Publication date: Available online 2 October 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Furkan Ayaz, Burcu Demirbag, Kasim Ocakoglu
Sat Oct 03, 2020 19:44
Publication date: Available online 2 October 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Jingya Ding, Mingxin Yu, Lianqing Zhu, Tao Zhang, Jiabin Xia, Guangkai Sun
Sat Oct 03, 2020 19:44
The objective of this study was to assess the resorption index of calvarial particulate graft in maxillary sinuses with residual alveolar bone less than or equal to 3 mm-thick, in patients undergoing total atrophic maxilla reconstruction.
Sat Oct 03, 2020 03:00
Abstract Purpose. Reconstructing the occlusal morphology of posterior teeth in definitive dental prosthesis can be challenging. The use of the correlation technique enables replication of the information and occlusal anatomy of interim dental prostheses to the definitive ones. The purpose of this controlled clinical trial was to compare the static and dynamic contacts (SDC) of monolithic zirconia crowns designed with correlation and library techniques. Material and methods. Twenty‐four patients...
Sat Oct 03, 2020 12:34
Abstract Purpose: Zirconia crowns often crack at the margin. This study determined the loads and the times at which cracks are initiated in high‐translucency monolithic zirconia crowns with different margin designs. Materials and Methods: A total of 90 crowns were fabricated from Zirconia blanks. The fabricated crowns had different margin thicknesses (light‐chamfer, CL and heavy‐chamfer, CH) and collar heights (no‐collar, NC; low‐collar, LC; high‐collar, HC). They were grouped as CLNC, CLLC, CLHC,...
Sat Oct 03, 2020 15:04
The purpose of this work is to create mathematical base and software for solving the problem of finding an evolutionarily stable strategy of zooplankton diel vertical migrations and explaining the observed effects in aquatic ecosystems using this software (in particular, in the northeastern part of the Black Sea). An essential feature of this study is the inclusion in the mathematical model of state constraints on the strategy of behavior, which reflect the vertical limited zone of zooplankton habitat....
Sat Oct 03, 2020 03:00
Abstract Pityriasis Rosea (PR) is an exanthematous disease whose etiology is related to reactivation of herpes human herpesviruses 6 (HHV‐6) and 7 (HHV‐7). We observed two cases of PR arising during Omalizumab therapy for chronic spontaneous urticaria (CSU). Here we report for the first time PR occurring during Omalizumab treatment. After PR diagnosis, viral serology was performed. Data in literature about Omalizumab mechanism of action, PR and HHV‐6/7 infection were analyzed in order to identify...
Fri Oct 02, 2020 21:39
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08785
Fri Oct 02, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c09177
Fri Oct 02, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07439
Fri Oct 02, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07146
Fri Oct 02, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08538
Fri Oct 02, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c09162
Fri Oct 02, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08589
Fri Oct 02, 2020 07:00
While common cuckoos mimic their host's eggs, new research has revealed that a group of parasitic finch species in Africa have evolved to mimic their host's chicks - and with astonishing accuracy.
Fri Oct 02, 2020 16:11
Medication-related osteonecrosis of the jaw (MRONJ) is generally difficult to treat. So far, no optimal strategy for MRONJ has been established. The aim of this study was to determine whether a new surgical technique, i.e. curettage with cortical perforations of healthy adjacent bone that enhances bone perfusion would be more effective than standard curettage in treating patients with MRONJ. Twenty-eight MRONJ patients who underwent curettage treatment with or without cortical perforation technique...
Sat Oct 03, 2020 03:00
The DNA methylation statuses of the paired box 1 (PAX1) and zinc finger protein 582 (ZNF582) genes have shown promise in the detection of oral squamous cell carcinoma (OSCC). The aim of this study was to investigate the ability of PAX1 and ZNF582 methylation to distinguish OSCC and the adjacent normal tissue among cancer patients. This study included 67 patients with OSCC. The methylation levels of these two genes were analysed in tissue specimens (lesion site and adjacent normal site) and in oral...
Sat Oct 03, 2020 03:00
Vocal cord vibration after transoral CO2 LASER-guided thyroarytenoid (TA) myoneurectomy in adductor spasmodic dysphonia (AdSD) patients is unclear to date. The precise vibratory patterns in AdSD patients are difficult to evaluate with routine videolaryngostroboscopy. High-speed videolaryngoscopy (HSV) is an ideal choice to evaluate such patients. This study was performed to compare pre- and postoperative, after 6 months, vocal fold vibratory onset delay (VFVOD) and closed phase glottal cycle (CPGC)...
Sat Oct 03, 2020 03:00
Publication date: Available online 2 October 2020Source: Behavioural Brain ResearchAuthor(s): Corinna Y. Franco, Jessica R. Petok, Jason Langley, Xiaoping Hu, Ilana J. Bennett
Sun Oct 04, 2020 00:49
Publication date: Available online 2 October 2020Source: Behavioural Brain ResearchAuthor(s): Vincent J. Coppola, Daniele Nardi, Verner P. Bingman
Sun Oct 04, 2020 00:49
Publication date: Available online 2 October 2020Source: Behavioural Brain ResearchAuthor(s): Juan Francisco Rodríguez-Landa, Gabriel Guillén-Ruiz, Fabiola Hernández-López, Jonathan Cueto-Escobedo, Eduardo Rivadeneyra-Domínguez, Blandina Bernal-Morales, Emma Virginia Herrera-Huerta
Sun Oct 04, 2020 00:49
Publication date: Available online 3 October 2020Source: Behavioural Brain ResearchAuthor(s): Belovičová Kristína, Šimončičová Eva, Viňas Noguera Mireia, Dubovický Michal, Bögi Eszter
Sun Oct 04, 2020 00:49
Publication date: Available online 3 October 2020Source: Behavioural Brain ResearchAuthor(s): Camila A. Cazarin, Ana P. Dalmagro, Ana E. Gonçalves, Thaise Boeing, Luísa M. da Silva, Rogério Corrêa, Luiz C. Klein-Júnior, Bernardo C. Pinto, Thaís S. Lorenzett, Thales U.C. Sobrinho, Ângelo de Fátima, Tiago C. de A. Lage, Sergio A. Fernandes, Márcia M. de Souza
Sun Oct 04, 2020 00:49
Abstract Kenny‐Caffey syndrome (KCS) is a rare hereditary skeletal disorder involving hypoparathyroidism. The autosomal dominant form (KCS2), caused by heterozygous pathogenic variants in the FAM111A gene, is distinguished from the autosomal recessive form (KCS1) and Sanjad‐Sakati syndrome (SSS), both caused by pathogenic variants in the tubulin folding cofactor E (TBCE) gene, by the absence of microcephaly and intellectual disability. We present a patient with KCS2 caused by a de novo pathogenic...
Sat Oct 03, 2020 20:33
A new app called the Brink Election Guide will, for the first time ever, make it easier for voters with disabilities to get the information they need to exercise their rights to vote, helping to increase turnout among the 61 million adults with disabilities in America. As COVID-19 pushes everyone online, there is a growing problem of digital accessibility that is negatively impacting voters with disabilities - making it particularly challenging for these users to get information they need on the...
Thu Oct 01, 2020 18:39
Abstract Purpose To determine the predictive factors of initial and long-term adherence to positive airway pressure (PAP) therapy and factors leading to an unfavorable shift of PAP compliance. Methods This follow-up study was comprised of newly diagnosed patients with obstructive sleep apnea (OSA) amenable to PAP therapy from January 2017 to April...
Sun Oct 04, 2020 02:17
Abstract Diagnosis, treatment and rehabilitation of patients suffering from oral cancer is a shared responsibility of primary care givers like dentists, physicians and oral medicine specialists, and intramural secondary care specialties. Because of the complex nature of treatment and the necessity of long term care in most patients, the treatment and follow‐up of head and neck cancer patients is confined to centers with dedicated teams in most countries.
Fri Oct 02, 2020 18:36
Abstract Chronic graft‐versus‐host disease (cGVHD), an alloimmune and autoimmune disease, is the leading cause of later illness and death after allogeneic hematopoietic stem‐cell transplantation (allo‐HSCT) (Kroger et al., 2016). Oral cavity is a main organ involved in cGVHD, affecting 45‐83% of cGVHD patients (Fall‐Dickson, Pavletic, Mays, & Schubert, 2019). Covering lichen planus‐like changes (diagnostic feature), erythema, ulceration, mucoceles, etc., the clinical presentations of oral cGVHD...
Fri Oct 02, 2020 19:11
Abstract Rationale Serotonin (5-HT) plays an important role in the organization of the central nervous system and in the development of social interaction deficits and psychiatric disorders, including anxiety, depression, and addiction disorders. Notably, disruption of the 5-HT system during sensitive periods of development exerts long-term consequences, including altered anxiety response and problematic use of alcohol. ...
Sun Oct 04, 2020 03:00
Abstract Objectives To assess oral health, caries prevalence, and subsequent complications among recently arrived refugees in Germany and to compare these findings with the German resident population. Methods This multicenter cross-sectional study recruited 544 refugees aged 3–75+ years; they were examined at ten registration institutions in four federal...
Sun Oct 04, 2020 03:00
High species richness and endemism in tropical mountains are recognized as major contributors to the latitudinal diversity gradient. The processes underlying mountain speciation, however, are largely untested. The prevalence of steep ecogeographic gradients and the geographic isolation of populations by topographic features are predicted to promote speciation in mountains. We evaluate these processes in a species-rich Neotropical genus of understory herbs that range from the lowlands to montane forests...
Sat Oct 03, 2020 03:00
Abstract Rationale Allergic asthma, typically controlled with inhaled corticosteroids (ICS), is the leading chronic health condition for youth under 18 years of age. During this peri-adolescent period, significant brain maturation occurs. Prior studies indicate that both chronic inflammation and corticosteroid medications increase risk for developing an internalizing disorder like anxiety. ...
Sun Oct 04, 2020 03:00
The ubiquity of recombination (and sex) in nature has defied explanation since the time of Darwin. Conditions that promote the evolution of recombination, however, are well-understood and arise when genomes contain more selectively mismatched combinations of alleles across loci than can be explained by chance alone. Recombination remedies this across-loci imbalance by shuffling alleles across individuals. The great difficulty in explaining the ubiquity of recombination in nature lies in identifying...
Sat Oct 03, 2020 03:00
Complete tumor resection (R0 margin) is an axiom of surgical oncology. Oral cancer ablation is challenging, due to anatomical, functional and aesthetic considerations. R0 margin is strongly linked to better survival outcomes with great variation in the R0 % across units. This is commonly attributed to disease biology. Without disputing the importance of biological characteristics, we contend that image-based anatomical surgical planning has an important role to play in achieving complete resection.
Sat Oct 03, 2020 03:00
Abstract In a recent issue of The Journal of Pathology, Iampietro et al isolated and characterized several clones of urine‐derived podocytes from three patients with Alport Syndrome (AS) and proteinuria and one age‐matched non‐proteinuric control. They reported differential expression of genes involved in cell motility, adhesion, survival and angiogenesis. The authors found AS podocytes to be less motile and have significantly higher permeability to albumin compared to control podocytes, highlighting...
Sat Oct 03, 2020 13:54
Abstract Neuroendocrine prostate cancer (NEPC) is a more aggressive subtype of castration‐resistant prostate cancer (CRPC). Although it is well established that PHF8 can enhance prostate cancer cell proliferation, whether PHF8 is involved in prostate cancer initiation and progression is relatively unclear. By comparing the transgenic adenocarcinoma of the mouse prostate (TRAMP) mice with or without Phf8 knockout, we systemically examined the role of PHF8 in prostate cancer development. We found...
Sat Oct 03, 2020 13:56
In this paper we develop and test algorithmic techniques to estimate genotypes fitnesses by analysis of observed daily frequency data monitoring the long-term evolution of bacterial populations. In particular, we develop a non-linear least squares approach to estimate selective advantages of emerging new mutant strains in locked-box stochastic models describing bacterial genetic evolution similar to the celebrated Lenski experiment on Escherichia Coli. Our algorithm first analyses emergence of new...
Sat Oct 03, 2020 03:00
Abstract The current research focuses on the effect of variable doses of red laser on the chick embryonic development. He-Ne laser of 632-nm wavelength was used as an irradiation source in the first 48 h post-laying of chicken eggs. We have used five different doses: 2, 1, 0.3, 0.2, and 0.1 mJ/cm2 that needed a time range for about 400–20 s. Those irradiated embryos were left for additional 11 days for incubation in normal conditions, where they are blindly studied after the 11th...
Sun Oct 04, 2020 03:00
Abstract Background Chronic hypersensitivity pneumonitis (CHP) remains a diagnostic challenge. The process of collecting and extracting serum and droppings from causative animals for the inhalation challenge test is complicated and the risk of inducing disease progression exists. Objective To investigate the utility and safety of an inhalation challenge test using pigeon eggs. Methods Pigeon eggs were pasteurized and mixed with a saline solution to produce an inhalation fluid. An...
Sat Oct 03, 2020 17:37
Abstract Background Dupilumab blocks the shared receptor component for interleukin (IL)‐4/IL‐13, key drivers of type 2 inflammation. In phase 2b (NCT01854047) and phase 3 LIBERTY ASTHMA QUEST (NCT02414854), add‐on dupilumab 200/300 mg every 2 weeks (q2w) reduced severe exacerbations, improved prebronchodilator (pre‐BD) forced expiratory volume in 1 second (FEV1) and quality‐of‐life measures and was generally well tolerated in patients with uncontrolled, persistent (phase 2b) or moderate‐to‐severe...
Sat Oct 03, 2020 16:28
In temperate climates, the mosquito Culex molestus lives almost exclusively in urban underground locations such as flooded basements, sewer systems and subway tunnels. Unlike most other mosquito taxa found at higher latitudes, Cx. molestus remains active and continues to breed throughout the winter. This is attributable to year-round above freezing temperatures in its preferred underground habitats combined with an inability to enter a state of arrested development ('diapause') in response to shortening...
Sat Oct 03, 2020 03:00
ABSTRACT In clinical exome/genome sequencing the American College of Medical Genetics and Genomics (ACMG) recommends reporting of secondary findings unrelated to a patient’s phenotype when pathogenic single‐nucleotide variants (SNVs) are observed in one of 59 genes associated with a life‐threatening, medically actionable condition. Little is known about the incidence and sensitivity of chromosomal microarray analysis (CMA) for detection of pathogenic copy number variants (CNVs) comprising...
Sat Oct 03, 2020 12:14
Abstract Ververi‐Brady syndrome (VBS, # 617982) is a rare developmental disorder, and loss‐of‐function variants in QRICH1 were implicated in its aetiology. Furthermore, a recognizable phenotype was proposed comprising delayed speech, learning difficulties and dysmorphic signs. Here, we present four unrelated individuals with one known nonsense variant (c.1954C>T; p.(Arg652*)) and three novel de novo QRICH1 variants, respectively. These included two frameshift mutations (c.832_833del;...
Sat Oct 03, 2020 12:30
Mutation analysis of tubulin beta 8 class VIII in infertile females with oocyte or embryonic defects
Abstract Variants of tubulin beta 8 class VIII (TUBB8) have been shown to be associated with female infertility characterized by oocyte or embryonic defects. To further investigate the mutational spectrum of TUBB8 and the prevalence of variants, we performed Sanger sequencing of TUBB8 on a total of 115 infertile females who had undergone repeated in vitro fertilization cycles with oocyte or embryonic defects and 200 healthy controls. A total of 31 variants which were absent from the controls...
Sat Oct 03, 2020 12:40
Abstract GZF1 was recently reported as a genetic factor associated with Larsen syndrome. Two patients presenting hip dislocation, scoliosis and severe myopia, as well as hearing loss and other abnormal features, were found to carry two novel compounds heterozygous variants in GZF1 (c.397 400del, p. Leu133fs; and c.1474del, p. Met492fs) through whole‐exome sequencing. The mRNA expression level of L133fs‐GZF1 did not significantly differ from that of WT‐GZF1. However, no HA‐conjugated mutant...
Sat Oct 03, 2020 12:50
Despite tropical psocids comprise ~60% of species diversity within the Psocidae (Insecta, Psocodea), previous studies on the Psocidae phylogeny have poorly sampled tropical species (<40% species in trees). Here we discuss the evolution and systematics of the Psocidae based on the most comprehensive species-level sampling of the Psocidae. We sequenced and inferred the phylogenetic position of 43 previously unsampled Neotropical species from COI, H3, WNT, 18S, 16S, and 12S. Based on our phylogenies...
Sun Oct 04, 2020 03:00
C4 photosynthesis evolved from the ancestral C3 photosynthesis by recruiting pre-existing genes to fulfill new functions. The enzymes and transporters required for the C4 photosynthesis have been intensively studied; however, the transcription factors (TFs) regulating these C4 metabolic genes are not well understood. In particular, how the TF regulatory network of C4 metabolic genes was rewired during the evolution is unclear. Here, we constructed TFs co-regulatory networks for core C4 metabolic...
Sun Oct 04, 2020 03:00
Premise of the study: Universal probesets for targeted sequence capture have facilitated phylogenomic research into diverse plant groups with limited genomic resources, including from low-quality DNA typical of herbarium specimens. Here, we leverage the Angiosperms353 loci to infer the first phylogeny of Otoba (Myristicaceae), a Neotropical tree genus that is ecologically dominant in low-to-mid elevation wet forests, exclusively from herbarium specimens. Methods: We use a combination of Angiosperms353...
Sun Oct 04, 2020 03:00
Abstract The competitive environment that animals experience during development constitutes an important source of selection that can influence the development, expression and evolution of traits. Here, we examine how the sex of focal and “competitor” individuals interact to affect development in the Eastern mosquitofish Gambusia holbrooki. We raised individuals of both sexes either alone or in the presence of a male or female conspecific (hereafter “competitor”), and measured...
Sun Oct 04, 2020 03:00
ABSTRACT Introduction Morton's neuroma is an entrapment neuropathy of the third common plantar digital nerve, caused by the deep transverse metatarsal ligament (DTML). Minimally‐invasive or percutaneous surgery is a very common procedure, but surgical effectivity of this technique remains controversial. The goal of our study was to prove the effectiveness and safety of a new ultrasound‐guided technique for DTML‐release in a cadaver model. Materials, Methods and Results The DTML was visualized...
Sat Oct 03, 2020 21:49
Publication date: Available online 1 October 2020Source: Sleep MedicineAuthor(s): Philip M. Becker
Sun Oct 04, 2020 12:44
Publication date: November 2020Source: Sleep Medicine, Volume 75Author(s): Alon Y. Avidan, Clete A. Kushida
Sun Oct 04, 2020 12:44
Publication date: November 2020Source: Sleep Medicine, Volume 75Author(s): Tao Wei, Cancan Li, Yuanyuan Heng, Xiang Gao, Guimei Zhang, Huachen Wang, Xuan Zhao, Zixiu Meng, Yanbo Zhang, Haifeng Hou
Sun Oct 04, 2020 12:44
Publication date: October 2020Source: Archives of Oral Biology, Volume 118Author(s):
Sun Oct 04, 2020 13:10
New Frontiers in Translational Research: Touchscreens, Open Science, and The Mouse Translational Research Accelerator Platform (MouseTRAP). Genes Brain Behav. 2020 Oct 03;:e12705 Authors: Sullivan JA, Dumont JR, Memar S, Skirzewski M, Wan J, Mofrad MH, Ansari HZ, Li Y, Muller L, Prado VF, Prado MAM, Saksida LM, Bussey TJ Abstract Many neurodegenerative and neuropsychiatric diseases and other brain disorders are accompanied by impairments in...
Sun Oct 04, 2020 13:11
Nasogastric Tube Feeding Versus Total Parenteral Nutrition in Older Dysphagic Patients with Pneumonia: Retrospective Cohort Study. J Nutr Health Aging. 2020;24(8):883-887 Authors: Honda Y, Momosaki R, Ogata N Abstract OBJECTIVES: Many older patients with pneumonia cannot intake orally after admission and may need nutritional care such as nasogastric tube feeding or total parenteral nutrition. This study sought to compare in-hospital outcomes...
Sun Oct 04, 2020 13:17
Advanced Fusion Imaging and Contrast-Enhanced Imaging (CT/MRI-CEUS) in Oncology. Cancers (Basel). 2020 Sep 30;12(10): Authors: Schwarze V, Rübenthaler J, Marschner C, Fabritius MP, Rueckel J, Fink N, Puhr-Westerheide D, Gresser E, Froelich MF, Schnitzer ML, Große Hokamp N, Afat S, Staehler M, Geyer T, Clevert DA Abstract Fusion imaging depicts an innovative technique that facilitates combining assets and reducing restrictions of advanced...
Sun Oct 04, 2020 13:28
Fertility Preservation in Childhood Cancer: Endocrine Activity in Prepubertal Human Testis Xenografts Exposed to a Pubertal Hormone Environment. Cancers (Basel). 2020 Sep 30;12(10): Authors: Hutka M, Kadam P, Van Saen D, Homer NZM, Onofre J, Wallace WHB, Smith LB, Stukenborg JB, Goossens E, Mitchell RT Abstract Survivors of childhood cancer are at risk for long-term treatment-induced health sequelae, including gonadotoxicity and iatrogenic...
Sun Oct 04, 2020 13:28
MicroRNAs as Biomarkers in Canine Osteosarcoma: A New Future? Vet Sci. 2020 Sep 30;7(4): Authors: Gourbault O, Llobat L Abstract Sarcomas are frequent in dogs and canine species are excellent animal models for studying the human counterpart. However, osteosarcomas are a rare form of sarcoma with high death rates in humans and dogs. miRNAs are small endogenous RNAs that regulate gene expression post-transcriptionally. The discovery of miRNAs...
Sun Oct 04, 2020 13:28
Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma. J Hematol Oncol. 2020 Oct 02;13(1):130 Authors: Qian Y, Gong Y, Fan Z, Luo G, Huang Q, Deng S, Cheng H, Jin K, Ni Q, Yu X, Liu C Abstract Pancreatic ductal adenocarcinoma (PDAC) is a malignancy characterized by a poor prognosis and high mortality rate. Genetic mutations and altered molecular pathways serve as targets in precise therapy. Using next-generation...
Sun Oct 04, 2020 13:28
Immunotherapy for Prostate Cancer: Treatments for the "Lethal" Phenotype. Urol Clin North Am. 2020 Nov;47(4):469-474 Authors: Slovin SF Abstract Multiple immunologic platforms have provided minimal impact in patients with metastatic castration-resistant prostate cancer, necessitating that novel approaches continue to be developed. Although checkpoint inhibitors have been largely ineffective, there remain small cohorts of patients who have...
Sun Oct 04, 2020 13:28
Time-to-event analysis of paclitaxel-associated peripheral neuropathy in advanced non-small cell lung cancer highlighting key influential treatment/patient factors. J Pharmacol Exp Ther. 2020 Oct 02;: Authors: Ojara FW, Henrich A, Frances N, Huisinga W, Hartung N, Joerger M, Kloft C Abstract Paclitaxel-associated peripheral neuropathy (PN), a major dose-limiting toxicity, significantly impacts patients' quality of life/treatment outcome....
Sun Oct 04, 2020 13:28
History through the eyes of a pandemic. Curr Opin Ophthalmol. 2020 Nov;31(6):538-548 Authors: Graversen VK, Hamichi SE, Gold A, Murray TG Abstract PURPOSE OF REVIEW: This review provides a historic perspective of the impact that major pandemics have had on human and their relationship with ophthalmology. The novel coronavirus epidemic is also analyzed, highlighting the relevance of the eye as a possible source of transmission, infection,...
Sun Oct 04, 2020 13:28
The role of new antimicrobials for Gram-negative infections in daily clinical practice. Curr Opin Infect Dis. 2020 Sep 29;: Authors: Bassetti M, Vena A, Battaglini D, Pelosi P, Giacobbe DR Abstract PURPOSE OF REVIEW: To discuss a possible clinical reasoning for treating resistant Gram-negative bacteria (GNB) infections in daily clinical practice, as well as developing a research agenda for the field. RECENT FINDINGS: Novel agents,...
