| British Journal of Dermatology Early View
Online Version of Record before inclusion in an issue
|
Research Letters
PAPASH, PsAPASH and PASS autoinflammatory syndromes: phenotypic heterogeneity, common biological signature and response to immunosuppressive regimens
Version of Record online: 25 July 2019
Open AccessClinical Trials
Sustained long‐term efficacy and safety of adalimumab in paediatric patients with severe chronic plaque psoriasis from a randomized, double‐blind, phase III study
Version of Record online: 25 July 2019
What's already known about this topic?
What does this study add?
- The results from the first three periods of this phase III trial in children aged 4–18 years with severe plaque psoriasis suggest that adalimumab is a safe and efficacious treatment option in this population.
What does this study add?
- This is the first study to evaluate long‐term treatment of adalimumab in children with severe psoriasis, and the first to evaluate switching from methotrexate to adalimumab in this population.
Clinical Trials
Benefits of a brief psychological intervention targeting fear of cancer recurrence in people at high risk of developing another melanoma: 12‐month follow‐up results of a randomized controlled trial
Version of Record online: 25 July 2019
What's already known about this topic?
What does this study add?
Respond to this article
- People treated for early‐stage melanoma are at 5–10 times greater risk of developing new primary disease relative to people without a history of melanoma.
- As a consequence, people who have had melanoma often experience fear of cancer recurrence (FCR) or progression.
What does this study add?
- In this randomized controlled trial, participants who received a brief, multifaceted, patient‐centred psychological intervention reported significantly lower FCR at 12‐months postintervention compared with those in the control arm.
- The intervention had no known adverse effects and its benefits persisted long after the last psychology session, supporting implementation as part of routine melanoma care.
Respond to this article
Research Letters
Treatment of moderate‐to‐severe atopic dermatitis with dupilumab in real clinical practice: a multicentre, retrospective case series
Version of Record online: 25 July 2019
Open AccessMedical Dermatology
Clinical response correlates with 4‐week postinjection ustekinumab concentrations in patients with moderate‐to‐severe psoriasis
Version of Record online: 24 July 2019
What's already known about this topic?
What does this study add?
- Monitoring drug concentrations is a valuable tool that can guide clinical decision‐making when drug concentrations are linked to clinical outcomes.
- The presence of a concentration–response relationship for ustekinumab at trough is still debated owing to the contradictory results reported.
What does this study add?
- A concentration–response relationship at week 4 after injection for ustekinumab‐treated patients with psoriasis was demonstrated.
- Monitoring 4‐week postinjection ustekinumab concentrations could timely identify underexposed patients who might benefit from treatment optimization.
- Based on the findings of this study, a treatment algorithm for patients with a suboptimal response is proposed.
Review Articles
Pathophysiology of pachyonychia congenita‐associated palmoplantar keratoderma: new insights into skin epithelial homeostasis and avenues for treatment
Version of Record online: 24 July 2019
What's already known about this topic?
What does this study add?
- Pachyonychia congenita (PC) is a rare genodermatosis caused by mutations in KRT6A, KRT6B, KRT6C, KRT16 and KRT17, which are normally expressed in skin appendages and induced following injury.
- Individuals with PC present with multiple clinical symptoms that usually include thickened and dystrophic nails, palmoplantar keratoderma (PPK), glandular cysts and oral leukokeratosis.
- The study of PC pathophysiology is made challenging because of its low incidence and high complexity. There is no cure or effective treatment for PC.
What does this study add?
- This text reviews recent progress made when studying the pathophysiology of PPK associated with PC.
- This recent progress points to new possibilities for devising effective therapeutics that may complement current palliative strategies.
Research Letters
Evaluating cutaneous lupus disease activity end points and their effects on quality of life as an outcome measure for clinical trials
Version of Record online: 24 July 2019
Research Letters
Finalizing the international core domain set for peripheral vascular malformations: the OVAMA project
Version of Record online: 24 July 2019
Research Letters
Xeroderma pigmentosum in South Africa: Evidence for a prevalent founder effect
Version of Record online: 24 July 2019
Qualitative and Outcomes Research
Validation of five patient‐reported outcomes for atopic dermatitis severity in adults
Version of Record online: 24 July 2019
What's already known about this topic?
What does this study add?
What are the clinical implications of this work?
Respond to this article
- Few studies have demonstrated the validity of the atopic dermatitis severity assessments Patient‐Oriented Scoring Atopic Dermatitis (PO‐SCORAD), PO‐SCORAD subscores, numerical rating scale (NRS)‐itch and Patient‐Oriented Eczema Measure (POEM).
What does this study add?
