputation among sepsis survivors, and to investigate factors independently associated with limb amputation. Methods In...
Tue Oct 06, 2020 03:00
Abstract Background In recent years, many devices have been developed to monitor free flaps. The Licox probe, which measures tissue oxygen pressure (PtO2), is one of the available devices. Our aim was to demonstrate that PtO2 could distinguish arterial from venous occlusion in a porcine fascio‐cutaneous flap model. Materials and methods Twenty pigs (Sus scrofa domestica, Youna strain, males) were included in this study. The median weight was 87.6 kg (84.6–90.8). Bilateral fascio‐cutaneous...
Tue Oct 06, 2020 13:40
Abstract Background Although the importance of ectopic lymphoid tissues (eLTs) in the pathophysiology of nasal polyps (NPs) is increasingly appreciated, the mechanisms underlying their formation remain unclear. Objective To study the role of interleukin (IL)‐17A, C‐X‐C motif chemokine ligand 13 (CXCL13), and lymphotoxin (LT) in eLT formation in NPs. Methods The expression levels of CXCL13 and LT and their receptors, in addition to the phenotypes of stromal cells in NPs, were studied...
Tue Oct 06, 2020 13:06
Abstract Purpose This study proposes optimal tracer-specific threshold-based window levels for PSMA PET–based intraprostatic gross tumour volume (GTV) contouring to reduce interobserver delineation variability. Methods Nine 68Ga-PSMA-11 and nine 18F-PSMA-1007 PET scans including GTV delineations of four expert teams (GTVmanual) and a majority-voted...
Tue Oct 06, 2020 03:00
Time-lapse imaging of live cells using multiple fluorescent reporters is an essential tool to study molecular processes in single cells. However, exposure to even moderate doses of visible excitation light can disturb cellular physiology and alter the quantitative behavior of the cells under study. Here, we set out to develop guidelines to avoid the confounding effects of excitation light in multi-color long-term imaging. We use widefield fluorescence microscopy to measure the effect of the administered...
Tue Oct 06, 2020 22:34
The genetic contribution of additive versus non-additive (epistatic) effects in the regulation of complex traits is unclear. While genome-wide association studies typically ignore gene-gene interactions, in part because of the lack of statistical power for detecting them, mouse chromosome substitution strains (CSSs) represent an alternate approach for detecting epistasis given their limited allelic variation. Therefore, we utilized CSSs to identify and map both additive and epistatic loci that regulate...
Tue Oct 06, 2020 22:34
Abstract Objectives The purpose of this study was to evaluate the incidence of complications following mandibular reconstruction and to analyse possible contributing factors. Materials and methods Clinical data and computed tomography scans of all patients who needed a mandibular reconstruction with a reconstruction plate, free fibula flap (FFF) or iliac...
Tue Oct 06, 2020 03:00
Abstract Objective To explore and evaluate the application of a surgical guide in the extraction of impacted mesiodentes. Materials and methods Patients with impacted mesiodentes approachable from the labial side of the maxilla were randomly divided into three groups. The surgical guide for group I was made using cone beam computed tomography (CBCT) and dental...
Tue Oct 06, 2020 03:00
Upregulation of EZH2 is associated with advanced stage and poor prognosis of PCa, it is therefore likely to be a promising therapeutic target. Metformin, a drug that has been used to treat type II diabetes, was found to have anti-neoplastic activity in different cancers. Herein, we report that the combination of metformin and EZH2 inhibitor GSK126 exerts synergistic inhibition on PCa cell growth, both in vitro and in vivo. Mechanistically, we identify that metformin can reduce EZH2's expression through...
Tue Oct 06, 2020 18:48
Most mammalian cytoplasmic tRNAs contain ribothymidine (T) and pseudouridine () at positions 54 and 55, respectively. However, some tRNAs contain at both positions. Several 54-containing tRNAs function as primers in retroviral DNA synthesis. The 54 of these tRNAs is produced by PUS10, which can also synthesize 55. Two other enzymes, TRUB1 and TRUB2 can also produce 55. By nearest-neighbor analyses of tRNAs treated with recombinant proteins and sub-cellular extracts of wild type and specific 55 synthase...
Tue Oct 06, 2020 17:59
In an annotated series of gastroesophageal adenocarcinomas differences in PD-L1 expression and TMB occur between both paired contemporaneous primary and metastatic biopsies and pre/post-treatment samples. This work has implications for optimizing patient selection, serial testing, need for mechanistic understanding, and may underlie variable responses to checkpoint inhibitors in gastroesophageal cancers.
Tue Oct 06, 2020 15:39
Purpose: Lung adenocarcinomas comprise the largest fraction of non-small cell lung cancer, which is the leading cause of cancer deaths. 75% of adenocarcinomas lack targeted therapies due to scarcity of druggable drivers. Here we classify tumors based on signaling similarities and discover subgroups within this unmet patient population. Experimental Design: We leverage transcriptional data from >800 early-stage and advanced patients. Results: We identify three robust subtypes dubbed Mucinous, Proliferative,...
Tue Oct 06, 2020 15:39
Purpose: For high-risk prostate cancer, standard treatment options include radical prostatectomy (RP) or radiation therapy plus androgen-deprivation therapy (ADT). Despite definitive therapy, many patients will have disease recurrence. Imaging has the potential to better define characteristics of response and resistance. In this study, we evaluated prostate multiparametric MRI (mpMRI) before and after neoadjuvant enzalutamide plus ADT. Experimental Design: Men with localized intermediate- or high-risk...
Tue Oct 06, 2020 15:39
Abstract Purpose Persistent Müllerian duct syndrome (PMDS) is characterized by the persistence of Müllerian structures in male with normal phenotype. Most cases occur as a result of mutations in the anti-Müllerian hormone (AMH) or AMHR2 genes. In this study, we aim to discuss the results of clinical, laboratory, and molecular genetic analysis of cases detected to have AMHR2 gene mutation. ...
Tue Oct 06, 2020 03:00
Abstract Purpose SARS-COV-2 is a pathogenic agent belonging to the coronavirus family, responsible for the current global world pandemic. Angiotensin-converting enzyme 2 (ACE-2) is the receptor for cellular entry of SARS-CoV-2. ACE-2 is a type I transmembrane metallo-carboxypeptidase involved in the Renin-Angiotensin pathway. By analyzing two independent databases, ACE-2 was identified in several human tissues including the thyroid....
Tue Oct 06, 2020 03:00
Abstract Purpose The serum metabolic changes occurring during the transition from hypothyroidism to euthyroidism are not known. This study aimed to determine the metabolomic profile in hypothyroid patients before (HypoT0) and after (HypoT1) euthyroidism achieved through levothyroxine (L-T4) treatment. Methods Eighteen patients with overt primary hypothyroidism...
Tue Oct 06, 2020 03:00
Abstract Background Familial non-medullary thyroid carcinoma (FNMTC), mainly of papillary histotype (FPTC), is defined by the presence of the disease in two or more first-degree relatives in the absence of other known familial syndromes. With the increasing incidence of PTC in the recent years, the familial form of the disease has also become more common than previously reported and constitutes nearly 10% of all thyroid cancers. Many...
Tue Oct 06, 2020 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου