Systematic review of the nonsurgical management of atlantoaxial rotatory fixation in childhood. J Neurosurg Pediatr. 2020 Oct 09;:1-12 Authors: Sae-Huang M, Borg A, Hill CS Abstract OBJECTIVE: Atlantoaxial rotatory fixation (AARF) is an acquired fixed abnormality of C1-2 joint rotation associated with torticollis in childhood. If the condition is left uncorrected, patients are at risk for developing C1-2 fusion with permanent limitation in...
Sat Oct 10, 2020 15:44
The interaction between parental concern and socioeconomic status in pediatric hydrocephalus management. J Neurosurg Pediatr. 2020 Oct 09;:1-7 Authors: Reynolds RA, Dixon M, Gannon S, CCRP, Zhao S, Bonfield CM, Naftel RP, Wellons JC, Shannon CN Abstract OBJECTIVE: Parent or guardian involvement is implicit in the care of pediatric patients with hydrocephalus. Some parents and guardians are more engaged than others. The relationship between...
Sat Oct 10, 2020 15:44
Abstract This systematic review analysed evidence relating to medication-related osteonecrosis of the jaws (MRONJ) associated with protein kinase inhibitors in antiresorptive naïve patients. A literature search of major biomedical databases was conducted in March 2020. Information extracted from relevant articles included bibliographic information, patient characteristics, MRONJ characteristics at diagnosis, management strategies and outcomes. Sixteen studies, representing data...
Sat Oct 10, 2020 03:00
Publication date: November 2020Source: Neoplasia, Volume 22, Issue 11Author(s): Zhaona Fan, Lihong He, Mianxiang Li, Ruoyan Cao, Miao Deng, Fan Ping, Xueyi Liang, Yuan He, Tong Wu, Xiaoan Tao, Jian Xu, Bin Cheng, Juan Xia
Sat Oct 10, 2020 14:44
Publication date: November 2020Source: Neoplasia, Volume 22, Issue 11Author(s): Seung Hyeon Kim, Soma Saeidi, Xiancai Zhong, Shin-Young Gwak, Ishrat Aklima Muna, Sin-Aye Park, Seong Hoon Kim, Hye-Kyung Na, Yeonsoo Joe, Hun Taeg Chung, Kyoung-Eun Kim, Wonshik Han, Young-Joon Surh
Fri Oct 09, 2020 14:19
Publication date: December 2020Source: Acta Histochemica, Volume 122, Issue 8Author(s): Heba M. Elhessy, Huda Eltahry, Omnia S. Erfan, Mohammed R. Mahdi, Noha M. Hazem, Mona A. El-Shahat
Sat Oct 10, 2020 14:19
Significant subcutaneous emphysema can result in airway compromise. Infraclavicular blowhole incision with negative pressure wound therapy is an emerging therapy. Novel way of creating a functional negative pressure wound therapy using PICO dressing and wall suction for ongoing air leak is described.
Thu Oct 08, 2020 20:34
Thu Oct 08, 2020 20:34
Publication date: Available online 9 October 2020Source: Pathology - Research and PracticeAuthor(s): Borislav A. Alexiev, Farres Obeidin, Daniel N. Johnson, Brian S. Finkelman, Rebecca Prince, Shaan N. Somani, Esther Cheng, Sandeep Samant
Sat Oct 10, 2020 14:02
Publication date: Available online 9 October 2020Source: Pathology - Research and PracticeAuthor(s): Reza Vaezi Astamal, Asma Maghoul, Sina Taefehshokr, Taha Bagheri, Ehsan Mikaeili, Afshin Derakhshani, Masoud Delashoub, Nima Taefehshokr, Alireza Isazadeh, Saba Hajazimian, Antalique Tran, Behzad Baradaran
Fri Oct 09, 2020 17:05
Publication date: Available online 9 October 2020Source: Pathology - Research and PracticeAuthor(s): Yasmin Thiel, Chafik Ghayor, Daniel Lindhorst, Harald Essig, Franz Weber, Martin Rücker, Paul Schumann
Fri Oct 09, 2020 17:05
Publication date: Available online 9 October 2020Source: Pathology - Research and PracticeAuthor(s): Ji Liu, Xu Li, Shanshan Yang, Junjun Mou, Haijun Lu
Fri Oct 09, 2020 17:05
Publication date: Available online 8 October 2020Source: Pathology - Research and PracticeAuthor(s): Ronan M.G. Berg, Andreas Ronit, Sara B. Rørvig, Ronni R. Plovsing
Fri Oct 09, 2020 17:05
Odontogenic cutaneous fistula is a pathologic communication between the cutaneous surface of the face and the oral cavity and it is a rare entity frequently misdiagnosed. Therefore, the lesion may persist for a long period before the correct diagnosis is made and odontogenic source is treated appropriately. Delay in diagnosis adds to the chronicity of the lesion and if not diagnosed in times fistula can even leave deforming scars. Considering the scarceness and diagnostic predicament of odontogenic...
Thu Oct 08, 2020 03:00
Isolated fractures of the anterior wall of the frontal sinus are most often treated through a coronal approach. Although the coronal approach is a relatively easy procedure, the size of the incision is causing more problems related to patient morbidity and recovery time than smaller approaches. A novel, minimal invasive procedure for reconstruction of the anterior wall fracture of the frontal sinus is presented in this article. An endoscopic assisted approach to camouflage the defect of the anterior...
Thu Oct 08, 2020 03:00
Cleft lip and palate (CLP) repair is typically performed in a staged fashion, which requires multiple instances of anesthetic exposure during a critical period of infant neurodevelopment. One solution to this concern includes the implementation of a single-stage CLP repair performed between 6 and 12 months of age. This study aimed to compare total anesthetic exposure between single-stage and staged CLP repairs. A retrospective review of unilateral CLP repairs between 2013 and 2018 conducted at a...
Thu Oct 08, 2020 03:00
A 74-year-old man presented with hemorrhage from the mandible after an injury caused by a 5 × 3 × 3-cm metal square column flying from a 45-ton press machine that struck the right side of his face. He is a known atrial fibrillation patient and is on rivaroxaban, a direct oral anticoagulant. An approximately 8-cm Y-shaped wound with persistent hemorrhage was observed in the right mandible, and the mandible was displaced between the right mandibular canine and first premolar. Although the patient showed...
Thu Oct 08, 2020 03:00
Contralateral Subfrontal Supraorbital Approach for Microsurgical Resection of Optic Canal Meningioma
Meningiomas are mostly benign tumors of the central nervous system. Recurrence can be seen in clinoidal meningiomas especially extending into optic canal. We present a patient with a history of left clinoidal meningioma excision via pterional approach and recurrence purely in left optic canal. Optic canal drilling is necessary for complete removal of these type of tumors. Contralateral subfrontal approach with an eyebrow incision and a keyhole supraorbital craniotomy was used for this patient. Contralateral...
Thu Oct 08, 2020 03:00
Background: Hemifacial atrophy (Romberg disease) is characterized by progressive soft tissue and bone atrophy on 1 side of the face. The process of atrophy usually starts in the late first or early second decade of life. Romberg Patients usually require soft tissue augmentation for the correction of their defect. There are many reconstructive tools available to correct such facial asymmetry. In this study, we evaluate the outcome of the free adipofacial flap followed by autologous fat grafting...
Thu Oct 08, 2020 03:00
Internal carotid artery (ICA) injury is a rare but disastrous complication during extended endoscopic endonasal surgery. The method of ICA sacrifice via endonasal clipping has only been reported in a few cases to treat ICA injury. To provide some technical experience of this method, here the authors present 2 cases of ICA injury during extended endoscopic endonasal surgery with 2-year follow-up. The 2-nostrils/4-hands technique was used to control the active bleeding. Based on the good collateral...
Thu Oct 08, 2020 03:00
Resorbable osteosynthesis systems are widely used for the fixation of zygomaticomaxillary complex (ZMC) fractures instead of titanium systems, because they do not have postoperative hardware-related complications. However, the strength of conventional resorbable systems is inferior to that of titanium systems. Recently, ultrasound-aided resorbable osteosynthesis systems, which have higher fixation than conventional resorbable osteosynthesis systems, have become available. The purpose of this...
Thu Oct 08, 2020 03:00
Purpose: Upper airway surgery comprises a set of techniques that modify the anatomy of the vocal tract, including tonsillectomy and septoplasty. The objective of this work is to study the changes in acoustic parameters and the effects on the identification or verification of the speaker through the speech produced after the vocal tract surgeries, comparing them with a control group. Methods: A prospective study was performed between January 2019 and June 2019 including. The final study...
Thu Oct 08, 2020 03:00
Background: The aim of this study was to explore the characteristics and correlation of maxillofacial fractures and concurrent injuries with different injury causes. Methods: In this retrospective study, data were collected from patients treated for maxillofacial fractures in 3 oral and maxillofacial surgery departments in Southeast China, from January 2010 to December 2019. The information was obtained from clinical notes and surgical records using a standardized data collection form,...
Thu Oct 08, 2020 03:00
Aim: To evaluate the contribution to patient satisfaction of the newly reshaped topographic anatomy of the nose, demographic, and functional results in the postoperative period of septorhinoplasty surgery. Method: A total of 370 patients applied with open and closed septorhinoplasty techniques for various reasons were grouped according to the postoperative Rhinoplasty Outcome Evaluation (ROE) Scale results; Group 1 (open rhinoplasty satisfied group, ROE ≥12 points, n:194), Group 2 (open...
Thu Oct 08, 2020 03:00
This study summarized the literature regarding the application of pre-bent titanium miniplates in orthognathic surgery and evaluated the extra deformation of the manually pre-bent titanium miniplates via finite element analysis for acquiring higher surgical accuracy. The literature was reviewed with a chart. Three models of titanium miniplates with different thicknesses (1.0 mm, 0.8 mm, 0.6 mm) were created using COMSOL Multiphysics software for biomechanical behavior analysis. The 3 models were...
Thu Oct 08, 2020 03:00
Little is known on career factors and expectations for female oral and maxillofacial surgeons (OMFS) in developing countries. The study aimed to explore career perceptions of females in 2 related surgical specialties: oral and maxillofacial surgery and otolaryngology (ENT) with a focus on career obstacles and success factors. A structured questionnaire was distributed to female surgeons working in Jordan in the 2 surgical specialties. Questions addressed socio-professional characteristics and career-promoting...
Thu Oct 08, 2020 03:00
Upper eyelid ectropion is rare. When it does occur, the cicatricial subset of upper eyelid ectropion is its most common manifestation. Due to its rarity, little has been published regarding its treatment. Herein, we present the case of a 27-year-old patient who suffered significant left sided facial trauma in a high-velocity motor vehicle accident, resulting in a soft tissue defect in the left lateral supra-orbital region, including loss of the lateral half of the left eyebrow. The defect was left...
Thu Oct 08, 2020 03:00
Maxillary sinus hypoplasia is a rare condition. The majority of patients are asymptomatic but in some cases, they suffer from headaches and facial pain. Awareness of this condition is important because of misdiagnosis and possible complications during endoscopic sinus surgery. This is a presentation of 24-year-old women with unilateral maxillary sinus hypoplasia who presented with headache and nasal blockage. Address correspondence and reprint requests to Banu Atalay Erdogan, MD, Department of...
Thu Oct 08, 2020 03:00
Deformity and tissue loss involving the craniomaxillofacial region occurs frequently as a result of trauma, oncologic resection, or a congenital malformation. In order to maximize the patient's quality of life, reconstruction of the craniomaxillofacial skeleton must seek to restore aesthetics as well as function. Advances in diagnostic technology, surgical technique, instrumentation, and innovative biomaterials used have transformed the way reconstructive surgeons approach their patients’ needs....
Thu Oct 08, 2020 03:00
Background: Advances in the understanding of wrinkling crow's feet while improving the safety and efficacy of botulinum toxin type A injection has pointed to drug dispersion in the lateral orbital wrinkles as a cause of adverse events of botulinum toxin type A injection. The purpose of this study is to identify the distribution of temporal and zygomatic branches of facial nerve in the orbicularis oculi muscles. Methods: Anatomical dissection of cadavers was performed in 31 cadavers,...
Thu Oct 08, 2020 03:00
No abstract available
Thu Oct 08, 2020 03:00
No abstract available
Thu Oct 08, 2020 03:00
No abstract available
Thu Oct 08, 2020 03:00
Previously, severe upper airway obstruction in patients with retrognathia and glossoptosis has been managed with tracheostomy. However, tracheostomy is associated with significant morbidity. In recent years, mandibular distraction has become an alternative management strategy in infants, but these applications have been limited to patient populations with retrognathia and glossoptosis. The authors present 2 unique cases of patients with KAT6B-related gene disorders, who present with a paradox of...
Thu Oct 08, 2020 03:00
Facial asymmetry is a challenge for surgeons. Some surgical strategies could be used involved soft or hard tissue of the face. The aim of this report is to show the use of patient specific implants (PSI) in a puzzle strategy based on computer aided design/computer aided manufacturer to solve a complex structural facial asymmetry after orthognathic surgery. Twenty-five-year-old male patient complain for facial asymmetry after orthognathic surgery; main deformity was related to the shape of mandibular...
Thu Oct 08, 2020 03:00
Abstract The year 2020 is unfolding as a year of multiple and never‐ending challenges, and also a year of developing new solutions and strategies to overcome obstacles. One such challenge was how to hold a scientific meeting, a bedrock of scientific societies, when travel is prohibited and social distancing is a must. The Federation of European Neuroscience Societies (FENS) chose to hold their biennial meeting, the FORUM, virtually in July 2020. As with most transitions, there were plusses and minuses,...
Sat Oct 10, 2020 13:06
New England Journal of Medicine, Ahead of Print.
Fri Oct 09, 2020 07:00
New England Journal of Medicine, Ahead of Print.
Thu Oct 08, 2020 12:00
New England Journal of Medicine, Ahead of Print.
Thu Oct 08, 2020 12:00
Abstract Objective Conduct a systematic review and meta‐analysis examining the association between hypertensive disorders of pregnancy (HDP) and risk of asthma, eczema, food allergies and allergic rhinitis in the offspring. Design A systematic review and random effects meta‐analyses were used to synthesise the published literature. PRISMA guidelines were followed throughout. Two independent reviewers carried out data extraction and quality assessment of included studies. Grading of Recommendations...
Fri Oct 09, 2020 18:20
Abstract Prior to the COVID‐19 pandemic, laryngoscopy was the mandatory gold standard for the accurate assessment and diagnosis of inducible laryngeal obstruction. However, upper airway endoscopy is considered an aerosol‐generating procedure in professional guidelines, meaning routine procedures are highly challenging and the availability of laryngoscopy is reduced. In response, we have convened a multidisciplinary panel with broad experience in managing this disease and agreed a recommended strategy...
Thu Oct 08, 2020 17:27
Abstract Paralysis of the frontalis muscle is extremely difficult to reverse. The best treatment for facial paralysis reanimation which preserves spontaneity and muscle specificity is end‐to‐end neurorrhaphy through cross‐face nerve grafting. However, it is rarely possible. Muscle‐nerve‐muscle (MNM) neurotization consists of an interposition of a nerve graft connecting the normal muscle to the denervated muscle. The axons of the muscle with intact innervation grow inside a neural graft towards the...
Fri Oct 09, 2020 18:45
Abstract Purpose The role of positron emission tomography/magnetic resonance (PET/MR) in evaluating the local extent of rectal cancer remains uncertain. This study aimed to investigate the possible role of PET/MR versus magnetic resonance (MR) in clinically staging rectal cancer. Methods This retrospective two-center cohort study of 62 patients with...
Fri Oct 09, 2020 03:00
Abstract Management of primates in captivity often presents the challenge of introducing new individuals into a group, and research investigating the stability of the social network in the medium term after the introduction can help inform management decisions. We investigated the behavior of a group of chimpanzees (Pan troglodytes) housed at Chester Zoo, UK over 12 months (divided into three periods of 4 months) following the introduction of a new adult female. We recorded grooming,...
Sat Oct 10, 2020 03:00
The world has already observed many devastating effects of human-induced climate change. A vivid manifestation is the several large wildfires that have occurred recently — in some cases, fires of unprecedented scale and duration — including wildfires in Australia in 2019 to 2020, the Amazon…
Fri Oct 09, 2020 03:00
A 47-year-old male with no significant medical history was hospitalized for bacteremia and diagnosed with endocarditis. The organism isolated was a Gram-negative bacillus—Sphingomonas paucimobilis. There are only a few reported cases of endocarditis caused by S. paucimobilis, and to our knowledge, this is the first in the United States.
Sat Oct 10, 2020 05:20
Mycobacterium peregrinum is a rapidly growing mycobacterium (RGM), subspecies of Mycobacterium fortuitum complex, which can cause infections in the skin, surgical sites, and central lines. It has also been associated with implantable devices such as cardiac devices. Our objective is to present an atypical clinical case of M. peregrinum infection associated with a cardiac device, review the published literature, and highlight the importance of this type of RGM infection to enhance their therapeutic...
Fri Oct 09, 2020 10:20
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disorder worldwide with no curative therapy. The aim of this study was to investigate the hepatoprotective effects of a novel Trihoney against biochemical and histological manifestations of NAFLD in hypercholesterolemic rabbits. Methodology. Forty-eight male New Zealand white (NZW) rabbits were grouped into normal diet (C), normal diet with 0.6 g/kg/day of Trihoney (C + H), 1% cholesterol diet (HCD), 1% cholesterol diet...
Fri Oct 09, 2020 19:50
Surgical Infections, Ahead of Print.
Fri Oct 09, 2020 10:00
The world has already observed many devastating effects of human-induced climate change. A vivid manifestation is the several large wildfires that have occurred recently — in some cases, fires of unprecedented scale and duration — including wildfires in Australia in 2019 to 2020, the Amazon…
Fri Oct 09, 2020 03:00
Abstract Rationale N-acylethanolamine acid amidase (NAAA) is an intracellular cysteine hydrolase that terminates the biological actions of oleoylethanolamide (OEA) and palmitoylethanolamide (PEA), two endogenous lipid-derived agonists of the nuclear receptor, and peroxisome proliferator–activated receptor-α. OEA and PEA are important regulators of energy balance, pain, and inflammation, but recent evidence suggests that they might also...
Sat Oct 10, 2020 03:00
Abstract Post-operative vision loss (POVL) can be a devastating complication of neurosurgical procedures and is unusual in the pediatric population. Mechanisms of POVL include direct optic nerve injury, vascular occlusion, or indirect malperfusion resultant from surgeries with substantial blood loss or fluid shifts, with prone positioning being a major risk factor for these events. Posterior ischemic optic neuropathy (PION) is a rare cause of POVL and is associated with a poor...
Sat Oct 10, 2020 03:00
Abstract Background Temporary anchorage devices have been used for decades in orthodontic practice for many applications. The aim of this systematic review was to assess the effectiveness of orthodontic temporary anchorage devices in canine retraction during the two-step technique. Methods A search was systematically performed for articles...
Sat Oct 10, 2020 03:00
Abstract Background Conventional brackets are often used during orthodontic therapy of patients with malocclusion. The complex construction of such brackets greatly inhibits oral hygiene, which predisposes to increased carriage of microbiota. Orthodontic brackets could act as reservoir of yeast and predispose to oral candidosis. The aim of this study was to assess Candida prevalence and the role of oral hygiene during fixed appliance...
Sat Oct 10, 2020 03:00
Abstract Background Concomitant cemento-osseous dysplasia (COD) and aneurysmal bone cyst (ABC) are rare in the head and neck region. In our search of the English language literature, we found only one case report describing the simultaneous occurrence of COD and ABC in the head and neck region. Here, we report a case of COD associated with ABC. Further, we performed a systematic search of the literature to identify studies on...
Fri Oct 09, 2020 03:00
Abstract Adenoid cystic carcinoma (AdCC) is a rare triple‐negative breast cancer with a favorable prognosis, although cases of distant metastases have been reported. Less than 10 cases of AdCC of the breast in males have been reported. We report a unique presentation of pleural fluid metastasis diagnosed by cytologic evaluation of pleural fluid in a 60‐year‐old male patient with AdCC of the breast. Careful surveillance and cytologic evaluation of effusion specimens can detect metastases with the...
Fri Oct 09, 2020 20:21
Purpose: 99mTc-Tilmanocept is a novel radiopharmaceutical for SLN biopsy in breast cancer. The aim was to describe the results with 99mTc-Tilmanocept in a heterogeneous group of breast cancer patients scheduled for SLN biopsy. Methods: Radiotracer preparation followed the manufacturer’s indications. Local protocols for SLN detection within 9 participant centers were not changed for the entire duration of the study. Three hundred and forty-four patients with T1-T4, N0-N2 breast cancer (352 lesions)...
Fri Oct 09, 2020 23:53
In recent years, targeted radionuclide therapy (TRT) has emerged as a promising strategy for cancer treatment. In contrast to conventional radiotherapy, TRT delivers ionising radiation to tumours in a targeted manner, reducing the dose that healthy tissues are exposed to. Existing TRT strategies include the use of 177Lu-DOTATATE and 131I-MIBG, FDA-approved agents for the treatment of neuroendocrine tumours, and 177Lu-PSMA, which is being investigated for the treatment of prostate cancer. Although...
Fri Oct 09, 2020 23:53
Quantitative imaging biomarkers are widely used in PET for both research and clinical applications, yet bias in the underlying image data has not been well-characterized. In the absence of a readily available reference standard for in vivo quantification, bias in PET images has been inferred using physical phantoms, even though arrangements of this sort provide only a poor approximation of the imaging environment in real patient examinations. In this study we used data acquired in patient volunteers...
Fri Oct 09, 2020 23:53
The aim of this study was to assess the repeatability of activated brown adipose tissue (BAT) radiomic features. In order to decipher radiomic features that may provide useful information on BAT, the impact of reconstruction methods and imaging modality choice was also evaluated. Methods: Twenty-seven healthy adults enrolled in this study. Following a cooling procedure to activate BAT, volunteers underwent 18F-fluorodeoxyglucose positron emission / computed tomography (FDG PET/CT) imaging. Participants...
Fri Oct 09, 2020 23:53
Diagnosing relapse after radiotherapy for lung cancer is challenging. The specificity of both CT and 2-deoxy-2-[18F]fluoro-D-glucose (FDG)-PET/CT is low due to radiation-induced changes. 3’-deoxy-3’-[18F]fluorothymidine (FLT)-PET has previously demonstrated higher specificity for malignancy than FDG-PET. We investigated the value of FLT-PET/CT for diagnosing relapse in irradiated lung cancer. Methods: Patients suspected for relapse of lung cancer after definitive radiotherapy (conventional fractionated...
Fri Oct 09, 2020 23:53
Enhancers are DNA sequences composed of transcription factor binding sites that drive complex patterns of gene expression in space and time. Until recently, studying enhancers in their genomic context was technically challenging. Therefore, minimal enhancers, the shortest pieces of DNA that can drive an expression pattern that resembles a gene's endogenous pattern, are often used to study features of enhancer function. However, evidence suggests that some enhancers require sequences outside the minimal...
