Long-term Follow-up After Radiation Therapy for Laryngeal Amyloidosis. Laryngoscope. 2020 Oct 03;: Authors: Bertelsen C, Chadwick K, Holland J, Flint P, Schindler JS Abstract OBJECTIVES: Laryngeal amyloidosis (LA) is a rare disease characterized by extracellular protein deposition within the larynx. Treatment is difficult due to the frequently submucosal and multifocal nature of disease. The mainstay of treatment is surgical resection; however,...
Sun Oct 04, 2020 15:18
Combined proteomic and transcriptomic approaches reveal externalized keratin 8 as a potential therapeutic target involved in invasiveness of head and neck cancers. Transl Oncol. 2020 Sep 30;14(1):100878 Authors: Albaret MA, Paré A, Malet L, De Souza G, Lavergne E, Goga D, De Pinieux G, Castellier C, Swalduz A, Robin V, Lavergne V, Mertani HC, Treilleux I, Vermot-Desroches C, Diaz JJ, Saintigny P Abstract Keratin 8 (K8) expressed at the...
Sun Oct 04, 2020 13:18
Impact of obstructive sleep apnea on cardiopulmonary performance, endothelial dysfunction, and pulmonary hypertension during exercise. Respir Physiol Neurobiol. 2020 Oct 01;:103557 Authors: Jen R, Orr JE, Gilbertson D, Fine J, Li Y, Wong D, Bosompra NO, Hopkins SR, Raisingani A, Malhotra A Abstract RATIONALE: OSA has been associated with reduced exercise capacity. Endothelial dysfunction and exercise-induced pulmonary hypertension (ePH)...
Sun Oct 04, 2020 13:18
Is Perineural Invasion a Reasonable Indicator for Neck Dissection in cT1N0M0 Squamous Cell Carcinoma of the Oral Cavity? J Oral Maxillofac Surg. 2020 Sep 06;: Authors: Alzahrani S, Feng Z, Cheng A, Han Z, Moe J, Ward BB Abstract AIM: Perineural invasion (PNI) is considered an adverse histological feature in oral squamous cell carcinoma (OSCC). Controversy exists regarding elective neck dissection (END) in cT1N0M0 OSCC with PNI as the only...
Sun Oct 04, 2020 13:18
Metastasizing basal cell carcinoma: A clinicopathologic and immunohistochemical study of twenty-two cases. J Cutan Pathol. 2020 Oct 03;: Authors: Mochel MC, Liaquat S, Moore JB, Hoang MP Abstract Basal cell carcinomas metastasize rarely, and there have been limited studies of potential drivers for this metastasis. Epithelial-mesenchymal transition (EMT) may play a role, although this has not been investigated in detail. We reviewed clinicopathologic...
Sun Oct 04, 2020 13:18
Late and Long-Term Treatment-Related Effects and Survivorship for Head and Neck Cancer Patients. Curr Treat Options Oncol. 2020 Oct 03;21(12):92 Authors: Nilsen ML, Belsky MA, Scheff N, Johnson JT, Zandberg DP, Skinner H, Ferris R Abstract OPINION STATEMENT: The demographics of head and neck cancer (HNC) survivors are changing, contributing to a growing number of survivors and a greater length of survivorship. Curative treatment involves...
Sun Oct 04, 2020 13:18
Long-term Follow-up After Radiation Therapy for Laryngeal Amyloidosis. Laryngoscope. 2020 Oct 03;: Authors: Bertelsen C, Chadwick K, Holland J, Flint P, Schindler JS Abstract OBJECTIVES: Laryngeal amyloidosis (LA) is a rare disease characterized by extracellular protein deposition within the larynx. Treatment is difficult due to the frequently submucosal and multifocal nature of disease. The mainstay of treatment is surgical resection;...
Sun Oct 04, 2020 13:18
Transorbital Endoscopic Approach for Repair of Frontal Sinus Cerebrospinal Fluid Leaks: Case-Series.
Transorbital Endoscopic Approach for Repair of Frontal Sinus Cerebrospinal Fluid Leaks: Case-Series. Laryngoscope. 2020 Oct 03;: Authors: Noiphithak R, Yanez-Siller JC, Nimmannitya P, Rukskul P Abstract OBJECTIVES: To highlight the feasibility and evaluate the outcomes of the transorbital endoscopic approach (TOEA) in the management of frontal sinus cerebrospinal fluid (CSF) leaks. STUDY DESIGN: Retrospective case series. ...
Sun Oct 04, 2020 13:18
Yield of Imaging to Evaluate Unilateral Vocal Fold Paralysis of Unknown Etiology. Laryngoscope. 2020 Oct 03;: Authors: Politano S, Morell F, Calamari K, DeSilva B, Matrka L Abstract OBJECTIVES/HYPOTHESIS: To identify the incidence and nature of positive findings on imaging studies ordered for evaluation of unilateral vocal fold paralysis (UVFP) of unknown etiology, to analyze these findings based on laterality, and to examine the use of...
Sun Oct 04, 2020 13:18
Self-reported medication adherence in differentiated thyroid cancer survivors: Role of illness perception and medication beliefs. Head Neck. 2020 Oct 02;: Authors: Basım P, Argun D, Özdenkaya Y Abstract BACKGROUND: To investigate medication adherence (MA) to Levothyroxine in differentiated thyroid cancer survivors and analyze the related factors for nonadherence. METHODS: The Medication Adherence Report Scale (MARS), Hospital...
Sun Oct 04, 2020 13:18
Prognostic value of immune-related genes and immune cell infiltration analysis in the tumor microenvironment of head and neck squamous cell carcinoma. Head Neck. 2020 Oct 03;: Authors: Wang Z, Yuan H, Huang J, Hu D, Qin X, Sun C, Chen G, Wang B Abstract BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is one of the few malignant tumors that respond well to immunotherapy. We aimed to investigate the immune-related genes and immune...
Sun Oct 04, 2020 13:18
Outpatient vs inpatient parotidectomy: Systematic review and meta-analysis. Head Neck. 2020 Oct 03;: Authors: Benito DA, Pasick LJ, Bestourous D, Thakkar P, Goodman JF, Joshi AS Abstract The primary aim of this study was to conduct a systematic review and meta-analysis to compare complications between outpatient vs inpatient parotidectomy. A systematic review was performed to identify patients undergoing either outpatient or inpatient...
Sun Oct 04, 2020 13:18
Blood-based circulating microRNAs as potential biomarkers for predicting the prognosis of head and neck cancer-a systematic review. Clin Oral Investig. 2020 Oct 03;: Authors: Patil S, Warnakulasuriya S Abstract OBJECTIVE: The aim of the present study was to systematically review the role of circulating miRNAs as potential prognostic biomarkers in head and neck cancer patients. MATERIALS AND METHODS: PubMed, EMBASE, Scopus, Web...
Sun Oct 04, 2020 13:18
Salivary alpha-1-antitrypsin and macrophage migration inhibitory factor may be potential prognostic biomarkers for oncologic treatment-induced severe oral mucositis. Support Care Cancer. 2020 Oct 02;: Authors: Palmier NR, Leme AFP, De Rossi T, Telles GP, Morais-Faria K, Kowalski LP, Marta GN, Brandão TB, Arany PR, Migliorati CA, Santos-Silva AR, Prado-Ribeiro AC Abstract AIMS: Evaluate the abundance of the selected targets, alpha-1-antitrypsin...
Sun Oct 04, 2020 13:18
Correction: ERCC2 gene single-nucleotide polymorphism as a prognostic factor for locally advanced head and neck carcinomas after definitive cisplatin-based radiochemotherapy. Pharmacogenomics J. 2020 Oct 02;: Authors: Guberina M, Sak A, Pöttgen C, Tinhofer-Keilholz I, Budach V, Balermpas P, Von der Grün J, Rödel CM, Gkika E, Grosu AL, Abdollahi A, Debus J, Belka C, Pigorsch S, Combs SE, Mönnich D, Zips D, De-Colle C, Welz S, Linge A, Lohaus F, Baretton G,...
Sun Oct 04, 2020 13:18
Interaction of protocadherin-15 with the scaffold protein whirlin supports its anchoring of hair-bundle lateral links in cochlear hair cells. Sci Rep. 2020 Oct 02;10(1):16430 Authors: Michel V, Pepermans E, Boutet de Monvel J, England P, Nouaille S, Aghaie A, Delhommel F, Wolff N, Perfettini I, Hardelin JP, Petit C, Bahloul A Abstract The hair bundle of cochlear hair cells is the site of auditory mechanoelectrical transduction. It is formed...
Sun Oct 04, 2020 13:18
Primary Lacrimal Gland Oncocytoma Associated With Hypervascularity: A Case Report With Imaging and Immunohistochemical Characterization. Ophthalmic Plast Reconstr Surg. 2020 Aug 06;: Authors: Sweeney AR, Allen RC Abstract Oncocytoma is a rare benign neoplasm with few cases reported to involve the orbit. When affecting the orbit, oncocytomas have very slow growth and often evade early diagnosis. The diagnostic evaluation of these orbital...
Sun Oct 04, 2020 13:18
Bupivacaine and Lidocaine Induce Apoptosis in Osteosarcoma Tumor Cells. Clin Orthop Relat Res. 2020 Sep 28;: Authors: Mirshahidi S, Shields TG, de Necochea-Campion R, Yuan X, Janjua A, Williams NL, Mirshahidi HR, Reeves ME, Duerksen-Hughes P, Zuckerman LM Abstract BACKGROUND: Osteosarcoma is the most common type of bone cancer in adolescents. There have been no significant improvements in outcomes since chemotherapy was first introduced....
Sun Oct 04, 2020 13:18
Risk Factors of Strabismus Surgery among Pediatric Cerebral Palsy Population with Strabismus in Taiwan: A Population-Based Cohort Study. J Chin Med Assoc. 2020 Sep 26;: Authors: Lai WY, Kuo TJ, Lee CC, Yin CH Abstract BACKGROUND: To identify the risk factors of strabismus surgery among Taiwanese children with severe cerebral palsy (CP) and strabismus. METHODS: This retrospective nationwide population-based cohort study examined...
Sun Oct 04, 2020 13:18
Photoacoustic Molecular Imaging for the Identification of Lymph Node Metastasis in Head and Neck Cancer using an anti-EGFR Antibody-Dye Conjugate. J Nucl Med. 2020 Oct 02;: Authors: Nishio N, van den Berg NS, Martin BA, van Keulen S, Fakurnejad S, Rosenthal EL, Wilson KE Abstract The presence of lymph node (LN) metastases is an essential prognostic indicator in patients with head and neck squamous cell carcinoma (HNSCC). This study assessed...
Sun Oct 04, 2020 13:18
Cochlear implant datalogging accurately characterizes children's 'auditory scenes'. Cochlear Implants Int. 2020 Oct 02;:1-11 Authors: Ganek H, Forde-Dixon D, Cushing SL, Papsin BC, Gordon KA Abstract Objectives: This study sought to determine if children's auditory environments are accurately captured by the automatic scene classification embedded in cochlear implant (CI) processors and to quantify the amount of electronic device use in...
Sun Oct 04, 2020 13:18
The Prognostic Value of Toll-Like Receptors in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis. Int J Mol Sci. 2020 Sep 30;21(19): Authors: Hasnat S, Hujanen R, Nwaru BI, Salo T, Salem A Abstract Head and neck squamous cell carcinoma (HNSCC) is a group of tumours which exhibit low 5 year survival rates. Thus, there is an urgent need to identify biomarkers that may improve the clinical utility of patients with...