Sun Oct 04, 2020 13:28
RNA expression profiling reveals PRAME, a potential immunotherapy target, is frequently expressed in solitary fibrous tumors. Mod Pathol. 2020 Oct 02;: Authors: Wang WL, Gokgoz N, Samman B, Andrulis IL, Wunder JS, Demicco EG Abstract Solitary fibrous tumors are a type of translocation-associated sarcoma with up to 30% rates of metastasis and poor response to conventional chemotherapy. Other translocation-associated sarcomas have been shown...
Sun Oct 04, 2020 13:28
Patterns of complex emergency general surgery in Canada. Can J Surg. 2020 Sep-Oct;63(5):E435-E441 Authors: Vogt KN, Allen L, Murphy PB, van Heest R, Saleh F, Widder S, Minor S, Engels PT, Joos E, Nenshi R, Meschino MT, Laane C, Lacoul A, Parry NG, Ball CG, Hameed SM Abstract BACKGROUND: Most of the literature on emergency general surgery (EGS) has investigated appendiceal and biliary disease; however, EGS surgeons manage many other complex...
Sun Oct 04, 2020 13:28
Late and Long-Term Treatment-Related Effects and Survivorship for Head and Neck Cancer Patients. Curr Treat Options Oncol. 2020 Oct 03;21(12):92 Authors: Nilsen ML, Belsky MA, Scheff N, Johnson JT, Zandberg DP, Skinner H, Ferris R Abstract OPINION STATEMENT: The demographics of head and neck cancer (HNC) survivors are changing, contributing to a growing number of survivors and a greater length of survivorship. Curative treatment involves...
Sun Oct 04, 2020 13:28
Publication date: Available online 3 October 2020Source: Academic RadiologyAuthor(s): Pohchoo Seow, Aditya T. Hernowo, Vairavan Narayanan, Jeannie Hsiu Ding Wong, Nor Faizal Ahmad Bahuri, Chun Yoong Cham, Nor Aniza Abdullah, Khairul Azmi Abdul Kadir, Kartini Rahmat, Norlisah Ramli
Sun Oct 04, 2020 13:38
Publication date: Available online 3 October 2020Source: Academic RadiologyAuthor(s): Marco Eichelberg, Klaus Kleber, Marc Kämmerer
Sun Oct 04, 2020 13:38
Publication date: Available online 3 October 2020Source: Academic RadiologyAuthor(s): Gary X. Wang, Shinn-Huey S. Chou, Leslie R. Lamb, Anand K. Narayan, Brian N. Dontchos, Constance D. Lehman, Randy C. Miles
Sun Oct 04, 2020 13:38
A 63-Year-Old Woman with a History of Non-Hodgkin Lymphoma with Persistent SARS-CoV-2 Infection Who Was Seronegative and Treated with Convalescent Plasma. Am J Case Rep. 2020 Oct 03;21:e927812 Authors: Moore JL, Ganapathiraju PV, Kurtz CP, Wainscoat B Abstract BACKGROUND This is a case report of an immunocompromised patient with a history of non-Hodgkin lymphoma and persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection...
Sun Oct 04, 2020 13:39
Dural Metastasis without Subdural Hematoma or Subdural Fluid Collection in a Patient with Signet Ring Cell Gastric Adenocarcinoma. Am J Case Rep. 2020 Oct 03;21:e925599 Authors: Cioni E, Marchiani C, Gagliano M, Bandini G, Palagano N, Ciuti G, Moggi Pignone A Abstract BACKGROUND Signet ring cell (SRC) gastric adenocarcinoma is an aggressive histotype associated with poor prognosis, especially in advanced gastric cancer. Dural metastasis is...
Sun Oct 04, 2020 13:39
Brain structural and neuroendocrine basis of sex differences in epilepsy. Handb Clin Neurol. 2020;175:223-233 Authors: Reddy DS Abstract This chapter reviews the current information about sex differences in epilepsy and potential mechanisms underlying sex differences in seizure susceptibility and epilepsy. The susceptibility to and occurrence of seizures are generally higher in men than women. There is gender-specific epilepsies such as catamenial...
Sun Oct 04, 2020 13:45
D-serine mitigates cell loss associated with temporal lobe epilepsy. Nat Commun. 2020 Oct 02;11(1):4966 Authors: Beesley S, Sullenberger T, Crotty K, Ailani R, D'Orio C, Evans K, Ogunkunle EO, Roper MG, Kumar SS Abstract Temporal lobe epilepsy (TLE) is the most common type of drug-resistant epilepsy in adults, with an unknown etiology. A hallmark of TLE is the characteristic loss of layer 3 neurons in the medial entorhinal area (MEA) that underlies...