Sat Oct 10, 2020 00:04
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Purpose:The purpose of this study was to investigate the clinical efficacy of salvage percutaneous radiofrequency ablation in patients with unresectable colorectal cancer liver metastases.Methods:The cohort consisted of 81 patients with 126 colorectal cancer liver metastases who underwent radiofrequency ablation between January 2012 and September 2016. The clinical data and ablation data were retrospectively analyzed....
Fri Oct 09, 2020 12:27
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC) accounts for about 20% to 30% of all BC subtypes and is characterized by invasive disease and poor prognosis. With the emergence of anti-HER2 target drugs, HER2-positive BC patient outcomes have changed dramatically. However, treatment failure is mostly due to drug resistance and the special treatment needs of different subgroups. Small...
Fri Oct 09, 2020 12:26
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Background:This preliminary simulation study aimed to compare the dosimetric outcomes of carotid arteries (CAs) and pharyngeal constrictor muscle (PCM) in patients with T1N0M0 glottic carcinoma undergoing helical tomotherapy-intensity modulated radiotherapy (HT-IMRT) and 3-dimensional conformal radiotherapy (3D-CRT) plans.Methods:In addition to the clinical target volume (CTV) which was defined as the entire larynx,...
Fri Oct 09, 2020 12:24
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Endometrial cancer (EC) is one of the most common cancers among women worldwide. Kinesin family member C1 (KIFC1) has been demonstrated to play crucial roles in various tumors. However, the function of KIFC1 in EC remains to be revealed. In this study, upregulation of KIFC1 expression in human EC tissues was found from analysis on data from The Cancer Genome Atlas (TCGA), and positively correlated with short survival...
Fri Oct 09, 2020 12:23
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Nipped-B-like protein plays a pivotal role as a cohesin loading factor in the segregation of chromosomes when cells divide. Accumulating evidence indicates that alterations of this protein are involved in human carcinogenesis, especially in the regulation of chemotherapeutic drug response. However, the role of Nipped-B-like protein in esophageal squamous cell carcinoma remains unknown. In this study, we investigated...
Fri Oct 09, 2020 12:21
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Background:Circulating tumor cells (CTCs) hold huge potential for both clinical applications and basic research into the management of cancer, but the relationship between CTC count and cervical cancer prognosis remains unclear. Therefore, research on this topic is urgently required.Objective:This study investigated whether CTCs were detectable in patients with cervical cancer and whether CTC count was an indicator...
Fri Oct 09, 2020 12:16
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Background:Non-small cell lung carcinoma (NSCLC) is a common malignant tumor with poor prognosis. CircRNA-100876 has been considered to be involved in NSCLC. However, the mechanism by which circRNA_100876 mediated the progression of NSCLC remains unclear.Methods:CCK8 assay and immunofluorescence were used to detect cell proliferation. Flow cytometry and transwell assay were performed to analyze cell apoptosis,...
Thu Oct 08, 2020 13:39
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. SENP3, a sentrin/SUMO2/3-specific protease, is recognized as a transcriptional factor that accumulates under cellular oxidative stress and plays a significant role in the removal of SUMO2/3 modification. In our study, we examined a TCGA dataset and found that the transcripts per million (TPM) value of SENP3 is high in sarcoma, including osteosarcoma (OS). We found that SENP3 was highly expressed in OS cancer tissues...
Thu Oct 08, 2020 13:38
Journal of International Medical Research, Volume 48, Issue 10, October 2020. PurposeTo evaluate the effectiveness and safety of gefitinib retreatment beyond disease progression in patients with advanced non-small cell lung cancer (NSCLC) with sensitive epidermal growth factor receptor (EGFR) mutations.MethodsData from patients with stage III/IV NSCLC were analyzed retrospectively. Patients with sensitive EGFR mutations received first-line treatment with gefitinib followed by retreatment with gefitinib...
