CD47-SIRPα Axis as a Biomarker and Therapeutic Target in Cancer: Current Perspectives and Future Challenges in Nonsmall Cell Lung Cancer. J Immunol Res. 2020;2020:9435030 Authors: Catalán R, Orozco-Morales M, Hernández-Pedro NY, Guijosa A, Colín-González AL, Ávila-Moreno F, Arrieta O Abstract CD47 is a cell surface protein in the immunoglobulin superfamily which is normally expressed at low levels in every healthy cell. It´s main physiologic...
Human skin biomarkers relationship to response to treatment with tyrosine kinase inhibitors in advanced EGFR-mutated lung adenocarcinoma. Thorac Cancer. 2020 Oct 05;: Authors: Castañeda-Zárraga A, Rodríguez-Cid JR, Flores-Mariñelarena RR, Trinidad-Bibiano H, Martínez-Herrera JF, Sánchez-Ríos CP, Fernández-Garibay VM, Alatorre-Alexander JA, Martínez-Barrera L, Santillán-Doherty PJ, Vega-Memije ME Abstract BACKGROUND: A relationship between the...
Pembrolizumab plus axitinib combination and the paradigm change in the treatment of advanced renal cell carcinoma. Future Oncol. 2020 Oct 05;: Authors: Spisarová M, Melichar B, Vitásková D, Študentová H Abstract Sequential administration of single targeted agents has been challenged as the dominant treatment paradigm in patients with metastatic renal cell carcinoma by improved outcomes obtained with combination regimens based on immune checkpoint...
Ethical health leadership: Lessons from low- and middle-income countries during COVID-19. Healthc Manage Forum. 2020 Oct 05;:840470420961913 Authors: Munezhi M, Hammad N Abstract We adopt a holistic-micro, meso, macro-approach to health leadership ethics to examine how low- and middle-income countries have responded to the COVID-19 pandemic. Healthcare delivery happens within complex settings in low- and middle-income countries and high-income...
Do we know the effects of colorectal cancer screening? A short communication on selective uptake and differential effects of colorectal cancer screening in Scandinavia. Scand J Public Health. 2020 Oct 04;:1403494820960641 Authors: Pallesen AVJ, Herrstedt J, Westendorp RGJ, Mortensen LH, Kristiansen M Abstract Colorectal cancer (CRC) contributes extensively to the overall cancer burden, with substantial and increasing social inequality in both...
High-grade serous peritoneal cancer follows a high stromal response signature and shows worse outcome than ovarian cancer. Mol Oncol. 2020 Oct 05;: Authors: Jacob F, Marchetti RL, Kind AB, Russell K, Schoetzau A, Heinzelmann-Schwarz VA Abstract In the era of personalized medicine, where transition from organ-based to individualized genetic diagnosis takes place, the tailoring of treatment in cancer becomes increasingly important. This is particularly...
mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer. J Clin Invest. 2020 Oct 05;: Authors: Cafri G, Gartner JJ, Zaks T, Hopson K, Levin N, Paria BC, Parkhurst MR, Yossef R, Lowery FJ, Jafferji MS, Prickett TD, Goff SL, McGowan CT, Seitter S, Shindorf ML, Parikh A, Chatani PD, Robbins PF, Rosenberg SA Abstract BACKGROUNDTherapeutic vaccinations against cancer have mainly targeted differentiation...
Identification of adolescents and young adults' preferences and priorities for future cancer treatment using a novel decision-making tool. Pediatr Blood Cancer. 2020 Oct 05;:e28755 Authors: Snaman JM, Helton G, Holder RL, Revette A, Baker JN, Wolfe J Abstract BACKGROUND: Adolescents and young adults (AYAs) with cancer receive high-intensity care and experience significant symptoms at the end of life. As novel cancer-directed therapies increase,...
Myelin water imaging depends on white matter fiber orientation in the human brain. Magn Reson Med. 2020 Oct 05;: Authors: Birkl C, Doucette J, Fan M, Hernández-Torres E, Rauscher A Abstract PURPOSE: The multi-exponential T2 decay of the MRI signal from cerebral white matter can be separated into short T2 components related to myelin water and long T2 components related to intracellular and extracellular water. In this study, we investigated...
Safety and Preliminary Efficacy of Ramucirumab in Combination with FOLFOX4 in Patients with Advanced Hepatocellular Carcinoma: A Nonrandomized, Open-Label, Phase Ib Study. Oncologist. 2020 Oct 05;: Authors: Lin CC, Yang TS, Yen CJ, Cheng R, Liu J, Hsu C Abstract LESSONS LEARNED: The combination of ramucirumab (8 mg/kg IV, day 1 every 2 weeks) and FOLFOX4 as first-line treatment in patients with advanced hepatocellular carcinoma (HCC) was not...
