Evaluation of deacetylase inhibition in metaplastic breast carcinoma using multiple derivations of preclinical models of a new patient-derived tumor. PLoS One. 2020;15(10):e0226464 Authors: Chang TC, Matossian MD, Elliott S, Burks HE, Sabol RA, Ucar DA, Wathieu H, Zabaleta J, Valle L, Gill S, Martin E, Riker AI, Miele L, Bunnell BA, Burow ME, Collins-Burow BM Abstract Metaplastic breast carcinoma (MBC) is a clinically aggressive and rare subtype...
Nonepithelial Tumors of the Larynx: Single-Institution 13-Year Review with Radiologic-Pathologic Correlation. Radiographics. 2020 Oct 09;:190210 Authors: Ong AC, Huh EH, Moreland AJ, Rooper LM, Aygun N, Akst LM, Best SR, Khan MA Abstract Nonepithelial tumors of the larynx are rare and represent a minority of all laryngeal neoplasms. Imaging has an important role in the diagnosis, treatment planning, and surveillance of these entities. However,...
A Rare Case of Massive Ovarian Mucinous Cystadenoma With Postmenopausal Bleeding. Cureus. 2020 Sep 02;12(9):e10198 Authors: Somagutta MR, Luvsannyam E, Jain MS, Elliott-Theberge K, Grewal AS, Pendyala SK, Edwards C Abstract Mucinous cystadenomas are among the most common benign ovarian neoplasms. They are known for their massive size causing compressive effects ranging from pressure, pain, bloating, and urinary symptoms. Over time, these adnexal...
A Risk-benefit Analysis of Prophylactic Anticoagulation for Patients with Metastatic Germ Cell Tumours Undergoing First-line Chemotherapy. Eur Urol Focus. 2020 Oct 05;: Authors: Fankhauser CD, Tran B, Pedregal M, Ruiz-Morales JM, Gonzalez-Billalabeitia E, Patrikidou A, Amir E, Seidel C, Bokemeyer C, Hermanns T, Rumyantsev A, Tryakin A, Brito M, Fléchon A, Kwan EM, Cheng T, Castellano D, Del Muro XG, Hamid AA, Ottaviano M, Palmieri G, Kitson R, Reid A, Heng...
Primary adenocarcinomas of the vulva and related structures: An enigmatic and diverse group of tumorsâ°. Semin Diagn Pathol. 2020 Sep 25;: Authors: Desouki MM, Fadare O Abstract Approximately half of adenocarcinomas that involve the vulva are secondary, either through direct extension or metastases from elsewhere. Primary vulvar adenocarcinomas are rare and encompass a diverse array of neoplasms that are nominally classified based on the presumed...
Related Articles A case of resected retroperitoneal metachronous solitary metastasis from caecal cancer. Ann R Coll Surg Engl. 2020 Oct;102(8):e198-e201 Authors: Kazama S, Anzai H, Matsuzawa N, Nishimura Y, Ishii H, Nishizawa Y, Kanda H, Kawashima Y, Sakamoto H Abstract Colorectal cancer metastasis to the retroperitoneum, especially solitary metastasis allowing curative resection, is rare. We report a case of complete resection of retroperitoneal...
Related Articles Haematuria caused by bladder cancer in the paediatric setting. Ann R Coll Surg Engl. 2020 Oct;102(8):e196-e197 Authors: Jones P, Eldakhakhny M, Hawary A Abstract Bladder cancer is a rare disease in childhood; however, it is one of great clinical significance. Investigation and management follow a tailored approach, which is largely driven by clinical practice patterns in adult patients with the disease. We present the case of...
Related Articles Primary colorectal linitis plastica presenting as rapid acute deterioration: a diagnostic dilemma. Ann R Coll Surg Engl. 2020 Oct;102(8):e187-e189 Authors: Brosnan C, Hannan E, Duggan W, Mullen D, Buckley M, Stafford AT Abstract We present a rare case of primary colorectal linitis plastica presenting as an acute admission to hospital with a wide range of systemic symptoms, sudden rapid deterioration and subsequent mortality....
Related Articles Transcompp: understanding phenotypic plasticity by estimating Markov transition rates for cell state transitions. Bioinformatics. 2020 05 01;36(9):2813-2820 Authors: Jagannathan NS, Ihsan MO, Kin XX, Welsch RE, Clément MV, Tucker-Kellogg L Abstract MOTIVATION: Gradual population-level changes in tissues can be driven by stochastic plasticity, meaning rare stochastic transitions of single-cell phenotype. Quantifying the rates...
Related Articles Mucoepidermoid Carcinoma of the Uterine Cervix-Single-Center Study Over a 10-Year Period. Medicina (Kaunas). 2020 Jan 18;56(1): Authors: Yordanov A, Karamanliev M, Tantchev L, Konsoulova A, Strashilov S, Vasileva-Slaveva M Abstract Background and objectives: Adenosquamous cancer of the uterine cervix is a rare type of cervical cancer with both malignant squamous and glandular components. A very rare subtype is mucoepidermoid...
Related Articles Fibroblast Growth Factor 23-Producing Phosphaturic Mesenchymal Tumor with Extraordinary Morphology Causing Oncogenic Osteomalacia. Medicina (Kaunas). 2020 Jan 16;56(1): Authors: Then C, Asbach E, Bartsch H, Thon N, Betz C, Reincke M, Schmidmaier R Abstract A possible cause of hypophosphatemia is paraneoplastic secretion of fibroblast growth factor 23 (FGF-23). Tumors secreting FGF-23 are rare, mostly of mesenchymal origin,...
Related Articles Total Exenteration En Bloc with a Nephrectomy for Locally Advanced Cervical Cancer Invading a Pelvic Kidney-a Case Report and Literature Review. Medicina (Kaunas). 2020 Jan 15;56(1): Authors: Bacalbasa N, Balescu I, Vilcu M, Dima S, Diaconu C, Iliescu L, Filipescu A, Brezean I Abstract Introduction: Extended pelvic resection might be the option of choice in patients presenting locally advanced cervical cancer. However, the...
Related Articles Endoscope-assisted anterolateral approach to a recurrent cervical spinal chordoma. Acta Neurochir (Wien). 2020 02;162(2):443-447 Authors: Giammattei L, di Russo P, Penet N, Froelich S Abstract BACKGROUND: The anterolateral approach (ALA) enables to access the craniovertebral junction (CVJ), lower and middle clivus, jugular foramen, and cervical spine from a lateral perspective. It is particularly indicated when dealing with...
Related Articles The Relationship Between Vasoproliferative Tumor and Uveitis in a Multiple Sclerosis Patient: A Case Report and Review of the Literature Turk J Ophthalmol. 2019 12 31;49(6):364-366 Authors: Ãzalp O, Atalay E, Bilgeç MD, Erol N, Yıldırım N Abstract Vasoproliferative retinal tumor (VPRT) is a rare, benign lesion with a variable clinical course depending on the individual. Favorable outcomes are obtained with early diagnosis...
Related Articles Clinicopathologic and Prognostic Significance of Gallbladder and Cystic Duct Invasion in Distal Bile Duct Carcinoma. Arch Pathol Lab Med. 2020 06;144(6):755-763 Authors: Jun SY, An S, Sung YN, Park Y, Lee JH, Hwang DW, Hong SM Abstract CONTEXT.—: The roles of the gallbladder and cystic duct (CD) invasions in distal bile duct carcinoma (DBDC) have not been well elucidated. OBJECTIVE.—: To define the characteristics...
Related Articles Spontaneous regression of a clival chordoma. Case report. Acta Neurochir (Wien). 2020 02;162(2):433-436 Authors: Bander ED, Kocharian G, Liechty B, Tsiouris AJ, Schwartz TH Abstract In this case report, we present a rare and previously unreported case of spontaneous regression of a histologically consistent clival chordoma. At the time of diagnosis, imaging demonstrated a T2 hyperintense and T1 isointense midline skull base...
Related Articles Primary Mediastinal Hydatid Cyst Causing Diaphragmatic Palsy. Braz J Cardiovasc Surg. 2020 02 01;35(1):123-126 Authors: Gopivallabha MM, Singh AK, Pasarad AK, Parashuraman P, Govindareddy AK Abstract Hydatid cystic disease is a significant clinical problem in endemic countries. Hydatid cysts are most commonly located in the liver and lungs. Primary mediastinal hydatid cyst is a rare clinical entity. The diagnosis must be considered...
Related Articles A library of Neo Open Reading Frame peptides (NOPs) as a sustainable resource of common neoantigens in up to 50% of cancer patients. Sci Rep. 2019 04 29;9(1):6577 Authors: Koster J, Plasterk RHA Abstract Somatic mutations in cancer can result in neoantigens against which patients can be vaccinated. The quest for tumor specific neoantigens has yielded no targets that are common to all tumors, yet foreign to healthy cells....
