Κυριακή 11 Οκτωβρίου 2020

 

Mechanism of TREM2/DAP12 complex affecting β-amyloid plaque deposition in Alzheimer's disease modeled mice through mediating inflammatory response
Publication date: Available online 11 October 2020Source: Brain Research BulletinAuthor(s): Xin Cui, Jun Qiao, Sha Liu, Ming Wu, Weiwei Gu
ScienceDirect Publication: Brain Research Bulletin
Sun Oct 11, 2020 15:40
Heterogeneous nuclear ribonucleoprotein A1 exerts protective role in intracerebral hemorrhage-induced secondary brain injury in rats
Publication date: Available online 11 October 2020Source: Brain Research BulletinAuthor(s): Weiye Zhu, Jiasheng Ding, Liang Sun, Jiang Wu, Xiang Xu, Wenjie Wang, Haiying Li, Haitao Shen, Xiang Li, Zhengquan Yu, Gang Chen
ScienceDirect Publication: Brain Research Bulletin
Sun Oct 11, 2020 15:40
SNHG16 aggravates chronic constriction injury-induced neuropathic pain in rats via binding with miR-124-3p and miR-141-3p to upregulate JAG1
Publication date: Available online 10 October 2020Source: Brain Research BulletinAuthor(s): Hui Li, Lianlian Fan, Yan Zhang, Yan Cao, Xin Liu
ScienceDirect Publication: Brain Research Bulletin
Sun Oct 11, 2020 15:40
Targeting PTEN to regulate autophagy and promote the repair of injured neurons
Publication date: Available online 10 October 2020Source: Brain Research BulletinAuthor(s): Haoyuan Yu, Junjie Shao, Runxin Huang, Yixiang Guan, Guicai Li, Shiyu Chen, Fei Zhou, Qi Yao, Jianhong Shen
ScienceDirect Publication: Brain Research Bulletin
Sun Oct 11, 2020 15:40
Zebrafish and mouse models for anxiety evaluation - a comparative study with xanthotoxin as a model compound
Publication date: Available online 10 October 2020Source: Brain Research BulletinAuthor(s): Monika Maciąg, Agnieszka Michalak, Krystyna Skalicka-Woźniak, Maria Zykubek, Andrzej Ciszewski, Barbara Budzyńska
ScienceDirect Publication: Brain Research Bulletin
Sun Oct 11, 2020 15:40
Dopamine Transporter is Downregulated and its Association with Chaperone Protein Hsc70 is Enhanced by Activation of Dopamine D<sub>3</sub> Receptor
Publication date: Available online 10 October 2020Source: Brain Research BulletinAuthor(s): Pi-Kai Chang, Kun-Yi Chien, Jin-Chung Chen
ScienceDirect Publication: Brain Research Bulletin
Sun Oct 11, 2020 15:40
Stability of fixation methods in large mandibular advancements after sagittal split ramus osteotomy: An in vitro biomechanical study
Publication date: Available online 10 October 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Karel Kuik, Jean-Pierre T.F. Ho, Maurits H.T. de Ruiter, Cornelis Klop, Cornelis J. Kleverlaan, Jan de Lange, Aarnoud Hoekema
British Journal of Oral and Maxillofacial Surgery
Sun Oct 11, 2020 14:49
Machine Learning methods applied to audit of surgical margins after curative surgery for Head and Neck Cancer
Publication date: Available online 8 October 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): David Tighe, Fabio Fabris, Alex Freitas
British Journal of Oral and Maxillofacial Surgery
Fri Oct 09, 2020 19:18
Comment on an article: “High dose folic acid is a potential treatment for pulmonary hypertension, including when associated with COVID-19 pneumonia”
Publication date: December 2020Source: Medical Hypotheses, Volume 145Author(s): Omer Ć. Ibrahimagić, Suljo Kunić
ScienceDirect Publication: Medical Hypotheses
Sun Oct 11, 2020 14:19
Contractile function of the cervix plays a role in normal and pathological pregnancy and parturition
Publication date: December 2020Source: Medical Hypotheses, Volume 145Author(s): Ourlad Alzeus G. Tantengco, Ramkumar Menon
ScienceDirect Publication: Medical Hypotheses
Sun Oct 11, 2020 14:19
Decreased smooth muscle component in Müller’s Muscle may induce or aggravate blepharoptosis in elderly Asians
Publication date: Available online 9 October 2020Source: Medical HypothesesAuthor(s): Minchen Zhang, Rong Zhou, Weicheng Gao
ScienceDirect Publication: Medical Hypotheses
Sun Oct 11, 2020 14:19
A possible application of hinokitiol as a natural zinc ionophore and anti-infective agent for the prevention and treatment of COVID-19 and viral infections
Publication date: December 2020Source: Medical Hypotheses, Volume 145Author(s): Ba X. Hoang, Bo Han
ScienceDirect Publication: Medical Hypotheses
Sat Oct 10, 2020 19:12
Dysimmunity and inflammatory storm: Watch out for bone lesions in COVID-19 infection
Publication date: December 2020Source: Medical Hypotheses, Volume 145Author(s): Huaqiang Tao, Gaoran Ge, Wenming Li, Xiaolong Liang, Hongzhi Wang, Ning Li, Houyi Sun, Wei Zhang, Dechun Geng
ScienceDirect Publication: Medical Hypotheses
Fri Oct 09, 2020 18:56
The morphogenesis of granular and lattice corneal dystrophy – A mutation combination hypothesis
Publication date: December 2020Source: Medical Hypotheses, Volume 145Author(s): Mohammed Sabir
ScienceDirect Publication: Medical Hypotheses
Fri Oct 09, 2020 18:56
'Bird Song' Ranks Among the Most Valuable Sounds in New Cross-Cultural Survey
Sound matters. And in a recent global survey conducted by hearing aid pioneer Widex, one surprising sound was consistently ranked within the top three most valuable across all cultures: bird song. However, according to WSA Head of Audiology Lise Henningsen, the universally-appreciated sound of a singing bird is also one of the first diminished sounds of hearing loss given its high-frequency tones."The deep appreciation for bird song spans oceans, borders and cultures, but due to its high frequency,...
Audiology
Fri Oct 09, 2020 16:29
Interacoustics Announces the Third Generation of VisualEyes™
Interacoustics announces the launch of the third generation of Micromedical VisualEyes™ by Interacoustics, which offers Videonystagmography, vHIT and Rotary Chair testing in one integrated system.To introduce the balance industry to the new release, Interacoustics will host two live virtual events in October. The first event is on October 22, offering expert interviews, product demonstrations and Q&A sessions.Online registrations are open, and participants can register for the event here: https://bit.ly/3lrY1mc.VisualEyes™...
Audiology
Fri Oct 09, 2020 16:05
'Bird Song' Ranks Among the Most Valuable Sounds in New Cross-Cultural Survey
Sound matters. And in a recent global survey conducted by hearing aid pioneer Widex, one surprising sound was consistently ranked within the top three most valuable across all cultures: bird song. However, according to WSA Head of Audiology Lise Henningsen, the universally-appreciated sound of a singing bird is also one of the first diminished sounds of hearing loss given its high-frequency tones."The deep appreciation for bird song spans oceans, borders and cultures, but due to its high frequency,...
Audiology
Fri Oct 09, 2020 16:29
Interacoustics Announces the Third Generation of VisualEyes™
Interacoustics announces the launch of the third generation of Micromedical VisualEyes™ by Interacoustics, which offers Videonystagmography, vHIT and Rotary Chair testing in one integrated system.To introduce the balance industry to the new release, Interacoustics will host two live virtual events in October. The first event is on October 22, offering expert interviews, product demonstrations and Q&A sessions.Online registrations are open, and participants can register for the event here: https://bit.ly/3lrY1mc.VisualEyes™...
Audiology
Fri Oct 09, 2020 16:05
Pulmonary tumor thrombotic microangiopathy caused by urothelial carcinoma: An autopsy‐proven case of a rare etiology
Pathology International
Sat Oct 10, 2020 21:31
Precise variant interpretation, phenotype ascertainment and genotype‐phenotype correlation of children in the EARLY PRO‐TECT Alport trial
Abstract Early initiation of therapy in patients with Alport syndrome (AS) slows down renal failure by many years. Genotype‐phenotype correlations propose that the location and character of the individual’svariant correlate with the renal outcome and any extrarenal manifestations. In‐depth clinical and genetic data of 60/62 children who participated in the EARLY PRO‐TECT Alport trial were analyzed.Genetic variants were interpreted according to current guidelines and criteria. Genetically...
Clinical Genetics
Sun Oct 11, 2020 13:37
Missing heritability in Bloom syndrome: First report of a deep‐intronic variant leading to pseudo‐exon activation in the BLM gene
ABSTRACT Pathogenic biallelic variants in the BLM/RECQL3 gene cause a rare autosomal recessive disorder called Bloom Syndrome (BS). This syndrome is characterized by severe growth delay, immunodeficiency, dermatological manifestations and a predisposition to a wide variety of cancers, often multiple and very early in life. Literature shows that the main mode of BLM inactivation is protein translation termination. We expanded the molecular spectrum of Bloom Syndrome by reporting the first...
Clinical Genetics
Fri Oct 09, 2020 20:45
Three-dimensional computed tomography image-oriented successful thoracoscopic subtotal esophagectomy for an esophageal cancer patient with an anomalous right superior pulmonary vein: A case report.
Three-dimensional computed tomography image-oriented successful thoracoscopic subtotal esophagectomy for an esophageal cancer patient with an anomalous right superior pulmonary vein: A case report. Int J Surg Case Rep. 2020 Oct 02;76:178-182 Authors: Matsubara T, Hirahara N, Zotani H, Tabara N, Tabara H, Tajima Y Abstract BACKGROUND: Subcarinal lymphadenectomy is an essential procedure in curative esophagectomy for esophageal cancer. The right...
Dysphagia - Rehabilitation
Sun Oct 11, 2020 13:12
The Development of a Multidimensional, Multigroup Measure of Self-Care for Inpatient Rehabilitation.
The Development of a Multidimensional, Multigroup Measure of Self-Care for Inpatient Rehabilitation. Arch Phys Med Rehabil. 2020 Oct 06;: Authors: Bodine AJ, Heinemann AW, Carpenter J, Taylor SM, Hansen P, Lieber RL, Sliwa J Abstract OBJECTIVE: Develop and evaluate a measure of clinician-observed and patient-performed self-care function for use during inpatient rehabilitation. DESIGN: Retrospective analysis of self-care assessments...
Dysphagia - Rehabilitation
Sat Oct 10, 2020 13:03
An adolescent girl with premature ovarian failure, Graves’ disease, and chronic urticaria: a case report
Premature ovarian failure is characterized by amenorrhea, hypoestrogenism, and hypergonadotropinism, and occurs in women under 40 years of age. The prevalence of premature ovarian failure in women younger than...
Journal of Medical Case Reports - Latest Articles
Sun Oct 11, 2020 03:00
Gradient washout and secondary nephrogenic diabetes insipidus after brain injury in an infant: a case report
Disorders of water and sodium balance can occur after brain injury. Prolonged polyuria resulting from central diabetes insipidus and cerebral salt wasting complicated by gradient washout and a type of secondar...
