Endoscopic Versus Microscopic Cartilage Myringoplasty in Chronic Otitis Media. Iran J Otorhinolaryngol. 2020 Sep;32(112):263-269 Authors: Daneshi A, Daneshvar A, Asghari A, Farhadi M, Mohebbi S, Mohseni M, Yazdani N, Mohammadi S, Hosseinzadeh F Abstract Introduction: Operations on the tympanic membrane of the middle ear, myringoplasty, and tympanoplasty are now widely accepted, and attempts are underway all over the world to standardize the...
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Predictors of Olfactory Impairment among Northern Iranian Population. Iran J Otorhinolaryngol. 2020 Sep;32(112):271-279 Authors: Jalali MM, Faghih Habibi A, Ghorbani Samin M Abstract Introduction: The performance in most smell identification tests is subjected to cultural variations. This study aimed to evaluate age, gender, and smoking-related effects on the test performance in the North of Iran. Materials and Methods: The olfactory...
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Our Experience with Kashimas Procedure for Bilateral Abductor Vocal Cord Palsy. Iran J Otorhinolaryngol. 2020 Sep;32(112):281-285 Authors: Maqbool T, Ahmed R, Ali I Abstract Introduction: Kashima operation, also known as endoscopic laser cordotomy is used for the treatment of bilateral abductor vocal cord palsy where the glottis chink is made posteriorly, sufficient enough for patient to breathe comfortably without any strider. Materials...
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Endoscopy Guided Eustachian Tube Balloon Dilation: Our Experiences. Iran J Otorhinolaryngol. 2020 Sep;32(112):287-294 Authors: Swain SK, Janardan S, Mohanty JN Abstract Introduction: Eustachian tube (ET) dysfunction is a common clinical entity but its treatment is still challenging to Otorhinolaryngologists. This study is done to know the effectiveness of transnasal endoscopic balloon dilatation of eustachian tube for treatment of chronic...
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Structural Characteristics of the Iranians Nose: An Anatomical Analysis. Iran J Otorhinolaryngol. 2020 Sep;32(112):295-301 Authors: Ghorbani J, Safavi Naeini A, Mehrparvar G, Doroudinia A, Kahkouee S, Emami H Abstract Introduction: Rhinoplasty is one of the most common surgical procedures performed among Iranians. An important issue to be considered by nasal surgeons is anatomical variations between different ethnic groups. Working on Iranians...
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Cryosurgery Vs Trichloroacetic Acid Chemical Cautery for the Treatment of Hypertrophied Nasal Turbinate: A Comparative Study. Iran J Otorhinolaryngol. 2020 Sep;32(112):303-309 Authors: Satpute SS, Joshi SV, Arora R, Prabha N, Keche P, Nagarkar NM Abstract Introduction: The Study Aimed To Compare The Results of Cryosurgery With Trichloroacetic Acid Chemical (TCA) Cautery For The Treatment of Hypertrophied Nasal Turbinates. Materials...
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The Effect of Cognitive Tasks on the Ocular Vestibular Evoked Myogenic Potentials in Healthy People.
The Effect of Cognitive Tasks on the Ocular Vestibular Evoked Myogenic Potentials in Healthy People. Iran J Otorhinolaryngol. 2020 Sep;32(112):311-317 Authors: Sanayi R, Rahimi V, Mohamadkhani R, Hoseinabadi R Abstract Introduction: The majority of the daily life activities involve the concurrent performance of simultaneously challenging motor and cognitive activities, such as talking while walking, which requires the vestibular system for...
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Post-Rhinoplasty Acne, Frequency and Role Players. Iran J Otorhinolaryngol. 2020 Sep;32(112):319-325 Authors: Bakhshaee M, Poursadegh M, Irani M, Yazdanpanah MJ, Fayyazi Bordbar MR, Rasoulian B Abstract Introduction: Acne is a common complain among post rhinoplasty patients. While rhinoplasty is done for aesthetic reasons and acne expressively affects the individual's appearance, we aimed to study its incidence and role players. Materials...
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Metastasis of Colon Adenocarcinoma to Maxillary Gingiva and Palate. Iran J Otorhinolaryngol. 2020 Sep;32(112):327-331 Authors: Dalirsani Z, Mohtasham N, Samiee N Abstract Introduction: Colon adenocarcinoma is one of the foremost causes of cancer mortality. Oral metastasis of colon adenocarcinoma is, however, rare and indicates an end-stage disease process. Case Report: We report a case of a 69-year-old female with a gingival mass...
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Dyspnea in Patient with Arteria Lusoria: A Case Report. Iran J Otorhinolaryngol. 2020 Sep;32(112):333-336 Authors: Massaro N, Verro B, Greco G, Saraniti C Abstract Introduction: Arteria lusoria is an aberrant right subclavian artery. In symptomatic cases, patients report dysphagia and only in few cases dyspnea, due to external compression of the trachea and esophagus. Symptoms occur in advanced age and diagnosis is made with chest HRCT, when...
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The authors conducted a multicenter retrospective study on the outcome of programmed death-ligand 1 tumor proportion score≥50% advanced non–small cell lung cancer patients treated with first-line pembrolizumab according to the presence/absence of brain metastases. A total of 282 patients were included, of whom 56 had brain metastases that were treated with upfront local radiation therapy in 80.3% of cases. The overall response rate was 39.2% and 44.4% in patients with and without brain metastases...
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Here, we report the presentation and management of a rare case of sight-threatening bilateral panuveitis with secondary chronic hypotony, subcapsular cataracts, exudative retinal detachments, and choroidal detachments, following initiation of pembrolizumab immunotherapy for metastatic melanoma. An 82-year-old white woman presented with painful, blurry vision 3 days after initiation of pembrolizumab immunotherapy. She had developed a marked panuveitis causing secondary hypotony. The fundal view was...
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Epithelioid sarcoma, in the relapse-refractory setting, has limited expected survival. SMARCB1 inactivation, common in epithelioid sarcoma, causes loss of INI1 protein expression and overexpression of the cancer cell growth promoting methyltransferase enzyme, EZH2. We treated a 19-year-old male with stage IV SMARCB1 inactivated epithelioid sarcoma presenting with recurrent end stage (Eastern Cooperative Oncology Group Performance Status 4) rapidly progressing bulky disease with combination ipilimumab...
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Expression of carbonic-anhydrase IX (CAIX) in clear cell renal cell carcinoma (RCC) makes it an attractive vaccine target. We developed a fusion-gene construct, granulocyte-macrophage (GM) colony-stimulating factor+CAIX, delivered by an adenoviral vector (Ad) into autologous dendritic cells (DCs) in this phase 1 study. The injected immature DCs were expected to stimulate an antigen-specific immune response against CAIX expressing RCC. Three dose-escalation cohorts (5, 15, and 50×106 cells/administration)...
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Colitis is a major immune-related adverse event associated with programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) inhibitors, but the risk of colitis with PD-1 versus PD-L1 inhibitors is not well characterized. We performed a meta-analysis for the incidence of all grade and grade 3–4 colitis with PD-1 inhibitor (nivolumab, pembrolizumab, and cemiplimab) or PD-L1 inhibitor (atezolizumab, avelumab, and durvalumab) monotherapy using a fixed effects model. We also conducted subgroup meta-analyses...
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Tumor-specific Tc9 cells exhibit an excellent antitumor potential in tumor immunotherapy. Identification of factors that contribute to Tc9-cell differentiation may have important clinical significance. In this study, we found that tumor necrosis factor (TNF)-α promotes Tc9 differentiation in vitro, and the TNF-α-induced Tc9 cells display enhanced cell survival and cell proliferation. More importantly, the TNF-α-induced tumor-specific Tc9 cells have increased antitumor capabilities in vivo. TNF-α...
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Abstract Purpose The aim of this study was to investigate whether bone mineral density (BMD) as measured in planning computed tomographies (CTs) by a new method is a risk factor for pelvic insufficiency fractures (PIF) after radio(chemo)therapy (R(C)T) for cervical cancer. Methods 62 patients with cervical cancer who received definitive or adjuvant...
Tue Oct 06, 2020 03:00
Abstract ObjectiveTo examine the relationship between fear of cancer recurrence (FCR) and healthcare utilization among long‐term breast cancer survivors (BCS).MethodsIn a cross‐sectional survey study, 505 younger survivors (YS: ≤45 years) and 622 older survivors (OS: 55‐70 years) 3‐8 years from diagnosis completed a questionnaire assessing demographics, medical history, FCR, and healthcare utilization. Healthcare utilization consisted of breast cancer (BC) and non‐BC‐related routine and non‐routine...
Tue Oct 06, 2020 13:47
Abstract There has been a rapid progress in developing genetically engineered T cells in recent years both in basic and clinical cancer studies. Chimeric antigen receptor (CAR)-T cells exert an immune response against various cancers, including the non-small-cell lung cancer (NSCLC). As novel agents of immunotherapy, CAR-T cells show great promise for NSCLC. However, targeting specific antigens in NSCLC with engineered CAR-T cells is complicated because of a lack of tumor-specific...
Tue Oct 06, 2020 03:00
Abstract Purpose Autoimmune thyroid disease (AITD) is a classic autoimmune disorder that mainly includes Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). In this study, we explored the potential relationship between single-nucleotide polymorphisms (SNPs) of methyltransferase like 3 (METTL3) gene and the development of AITD. Methods The distribution...
Tue Oct 06, 2020 03:00
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Tue Oct 06, 2020 03:00
Abstract Purpose To investigate the changes of the serum parathyroid hormone (PTH) and calcium level, as well as bone mineral density (BMD), after percutaneous ultrasound-guided microwave ablation (MWA) for primary hyperparathyroidism (pHPT) caused by single hyperfunctional nodule. Methods The study enrolled 20 patients with a total of 20 nodules of...
Tue Oct 06, 2020 03:00
Abstract Purpose After the accidents of nuclear power plants at Chernobyl and at Fukushima, huge amounts of radioactive iodine were released into the atmosphere. Methods We reviewed data on the health consequences of these accidents with a focus on thyroid consequences. Results ...
Tue Oct 06, 2020 03:00
Abstract Objective The hobnail variant of papillary thyroid carcinoma (HVPTC) has emerged as a rare and aggressive variant of papillary thyroid carcinoma (PTC). We aim to determine the prevalence and clinicopathologic factors of HVPTC. Methods A systematic review of the literature for studies examining HVPTC was performed. Four databases (PubMed, Scopus,...
Tue Oct 06, 2020 03:00
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Tue Oct 06, 2020 03:00
Abstract Objective DNA methylation regulates the expression of various genes involved in tumorigenesis. Ameloblastoma is a benign odontogenic jaw tumor. It is locally aggressive with a high level of recurrence. A delay in treatment can lead to severe facial disfigurement. To the best of our knowledge, this is the first integrated analysis of DNA methylation and gene expression in ameloblastoma with the aim to identify genes that may be regulated by DNA methylation. Materials and Methods...
Tue Oct 06, 2020 12:57
Tue Oct 06, 2020 13:07
Abstract Omega‐3 polyunsaturated fatty acids (ω‐3 PUFAs) have been reported to exert important roles in the inflammatory response. There are many inflammatory diseases in dentistry which support the administration of ω‐3 PUFAs as an adjunct therapy during the treatment of these diseases. The aim of this review was to evaluate the use of ω‐3 PUFAs as an adjuvant therapy during the treatment of buccal diseases. The review showed that supplementation with ω‐3 PUFAs was used for treatment of gingivitis,...
Tue Oct 06, 2020 13:09
Objectives. Parents play a crucial role in health-related practices of children with autism spectrum disorder (ASD). This study assessed the association between oral health status and oral health practices of children with ASD in relation to their parental attitudes and comfort in providing oral care. Methods. This cross-sectional study included 75 children with ASD attending the special needs schools in Eastern Saudi Arabia from 2015–2018. Parents responded to a self-administered questionnaire assessing...
Tue Oct 06, 2020 13:05
Opuntia dillenii (Ker-Gawl.) Haw. is a medicinal plant that is widely used by the Moroccan population to treat many diseases, thanks to its richness in bioactive molecules. This study aims to evaluate the total phenolic content and antioxidant, antihyperlipidemic, and antidiabetogenic activities of O. dillenii seeds oil (ODSO), in vivo. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay and the Folin–Ciocalteu method were applied in this study to determine antioxidant activity and total phenolic...
Tue Oct 06, 2020 20:35
British Journal of Cancer, Published online: 07 October 2020; doi:10.1038/s41416-020-01095-xThymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer
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British Journal of Cancer, Published online: 07 October 2020; doi:10.1038/s41416-020-01110-1Artificial selection for host resistance to tumour growth and subsequent cancer cell adaptations: an evolutionary arms race
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British Journal of Cancer, Published online: 07 October 2020; doi:10.1038/s41416-020-01092-0Correlative serum biomarker analyses in the phase 2 trial of lenvatinib-plus-everolimus in patients with metastatic renal cell carcinoma
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British Journal of Cancer, Published online: 07 October 2020; doi:10.1038/s41416-020-01089-9Treatments after progression to first-line FOLFOXIRI and bevacizumab in metastatic colorectal cancer: a pooled analysis of TRIBE and TRIBE2 studies by GONO
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British Journal of Cancer, Published online: 07 October 2020; doi:10.1038/s41416-020-01112-zLysine demethylase 2A expression in cancer-associated fibroblasts promotes breast tumour growth
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British Journal of Cancer, Published online: 07 October 2020; doi:10.1038/s41416-020-01096-wNme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma
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British Journal of Cancer, Published online: 07 October 2020; doi:10.1038/s41416-020-01108-9Association of post-diagnostic use of cholera vaccine with survival outcome in breast cancer patients
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British Journal of Cancer, Published online: 07 October 2020; doi:10.1038/s41416-020-01090-2The mutational landscape of melanoma brain metastases presenting as the first visceral site of recurrence
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Abstract Purpose Wound healing is an important factor influencing morbidity following surgical procedures. The association of obstructive sleep apnea (OSA) with numerous postoperative complications has been previously reported. In this study, we report the impact of OSA-related symptoms on wound complications in breast cancer patients in the postoperative period. Methods...
Tue Oct 06, 2020 03:00
Abstract Purpose Infarct growth and final infarct volume are established outcome modifiers following endovascular thrombectomy (EVT) for patients with large vessel occlusion stroke (LVO). Simple techniques for final infarct volume measurement are lacking, and therefore, we tested whether post-EVT ASPECTS can be used for prognostic evaluation after EVT. Methods ...
Tue Oct 06, 2020 03:00
Abstract Purpose The ultrasonographic and hemodynamic features of patients with carotid near-occlusion (CNO) are still not well known. Our aim was to describe the ultrasonographic and hemodynamic characteristics of a cohort of patients with CNO. Methods A prospective, observational, nationwide, and multicenter study was conducted from January/2010...
Tue Oct 06, 2020 03:00
Abstract Purpose We investigated the hypothesis that increasing fMRI temporal resolution using a multiband (MB) gradient echo-echo planar imaging (GRE-EPI) pulse sequence provides fMRI language maps of higher statistical quality than those acquired with a traditional GRE-EPI sequence. Methods This prospective study enrolled 29 consecutive patients...
Tue Oct 06, 2020 03:00
Abstract Purpose Evaluation of water material density images (wMDIm) of dual-energy CT (DECT) for earlier prediction of final infarct volume (fiV) in follow-up single-energy CT (SECT) and correlation with clinical outcome. Methods Fifty patients (69 years, ± 12.1, 40–90, 50% female) with middle cerebral artery (MCA) occlusions were included. Early...
Tue Oct 06, 2020 03:00
Abstract Purpose To elucidate the effect of deep learning–based computer-assisted detection (CAD) on the performance of different-level physicians in detecting intracranial haemorrhage using CT. Methods A total of 40 head CT datasets (normal, 16; haemorrhagic, 24) were evaluated by 15 physicians (5 board-certificated radiologists, 5 radiology residents,...
Tue Oct 06, 2020 03:00
Journal of Neurotrauma, Ahead of Print.
Tue Oct 06, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Tue Oct 06, 2020 10:00
Abstract Purpose To evaluate the clinical characteristics and prognosis of elderly nasopharyngeal carcinoma (NPC) patients receiving intensity-modulated radiotherapy (IMRT). Methods From June 2008 to October 2014, 148 newly diagnosed non-metastatic elderly NPC patients (aged ≥ 70 years) receiving IMRT were recruited. Comorbid condition was evaluated using...
Tue Oct 06, 2020 03:00
Abstract Objectives There is a lack of data on patients’ and diagnostic factors for prognostication of complete recovery in patients with non-idiopathic peripheral facial palsy (FP). Methods Cohort register-based study of 264 patients with non-idiopathic peripheral FP and uniform diagnostics and standardized treatment in a university hospital from 2007 to...