Sun Oct 04, 2020 13:45
Repetitive transcranial magnetic stimulation in drug-resistant idiopathic epilepsy of dogs: A noninvasive neurostimulation technique. J Vet Intern Med. 2020 Oct 03;: Authors: Charalambous M, Van Ham L, Broeckx BJG, Roggeman T, Carrette S, Vonck K, Kervel RR, Cornelis I, Bhatti SFM Abstract BACKGROUND: Although repetitive transcranial magnetic stimulation (rTMS) has been assessed in epileptic humans, clinical trials in epileptic dogs can provide...
Sun Oct 04, 2020 13:45
Patterns of anticonvulsant use and adverse drug events in older adults. Pharmacoepidemiol Drug Saf. 2020 Oct 02;: Authors: Moura LMVR, Smith JR, Yan Z, Blacker D, Schwamm LH, Newhouse JP, Hernandez-Diaz S, Hsu J Abstract PURPOSE: To examine indications for, duration of use, and rate of adverse drug events (ADE) attributable to anticonvulsant initiation, as adjudicated by expert review of electronic health records (EHR) of older adults. ...
Sun Oct 04, 2020 13:45
Lister hooded rats as a novel animal model of attention-deficit/hyperactivity disorder. Neurochem Int. 2020 Sep 30;:104857 Authors: Jogamoto T, Utsunomiya R, Sato A, Kihara N, Choudhury ME, Miyanishi K, Kubo M, Nagai M, Nomoto M, Yano H, Shimizu YI, Fukuda M, Ishii E, Eguchi M, Tanaka J Abstract Appropriate animal models are necessary to determine the molecular and cellular mechanisms underlying attention-deficit/hyperactivity disorder (ADHD)....
Sun Oct 04, 2020 13:45
How does the COVID-19 cause seizure and epilepsy in patients? The potential mechanisms. Mult Scler Relat Disord. 2020 Sep 28;46:102535 Authors: Nikbakht F, Mohammadkhanizadeh A, Mohammadi E Abstract The new coronavirus has spread throughout the world in a very short time and now has become a pandemic. Most infected people have symptoms such as dry cough, dyspnea, tiredness, and fever. However, the Covid-19 infection disrupts various organs,...
Sun Oct 04, 2020 13:45
Digoxin enhances the effect of antiepileptic drugs with different mechanism of action in the pentylenetetrazole-induced seizures in mice. Epilepsy Res. 2020 Sep 11;167:106465 Authors: Tsyvunin V, Shtrygol' S, Shtrygol' D Abstract The worldwide prevalence of epilepsy with high percentage of multidrug-resistant patients make it urgent to find new approaches to treating, including the use of combinations of classic anticonvulsants with drugs that...
Sun Oct 04, 2020 13:45
Advanced Fusion Imaging and Contrast-Enhanced Imaging (CT/MRI-CEUS) in Oncology. Cancers (Basel). 2020 Sep 30;12(10): Authors: Schwarze V, Rübenthaler J, Marschner C, Fabritius MP, Rueckel J, Fink N, Puhr-Westerheide D, Gresser E, Froelich MF, Schnitzer ML, Große Hokamp N, Afat S, Staehler M, Geyer T, Clevert DA Abstract Fusion imaging depicts an innovative technique that facilitates combining assets and reducing restrictions of advanced ultrasound...
Sun Oct 04, 2020 13:53
Fertility Preservation in Childhood Cancer: Endocrine Activity in Prepubertal Human Testis Xenografts Exposed to a Pubertal Hormone Environment. Cancers (Basel). 2020 Sep 30;12(10): Authors: Hutka M, Kadam P, Van Saen D, Homer NZM, Onofre J, Wallace WHB, Smith LB, Stukenborg JB, Goossens E, Mitchell RT Abstract Survivors of childhood cancer are at risk for long-term treatment-induced health sequelae, including gonadotoxicity and iatrogenic...
Sun Oct 04, 2020 13:53
MicroRNAs as Biomarkers in Canine Osteosarcoma: A New Future? Vet Sci. 2020 Sep 30;7(4): Authors: Gourbault O, Llobat L Abstract Sarcomas are frequent in dogs and canine species are excellent animal models for studying the human counterpart. However, osteosarcomas are a rare form of sarcoma with high death rates in humans and dogs. miRNAs are small endogenous RNAs that regulate gene expression post-transcriptionally. The discovery of miRNAs...
Sun Oct 04, 2020 13:53
Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma. J Hematol Oncol. 2020 Oct 02;13(1):130 Authors: Qian Y, Gong Y, Fan Z, Luo G, Huang Q, Deng S, Cheng H, Jin K, Ni Q, Yu X, Liu C Abstract Pancreatic ductal adenocarcinoma (PDAC) is a malignancy characterized by a poor prognosis and high mortality rate. Genetic mutations and altered molecular pathways serve as targets in precise therapy. Using next-generation sequencing...
Sun Oct 04, 2020 13:53
Immunotherapy for Prostate Cancer: Treatments for the "Lethal" Phenotype. Urol Clin North Am. 2020 Nov;47(4):469-474 Authors: Slovin SF Abstract Multiple immunologic platforms have provided minimal impact in patients with metastatic castration-resistant prostate cancer, necessitating that novel approaches continue to be developed. Although checkpoint inhibitors have been largely ineffective, there remain small cohorts of patients who have durable...