Journal of Medical Case Reports - Latest Articles
Sat Oct 10, 2020 03:00
Unusual case of classic testicular seminoma in a 90-year-old patient: a case report
Seminoma is the most common subtype of testicular cancer and occurs most commonly in patients aged 30–49 years, but decreases to a very low level in men in their 60s or older.
Journal of Medical Case Reports - Latest Articles
Fri Oct 09, 2020 03:00
Clinical utilization of whole-body PET/MRI in childhood sarcoma
Abstract Hybrid positron emission tomography (PET)/magnetic resonance imaging (MRI) has emerged as a useful tool that combines the superior tissue contrast of MRI with the targeted functional imaging of PET. In the assessment of sarcomas in children, PET/MRI has the potential to serve as a single point of service, allowing superior anatomical imaging and evaluation of metabolic uptake during one imaging session. In this pictorial essay, we review our preliminary experience with...
Pediatric Radiology
Sun Oct 11, 2020 03:00
Assistant editor transitions: thank you, thank you, thank you (and welcome ×3!)
Pediatric Radiology
Sat Oct 10, 2020 03:00
Severe COVID-19 initially presenting as mesenteric adenopathy
Abstract Coronavirus disease 2019 (COVID-19) can present with abdominal pain in children and adults. Most imaging findings have been limited to characteristic lung findings, as well as one report of bowel-ischemia-related findings in adults. We report a case of COVID-19 in a healthy teenager who initially presented with isolated mesenteric adenopathy, typically a self-limited illness, which progressed to severe illness requiring intensive care before complete recovery. The boy...
Pediatric Radiology
Sat Oct 10, 2020 03:00
Construction and Validation of a Robust Cancer Stem Cell-Associated Gene Set-Based Signature to Predict Early Biochemical Recurrence in Prostate Cancer
Background. Postoperative early biochemical recurrence (BCR) was an essential indicator for recurrence and distant metastasis of prostate cancer (PCa). The aim of this study was to construct a cancer stem cell- (CSC-) associated gene set-based signature to identify a subgroup of PCa patients who are at high risk of early BCR. Methods. The PCa dataset from The Cancer Genome Atlas (TCGA) was randomly separated into discovery and validation set. Patients in discovery set were divided into early BCR...
Disease Markers
Sat Oct 10, 2020 20:35
DEC2 Serves as Potential Tumor Suppressor in Breast Carcinoma
Background. Identification of new biomarkers can facilitate the development of effective therapeutic strategies in breast cancer (BC). Data from previous studies have revealed that differentiated embryonic chondrocyte gene (DEC) 1 and DEC2 might involve in the progression of various cancer types. We explored the expression profiles and function of DEC1/2 in BC patients in this study. Methods. The mRNA expression of DEC1/2 in BC patients and cell lines were taken from the Oncomine and Cancer Cell...
Disease Markers
Sat Oct 10, 2020 13:05
Diagnosis Test Meta-Analysis for Apolipoprotein E in Alzheimer’s Disease
Objective. To evaluate the diagnostic value of apolipoprotein E (APOE) gene in Alzheimer’s disease (AD). Methods. Databases including PubMed, EMBASE, Google Scholar, Wanfang Med online, China National Knowledge Infrastructure (CNKI), and China Biomedical Literature Database (CBM) were searched for literatures in English or Chinese. No limitations on the date. The sensitivity, specificity, likelihood ratio, and diagnostic odds ratio were pooled for meta-analysis. The symmetric receiver operator characteristic...
Disease Markers
Sat Oct 10, 2020 10:20
Clinical Characteristics of Colorectal Cancer Patients in terms of Selected Platelet Indices
Mounting evidence suggests that inflammation, immune response, and coagulation status determine many processes during the carcinogenesis pathway in colorectal cancer (CRC). Inflammation strongly promotes tumor formation, progression, and metastasis. The systemic inflammatory response (SIR) may be reflected by simple indicators evaluated on the basis of peripheral blood morphology parameters. The indices are easily obtained by the peripheral blood test and could be promising biomarkers for CRC. We...
Disease Markers
Fri Oct 09, 2020 19:20
Role of the IL-23-T-bet/GATA3 Axis for the Pathogenesis of Ulcerative Colitis
Abstract Ulcerative colitis (UC) has been considered a Th2- and Th17-related disease. However, anti-IL-12/23 p40 antibody, which blocks Th1 and Th17 cell induction and maintenance, has shown efficacy in treating UC, suggesting that UC might not be a prototypical Th2 and Th17 cell-mediated autoimmune disease. To verify how the immune responses in UC patients interact with each other, we analyzed the cytokine expression and transcription...
Latest Results for Inflammation
Sat Oct 10, 2020 03:00
Src Family Protein Kinase Controls the Fate of B Cells in Autoimmune Diseases
Abstract There are more than 80 kinds of autoimmune diseases known at present, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), inflammatory bowel disease (IBD), as well as other disorders. Autoimmune diseases have a characteristic of immune responses directly attacking own tissues, leading to systematic inflammation and subsequent tissue damage. B cells play a vital role in the development...
Latest Results for Inflammation
Sat Oct 10, 2020 03:00
Amitriptyline Downregulates Chronic Inflammatory Response to Biomaterial in Mice
Abstract Recent data has signaled that in addition to its therapeutic indications as antidepressant and analgesic, amitriptyline (AM) exerts anti-inflammatory effects in humans and experimental animal models of acute inflammation. We tested the hypothesis that this compound could also modulate the chronic inflammatory process induced by synthetic matrix in mice. Polyether-polyurethane sponge disks were implanted subcutaneously in 9-week-old...
Latest Results for Inflammation
Fri Oct 09, 2020 03:00
Topical sirolimus for management of refractory oral chronic graft‐versus‐host disease
Oral Diseases
Sat Oct 10, 2020 22:00
Cancer stemness of CD10‐positive cells regulated by Hedgehog pathway promotes the resistance to cisplatin in oral squamous cell carcinoma
Abstract Objective To explore the role of CD10 in cisplatin‐resistance of oral squamous cell carcinoma (OSCC) and its association with the Hedgehog (Hh) signaling pathway and cancer stem cells (CSCs). Methods The correlation between cell viability and CD10 expression was analyzed in different OSCC cell lines after the cisplatin treatment. Genes related to chemotherapy‐resistance, cancer stem cells, and the epithelial‐mesenchymal transition were detected by qPCR in CD10high and CD10low OSCC...
Oral Diseases
Fri Oct 09, 2020 18:46
Regeneration of lingual musculature in rats using myoblasts over porcine bladder acellular matrix
ABSTRACT Objectives To use tissue engineering muscle repair (TEMR) for regenerating the lingual musculature of hemiglossectomized rats using neonatal myoblasts (NM) on porcine acellular urinary bladder matrix (AUBM). Material and Methods The study used 80 male rats. A volumetric muscle loss (VML) injury was created on the left side of the tongue. The rats were randomized into four groups: Group 1 (AUBM + myoblasts); Group 2 (AUBM); Group 3 (myoblasts); and Group 4 (control). NM were obtained...
Oral Diseases
Thu Oct 08, 2020 21:16
The inhibitory effect of the deubiquitinase cylindromatosis (CYLD) on inflammatory responses in human gingival fibroblasts
Abstract Objective Experiments were performed to evaluate CYLD expression in human gingival tissue samples and to examine the effects of CYLD on inflammatory responses in lipopolysaccharide (LPS)‐ or TNF‐α‐stimulated human gingival fibroblasts (HGFs). Methods Immunohistochemistry for CYLD and p65 expression was performed with healthy and inflamed gingival tissue samples. siRNA was used to knock down the expression of CYLD in HGFs. Upon LPS or TNF‐α stimulation, NF‐κB activation was detected...
Oral Diseases
Thu Oct 08, 2020 21:11
The budding and depth of invasion model in oral cancer – a systematic review and meta‐analysis
ABSTRACT Background Tumour budding (B) and depth of invasion (D) have both been reported as promising prognostic markers in oral squamous cell carcinoma (OSCC). This meta‐analysis assessed the prognostic value of the tumour budding and depth of invasion combination (BD model) in OSCC. Methods Databases including OvidMedline, PubMed, Scopus, and Web of Science were searched for articles that studied the BD model as a prognosticator in OSCC. PICO search strategy was “In OSCC patients, does...
Oral Diseases
Thu Oct 08, 2020 20:55
Complex vascular anatomy is a predictor of silent cerebral ischemia after carotid artery stenting
Neuroradiology
Sat Oct 10, 2020 03:00
Deep learning–based image reconstruction for brain CT: improved image quality compared with adaptive statistical iterative reconstruction-Veo (ASIR-V)
Abstract Purpose To compare the image quality of brain computed tomography (CT) images reconstructed with deep learning–based image reconstruction (DLIR) and adaptive statistical iterative reconstruction-Veo (ASIR-V). Methods Sixty-two patients underwent routine noncontrast brain CT scans and datasets were reconstructed with 30% ASIR-V and DLIR with...
Neuroradiology
Sat Oct 10, 2020 02:48
Mica Can Alleviate TNBS-Induced Colitis in Mice by Reducing Angiotensin II and IL-17A and Increasing Angiotensin-Converting Enzyme 2, Angiotensin 1-7, and IL-10
Aim. To explore the treatment effect of mica on 2,4,6-trinitrobenzenesulfonic acid solution- (TNBS-) induced colitis in mice. Materials and Methods. Thirty male BALB/C mice were randomly divided into the control group, the TNBS group, and the mica group. Control mice were treated with saline solution. Experimental colitis was induced by TNBS (250 mg/kg/d) in the TNBS group and the mica group. After modeling, the mica group was treated with mica (180 mg/kg/d) for 3 days, while the TNBS group continued...
Mediators of Inflammation
Sat Oct 10, 2020 17:05
Molecular Mechanisms of Glial Cells Related Signaling Pathways Involved in the Neuroinflammatory Response of Depression
Dysfunction of the glial cells, such as astrocytes and microglia, is one of the pathological features in many psychiatric disorders, including depression, which emphasizes that glial cells driving neuroinflammation is not only an important pathological change in depression but also a potential therapeutic target. In this review, we summarized a recent update about several signaling pathways in which glial cells may play their roles in depression through neuroinflammatory reactions. We focused on...
Mediators of Inflammation
Sat Oct 10, 2020 10:35
Guttiferone K Exerts the Anti-inflammatory Effect on Mycobacterium Tuberculosis- (H37Ra-) Infected Macrophages by Targeting the TLR/IRAK-1 Mediated Akt and NF-κB Pathway
Mycobacterium tuberculosis (Mtb) remains a great threat to global health, killing more people than any other single infectious agent and causing uncontrollable inflammation in the host. Poorly controlled inflammatory processes can be deleterious and result in immune exhaustion. The current tuberculosis (TB) control is facing the challenge of drugs deficiency, especially in the context of increasingly multidrug resistant (MDR) TB. Under this circumstance, alternative host-directed therapy (HDT) emerges...
Mediators of Inflammation
Sat Oct 10, 2020 09:50
CD4+ T Cell Profile and Activation Response in Sickle Cell Disease Patients with Osteonecrosis
Recent evidence suggests that abnormalities involving CD4+T lymphocytes are associated with the pathophysiology of osteonecrosis (ON); however, few studies have addressed the CD4+T cells in ON related to sickle cell disease (SCD/ON). In addition, T cells producing multiple cytokines simultaneously are often present in the inflammatory milieu and may be implicated in the immune response observed in SCD/ON. In the present study, we aimed to characterize the functional status of CD4+T cells in SCD by...