Acute Graft-versus-Host-Disease other than typical targets: between myths and facts. Biol Blood Marrow Transplant. 2020 Oct 02;: Authors: Mariotti J, Penack O, Castagna L Abstract Donor alloreactivity after allogeneic hematopoietic stem cell transplantation results in graft-versus-host reaction (GVHR) that may affect different organs. While skin, liver and gastrointestinal tract are well recognized targets of such alloreactivity early after...
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[Clinicopathological features of primary EB virus positive nodal T/NK cell lymphoma]. Zhonghua Bing Li Xue Za Zhi. 2020 Oct 08;49(10):1009-1014 Authors: Wang GN, Zhao WG, Zhang DD, Zhang YP, Huang XJ, Li WC Abstract Objective: To investigate the clinicopathological features of primary Epstein-Barrvirus (EBV) positive nodal T/NK-cell lymphomas (EBV+nodal TNKL). Methods: The clinicopathological features of 7 cases of EBV+nodal TNKL diagnosed...
[CD20-positive T cell lymphoma: clinicopathological features of five cases]. Zhonghua Bing Li Xue Za Zhi. 2020 Oct 08;49(10):1021-1026 Authors: Shao SH, Wang Y, Dai XY, Xiao YJ, Guan JJ, Lin DL, Wang JG, Li YJ, Xing XM, Zhao P Abstract Objective: To investigate the clinicopathological characteristics of the T cell lymphomas with CD20 expression, and to better understand this rare entity. Methods: Two-hundred cases of T-cell lymphoma diagnosed...
Oral melanotic neuroectodermal tumor of infancy: Management of a case affecting the maxilla. J Indian Soc Pedod Prev Dent. 2020 Jul-Sep;38(3):319-322 Authors: Agrawal A, Joshi J, Agrawal D, Kumar P, Modi B Abstract Melanotic neuroectodermal tumor is a rare benign congenital neoplasm involving the head-and-neck region found in infants <1 year of age. The lesion most commonly affects the maxilla. We report the case of a 4-month-old male child...
Epithelioid trophoblastic tumor coexisting with choriocarcinoma around an abdominal wall cesarean scar: a case report and review of the literature. J Med Case Rep. 2020 Oct 05;14(1):178 Authors: Yang C, Li J, Zhang Y, Xiong H, Sheng X Abstract BACKGROUND: Mixed gestational trophoblastic neoplasms are extremely rare and comprise a group of fetal trophoblastic tumors including choriocarcinomas, epithelioid trophoblastic tumors, and placental...
Anaplastic extraosseous (extramedullary) plasmacytoma in the right nostril. Rev Esp Patol. 2020 Oct - Dec;53(4):257-263 Authors: Ramos-Martínez E, Lagunas-Rangel FA Abstract Extraosseous (extramedullary) plasmacytomas are rare plasma cell neoplasms that can result in an erroneous and/or delayed diagnosis as often they are not considered in the differential diagnosis due to their rarity. Furthermore, the anaplastic type is one of the most difficult...
Myeloid, mast cell, histiocytic and dendritic cell neoplasms and proliferations involving the spleen. Semin Diagn Pathol. 2020 Jul 31;: Authors: Prakash S, Padilla O, Tam W Abstract Splenic involvement and consequent splenomegaly are usually seen as part of systemic involvement by myeloid neoplasms as well as mast cell and histiocytic neoplasms. Primary splenic involvement by these neoplasms is rare. Splenectomy is usually not performed for...
Malignant Granular Cell Tumor of the Esophagus: A Case Report. Ann Thorac Cardiovasc Surg. 2020 Oct 02;: Authors: Stašek M, Aujeský R, Škarda J, Švébišová H, Vrba R, Szkorupa M, Neoral C Abstract INTRODUCTION: Malignant granular cell tumor (MGCT) of the esophagus is an extremely rare malignancy with a poor prognosis. Literature describing this condition is not sufficient, especially regarding long-term survival. PRESENTATION OF CASE:...
Imaging performance and preoperative differential diagnosis of multiple myopericytoma in the liver: A case report. Mol Clin Oncol. 2020 Dec;13(6):66 Authors: Kang X, Li F, Gao H, Wang S Abstract Myopericytoma is a rare type of benign tumor, which commonly affects all four limbs. The occurrence of myopericytoma in the liver is extremely rare. Myopericytoma with a size of >1 cm in diameter in the liver has not been previously reported. Due...
Non-Small Cell Lung Cancer With Synchronous Peritoneal Adenocarcinoma: A Rare Independent Combination. Cureus. 2020 Aug 31;12(8):e10166 Authors: Mandal S, Pradhan RR, Bethala MG, Khan S, Karki A Abstract Lung cancer is one of the most common malignancies worldwide, and metastasis occurs in more than one-third of cases. Common sites of metastatic disease are the brain, spine, nerve, adrenal glands, bone, liver, and pleura. Peritoneal involvement,...
Pembrolizumab in a Patient With Heavily Pre-Treated Squamous Cell Thymic Carcinoma and Cardiac Impairment: A Case Report and Literature Review. Front Oncol. 2020;10:1478 Authors: Cafaro A, Bongiovanni A, Di Iorio V, Oboldi D, Masini C, Ibrahim T Abstract Immunotherapy directed at the programmed cell death-1 receptor (PD-1) or its ligand PD-L1 has proven effective in solid malignancies such as melanoma, non-small cell lung cancer (NSCLC), urothelial...
CDKN2C-Null Leiomyosarcoma: A Novel, Genomically Distinct Class of TP53/RB1-Wild-Type Tumor With Frequent CIC Genomic Alterations and 1p/19q-Codeletion. JCO Precis Oncol. 2020;4: Authors: Williams EA, Sharaf R, Decker B, Werth AJ, Toma H, Montesion M, Sokol ES, Pavlick DC, Shah N, Williams KJ, Venstrom JM, Alexander BM, Ross JS, Albacker LA, Lin DI, Ramkissoon SH, Elvin JA Abstract PURPOSE: Leiomyosarcoma (LMS) harbors frequent mutations in...
Clear Cell carcinoma of the urinary bladder, A case report: Surgical and oncological management. Arch Ital Urol Androl. 2020 10 02;92(3): Authors: Corongiu E, Grande P, Liberati E, Iacovelli R, Amini M, Mascioli P, Pagliarella G, Squillacciotti S, Di Santo A, Zampelli A, Forte F, Olivieri V Abstract INTRODUCTION: Bladder cancer is a condition characterized by a broad spectrum of histological variants and clinical courses. The morphological...
BCL-XL inhibition by BH3-mimetic drugs induces apoptosis in models of Epstein-Barr virus-associated T/NK-cell lymphoma. Blood Adv. 2020 Oct 13;4(19):4775-4787 Authors: Sejic N, George LC, Tierney RJ, Chang C, Kondrashova O, MacKinnon RN, Lan P, Bell AI, Lessene G, Long HM, Strasser A, Shannon-Lowe C, Kelly GL Abstract Epstein-Barr virus (EBV)-associated T- and natural killer (NK)-cell malignancies, such as extranodal NK-/T-cell lymphoma (ENKTL),...
Molecular Epidemiology of IDH2 Hotspot Mutations in Cancer and Immunohistochemical Detection of R172K, R172G and R172M Variants. Hum Pathol. 2020 Oct 02;: Authors: Dogan S, Frosina D, Geronimo JA, Hernandez E, Mohanty A, Bale T, Hechtman JF, Arcila ME, Hameed MR, Jungbluth AA Abstract IDH1/2 hotspot mutations occur in glioma, cholangiocarcinoma, chondrosarcoma, sinonasal carcinoma and T-cell lymphoma and have diagnostic, prognostic and/or therapeutic...
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Use of Nitrous Oxide to Facilitate Induction for Electroconvulsive Therapy: A Case Report. Am J Case Rep. 2020 Oct 05;21:e925883 Authors: Lee K, Sparkle T Abstract BACKGROUND The choice of pharmacologic agents used for electroconvulsive therapy (ECT) is critical as this can affect seizure duration and, ultimately, the effectiveness of ECT for the underlying condition. We report the use of nitrous oxide (N2O) to sedate and place an intravenous...
Sclerosing Mesenteritis in a Patient Heterozygous for Factor V Leiden. Am J Case Rep. 2020 Oct 05;21:e926332 Authors: Reddington H, Ballinger Z, Abghari M, Modukuru V, Wallack M Abstract BACKGROUND Sclerosing mesenteritis is an inflammatory and fibrotic disease that affects the mesentery of the small intestine. This condition is non-neoplastic, although it is frequently associated with underlying malignancies. The overall etiology is unclear...
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Related Articles Ciliary beat frequency in children with adenoid hypertrophy. Pediatr Pulmonol. 2020 03;55(3):666-673 Authors: Marusiakova L, Durdik P, Jesenak M, Bugova G, Kvassayova J, Oppova D, Banovcin P Abstract BACKGROUND: Children with adenoid hypertrophy (AH) have impaired respiratory system defense mechanisms, such as mucociliary clearance. We hypothesized that AH negatively affects one of the most important aspects of mucociliary...