Sun Oct 04, 2020 13:53
Time-to-event analysis of paclitaxel-associated peripheral neuropathy in advanced non-small cell lung cancer highlighting key influential treatment/patient factors. J Pharmacol Exp Ther. 2020 Oct 02;: Authors: Ojara FW, Henrich A, Frances N, Huisinga W, Hartung N, Joerger M, Kloft C Abstract Paclitaxel-associated peripheral neuropathy (PN), a major dose-limiting toxicity, significantly impacts patients' quality of life/treatment outcome. Evaluation...
Sun Oct 04, 2020 13:53
History through the eyes of a pandemic. Curr Opin Ophthalmol. 2020 Nov;31(6):538-548 Authors: Graversen VK, Hamichi SE, Gold A, Murray TG Abstract PURPOSE OF REVIEW: This review provides a historic perspective of the impact that major pandemics have had on human and their relationship with ophthalmology. The novel coronavirus epidemic is also analyzed, highlighting the relevance of the eye as a possible source of transmission, infection, and...
Sun Oct 04, 2020 13:53
The role of new antimicrobials for Gram-negative infections in daily clinical practice. Curr Opin Infect Dis. 2020 Sep 29;: Authors: Bassetti M, Vena A, Battaglini D, Pelosi P, Giacobbe DR Abstract PURPOSE OF REVIEW: To discuss a possible clinical reasoning for treating resistant Gram-negative bacteria (GNB) infections in daily clinical practice, as well as developing a research agenda for the field. RECENT FINDINGS: Novel agents,...
Sun Oct 04, 2020 13:53
RNA expression profiling reveals PRAME, a potential immunotherapy target, is frequently expressed in solitary fibrous tumors. Mod Pathol. 2020 Oct 02;: Authors: Wang WL, Gokgoz N, Samman B, Andrulis IL, Wunder JS, Demicco EG Abstract Solitary fibrous tumors are a type of translocation-associated sarcoma with up to 30% rates of metastasis and poor response to conventional chemotherapy. Other translocation-associated sarcomas have been shown...
Sun Oct 04, 2020 13:53
Patterns of complex emergency general surgery in Canada. Can J Surg. 2020 Sep-Oct;63(5):E435-E441 Authors: Vogt KN, Allen L, Murphy PB, van Heest R, Saleh F, Widder S, Minor S, Engels PT, Joos E, Nenshi R, Meschino MT, Laane C, Lacoul A, Parry NG, Ball CG, Hameed SM Abstract BACKGROUND: Most of the literature on emergency general surgery (EGS) has investigated appendiceal and biliary disease; however, EGS surgeons manage many other complex...
Sun Oct 04, 2020 13:53
Late and Long-Term Treatment-Related Effects and Survivorship for Head and Neck Cancer Patients. Curr Treat Options Oncol. 2020 Oct 03;21(12):92 Authors: Nilsen ML, Belsky MA, Scheff N, Johnson JT, Zandberg DP, Skinner H, Ferris R Abstract OPINION STATEMENT: The demographics of head and neck cancer (HNC) survivors are changing, contributing to a growing number of survivors and a greater length of survivorship. Curative treatment involves intense...
Sun Oct 04, 2020 13:53
Free Vascularized Fibula Flap Reconstruction of Total and Near-total Destabilizing Resections of the Sacrum. Ann Plast Surg. 2020 Oct 01;: Authors: Asaad M, Mericli AF, Hanasono MM, Roubaud MS, Bird JE, Rhines LD Abstract BACKGROUND: Vascularized bone grafts (VBGs) are associated with improved union and fewer instrumentation complications in the mobile spine. It is not known if VBGs are similarly efficacious after sacrectomy. METHODS:...
Sun Oct 04, 2020 13:55
New Chimeric Groin Flap: Experimental Model in Rats. Ann Plast Surg. 2020 Oct 01;: Authors: Morarasu S, Ghetu N, Coman CG, Boicu D, Spiridon IA, Gardikiotis I, Danciu M, Pieptu D Abstract AIM: Increased emphasis is on using tissue substitutes and stem cells to improve flap applicability and survival rates. To accomplish this, the first step is to have a versatile experimental flap, easy to harvest and use as a template. We sought to develop...
Sun Oct 04, 2020 13:55
Course Review: The Norwich and Chelmsford FRCS (Plast) Examination Revision Course. Ann Plast Surg. 2020 Oct 01;: Authors: Johal KS, Din AH Abstract The combined Norfolk and Norwich & St. Andrew's (Chelmsford) FRCS (Plast) revision course is aimed at preparing candidates for Part 2 of the FRCS examination. It aims to closely replicate the actual examination and is delivered in the same format over 2 days. It differs from other FRCS courses...
Sun Oct 04, 2020 13:55
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