Mediators of Inflammation
Fri Oct 09, 2020 17:35
Chinese Medicine Huzhen Tongfeng Formula Effectively Attenuates Gouty Arthritis by Inhibiting Arachidonic Acid Metabolism and Inflammatory Mediators
The Chinese herbal medicine, Huzhen Tongfeng Formula (HZTF), derived from traditional Chinese medicine (TCM) practice, has recognized therapeutic benefits for gouty arthritis (GA). HZTF is currently in the late stage of approval process as a new anti-GA drug application. However, the underlying mechanism of HZTF as an antigout medication is unclear. In this study, we combined network pharmacology and experimental validation approaches to elucidate the mechanism of action of HZTF. First, the relative...
Mediators of Inflammation
Fri Oct 09, 2020 12:20
Identification of Potential Biomarkers and Immune Features of Sepsis Using Bioinformatics Analysis
Sepsis remains a major global concern and is associated with high mortality and morbidity despite improvements in its management. Markers currently in use have shortcomings such as a lack of specificity and failures in the early detection of sepsis. In this study, we aimed to identify key genes involved in the molecular mechanisms of sepsis and search for potential new biomarkers and treatment targets for sepsis using bioinformatics analyses. Three datasets (GSE95233, GSE57065, and GSE28750) associated...
Mediators of Inflammation
Fri Oct 09, 2020 09:20
A Standardized Method for Measurement of Elbow Kinesthesia
Here, we present a standardized method for measurement of elbow passive kinesthesia using the threshold to detection of passive movement (TDPM) that is appropriate for a research setting.
JoVE: Journal of Visualized Experiments
Sat Oct 10, 2020 22:20
Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
Glutathione S-transferases (GSTs) are detoxification enzymes involved in the metabolism of numerous chemotherapeutic drugs. Overexpression of GSTs is correlated with cancer chemotherapy resistance. One way to counter this phenotype is to use inhibitors. This protocol describes a method using a spectrophotometric assay to screen for potential GST inhibitors.
JoVE: Journal of Visualized Experiments
Sat Oct 10, 2020 22:00
A Small-Scale Setup for Algal Toxicity Testing of Nanomaterials and Other Difficult Substances
We demonstrate algal toxicity testing for difficult substances (e.g., colored substances or nanomaterials) using a setup illuminated vertically with an LED.
JoVE: Journal of Visualized Experiments
Sat Oct 10, 2020 21:21
Isolation, Transfection, and Long-Term Culture of Adult Mouse and Rat Cardiomyocytes
Here, we present a protocol for the isolation, transfection, and long-term culture of adult mouse and rat cardiomyocytes.
JoVE: Journal of Visualized Experiments
Sat Oct 10, 2020 20:21
Field Identification of Matricaria chamomilla using a Portable qPCR System
Presented here is a protocol for field identification of Matricaria chamomilla using a portable qPCR system. This easy-to-perform protocol is ideal as a method to confirm the identity of a botanical species at locations where access to laboratory equipment and expertise is limited, such as farms and warehouses.
JoVE: Journal of Visualized Experiments
Sat Oct 10, 2020 20:00
Preparation of Small RNA Libraries for Sequencing from Early Mouse Embryos
We describe a technique for profiling microRNAs in early mouse embryos. This protocol overcomes the challenge of low cell input and small RNA enrichment. This assay can be used to analyze changes in miRNA expression over time in different cell lineages of the early mouse embryo.
JoVE: Journal of Visualized Experiments
Fri Oct 09, 2020 20:31
Probing the neural signature of mind wandering with simultaneous fMRI-EEG and pupillometry
Publication date: 1 January 2021Source: NeuroImage, Volume 224Author(s): Josephine M Groot, Nya M Boayue, Gábor Csifcsák, Wouter Boekel, René Huster, Birte U Forstmann, Matthias Mittner
NeuroImage
Sat Oct 10, 2020 21:27
Inter-individual and age-dependent variability in simulated electric fields induced by conventional transcranial electrical stimulation
Publication date: 1 January 2021Source: NeuroImage, Volume 224Author(s): Daria Antonenko, Ulrike Grittner, Guilherme Saturnino, Till Nierhaus, Axel Thielscher, Agnes Flöel
NeuroImage
Sat Oct 10, 2020 21:27
Exome sequencing identifies novel missense and deletion variants in RTN4IP1 associated with optic atrophy, global developmental delay, epilepsy, ataxia, and choreoathetosis
Abstract Inherited optic neuropathies (IONs) are neurodegenerative disorders characterized by optic atrophy with or without extraocular manifestations. Optic atrophy‐10 (OPA10) is an autosomal recessive ION recently reported to be caused by mutations in RTN4IP1, which encodes reticulon 4 interacting protein 1 (RTN4IP1), a mitochondrial ubiquinol oxydo‐reductase. Here we report novel compound heterozygous mutations in RTN4IP1 in a male proband with developmental delay, epilepsy, optic atrophy, ataxia,...
American Journal of Medical Genetics Part A
Fri Oct 09, 2020 21:38
Chimerism involving a RB1 pathogenic variant in monochorionic dizygotic twins with twin–twin transfusion syndrome
Abstract We report the first case of blood chimerism involving a pathogenic RB1 variant in naturally conceived monochorionic‐dizygotic twins (MC/DZ) with the twin–twin‐transfusion syndrome (TTTS), presumably caused by the exchange of stem‐cells. Twin A developed bilateral retinoblastoma at 7 months of age. Initial genetic testing identified a de novo RB1 pathogenic variant, with a 20% allelic ratio in both twins' blood. Subsequent genotyping of blood and skin confirmed dizygosity, with the affected...
American Journal of Medical Genetics Part A
Fri Oct 09, 2020 21:36
Parenting a child with Marfan syndrome: Distress and everyday problems
Abstract Marfan syndrome (MFS) is a multisystemic, autosomal dominant connective tissue disorder that occurs de novo in 25%. In many families, parent and child(ren) are affected, which may increase distress in parents. To assess distress, 42 mothers (29% MFS) and 25 fathers (60% MFS) of 43 affected children, completed the validated screening‐questionnaire Distress thermometer for parents of a chronically ill child, including questions on overall distress (score 0–10; ≥4 denoting “clinical distress”)...
American Journal of Medical Genetics Part A
Fri Oct 09, 2020 15:20
Haploinsufficiency of ATP6V0C possibly underlies 16p13.3 deletions that cause microcephaly, seizures, and neurodevelopmental disorder
Abstract We recently contributed to the description of eight individuals with a novel condition caused by 16p13.3 microdeletions encompassing TBC1D24, ATP6V0C, and PDPK1 and resulting in epilepsy, microcephaly and neurodevelopmental problems. The phenotypic spectrum, the minimum overlapping region and the underlying disease mechanism for this disorder remain to be clarified. Here we report a 3.5‐year‐old male, with microcephaly, autism spectrum disorder and a de novo 16p13.3 microdeletion. We performed...
American Journal of Medical Genetics Part A
Thu Oct 08, 2020 21:48
Acoustic and articulatory analysis and synthesis of shouted vowels
Publication date: March 2021Source: Computer Speech & Language, Volume 66Author(s): Yawen Xue, Michael Marxen, Masato Akagi, Peter Birkholz
Computer Speech & Language
Sat Oct 10, 2020 20:32
Deep-learning approach with convolutional neural network for classification of maximum intensity projections of dynamic contrast-enhanced breast magnetic resonance imaging
Publication date: Available online 10 October 2020Source: Magnetic Resonance ImagingAuthor(s): Tomoyuki Fujioka, Yuka Kikuchi, Jun Oyama, Mio Mori, Kazunori Kubota, Leona Katsuta, Koichiro Kimura, Emi Yamaga, Goshi Oda, Tsuyoshi Nakagawa, Yoshio Kitazume, Ukihide Tateishi
Magnetic Resonance Imaging
Sat Oct 10, 2020 20:18
Low-field magnetic resonance imaging using multiplicative regularization
Publication date: Available online 9 October 2020Source: Magnetic Resonance ImagingAuthor(s): Merel de Leeuw den Bouter, Martin van Gijzen, Rob Remis
Magnetic Resonance Imaging
Fri Oct 09, 2020 23:36
Addressing sexuality among people living with chronic disease and disability: A systematic mixed methods review of knowledge, attitudes and practices of healthcare professionals.
Publication date: Available online 9 October 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Margaret McGrath, Michelle Anne Low, Emma Power, Annie McCluskey, Sandra Lever
Archives of Physical Medicine and Rehabilitation
Sat Oct 10, 2020 19:48
Bone tools from Beds II–IV, Olduvai Gorge, Tanzania, and implications for the origins and evolution of bone technology
Publication date: November 2020Source: Journal of Human Evolution, Volume 148Author(s): Michael Pante, Ignacio de la Torre, Francesco d’Errico, Jackson Njau, Robert Blumenschine
Journal of Human Evolution
Sat Oct 10, 2020 18:58
Hominin diversity in East Asia during the Middle Pleistocene: A premolar endostructural perspective
Publication date: November 2020Source: Journal of Human Evolution, Volume 148Author(s): Lei Pan, Jean Dumoncel, Arnaud Mazurier, Clément Zanolli
Journal of Human Evolution
Sat Oct 10, 2020 00:03
The Fauresmith of South Africa: A new assemblage from Canteen Kopje and significance of the technology in human and cultural evolution
Publication date: November 2020Source: Journal of Human Evolution, Volume 148Author(s): Kathleen Kuman, Matt G. Lotter, George M. Leader
Journal of Human Evolution
Sat Oct 10, 2020 00:03
Electrical brain activity and facial electromyography responses to irony in dysphoric and non-dysphoric participants
Publication date: December 2020Source: Brain and Language, Volume 211Author(s): Xueqiao Li, Janne Pesonen, Elina Haimi, Huili Wang, Piia Astikainen
Brain and Language
Sat Oct 10, 2020 18:14
Heterogeneity in abstract verbs: An ERP study
Publication date: December 2020Source: Brain and Language, Volume 211Author(s): Emiko J. Muraki, Filomeno Cortese, Andrea B. Protzner, Penny M. Pexman
Brain and Language
Fri Oct 09, 2020 16:26
Is Breast Implant-Associated Anaplastic Large Cell Lymphoma Better Classified as a Lymphoproliferative Disorder and How Surgeons Reduce Risk?