Tue Oct 06, 2020 03:00
Abstract The coronavirus disease (COVID-19) is caused by Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and presents with respiratory symptoms which can be life threatening in severe cases. At the start of the pandemic, allergy, asthma, and chronic obstructive pulmonary disease (COPD) were considered as risk factors for COVID-19 as they tend to exacerbate during respiratory viral infections. Recent literature has not shown that airway allergic diseases is a high-risk...
Tue Oct 06, 2020 03:00
Abstract Purpose In cases of small- to medium-sized vestibular schwannomas, three management strategies can be opted for: active surveillance, surgery or radiotherapy. In these cases, the patient’s preference is pivotal in decision-making. The aim of this study was to identify factors that influence a patient’s decision for a particular management strategy. Methods ...
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FIGO grade 3 endometrioid endometrial carcinoma (EEC) is a heterogenous group of tumors with variable molecular and clinicopathologic characteristics but is treated clinically as a single entity. There is a need for additional objective markers to help guide management. The aim of this study was to evaluate a cohort of FIGO grade 3 EEC to validate the prognostic impact of molecular classification using POLE mutation (POLE-mut) analysis and immunohistochemistry for p53 and mismatch repair proteins....
Mon Oct 05, 2020 03:00
Pericytic tumors encompass several entities sharing morphologic and immunohistochemical features. A subset of perivascular myoid tumors associated with the SRF-RELA fusion gene was previously described. Herein, we report a series of 13 tumors belonging to this group, in which we have identified new fusion genes by RNA-sequencing, thus expanding the molecular spectrum of this entity. All patients except 1 were children and infants. The tumors, frequently located in the head (n=8), had a mean size...
Mon Oct 05, 2020 03:00
Abstract Gefitinib (Iressa), is a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), used in the targeted treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC). Skin toxicity is the major adverse effect observed in patients treated with EGFR-targeted TKIs such as gefitinib and erlotinib. To date, a corresponding skin animal model has not been established to address the mechanisms of these effects. Therefore, we analyzed...
Tue Oct 06, 2020 03:00
After publication of our article [1], we found that the second images in the first row in Figure 2a were inadvertently replaced with the first image in Figure 2a.
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Abstract The commercial reality of microalgal biotechnology for the production of individual bioactives is constrained by the high cost of production and requires a biorefinery approach. In this investigation, we examined the influence of different nutrient deprivation (nitrogen (N), phosphorus (P), sulphur (S) and manganese (Mn)) on growth, chlorophyll a (Chl a), biohydrogen (H2) and fatty acid profiles in Parachlorella kessleri EMCCN 3073 under both...
Tue Oct 06, 2020 03:00
Abstract Immobilizarion of PGPR for agricultural applications aims to provide temporary physical protection from stressful environmental conditions and the gradual release of cells for successful root colonization, release the cells gradually. In this work, we immobilized Bradyrhizobium sp. SEMIA6144 or Azospirillum brasilense Az39 cells in 2% alginate beads prepared by ionic gelation process, and then stored up to 12 months at 4 °C. Alginate matrix showed...
Tue Oct 06, 2020 03:00
Abstract Agrobacterium tumefaciens synthesizes polyphosphate (polyP) in the form of one or two polyP granules per cell during growth. The A. tumefaciens genome codes for two polyphosphate kinase genes, ppk1AT and ppk2AT, of which only ppk1AT is essential for polyP granule formation in vivo. Biochemical characterization of the purified PPK1AT and PPK2AT proteins revealed a higher substrate specificity of PPK1AT (in particular for adenine nucleotides) than...
Tue Oct 06, 2020 03:00
Abstract Overproduction of recombinant secretory proteins triggers numerous physiological perturbations. Depending on a given heterologous protein characteristics, the producer cell is faced with different challenges which lead to varying responses in terms of its physiology and the target protein production rate. In the present study, we used steady-state-maintained Yarrowia lipolytica cells to investigate the impact of different heterologous proteins on the physiological behavior...