Related Articles Cetuximab-associated pulmonary toxicity in concurrent chemoradiation for the treatment of a squamous cell carcinoma of the head and neck. Head Neck. 2019 04;41(4):E55-E58 Authors: Mayfield JD, Mercado CE, Kaye FJ, Mendenhall WM Abstract BACKGROUND: Cetuximab is a common EGFR monoclonal antibody used with radiotherapy to treat head-and-neck cancer. Severe pulmonary toxicity, including interstitial lung disease (ILD), caused...
Mixed neuroendocrine-non-neuroendocrine neoplasms of ascending colon: A case report. Int J Surg Case Rep. 2020 Sep 23;76:125-129 Authors: Mukai S, Hirata Y, Ishikawa S, Kai A, Kohata A, Okimoto S, Fujisaki S, Fukuda S, Takahashi M, Fukuda T, Nishida T, Egi H, Ohdan H Abstract INTRODUCTION: Neuroendocrine tumor (NET) that develops in the right-sided colon is relatively rare. Coexistence of adenocarcinoma and NET is extremely rare, and such cases...
HLA-B27 association of autoimmune encephalitis induced by PD-L1 inhibitor. Ann Clin Transl Neurol. 2020 Oct 08;: Authors: Chang H, Shin YW, Keam B, Kim M, Im SA, Lee ST Abstract OBJECTIVE: While immune checkpoint inhibitors are increasingly used for various cancers, unpredictable immune-related adverse events (irAEs) such as autoimmune encephalitis is life-threatening. Here, we report an association between human leukocyte antigen (HLA) and...
Xanthogranulomatous cholecystitis: a rare gallbladder pathology from a single-center perspective. Ann Surg Treat Res. 2020 Oct;99(4):230-237 Authors: Saritas AG, Gul MO, Teke Z, Ulku A, Rencuzogullari A, Aydin I, Akcam AT Abstract Purpose: The aim of this study was to review patients with xanthogranulomatous cholecystitis (XGC). Methods: A total of 79 patients diagnosed with XGC were included in the study. The criteria for XGC in the...
Squamous Cell Carcinoma of the Tonsil Causing Small Bowel Perforation in the Setting of Metastasis and Treatment With Programmed Death-1 Inhibitors: A Case Report. Cureus. 2020 Sep 30;12(9):e10739 Authors: Dabek RJ, Bizanti A, Thomas S, Kalla A, Hamdallah I Abstract Metastasis of extra-intestinal carcinoma to the gastrointestinal tract (GIT) is a rare event, most commonly occurring with malignant melanoma. Anti-PD-1 (programmed death-1) immunotherapeutic...
Undiagnosed Acquired Hemophilia A: Presenting as Recurrent Gastrointestinal Bleeding. Cureus. 2020 Sep 01;12(9):e10188 Authors: Roy AM, Siddiqui A, Venkata A Abstract Acute gastrointestinal bleeding (GIB) is a frequently encountered medical emergency and it can be life-threatening depending on the etiology and the clinical condition of the patient. The most common causes of GIB are peptic ulcer disease, aspirin-induced gastritis, variceal hemorrhage, esophagitis,...
Incidentally detected microcystic serous cystadenoma of the pancreas with splenic invasion: a case report and literature review. BJR Case Rep. 2020 Sep;6(2):20190109 Authors: Yagi F, Akita H, Ueno A, Takano K, Masugi Y, Sakamoto M, Kitago M, Shinoda M, Kitagawa Y, Toyama K, Matsusaka Y, Yashiro H, Okuda S, Jinzaki M Abstract Serous cystic neoplasms are relatively uncommon and rarely possess malignant potential. We report a rare case of pancreatic...
Optic nerve sheath meningioma. Curr Opin Ophthalmol. 2020 Nov;31(6):455-461 Authors: Douglas VP, Douglas KAA, Cestari DM Abstract PURPOSE OF REVIEW: Optic nerve sheath meningiomas (ONSMs) are rare benign tumors of the anterior visual pathway which present with slowly progressive and painless vision loss and account for approximately 2% of all orbital tumors. This article provides an overview as well as an update on the ONSMs with regards to...