Prediction of Radiosensitivity in Head and Neck Squamous Cell Carcinoma Based on Multiple Omics Data. Front Genet. 2020;11:960 Authors: Liu J, Han M, Yue Z, Dong C, Wen P, Zhao G, Wu L, Xia J, Bin Y Abstract Head and neck squamous cell carcinoma (HNSCC) is a malignant tumor. Radiotherapy (RT) is an important treatment for HNSCC, but not all patients derive survival benefit from RT due to the individual differences on radiosensitivity. A prediction...
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MMs established cell‐to‐cell contact with muscle cells and telocytes whereas they are spaced from ICC and enteric neurons with a distance of 100‐200 nm. The different nature of interaction that macrophages establish with the different cells of the gut may underline a different way to communicate that needs further understanding. Abstract Background and Aim Muscularis macrophages (MMs) not only mediate the innate immunity, but also functionally interact with cells important for gastrointestinal...
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Treatment and outcome of Philadelphia chromosome-positive acute lymphoblastic leukemia in adults after relapse. Expert Rev Anticancer Ther. 2020 Oct 03;: Authors: Balsat M, Cacheux V, Carre M, Tavernier-Tardy E, Thomas X Abstract INTRODUCTION: Despite the significant progress that has been made over the last years in the front-line treatment of Philadelphia (Ph) chromosome-positive acute lymphoblastic leukemia (ALL), relapses are frequent and...
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Nasal specific IgE to Der p is not an acceptable screening test to predict the outcome of the nasal challenge test in patients with non-allergic rhinitis. World Allergy Organ J. 2020 Sep;13(9):100461 Authors: Santamaría L, Calle A, Tejada-Giraldo Biol M, Calvo V, Sánchez J, Cardona R Abstract Objectives: Nasal specific IgE (NsIgE) is the most common marker to identify type-2 inflammation in local allergic rhinitis (LAR). However, the comparison...
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A multicenter non-randomized phase III study of sentinel node navigation surgery for early gastric cancer. Jpn J Clin Oncol. 2020 Oct 05;: Authors: Kamiya S, Takeuchi H, Fukuda K, Kawakubo H, Takahashi N, Mitsumori N, Terashima M, Tsujimoto H, Kinami S, Natsugoe S, Ohi M, Kadoya S, Fushida S, Hayashi H, Nabeshima K, Sakamoto J, Matsuda S, Mayanagi S, Irino T, Sato Y, Kitagawa Y Abstract This prospective multicenter non-randomized phase III...
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Inter- and Intra-subject Template-Based Multivariate Synchronization Index Using an Adaptive Threshold for SSVEP-Based BCIs. Front Neurosci. 2020;14:717 Authors: Wang H, Sun Y, Li Y, Chen S, Zhou W Abstract The steady-state visually evoked potential (SSVEP) has been widely used in brain-computer interfaces (BCIs). Many studies have proved that the Multivariate synchronization index (MSI) is an efficient method for recognizing the frequency...
Non-invasive Brain Stimulation for Gambling Disorder: A Systematic Review. Front Neurosci. 2020;14:729 Authors: Zucchella C, Mantovani E, Federico A, Lugoboni F, Tamburin S Abstract Background: Gambling disorder (GD) is the most common behavioral addiction and shares pathophysiological and clinical features with substance use disorders (SUDs). Effective therapeutic interventions for GD are lacking. Non-invasive brain stimulation (NIBS) may...
Association of Low-Density Lipoprotein Receptor-Related Protein 1 and Its rs1799986 Polymorphism With Mild Cognitive Impairment in Chinese Patients With Type 2 Diabetes. Front Neurosci. 2020;14:743 Authors: Cao W, Tian S, Zhang H, Zhu W, An K, Shi J, Yuan Y, Wang S Abstract Background: Low-density lipoprotein receptor-related protein 1 (LRP1) is involved in cerebral glucose metabolism and amyloid-β clearance. This study aimed to investigate...
Biologically Plausible Class Discrimination Based Recurrent Neural Network Training for Motor Pattern Generation. Front Neurosci. 2020;14:772 Authors: Wijesinghe P, Liyanagedera C, Roy K Abstract Biological brain stores massive amount of information. Inspired by features of the biological memory, we propose an algorithm to efficiently store different classes of spatio-temporal information in a Recurrent Neural Network (RNN). A given spatio-temporal...