Tue Oct 06, 2020 03:00
Abstract The enzymatic synthesis of alkyl ferulates is an important reaction in cosmetic and pharmaceutical chemistries, since it may allow to expand the biorefinery concept valorizing biomass wastes enriched in ferulic acid. However, robust biocatalysts for that purpose are scarce. Herein, we have immobilized the type A feruloyl esterase from Aspergillus niger (AnFaeA) as cross-linked enzyme aggregates, employing chitosan as co-feeder (ChCLEAs). High immobilization...
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Abstract Wheat seedlings are significantly impacted by the presence of bacteria. However, bacteria are unavoidably growing together with wheat. The study aimed to reveal wheat photosynthesis, phyllosphere bacterial community composition, and a shift in the bacterial community following different density treatments in a closed artificial ecosystem. Here, we report the relationship between photosynthesis and bacterial community in wheat seedlings for different planting densities....
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Abstract Recent studies reveal that glycerol monolaurate (GML) is regarded as an effective feed supplement in the production of broilers; however, the underlying mechanism remains unknown. The current study aimed to investigate how GML affected production performance and meat quality in yellow-feathered broilers. A total of 528 chicks were randomly assigned into four groups for a 56-day feeding trial. The control group received a basal diet, and the treated...
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Abstract Purpose of Review To review the peripheral neurological complications of the acute hepatic porphyrias, as well as the latest advances in their pathophysiology and management. Recent Findings The diagnosis of porphyric neuropathy remains challenging as varying neuropathic patterns are encountered depending on disease stage, including...
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In a series of comment letters delivered today to the Centers for Medicare & Medicaid Services (CMS), the American Speech-Language-Hearing Association (ASHA) is advocating for agency action on multiple fronts to improve access to telehealth services during the continuing COVID-19 public health emergency as well as to preserve Medicare beneficiaries' access to medically necessary services provided by audiologists and speech-language pathologists, who are set to experience significant payment reductions...
Mon Oct 05, 2020 20:25
By Laura ArenschieldWe hear sounds in part because tiny filaments inside our inner ears help convert voices, music and noises into electrical signals that are sent to our brains for processing. Now, scientists have mapped and simulated those filaments at the atomic level, a discovery that shed lights on how the inner ear works and that could help researchers learn more about how and why people lose the ability to hear.The findings, published last week in the Proceedings of the National Academy of...
Tue Oct 06, 2020 15:50
Abstract Nasolabial flap is very versatile flap for the lesion of basal cell carcinoma of nose. It is preferred choice for the closure of surgical defect of nose after removing the lesion of basal cell carcinoma. This flap has very good vascularity and scar is almost invisible. The objective of this study to evaluate the suitability of nasolabial flap for the basal cell carcinoma, the survival of the flap, cosmetic appearance of the patient after the surgery and patient satisfaction....
Tue Oct 06, 2020 03:00
Abstract Maxillary swing approaches provide excellent exposure of the anterior, mid, and anterolateral skull base offering a wide window to approach nasopharyngeal neoplasms; however, they are also associated with complications. The present study aimed to evaluate the results of a modified total maxillary swing (TMS) approach developed to minimize postoperative complications. The modified TMS approach was used to treat five patients who had extensive juvenile nasopharyngeal angiofibromas...
Tue Oct 06, 2020 03:00
Abstract IJP is a rare, congenital, benign, isolated, sporadically occurring fusiform or saccular dilatation of Internal Jugular Vein (IJV) of unknown aetiology usually presenting as a unilateral neck mass. It is mostly seen in children and young adults. We report a 4 year old male presented to Expert ENT & Diagnostic Centre presenting with history of painless right neck swelling in the right carotid triangle first observed on crying with no history of trauma, facial congestion,...
Tue Oct 06, 2020 03:00
Abstract Laryngeal cleft is a rare pathology and needs a high index of suspicion for diagnosis. Various classifications are used but the Inglis classification which describes 4 grades of cleft is most widely accepted. Grade 3 and 4 clefts are very rare and are usually associated with other congenital abnormalities. Grade 1 and 2 clefts are more common and can be easily corrected with good outcomes. We are presenting our experience with 9 cases of low grade (Grade 1 and 2) laryngeal...
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Most similarities between kangaroo and human spines were found for the vertebral bodies in the cervical and the lumbar spine. The largest differences were evident for the spinous processes. Although both species are somehow upright, these differences may be explained by the way how they move. Jumping probably requires more muscle strength than walking on two legs. Abstract The upright posture of the kangaroo suggests that the spine of the kangaroo could be a possible substitute model for biomechanical...