Sun Oct 04, 2020 13:18
Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing Loss. Int J Mol Sci. 2020 Sep 30;21(19): Authors: Doo JG, Kim D, Kim Y, Yoo MC, Kim SS, Ryu J, Yeo SG Abstract Sudden sensorineural hearing loss (SSNHL) is a medical emergency, making detailed examination to determine possible causes and early treatment important. However, etiological examinations in SSNHL do not always reveal a cause, and several factors...
Sun Oct 04, 2020 13:18
Management of Anterocapitis and Anterocollis: A Novel Ultrasound Guided Approach Combined with Electromyography for Botulinum Toxin Injection of Longus Colli and Longus Capitis. Toxins (Basel). 2020 Sep 30;12(10): Authors: Farrell M, Karp BI, Kassavetis P, Berrigan W, Yonter S, Ehrlich D, Alter KE Abstract Chemodenervation of cervical musculature using botulinum neurotoxin (BoNT) is established as the gold standard or treatment of choice...
Sun Oct 04, 2020 13:18
The Additional Value of Ultrafast DCE-MRI to DWI-MRI and 18F-FDG-PET to Detect Occult Primary Head and Neck Squamous Cell Carcinoma. Cancers (Basel). 2020 Sep 30;12(10): Authors: Martens RM, Stappen RV, Koopman T, Noij DP, Comans EF, Zwezerijnen GJ, Vergeer MR, Leemans CR, de Bree R, Boellaard R, Castelijns JA, de Graaf P Abstract To evaluate diagnostic accuracy of qualitative analysis and interobserver agreement of single ultrafast-DCE,...
Sun Oct 04, 2020 13:18
Extracellular Vesicles as Biomarkers in Cancer Immunotherapy. Cancers (Basel). 2020 Sep 30;12(10): Authors: Mathew M, Zade M, Mezghani N, Patel R, Wang Y, Momen-Heravi F Abstract Extracellular vesicles (EVs), including exosomes and microvesicles, are membrane-bound vesicles secreted by most cell types during both physiologic conditions as well in response to cellular stress. EVs play an important role in intercellular communication and...
Sun Oct 04, 2020 13:18
SOS Teeth: First Priority Teeth with Advanced Caries and Its Associations with Metabolic Syndrome among a National Representative Sample of Young and Middle-Aged Adults. J Clin Med. 2020 Sep 30;9(10): Authors: Almoznino G, Kessler Baruch O, Kedem R, Protter NE, Shay B, Yavnai N, Zur D, Mijiritsky E, Abramovitz I Abstract "SOS teeth" are defined as the first priority teeth for treatment, that have distinct cavitation reaching the pulp chamber...
Sun Oct 04, 2020 13:18
Endocrine and Growth Abnormalities in 4H Leukodystrophy Caused by Variants in POLR3A, POLR3B, and POLR1C. J Clin Endocrinol Metab. 2020 Oct 01;: Authors: Pelletier F, Perrier S, Cayami FK, Mirchi A, Saikali S, Tran LT, Ulrick N, Guerrero K, Rampakakis E, van Spaendonk RML, Naidu S, Pohl D, Gibson WT, Demos M, Goizet C, Tejera-Martin I, Potic A, Fogel BL, Brais B, Sylvain M, Sebire G, Lourenço CM, Bonkowsky JL, Catsman-Berrevoets C, Pinto PS, Tirupathi S, Strømme...
Sat Oct 03, 2020 15:43
Isolated Aspergillus Laryngitis: Spectrum, Management, and Review of Literature. J Voice. 2020 Sep 28;: Authors: Sheth MC, Paul RR, Mathews SS, Albert RR Abstract PURPOSE: Isolated aspergillus laryngitis is rare and often diagnosed after surgical excision or biopsy for a suspected premalignant or malignant pathology. Unlike other systemic or localized aspergillosis, there are no specific guidelines for isolated laryngeal aspergillosis. Our...
Sat Oct 03, 2020 15:10
Intranasal fluticasone furoate in pediatric allergic rhinitis: randomized controlled study. Pediatr Res. 2020 Oct 02;: Authors: Zhang Y, Wei P, Chen B, Li X, Luo X, Chen X, Xiang M, Li L, Zhao S, Xiao X, Yang X, Chen J, Fu Y, Xiao S, Liu H, Cheng L, Yao H Abstract BACKGROUND: Intranasal corticosteroids are the most efficacious anti-inflammatory medications for allergic rhinitis (AR). However, the efficacy and safety of intranasal corticosteroids...
Sat Oct 03, 2020 13:18
Predictive dose accumulation for HN adaptive radiotherapy. Phys Med Biol. 2020 Oct 02;: Authors: Lee D, Zhang P, Nadeem S, R Alam S, Jiang J, Caringi A, Allgood N, Aristophanous M, Mechalakos JG, Hu Y Abstract During radiation therapy (RT) of head and neck cancer, the shape and volume of the parotid glands (PG) may change significantly, resulting in clinically relevant deviations of delivered dose from the planning dose. Early and accurate...
Sat Oct 03, 2020 13:18
Consensus-based perioperative protocols during the COVID-19 pandemic. J Neurosurg Spine. 2020 Oct 02;:1-9 Authors: Mummaneni PV, Burke JF, Chan AK, Sosa JA, Lobo EP, Mummaneni VP, Antrum S, Berven SH, Conte MS, Doernberg SB, Goldberg AN, Hess CP, Hetts SW, Josephson SA, Kohi MP, Ma CB, Mahadevan VS, Molinaro AM, Murr AH, Narayana S, Roberts JP, Stoller ML, Theodosopoulos PV, Vail TP, Wienholz S, Gropper MA, Green A, Berger MS Abstract ...