Fri Oct 09, 2020 11:34
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveThis study aimed to examine the characteristics of blood lactate in neonates undergoing mechanical ventilation in Tibet.MethodsWe recruited 67 neonates undergoing mechanical ventilation in Naqu People’s Hospital as the plateau observation group and 94 neonates undergoing mechanical ventilation in Shengjing Hospital as the control group. We analyzed the differences in lactate levels between the two groups.ResultsThe...
Fri Oct 09, 2020 11:33
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo investigate the related risk factors and predictive nomogram of postoperative hypoxaemia in elderly patients with femoral neck fractures.MethodsThis study included patients aged ≥65 years who underwent surgical treatment of acute femoral neck fractures. Univariate and multivariate logistic analyses were performed to determine the incidence of and risk factors for postoperative hypoxaemia. A predictive nomogram...
Thu Oct 08, 2020 11:28
There is limited evidence regarding the association between dietary acid load and muscle strength. Thus, in this study, we investigated the association between dietary acid–base load indices and muscle strengt...
Fri Oct 09, 2020 03:00
Hard ticks (Acari: Ixodidae) are ectoparasites of medical and veterinary importance. They are obligate blood-feeding vectors with the ability to transmit a wide variety of pathogens. Standard morphological key...
Fri Oct 09, 2020 03:00
Current guidelines on rectal cancer (RC) management recommend pre-operative MRI for loco-regional staging and CT for staging of metastases. This allows appropriate selection of patients for chemo-radiotherapy ...
Fri Oct 09, 2020 03:00
The bacterial cell cycle comprises initiation of replication and ensuing elongation, concomitant chromosome segregation (in some organisms with a delay termed cohesion), and finally cell division. By quantifyi...
Fri Oct 09, 2020 03:00
Abstract The aim of the present study was to investigate the effects of photobiomodulation (PBM) therapy on the expression of heat shock protein 70 (HSP70) and tissue repair in an experimental model of collagenase-induced Achilles tendinitis. Thirty Wistar rats (aged 12 weeks) were randomly distributed among control group (n = 8), tendinitis group (n = 11), and LED group (n = 11). Tendinitis was induced in the tendinitis and LED groups through a peritendinous injection of collagenase...
Sat Oct 10, 2020 03:00
Abstract The meta-analysis aimed to systematically evaluate all the available pieces of evidence concerning the clinical effectiveness of Er,Cr:YSGG lasers (erbium, chromium, yttrium scandium gallium garnet laser) in the non-surgical treatment of patients with chronic periodontitis, and provide guidance for clinicians about the application of Er,Cr:YSGG lasers during the process of non-surgical periodontal treatments. The meta-analysis was conducted with data extracted from 16...
Fri Oct 09, 2020 03:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07854
Fri Oct 09, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c09254
Fri Oct 09, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07397
Fri Oct 09, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08269
Fri Oct 09, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08631
Fri Oct 09, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04537
Fri Oct 09, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08178
Fri Oct 09, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06177
Fri Oct 09, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08526
Fri Oct 09, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07392
Fri Oct 09, 2020 07:00
Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1261-5282 Let7b-5p is a member of the Let-7 miRNA family and one of the top expressed miRNAs in human islets that implicated in glucose homeostasis. The levels of Let7b-5p in type 2 diabetes (T2DM) patients or its role in β-cell function is still unclear. In the current study, we measured the serum levels of let7b-5p in Emirati patients with T2DM (with/without complications) and control subjects. Overexpression or silencing of let7b-5p in INS-1 (832/13)...
Fri Oct 09, 2020 02:00
The overwhelming majority of pediatric cases of SARS-CoV-2 infection are mild or asymptomatic with only a handful of pediatric deaths reported. We present a case of severe COVID-19 infection in a pediatric patient with signs of hyperinflammation and consumptive coagulopathy requiring intubation and extracorporeal membrane oxygenation (ECMO) and eventual death due to ECMO complications.
Fri Oct 09, 2020 17:35
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