Related Articles [Are men and women with breast cancer treated equally in Germany?] Z Evid Fortbild Qual Gesundhwes. 2020 Sep;155:1-10 Authors: Dippmann AK, Damrau C, Hengelbrock J, Albert US, Lebeau A, Lux MP, Veit C Abstract INTRODUCTION: Within the statutory health insurance system of the Federal Republic of Germany, a system of quality assurance has been implemented and operationalised through the measurement of quality indicators. For...
Related Articles [Seeking colleagues' advice when facing complex clinical situations]. Cancer Radiother. 2020 Oct;24(6-7):623-627 Authors: Blanchard P, Peiffert D, Truc G Abstract Seeking a second medical advice as a medical practitioner is a frequent situation that should be facilitated to best suit patients' expectations, while maintaining medical confidentiality. The patient and his relatives need to be involved with diagnostic and therapeutic...
Related Articles Pre- or postoperative radiotherapy for soft tissue sarcomas. Cancer Radiother. 2020 Oct;24(6-7):501-512 Authors: Llacer-Moscardo C, Terlizzi M, Bonvalot S, Le Loarer F, Carrère S, Tetrau R, D'ascoli A, Lerouge D, Le Péchoux C, Thariat J Abstract Sarcomas are rare tumours arising from mesenchymal tissue. A multimodal management in an expert centre combining surgery and radiotherapy is the current standard of care for localized...
Related Articles Proton therapy and the European Particle Therapy Network: The past, present and future. Cancer Radiother. 2020 Oct;24(6-7):687-690 Authors: Weber DC, Langendijk JA, Grau C, Thariat J Abstract Proton therapy is delivered to selected cancer patients presenting with rare tumours, for which a dose escalation paradigm and/or a reduced dose-bath to the organs at risk is pursued. It is a costly treatment with an additional cost factor...
Related Articles Unusual subcutaneous dedifferentiated liposarcoma exhibiting coexistence of meningothelial-like whorls and inflammatory myofibroblastic tumor-like structures. J Cutan Pathol. 2020 Feb;47(2):171-178 Authors: Chen S, He S, Huang H, Li L, Wang W, Cui Z, Zhang R Abstract To explore the clinicopathological features of a rare dedifferentiated liposarcoma (DDLPS) with meningothelial-like whorls, we retrospectively analyzed 46 reported...
Related Articles Commentary: Rare Primary Embryonal Carcinoma in the Brachial Plexus: A Case Report and Literature Review. Neurosurgery. 2020 08 01;87(2):E156-E157 Authors: McCutcheon IE PMID: 31690934 [PubMed - indexed for MEDLINE]
Related Articles A concise review of angiofibroma of soft tissue: A rare newly described entity that can be encountered by dermatopathologists. J Cutan Pathol. 2020 Feb;47(2):179-185 Authors: Mindiola-Romero AE, Maloney N, Bridge JA, Korkolopoulou P, Sakellariou S, Linos K Abstract Angiofibroma of soft tissue (AFST) is a newly described, rare mesenchymal neoplasm with fibroblastic and vascular components; it can be seen in both sexes and in...
Related Articles Concurrent cutaneous localization of Langerhans cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma in a patient with a history of chronic lymphocytic leukemia/small lymphocytic lymphoma. J Cutan Pathol. 2020 Feb;47(2):161-165 Authors: Papoudou-Bai A, Vassou A, Marinos L, Papathanasiou K, Kapsali E, Kanavaros P Abstract The phenomenon of histiocytic/dendritic cell sarcomas arising through transformation...
Related Articles A Patient with Sjogren's Syndrome and Subsequent Diagnosis of Inclusion Body Myositis and Light-Chain Amyloidosis. J Gen Intern Med. 2019 06;34(6):1058-1062 Authors: Hom J, Marwaha S, Postolova A, Kittle J, Vasquez R, Davidson J, Kohler J, Dries A, Fernandez-Betancourt L, Majcherska M, Dearlove J, Raghavan S, Vogel H, Bernstein JA, Fisher P, Ashley E, Sampson J, Wheeler M, Undiagnosed Diseases Network Abstract We discuss a...
Related Articles Clinical features, radiological findings, and treatment outcomes of high-grade lateral ventricular meningiomas: a report of 26 cases. Neurosurg Rev. 2020 Apr;43(2):565-573 Authors: Jiang Y, Lv L, Li J, Ma W, Chen C, Zhou P, Jiang S Abstract High-grade meningiomas in ventricles are rare, where most published series only include a few patients. A retrospective analysis was performed on the clinical features, radiological findings,...
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