Publication date: Available online 9 October 2020Source: Clinics in Plastic SurgeryAuthor(s): Robert J. Lukavsky, Rafael A. Couto, William P. Adams
Plastic Surgery
Sat Oct 10, 2020 18:07
Various Properties of Silicone Breast Implant Surfaces and Multimodal Techniques for the Functional Surface Modification
Publication date: Available online 9 October 2020Source: Clinics in Plastic SurgeryAuthor(s): Shin Hyuk Kang, Bradley P. Bengtson, Chan Yeong Heo
Plastic Surgery
Sat Oct 10, 2020 18:07
Wildfires, Global Climate Change, and Human Health
The world has already observed many devastating effects of human-induced climate change. A vivid manifestation is the several large wildfires that have occurred recently — in some cases, fires of unprecedented scale and duration — including wildfires in Australia in 2019 to 2020, the Amazon…
The New England Journal of Medicine: Search Results in Primary Care\Hospitalist\Clinical Practice
Fri Oct 09, 2020 03:00
Exertional heat stroke leads to concurrent long‐term epigenetic memory, immunosuppression and altered heat shock response in female mice
Key points Exposure to exertional heat stroke (EHS) has been linked to increased long‐term decrements of health. Epigenetic reprogramming is involved in the response to heat acclimation, however, whether long‐term effects of EHS are mediated by epigenetic reprogramming is unknown. In female mice, we observed DNA methylation reprogramming in bone marrow‐derived (BMD) monocytes as early as 4 days of recovery from EHS and as late as 30 days compared to sham exercise controls (EXC). Whole blood,...
The Journal of Physiology
Fri Oct 09, 2020 21:41
Keto or carbo? Low‐ versus high‐carbohydrate diets for fueling elite endurance sport performance
The Journal of Physiology
Fri Oct 09, 2020 13:44
Transitioning from trainee to breast radiologist: A guide for a successful first year
Publication date: January 2021Source: Clinical Imaging, Volume 69Author(s): Ann L. Brown, Rend Al-Khalili, Judy H. Song, Mary C. Mahoney
Clinical Imaging
Sat Oct 10, 2020 16:36
Is specimen radiography still necessary in patients with non-palpable breast cancer undergoing breast-conserving surgery using radioactive I-125 seed localization?
Publication date: January 2021Source: Clinical Imaging, Volume 69Author(s): Yvonne E. van Riet, Robert-Jan Schipper, Franca van Merrienboer, Ricardo G. Orsini, Johanne G. Bloemen, Frits H. Jansen, Grard A.P. Nieuwenhuijzen
Clinical Imaging
Sat Oct 10, 2020 16:36
Use of a 3D virtual dynamic hip model to quantify the amount of osteoplasty required in femoroacetabular impingement patients
Publication date: January 2021Source: Clinical Imaging, Volume 69Author(s): Hamid Bagce, Thomas S. Lynch, Tony T. Wong
Clinical Imaging
Fri Oct 09, 2020 19:41
Low contrast volume dual-energy CT of the chest: Quantitative and qualitative assessment
Publication date: January 2021Source: Clinical Imaging, Volume 69Author(s): Subba R. Digumarthy, Ramandeep Singh, Shivam Rastogi, Alexi Otrakji, Fatemeh Homayounieh, Eric W. Zhang, Shaunagh McDermott, Mannudeep K. Kalra
Clinical Imaging
Fri Oct 09, 2020 19:41
Developments in asthma incidence and prevalence in Alberta between 1995 and 2015
Asthma is a chronic respiratory disease characterized by reversible bronchoconstriction and airway inflammation. According to Statistics Canada in 2014, 8.1% of Canadians aged 12 and older reported having asth...
Allergy, Asthma & Clinical Immunology - Latest Articles
Fri Oct 09, 2020 03:00
STAT3 couples with 14-3-3σ to regulate BCR signaling, B cell differentiation, and IgE production
Publication date: Available online 9 October 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Zuochen Du, Anwei Chen, Lu Huang, Xin Dai, Qiuyue Chen, Di Yang, Liling Li, Heather Miller, Lisa Westerberg, Yuan Ding, Xuemei Tang, Masato Kubo, Liping Jiang, Xiaodong Zhao, Hua Wang, Chaohong Liu
Allergy and Clinical Immunology
Sat Oct 10, 2020 16:29
COVID-19 risk stratification algorithms based on sTREM-1 and IL-6 in emergency department
Publication date: Available online 9 October 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Mathias Van Singer, Thomas Brahier, Michelle Ngai, Julie Wright, Andrea M. Weckman, Clara Erice, Jean-Yves Meuwly, Olivier Hugli, Kevin C. Kain, Noémie Boillat-Blanco
Allergy and Clinical Immunology
Sat Oct 10, 2020 16:29
Trained immunity and tolerance in innate lymphoid cells, monocytes, and dendritic cells during allergen-specific immunotherapy
Publication date: Available online 9 October 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Andrzej Eljaszewicz, Fiorella Ruchti, Urszula Radzikowska, Anna Globinska, Tadech Boonpiyathad, Anna Gschwend, Hideaki Morita, Arthur Helbling, Stefania Arasi, Helga Kahlert, Nadine Berek, Andreas Nandy, Mübeccel Akdis, Christoph Willers, Marcin Moniuszko, Cezmi A. Akdis, Milena Sokolowska
Allergy and Clinical Immunology
Fri Oct 09, 2020 12:50
Glycosylation enhances allergenic activity of major bee venom allergen Api m 1 by adding IgE epitopes
Publication date: Available online 9 October 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Pia Gattinger, Urska Bidovec –Stojkovic, Mihaela Zidarn, Peter Korosec, Rudolf Valenta, Irene Mittermann
Allergy and Clinical Immunology
Fri Oct 09, 2020 12:50
Atopic dermatitis microbiomes stratify into ecological dermotypes enabling microbial virulence and disease severity