Tue Oct 06, 2020 21:03
Abstract Cancer of Unknown Primary (CUP) is a metastasised malignancy with no identifiable primary tumour origin. Despite the frequent occurrence and bleak prognosis of CUP, research into its aetiology is scarce. This study investigates alcohol consumption, tobacco smoking and CUP risk. We used data from the Netherlands Cohort Study, a cohort that includes 120,852 participants aged 55‐69 years, who completed a self‐administered questionnaire on cancer risk factors at baseline. Cancer follow‐up was...
Tue Oct 06, 2020 13:46
Desmoid tumors (DTs) are a rare disease of intermediate malignancy characterized histologically by a locally aggressive, monoclonal, fibroblastic proliferation and clinically by a variable and often unpredictable course. For decades, surgical resection has been the standard initial treatment approach; however, more recently, a paradigm shift toward a more conservative treatment strategy has been introduced. More than 5 years ago, The Desmoid Tumor Working Group started a consensus initiative in Europe...
Tue Oct 06, 2020 11:54
Background CABOSUN was a randomized, open‐label, phase 2 trial evaluating first‐line cabozantinib versus sunitinib in patients with advanced renal cell carcinoma (aRCC). This post hoc analysis evaluated quality‐adjusted survival using Quality‐adjusted Time Without Symptoms of disease or Toxicity of treatment (Q‐TWiST). Methods Survival plots for cabozantinib and sunitinib (650‐day follow‐up) were partitioned into 3 health states: time spent before disease progression without toxicity (TWiST;...
Tue Oct 06, 2020 11:59
Abstract Biologists usually pursue the adaptationist paradigm in trying to explain the functional significance of animal coloration. Here I collate instances in which coloration may be a poor match in the context of background matching, Batesian mimicry, aposematism, and colour polymorphisms. This can occur because of trade-offs with other functions, relaxed selection from predation, or colour trait neutrality. Also, mechanistic, pleiotropic and chance genetic effects can all...
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African maternal ancestry and diversity of the Anson Street Ancestors. Abstract Objectives In 2013, the burials of 36 individuals of putative African ancestry were discovered during renovation of the Gaillard Center in downtown Charleston, South Carolina. The Charleston community facilitated a bioarchaeological and mitogenomic study to gain insights into the lives of these unknown persons, referred to as the Anson Street Ancestors, including their ancestry, health, and lived experiences...
Tue Oct 06, 2020 19:58
A geometric morphometric approach to the study of sexual dimorphism in the modern human frontal bone
Shape variation associated to the female (left) and male (right) morphology. Abstract Objectives We analyzed the main anatomical traits found in the human frontal bone by using a geometric morphometric approach. The objectives of this study are to explore how the frontal bone morphology varies between the sexes and to detect which part of the frontal bone are sexually dimorphic. Materials and methods The sample is composed of 161 skulls of European and North American individuals...
Tue Oct 06, 2020 20:40
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo identify Parkinson’s disease (PD)-associated deregulated pathways and genes, to further elucidate the pathogenesis of PD.MethodsDataset GSE100054 was downloaded from the Gene Expression Omnibus, and differentially expressed genes (DEGs) in PD samples were identified. Functional enrichment analyses were conducted for the DEGs. The top 10 hub genes in the protein–protein interaction (PPI) network were screened...
Tue Oct 06, 2020 13:01
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectivePatients receiving carbon-ion radiation therapy and astronauts exploring outer space are inevitably exposed to heavy ion radiation. The aim of this study was to develop radioprotectors to minimize the injuries induced by carbon ion radiation.MethodsHeat-killed Salmonella Typhimurium (HKST) was administered to mice by gavage prior to irradiation with a 12C6+ heavy ion accelerator. Hematoxylin and eosin staining...
Tue Oct 06, 2020 05:19
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveOsteoporosis and osteoarthritis are metabolic skeletal disorders. This study aimed to identify specific networks of competitive endogenous RNA (ceRNA) in osteoporosis that differ from those in osteoarthritis.MethodsThe dataset GSE74209 was downloaded from the Gene Expression Omnibus, and differentially expressed microRNAs (DEmiRNAs) in osteoporotic samples and osteoarthritic samples were identified. After predicting...
Tue Oct 06, 2020 07:39
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