Corrigendum: Tracing the Origins of the Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP). Front Neurosci. 2020;14:801 Authors: Cardoso JCR, Garcia MG, Power DM Abstract [This corrects the article DOI: 10.3389/fnins.2020.00366.]. PMID: 33013283 [PubMed]
An Intelligence EEG Signal Recognition Method via Noise Insensitive TSK Fuzzy System Based on Interclass Competitive Learning. Front Neurosci. 2020;14:837 Authors: Ni T, Gu X, Zhang C Abstract Epilepsy is an abnormal function disease of movement, consciousness, and nerve caused by abnormal discharge of brain neurons in the brain. EEG is currently a very important tool in the process of epilepsy research. In this paper, a novel noise-insensitive...
High-Intensity Interval Training Decreases Muscle Sympathetic Nerve Activity in Men With Essential Hypertension and in Normotensive Controls. Front Neurosci. 2020;14:841 Authors: Ehlers TS, Sverrisdottir Y, Bangsbo J, Gunnarsson TP Abstract Exercise training is a cornerstone in reducing blood pressure (BP) and muscle sympathetic nerve activity (MSNA) in individuals with essential hypertension. High-intensity interval training (HIIT) has been...
Melatonin Enhances the Therapeutic Effect of Plasma Exosomes Against Cerebral Ischemia-Induced Pyroptosis Through the TLR4/NF-κB Pathway. Front Neurosci. 2020;14:848 Authors: Wang K, Ru J, Zhang H, Chen J, Lin X, Lin Z, Wen M, Huang L, Ni H, Zhuge Q, Yang S Abstract Introduction: Ischemic stroke-induced inflammation and inflammasome-dependent pyroptotic neural death cause serious neurological injury. Nano-sized plasma exosomes have exhibited...
The CB2 Agonist β-Caryophyllene in Male and Female Rats Exposed to a Model of Persistent Inflammatory Pain. Front Neurosci. 2020;14:850 Authors: Ceccarelli I, Fiorenzani P, Pessina F, Pinassi J, Aglianò M, Miragliotta V, Aloisi AM Abstract Cannabinoids help in pain treatment through their action on CB1 and CB2 receptors. β-caryophyllene (BCP), an ancient remedy to treat pain, is a sesquiterpene found in large amounts in the essential oils of...
Surprise Acts as a Reducer of Outcome Value in Human Reinforcement Learning. Front Neurosci. 2020;14:852 Authors: Sumiya M, Katahira K Abstract Surprise occurs because of differences between a decision outcome and its predicted outcome (prediction error), regardless of whether the error is positive or negative. It has recently been postulated that surprise affects the reward value of the action outcome; studies have indicated that increasing...
Abnormal Serum Bilirubin/Albumin Concentrations in Dementia Patients With Aβ Deposition and the Benefit of Intravenous Albumin Infusion for Alzheimer's Disease Treatment. Front Neurosci. 2020;14:859 Authors: Zhong X, Liao Y, Chen X, Mai N, Ouyang C, Chen B, Zhang M, Peng Q, Liang W, Zhang W, Wu Z, Huang X, Li C, Chen H, Lao W, Zhang CE, Wang X, Ning Y, Liu J Abstract Background: Our previous study in animal models revealed that bilirubin could...
The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson's Disease. Front Neurosci. 2020;14:865 Authors: Rideout HJ, Chartier-Harlin MC, Fell MJ, Hirst WD, Huntwork-Rodriguez S, Leyns CEG, Mabrouk OS, Taymans JM Abstract Evidence is mounting that LRRK2 function, particularly its kinase activity, is elevated in multiple forms of Parkinson's disease, both idiopathic as well as familial forms linked to mutations in...
Metabolomics Analysis of Hippocampus and Cortex in a Rat Model of Traumatic Brain Injury in the Subacute Phase. Front Neurosci. 2020;14:876 Authors: Zheng F, Zhou YT, Li PF, Hu E, Li T, Tang T, Luo JK, Zhang W, Ding CS, Wang Y Abstract Traumatic brain injury (TBI) is a complex and serious disease as its multifaceted pathophysiological mechanisms remain vague. The molecular changes of hippocampal and cortical dysfunction in the process of TBI...
A Deep Network Model on Dynamic Functional Connectivity With Applications to Gender Classification and Intelligence Prediction. Front Neurosci. 2020;14:881 Authors: Fan L, Su J, Qin J, Hu D, Shen H Abstract Increasing evidence has suggested that the dynamic properties of functional brain networks are related to individual behaviors and cognition traits. However, current fMRI-based approaches mostly focus on statistical characteristics of the...
Editorial: Functional Adult Neurogenesis. Front Neurosci. 2020;14:885 Authors: Gu Y, Ge S, Fitzsimons CP PMID: 33013293 [PubMed]
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