Publication date: Available online 8 October 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Angeline S.L. Tay, Chenhao Li, Tannistha Nandi, Kern Rei Chng, Anand Kumar Andiappan, Vijaya Saradhi Mettu, Camille de Cevins, Aarthi Ravikrishnan, Charles-Antoine Dutertre, X.F. Colin C. Wong, Amanda Hui Qi Ng, Sri Anusha Matta, Florent Ginhoux, Olaf Rötzschke, Fook Tim Chew, Mark B.Y. Tang, Yik Weng Yew, Niranjan Nagarajan, John E.A. Common
Allergy and Clinical Immunology
Fri Oct 09, 2020 12:50
Single Cell Transcriptomic Analysis Reveals Key Immune Cell Phenotypes in the lung of Asthma Exacerbation
Publication date: Available online 8 October 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Hui Li, Huaqi Wang, Leon Sokulsky, Shaoxia Liu, Rui Yang, Xiaojie Liu, Lujia Zhou, Juan Li, Chun Huang, Fangfang Li, Xu Lei, Hongxia Jia, Jiuling Cheng, Fuguang Li, Ming Yang, Guojun Zhang
Allergy and Clinical Immunology
Fri Oct 09, 2020 12:50
Wildfires, Global Climate Change, and Human Health
The world has already observed many devastating effects of human-induced climate change. A vivid manifestation is the several large wildfires that have occurred recently — in some cases, fires of unprecedented scale and duration — including wildfires in Australia in 2019 to 2020, the Amazon…
The New England Journal of Medicine: Search Results in Emergency Medicine
Fri Oct 09, 2020 03:00
Putting the muscle back in microcirculation: From firefighters to near‐infrared spectroscopy
Experimental Physiology
Fri Oct 09, 2020 17:03
A novel approach to validate the efficacy of single task ERP paradigms to measure cognitive workload
Publication date: Available online 9 October 2020Source: International Journal of PsychophysiologyAuthor(s): Usman Ghani, Nada Signal, Imran Khan Niazi, Denise Taylor
International Journal of Psychophysiology
Sat Oct 10, 2020 16:02
Context influences the FN400 recognition event-related potential
Publication date: Available online 8 October 2020Source: International Journal of PsychophysiologyAuthor(s): P. Andrew Leynes, Brittany A. Mok
International Journal of Psychophysiology
Fri Oct 09, 2020 15:45
Cepstral Measures in the Fado Voice: Gender, Age and Phonatory Tasks
Publication date: Available online 10 October 2020Source: Journal of VoiceAuthor(s): Ana P. Mendes, Nuno Nunes, Soraia Ibrahim, Ana C. Coelho, Marina A. Francisco
Voice
Sat Oct 10, 2020 15:55
Blood Glucose Estimation From Voice: First Review of Successes and Challenges
Publication date: Available online 9 October 2020Source: Journal of VoiceAuthor(s): Julia Sidorova, Pablo Carbonell, Milena Čukić
Voice
Sat Oct 10, 2020 15:55
The Cutoff Point and Diagnostic Accuracy of the Voice Handicap Index in Cantonese-Speaking Population
Publication date: Available online 9 October 2020Source: Journal of VoiceAuthor(s): Eugenie Ng, Thomas Law, Eric C.-H. Tang, Fiona N.-Y. Ho, Michael C.-F. Tong, Kathy Y.-S. Lee
Voice
Sat Oct 10, 2020 15:55
Acoustic Characteristics of the Voice for Brazilian Portuguese Speakers Across the Life Span
Publication date: Available online 9 October 2020Source: Journal of VoiceAuthor(s): Evelyn Alves Spazzapan, Eliana Maria Gradim Fabron, Larissa Cristina Berti, Eduardo Federighi Balsi Chagas, Viviane Cristina de Castro Marino
Voice
Fri Oct 09, 2020 19:04
Work ability of teachers associated with voice disorders, stress, and the indoor environment: A questionnaire study in Finland
Publication date: Available online 9 October 2020Source: Journal of VoiceAuthor(s): Hanna Vertanen-Greis, Eliisa Loyttyniemi, Jukka Uitti, Tuula Putus
Voice
Fri Oct 09, 2020 19:04
Worldwide Healthy Adult Voice Baseline Parameters: A Comprehensive Review
Publication date: Available online 8 October 2020Source: Journal of VoiceAuthor(s): Giovanni Saggio, Giovanni Costantini
Voice
Fri Oct 09, 2020 19:04
The Patient Reported Outcome Measures In Skin Cancer Reconstruction (PROMISCR) study – anglicisation and initial validation of the FACE-Q Skin Cancer module in a UK cohort
Publication date: Available online 9 October 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Mr Thomas D Dobbs, Dr Maarten Ottenhof, Mr John AG Gibson, Professor Iain S Whitaker, Professor Hayley A Hutchings
British Association of Plastic Surgeons
Sat Oct 10, 2020 15:45
Conus-level combined dorsal and ventral lumbar rhizotomy for treatment of mixed hypertonia: technical note and complications.
Conus-level combined dorsal and ventral lumbar rhizotomy for treatment of mixed hypertonia: technical note and complications. J Neurosurg Pediatr. 2020 Oct 09;:1-6 Authors: Ahluwalia R, Bass P, Flynn L, Martin E, Riordan H, Lawrence A, Naftel RP Abstract Combined dorsal and ventral rhizotomy is an effective treatment for patients with concurrent spasticity and dystonia, with the preponderance of complaints relating to their lower extremities....
Pediatric Neurosurgeons
Sat Oct 10, 2020 15:44
Pediatric neurosurgery in Asia and Australasia: training and clinical practice.
Pediatric neurosurgery in Asia and Australasia: training and clinical practice. J Neurosurg Pediatr. 2020 Oct 09;:1-9 Authors: Baticulon RE, Dewan MC, Wittayanakorn N, Aldana PR, Maixner WJ Abstract OBJECTIVE: There are limited data on the pediatric neurosurgical workforce in Asia and Australasia. The training and clinical practice of pediatric neurosurgeons need to be characterized in order to identify gaps in knowledge and skills, thereby...
Pediatric Neurosurgeons
Sat Oct 10, 2020 15:44

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