Sat Oct 03, 2020 13:18
Health-related quality of life outcomes in head and neck cancer: results from a prospective, real world data study with Brazilian patients treated with IMRT, conformal and conventional radiation techniques. Int J Radiat Oncol Biol Phys. 2020 Sep 29;: Authors: Santos M, Oliveira E Silva LF, Kohler HF, Curioni O, Vilela R, Fang M, Passos Lima CS, Gomes JP, Chaves A, Resende B, Trindade K, Collares M, Obs F, Brollo J, Cavalieri R, Ferreira E, Brust L, Rabello...
Sat Oct 03, 2020 13:18
Human papillomavirus-positivity is associated with EREG down-regulation and promoter hypermethylation in head and neck squamous cell carcinoma. Exp Mol Pathol. 2020 Sep 29;:104549 Authors: Khanal S, Strickley JD, Ha T, Demehri S, Ghim SJ, Jenson AB, Redman RA, Joh JJ Abstract BACKGROUND: Human papillomavirus (HPV) etiology has become evident in head and neck cancers (HNCs) and HPV positivity showed a strong association with its malignant...
Sat Oct 03, 2020 13:18
Factors associated with facial weakness following surgery for benign parotid disease: a retrospective multicenter study. Ann Saudi Med. 2020 Sep-Oct;40(5):408-416 Authors: Albosaily A, Aldrees T, Doubi A, Aldhwaihy L, Al-Gazlan NS, Alessa M, Al-Dhahri S, Al-Qahtani K Abstract BACKGROUND: Facial nerve weakness is the most common and most concerning complication after parotidectomy. Risk factors for this complication following surgery for...
Sat Oct 03, 2020 13:18
Cooperation as core value in an innovative era. Oral Dis. 2020 Oct 02;: Authors: Witjes MJ, Vissink A Abstract Diagnosis, treatment and rehabilitation of patients suffering from oral cancer is a shared responsibility of primary care givers like dentists, physicians and oral medicine specialists, and intramural secondary care specialties. Because of the complex nature of treatment and the necessity of long term care in most patients, the...
Sat Oct 03, 2020 13:18
Inactivation of TMEM106A promotes lipopolysaccharide-induced inflammation via the MAPK and NF-κB signaling pathways in macrophages. Clin Exp Immunol. 2020 Oct 02;: Authors: Zhang X, Feng T, Zhou X, Sullivan PM, Hu F, Lou Y, Yu J, Feng J, Liu H, Chen Y Abstract Pattern recognition receptors, such as Toll-like receptors (TLRs) play an important role in host defense against invading microbial pathogens. Their activation must be precisely...
Sat Oct 03, 2020 13:18
External jugular vein aneurysm: a rare cause of fluctuating neck swelling. Intern Emerg Med. 2020 Oct 02;: Authors: Chandran A, Kumar D, Kumar R, Sharma N, Kumar R PMID: 33006739 [PubMed - as supplied by publisher]
Sat Oct 03, 2020 13:18
A case of bleeding from maxillary carcinoma embolized from the maxillary and ophthalmic arteries. CVIR Endovasc. 2020 Oct 02;3(1):74 Authors: Sanomura T, Norikane T, Fujimoto K, Kawanishi M, Hoshikawa H, Nishiyama Y Abstract BACKGROUND: The majority of maxillary sinus cancers are advanced at initial detection due to anatomical limitations and lack of early symptoms. In patients with orbital invasion, the feeding arteries of the tumor are...
Sat Oct 03, 2020 13:18
microRNA-18a from M2 Macrophages Inhibits TGFBR3 to Promote Nasopharyngeal Carcinoma Progression and Tumor Growth via TGF-β Signaling Pathway. Nanoscale Res Lett. 2020 Oct 02;15(1):196 Authors: Peng Y, Li X, Liu H, Deng X, She C, Liu C, Wang X, Liu A Abstract OBJECTIVES: Nasopharyngeal carcinoma (NPC) is a type of nasopharyngeal disease with high metastasis and invasion properties. Tumor-associated alternative activated (M2) macrophages...
Sat Oct 03, 2020 13:18
Microwave ablation enhances tumor-specific immune response in patients with hepatocellular carcinoma. Cancer Immunol Immunother. 2020 Oct 02;: Authors: Leuchte K, Staib E, Thelen M, Gödel P, Lechner A, Zentis P, Garcia-Marquez M, Waldschmidt D, Datta RR, Wahba R, Wybranski C, Zander T, Quaas A, Drebber U, Stippel DL, Bruns C, von Bergwelt-Baildon M, Wennhold K, Schlößer HA Abstract Thermal ablative therapies are standard treatments for...
Sat Oct 03, 2020 13:18
Locally advanced nasal pyramid squamous cell carcinoma: our 15 years' experience in a series of 35 total rhinectomies. Rhinology. 2020 Oct 02;: Authors: Bouaoud J, Benmoussa N, Hennocq Q, Hennocq JF, Breuskin I, Gorphe P, Casiraghi O, Classe M, Blanchard P, Janot F, Kolb F, Leymarie N, Temam S, Moya-Plana A Abstract Locally advanced nasal pyramid squamous cell carcinoma (LA-NPSCC) are rare malignancies. Their specific outcomes are unclear....
Sat Oct 03, 2020 13:18
Squamous Cell Carcinoma of Nasal Vestibule and Pyramid: Outcomes and Reconstructive Strategies. Laryngoscope. 2020 Oct 02;: Authors: Lambertoni A, Cherubino M, Battaglia P, De Col A, Giovannardi M, Antognoni P, Valdatta L, Karligkiotis A, Bignami M, Castelnuovo P, Turri-Zanoni M Abstract OBJECTIVES: Squamous cell carcinoma of nasal vestibule and pyramid is rare, thus classification, treatment protocol, and indications for elective neck...
Sat Oct 03, 2020 13:18
Unbiased Measure of General Quality of Life in Chronic Rhinosinusitis Reveals Disease Modifiers. Laryngoscope. 2020 Oct 02;: Authors: Epperson MV, McCann AC, Phillips KM, Caradonna DS, Gray ST, Sedaghat AR Abstract INTRODUCTION: Chronic rhinosinusitis (CRS) is associated with a significant decrease in general health-related quality of life (QOL). The EuroQol 5-dimensional questionnaire measures general health-related quality of life through...
Sat Oct 03, 2020 13:18
The Association of Vestibular Schwannoma Volume With Facial Nerve Outcomes After Surgical Resection.
The Association of Vestibular Schwannoma Volume With Facial Nerve Outcomes After Surgical Resection. Laryngoscope. 2020 Oct 02;: Authors: Killeen DE, Barnett SL, Mickey BE, Hunter JB, Isaacson B, Kutz JW Abstract OBJECTIVE: To explore the relationship between tumor size and facial nerve outcomes following vestibular schwannoma (VS) resection. STUDY DESIGN: Single institutional retrospective chart review of all adult patients...
Sat Oct 03, 2020 13:18
The co-presence of high-risk human papillomaviruses and Epstein-Barr virus is linked with tumor grade and stage in Qatari women with breast cancer. Hum Vaccin Immunother. 2020 Oct 02;:1-8 Authors: Gupta I, Jabeen A, Al-Sarraf R, Farghaly H, Vranic S, Sultan AA, Al Moustafa AE, Al-Thawadi H Abstract High-risk human papillomaviruses (HPV) can be present and cooperate with Epstein-Barr virus (EBV) to promote the onset and/or progression of...
Sat Oct 03, 2020 13:18
Animal model and bioinformatics analyses suggest the TIMP1/MMP9 axis as a potential biomarker in oral squamous cell carcinoma. Mol Carcinog. 2020 Nov;59(11):1302-1316 Authors: Xu G, Wei J, Huangfu B, Gao J, Wang X, Xiao L, Xuan R, Chen Z, Song G Abstract Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck. However, the molecular mechanism underlying its development and progression is yet unclear. Genes...
Sat Oct 03, 2020 13:18
Extent of salvage neck dissection following chemoradiation for locally advanced head and neck cancer. Head Neck. 2020 Oct 01;: Authors: Okano W, Hayashi R, Matsuura K, Shinozaki T, Tomioka T Abstract BACKGROUND: Salvage neck dissection (ND) is the only treatment modality for persistent or recurrent nodal disease after chemoradiotherapy (CRT) for locally advanced head and neck cancer. However, the optimal extent of ND at salvage surgery...
Sat Oct 03, 2020 13:18
Adoption of the transoral endoscopic vestibular approach by head and neck surgeons without prior laparoscopic/robotic experience. Head Neck. 2020 Oct 01;: Authors: Khafif A, Cohen O, Masalha M, Yaish I, Hod K, Assadi N Abstract BACKGROUND: Transoral endoscopic vestibular approach (TOEVA) for thyroidectomy (TOETVA) and parathyroidectomy (TOEPVA) is gaining popularity, yet knowledge is based on a limited number of studies, mostly performed...
Sat Oct 03, 2020 13:18
Comprehensive in silico analysis for identification of novel candidate target genes, including DHX36, OPA1, and SENP2, located on chromosome 3q in head and neck cancers. Head Neck. 2020 Oct 01;: Authors: Karatas OF, Capik O, Barlak N, Aydin Karatas E Abstract BACKGROUND: Major milestones of head and neck carcinogenesis have been associated with various genetic abnormalities; however, a clear picture of the molecular networks deregulated...
Sat Oct 03, 2020 13:18
Clear cell sarcoma-like/malignant gastrointestinal neuroectodermal tumor of the tongue: a clinicopathologic and molecular case report. Virchows Arch. 2020 Oct 02;: Authors: Sbaraglia M, Zanatta L, Toffolatti L, Spallanzani A, Bertolini F, Mattioli F, Lami F, Presutti L, Dei Tos AP Abstract Malignant gastrointestinal neuroectodermal tumor (M-GNET) and clear cell sarcoma (CCS) of soft tissue represent closely related, extremely rare, malignant...
Sat Oct 03, 2020 13:18
Transoral Laser Microsurgery (TLM) for Glottic Cancer: Prospective Assessment of a New Pathology Workup Protocol. Front Surg. 2020;7:56 Authors: Meulemans J, Hauben E, Peeperkorn S, Nuyts S, Delaere P, Vander Poorten V Abstract Background/Purpose: The value of margin status after TLM for glottic cancer is debatable, due to difficulties in specimen orientation and margin analysis. Purpose of this study was the prospective evaluation of...
Sat Oct 03, 2020 13:18
The relationship between IL-6 and thrombocytosis accompanying gastrointestinal tumours. Prz Gastroenterol. 2020;15(3):215-219 Authors: Jósa V, Brodszky V, Zaránd A, Mezei T, Szilasi Z, Merkel K, Fehér A, Szállási Z, Baranyai Z Abstract Introduction: Several reports have stated that thrombocytosis is associated with worse survival and higher rate of metastasis in solid tumours. A study in ovarian tumours implicated IL-6 produced by tumour...
Sat Oct 03, 2020 13:18
Influence of multiple apolipoprotein A-I and B genetic variations on insulin resistance and metabolic syndrome in obstructive sleep apnea. Nutr Metab (Lond). 2020;17:83 Authors: Li X, Fu Z, Xu H, Zou J, Zhu H, Li Z, Su K, Huai, Yi H, Guan J, Yin S Abstract Background: The relationships between apolipoprotein A-I (APOA-I), apolipoprotein B (APOB) with insulin resistance, metabolic syndrome (MetS) are unclear in OSA. We aimed to evaluate...
Sat Oct 03, 2020 13:18
Systematic Transcriptome Analysis of Noise-Induced Hearing Loss Pathogenesis Suggests Inflammatory Activities and Multiple Susceptible Molecules and Pathways. Front Genet. 2020;11:968 Authors: Wang Q, Shen Y, Hu H, Fan C, Zhang A, Ding R, Ye B, Xiang M Abstract Noise-induced hearing loss (NIHL) is characterized by damage to cochlear neurons and associated hair cells; however, a systematic evaluation of NIHL pathogenesis is still lacking....
Sat Oct 03, 2020 13:18
Identification and validation of methylation-driven genes prognostic signature for recurrence of laryngeal squamous cell carcinoma by integrated bioinformatics analysis. Cancer Cell Int. 2020;20:472 Authors: Cui J, Wang L, Zhong W, Chen Z, Chen J, Yang H, Liu G Abstract Background: Recurrence remains a major obstacle to long-term survival of laryngeal squamous cell carcinoma (LSCC). We conducted a genome-wide integrated analysis of methylation...
Sat Oct 03, 2020 13:18
Promotion of BZW2 by LINC00174 through miR-4500 inhibition enhances proliferation and apoptosis evasion in laryngeal papilloma. Cancer Cell Int. 2020;20:471 Authors: Liu J, Yang T, Zhang Y, Wang S Abstract Background: We aimed to explore the roles of basic leucine zipper and W2 domains (BZW) 2 in the human papillomavirus-infected laryngeal papillomatosis. Methods: In the present study, BZW 2 knockdown and overexpressed cell lines...
Sat Oct 03, 2020 13:18
The influence of PI3K inhibition on the radiotherapy response of head and neck cancer cells. Sci Rep. 2020 Oct 01;10(1):16208 Authors: Glorieux M, Dok R, Nuyts S Abstract Radiotherapy has a central role in the treatment of head and neck squamous cell carcinoma (HNSCC). Activation of the PI3K/AKT/mTOR pathway can decrease the efficiency of radiotherapy via the promotion of cell survival and DNA repair. Here, the influence of PI3K pathway...
Sat Oct 03, 2020 13:18
Author Correction: Cellulose Mediated Transferrin Nanocages for Enumeration of Circulating Tumor Cells for Head and Neck Cancer. Sci Rep. 2020 Oct 01;10(1):16607 Authors: Hazra RS, Kale N, Aland G, Qayyumi B, Mitra D, Jiang L, Bajwa D, Khandare J, Chaturvedi P, Quadir M Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper. PMID: 33004848 [PubMed]
Sat Oct 03, 2020 13:18
CT-based dentulous mandibular alveolar ridge measurements as predictors of crown-to-implant ratio for short and extra short dental implants. Sci Rep. 2020 Oct 01;10(1):16229 Authors: Sivolella S, Meggiorin S, Ferrarese N, Lupi A, Cavallin F, Fiorino A, Giraudo C Abstract The purpose was to predict the crown-to-implant ratio variation in the edentulous posterior mandibles rehabilitated with short dental implants. Hence, vertical and horizontal...
Sat Oct 03, 2020 13:18
Long-term outcomes of patients with papillary thyroid cancer who did not undergo prophylactic central neck dissection. J Cancer Res Ther. 2020 Sep;16(5):1077-1081 Authors: Huang H, Wu L, Liu W, Liu J, Liu Y, Xu Z Abstract Aims: The role of prophylactic central neck dissection (CND) in the management of papillary thyroid carcinoma (PTC) is controversial. This study reports outcomes of an observational approach in PTC patients without clinical...
Sat Oct 03, 2020 13:18
Oral melanotic neuroectodermal tumor of infancy: Management of a case affecting the maxilla. J Indian Soc Pedod Prev Dent. 2020 Jul-Sep;38(3):319-322 Authors: Agrawal A, Joshi J, Agrawal D, Kumar P, Modi B Abstract Melanotic neuroectodermal tumor is a rare benign congenital neoplasm involving the head-and-neck region found in infants <1 year of age. The lesion most commonly affects the maxilla. We report the case of a 4-month-old male...
Sat Oct 03, 2020 13:18
A microstructural neural network biomarker for dystonia diagnosis identified by a DystoniaNet deep learning platform. Proc Natl Acad Sci U S A. 2020 Oct 01;: Authors: Valeriani D, Simonyan K Abstract Isolated dystonia is a neurological disorder of heterogeneous pathophysiology, which causes involuntary muscle contractions leading to abnormal movements and postures. Its diagnosis is remarkably challenging due to the absence of a biomarker...
Sat Oct 03, 2020 13:18
Opinion and Special Articles: Remote evaluation of acute vertigo: Strategies and technological considerations. Neurology. 2020 Oct 01;: Authors: Green KE, Pogson JM, Otero-Millan J, Gold DR, Tevzadze N, Saber Tehrani AS, Zee DS, Newman-Toker DE, Kheradmand A Abstract Patients with acute vestibular disorders are often a diagnostic challenge for neurologists-especially when the evaluation must be conducted remotely. The clinical dilemma...
Sat Oct 03, 2020 13:18
A 15-year-old with a Slowly Enlarging Submental Mass. Pediatr Rev. 2020 Oct;41(Suppl 1):S50-S53 Authors: Wikner EE, Mulcahy CF, Gitman L, Mudd PA PMID: 33004582 [PubMed - in process]
Sat Oct 03, 2020 13:18
Nutrition screening and assessment tools for patients with cancer and survivors of cancer: a systematic review protocol. BMJ Open. 2020 Oct 01;10(10):e037844 Authors: Kristensen MB, Wessel I, Ustrup KS, Dieperink KB, Zwisler AD, Beck AM Abstract INTRODUCTION: Nutritional challenges are common consequences of cancer, and they do not only occur in the hospital setting. They are also frequent after completion of treatment, and nutritional...
Sat Oct 03, 2020 13:18
Upfront surgery or definitive radiotherapy for patients with p16-negative oropharyngeal squamous cell carcinoma. A GETTEC multicentric study. Eur J Surg Oncol. 2020 Sep 10;: Authors: Culié D, Viotti J, Modesto A, Schiappa R, Chamorey E, Dassonville O, Poissonnet G, Guelfucci B, Bizeau A, Vergez S, Dupret-Bories A, Garrel R, Fakhry N, Santini L, Lallemant B, Chambon G, Sudaka A, Peyrade F, Saada-Bouzid E, Benezery K, Jourdan-Soulier F, Chapel F, Ramay AS,...
Sat Oct 03, 2020 13:18
G Protein-Coupled Receptor Genes, PTGDR1, PTGDR2, and PTGIR, Are Candidate Epigenetic Biomarkers and Predictors for Treated Patients with HPV-Associated Oropharyngeal Cancer. Microorganisms. 2020 Sep 29;8(10): Authors: Misawa K, Imai A, Kanazawa T, Mima M, Yamada S, Mochizuki D, Yamada T, Shinmura D, Ishikawa R, Kita J, Yamaguchi Y, Misawa Y, Mineta H Abstract Differences in the biology of human papillomavirus (HPV)-associated oropharyngeal...
Sat Oct 03, 2020 13:18
Comparison of the Tree-Based Machine Learning Algorithms to Cox Regression in Predicting the Survival of Oral and Pharyngeal Cancers: Analyses Based on SEER Database. Cancers (Basel). 2020 Sep 29;12(10): Authors: Du M, Haag DG, Lynch JW, Mittinty MN Abstract This study aims to demonstrate the use of the tree-based machine learning algorithms to predict the 3- and 5-year disease-specific survival of oral and pharyngeal cancers (OPCs) and...
Sat Oct 03, 2020 13:18
Age-Related Hearing Loss in C57BL/6J Mice Is Associated with Mitophagy Impairment in the Central Auditory System. Int J Mol Sci. 2020 Sep 29;21(19): Authors: Youn CK, Jun Y, Jo ER, Cho SI Abstract Aging is associated with functional and morphological changes in the sensory organs, including the auditory system. Mitophagy, a process that regulates the turnover of dysfunctional mitochondria, is impaired with aging. This study aimed to investigate...
Sat Oct 03, 2020 13:18
Ceramide-Enriched Membrane Domains Contribute to Targeted and Nontargeted Effects of Radiation through Modulation of PI3K/AKT Signaling in HNSCC Cells. Int J Mol Sci. 2020 Sep 29;21(19): Authors: Ladjohounlou R, Louati S, Lauret A, Gauthier A, Ardail D, Magne N, Alphonse G, Rodriguez-Lafrasse C Abstract We investigated the potential involvement of ceramide-enriched membrane domains in radiation-induced targeted and nontargeted effects...
Sat Oct 03, 2020 13:18
Nanoparticle-Based Chemotherapy Formulations for Head and Neck Cancer: A Systematic Review and Perspectives. Nanomaterials (Basel). 2020 Sep 29;10(10): Authors: de Lima JM, Bonan PR, da Cruz Perez DE, Hier M, Alaoui-Jamali MA, da Silva SD Abstract Head and neck cancer (HNC) is a complex and heterogeneous disease associated with high mortality and morbidity worldwide. Standard therapeutic management of advanced HNC, which is based on radiotherapy...
Sat Oct 03, 2020 13:18
Evolving Profile of HPV-Driven Oropharyngeal Squamous Cell Carcinoma in a National Cancer Institute in Italy: A 10-Year Retrospective Study. Microorganisms. 2020 Sep 29;8(10): Authors: Donà MG, Rollo F, Pichi B, Spriano G, Moretto S, Covello R, Pellini R, Benevolo M Abstract Globally, 30% of oropharyngeal carcinomas (OPSCC) are caused by Human Papillomavirus (HPV). Recently, increasing incidence trends for HPV-driven OPSCC have been reported...
Sat Oct 03, 2020 13:18
Deletion of Budding Yeast MAD2 Suppresses Clone-to-Clone Differences in Artificial Linear Chromosome Copy Numbers and Gives Rise to Higher Retention Rates. Microorganisms. 2020 Sep 29;8(10): Authors: Schuyler SC, Wang LI, Ding YS, Lee YC, Chen HY Abstract Our goal was to investigate the changes in artificial short-linear chromosome average copy numbers per cell arising from partial or full loss of Mitotic Arrest-Deficient 2 (MAD2) spindle...
Sat Oct 03, 2020 13:18
Related Articles The Upper Lip Squamous Cell Carcinoma the Role of Wedge Excision. J Craniofac Surg. 2020 Jun;31(4):e332-e333 Authors: Obradovic B Abstract Lip cancer is the most common malignant lesion of the oral cavity. Most of the tumors have been presented in the lower lip as a SCC, whereas the upper lip SCC is rare. Surgical excision with negative margins is the mainstay of treatment for lip SCC. The author presents a patient with the...
Sat Oct 03, 2020 13:18
Related Articles Pseudoglandular schwannoma mimicking alveolar rhabdomyosarcoma: A diagnostic challenge on fine-needle cytology. Diagn Cytopathol. 2020 Mar;48(3):228-233 Authors: Yaprak Bayrak B, Vural Ç, Paksoy N Abstract Pseudoglandular schwannoma (PGS) is a rare morphological variant of benign schwannoma. PGS is quite distinct from the somewhat better characterized glandular schwannoma variant. PGS is characterized by the presence of gland-like...
Sat Oct 03, 2020 13:18
Related Articles Increased calcium channel in the lamina propria of aging rat. Aging (Albany NY). 2019 10 31;11(20):8810-8824 Authors: Kim JM, Heo HS, Shin SC, Kwon HK, Lee JC, Sung ES, Kim HS, Park GC, Lee BJ Abstract The alterations of the extracellular matrix (ECM) in lamina propria of the vocal folds are important changes that are associated with decreased vibrations and increased stiffness in aging vocal fold. The aim of this study was...
Sat Oct 03, 2020 13:18
Late attentional processes potentially compensate for early perceptual multisensory integration deficits in children with autism: evidence from evoked potentials. Sci Rep. 2020 Sep 30;10(1):16157 Authors: Stefanou ME, Dundon NM, Bestelmeyer PEG, Ioannou C, Bender S, Biscaldi M, Smyrnis N, Klein C Abstract Sensory processing deficits and altered long-range connectivity putatively underlie Multisensory Integration (MSI) deficits in Autism Spectrum...
Fri Oct 02, 2020 16:15
A Rare Case of Sinonasal Lymphoepithelial Carcinoma Presented With Clinically Stage IV Disease. Ear Nose Throat J. 2020 Sep 30;:145561320955125 Authors: Bonnerup S, Gitau M, Shafique K Abstract Sinonasal lymphoepithelial carcinoma (SLEC) is an extremely rare malignancy. We present a case of SLEC in a 77-year-old man who presented with nasal congestion and persistent sinusitis. Imaging revealed a large right nasal mass involving right paranasal...
Fri Oct 02, 2020 15:47
Spontaneous Regression of a Large Nasal Hemangioma in a 55-Year-Old Male. Ear Nose Throat J. 2020 Sep 30;:145561320963695 Authors: Lee JH Abstract Lobular capillary hemangiomas (LCHs) are benign vascular lesions of the skin, oral cavity, and, rarely, the nasal cavity that are histologically characterized by capillary proliferation and a lobular architecture. The etiology of LCH is not well understood, but the possible underlying factors...
Fri Oct 02, 2020 15:47
Do Not Ignore Tuberculosis of the Parotid Gland When Meeting Obvious Infiltration of Neutrophils in a Suspicious Swelling by FNAC. Ear Nose Throat J. 2020 Oct 01;:145561320964267 Authors: Yang F, Wu M, Peng Y, Dong X, Ge Y Abstract Parotid gland tuberculosis constantly results in unnecessary medical examinations and surgery because of its similarities in the presentation to neoplasms of the parotid gland. Although parotid gland involvement...
Fri Oct 02, 2020 15:47
A Cheek Mass in a 5-Year-Old Child. Ear Nose Throat J. 2020 Oct 01;:145561320964270 Authors: Abijay C, Miller S, Booth T, Mitchell RB, Liu C Abstract OBJECTIVES: To describe the management of a 5-year old female with a painless, mobile cheek mass. METHODS: A retrospective chart review of presentation, imaging, pathology and management. RESULTS: Magnetic resonance imaging showed a heterogenous mass with solid and lipomatous...
Fri Oct 02, 2020 15:47
Immune Co-inhibitory Receptors PD-1, CTLA-4, TIM-3, LAG-3 and TIGIT in Medullary Thyroid Cancers: A Large Cohort Study. J Clin Endocrinol Metab. 2020 Sep 30;: Authors: Shi X, Li CW, Tan LC, Wen SS, Liao T, Zhang Y, Chen TZ, Ma B, Yu PC, Lu ZW, Qu N, Wang Y, Shi RL, Wang YL, Ji QH, Wei WJ Abstract CONTEXT: PD-1, CTLA-4, TIM-3, LAG-3 and TIGIT are considered as major immune co-inhibitory receptors (CIRs) and most promising immunotherapeutic targets...
Fri Oct 02, 2020 15:42
A Pilot Study of Gut-Brain Signaling After Octreotide Therapy for Unintentional Weight Loss After Esophagectomy. J Clin Endocrinol Metab. 2020 Sep 30;: Authors: Murphy CF, Stratford N, Docherty NG, Moran B, Elliott JA, Healy ML, McMorrow JP, Ravi N, Goldstone AP, Reynolds JV, le Roux CW Abstract BACKGROUND: Recurrence-free patients after esophageal cancer surgery face long-term nutritional consequences, occurring in the context of an exaggerated...
Fri Oct 02, 2020 15:42
Aldosterone is aberrantly regulated by various stimuli in a high proportion of patients with primary aldosteronism. J Clin Endocrinol Metab. 2020 Sep 30;: Authors: St-Jean M, Bourdeau I, Martin M, Lacroix A Abstract CONTEXT: In primary aldosteronism (PA), aldosterone secretion is relatively independent of the renin-angiotensin system, but can be regulated by several other stimuli. OBJECTIVE: To evaluate aldosterone response to several...
Fri Oct 02, 2020 15:42
Targeting Corticotroph HDAC and PI3-Kinase in Cushing Disease. J Clin Endocrinol Metab. 2020 Sep 30;: Authors: Zhang D, Damoiseaux R, Babayan L, Rivera-Meza EK, Yang Y, Bergsneider M, Wang MB, Yong WH, Kelly K, Heaney AP Abstract CONTEXT: Cushing Disease (CD) is a life-threatening disorder. Therapeutic goals include symptom relief, biochemical control and tumor growth inhibition. Current medical therapies for CD by and large exert no action...
Fri Oct 02, 2020 15:42
Development of machine learning models for predicting postoperative delayed remission of patients with Cushing's disease. J Clin Endocrinol Metab. 2020 Oct 01;: Authors: Fan Y, Li Y, Bao X, Zhu H, Lu L, Yao Y, Li Y, Su M, Feng F, Feng S, Feng M, Wang R Abstract CONTEXT: Postoperative hypercortisolemia mandates further therapy in patients with Cushing's disease (CD). Delayed remission (DR) is defined as not achieving postoperative immediate...
Fri Oct 02, 2020 15:42
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