- This study demonstrates that PO‐SCORAD, PO‐SCORAD subscores, NRS‐itch and POEM all had good construct validity in the assessment of atopic dermatitis severity in adults.
- Only POEM demonstrated floor effects.
What are the clinical implications of this work?
- PO‐SCORAD, PO‐SCORAD subscores, NRS‐itch and POEM all appear to have sufficient validity to be used as assessments of atopic dermatitis severity in clinical practice.
Respond to this article
Medical dermatology
Persistence of apremilast in moderate‐to‐severe psoriasis: a real‐world analysis of 14 147 apremilast‐ and methotrexate‐naive patients in the French National Health Insurance database
Version of Record online: 22 July 2019
What's already known about this topic?
What does this study add?
- Psoriasis is a common chronic, relapse–remitting, inflammatory skin disease associated with severe psychosocial impact.
- Apremilast, a phosphodiesterase 4 inhibitor, is one of the most recently commercialized psoriasis drugs.
- Little is known about the long‐term clinical effectiveness of apremilast.
What does this study add?
- The discontinuation rate at 1 year for apremilast was 69%, compared with 58% for methotrexate, in a nationwide population‐based cohort including 14 147 nonselected adult patients with psoriasis.
- Patients in the apremilast cohort had a higher risk of discontinuation than patients in the methotrexate cohort using propensity‐score matching, including potentially relevant individual risk factors such as age, sex, comorbidities and psoriatic arthritis, and regardless of the previous therapeutic lines received.
- In daily practice, physicians should take these results into account when choosing between methotrexate and apremilast as a first‐line systemic therapy.
Critically Appraised Research Paper
Direct infant ultraviolet light exposure is associated with eczema and immune development: a critical appraisal
Version of Record online: 22 July 2019
Open AccessResearch Letters
CD11b+ cells markedly express the itch cytokine interleukin‐31 in polymorphic light eruption
Version of Record online: 21 July 2019
Qualitative and Outcomes Research
Development of a new patient‐reported outcome measure to evaluate treatments for acne and acne scarring: the ACNE‐Q
Version of Record online: 21 July 2019
What's already known about this topic?
What does this study add?
What are the clinical implications of this work?
Respond to this article
- Acne is a common dermatological condition that can have an important impact on psychosocial function.
- Current patient‐reported outcome measures specific to acne focus mostly on measuring psychological and social impact.
What does this study add?
- The ACNE‐Q provides a set of independently functioning scales that measure appearance of facial, back and chest acne, acne scarring and facial skin.
- Additional scales measure appearance‐related distress and acne symptoms.
What are the clinical implications of this work?
- ACNE‐Q provides the dermatology community with a rigorously developed patient‐reported measure for acne that can be applied in clinical trials, research and patient care.
- The measurement of appearance by ACNE‐Q scales is more comprehensive than in other instruments providing important information on appearance of their acne and/or acne scars from the patient perspective.
Respond to this article
General Dermatology
A multiyear cross‐sectional study of U.S. national prescribing patterns of first‐generation sedating antihistamines in older adults with skin disease
Version of Record online: 21 July 2019
What's already known about this topic?
What does this study add?
Respond to this article
- First‐generation antihistamines (FGAs) have been shown to pose substantial risks to older adults, including cognitive impairment, falls, confusion, dry mouth and constipation.
- Therefore, FGAs have been classified as ‘potentially inappropriate’ for use in older patients by the American Geriatrics Society.
- It has also been shown that dermatologists do not always take patient characteristics (e.g. age or life expectancy) into account when deciding on a treatment, instead following a ‘one‐size‐fits‐all’ approach.
What does this study add?
- FGAs are often prescribed during dermatology visits, and prescription rates do not differ between older and younger patients.
- There were no significant differences in prescription rates when comparing younger and older adults with the same diagnosis or symptom (e.g. dermatitis, pruritus or itch).
- FGAs are prescribed at higher rates in primary‐care offices than in dermatology offices.
Respond to this article
Case Report: Clinical and Diagnostic
Refining the dermatological spectrum in primary immunodeficiency: mucosa‐associated lymphoid tissue lymphoma translocation protein 1 deficiency mimicking Netherton/Omenn syndromes
Version of Record online: 21 July 2019
What's already known about this topic?
What does this study add?
- Mucosa‐associated lymphoid tissue lymphoma translocation protein 1 (MALT1) deficiency is a combined immunodeficiency.
- MALT1 is part of the caspase recruitment domain‐containing protein 11–B‐cell lymphoma 10–MALT1 signalosome complex, which is essential for nuclear factor kappa B activation.
- Current publications describe a phenotype of recurrent systemic infections; only in a few cases has an inflammatory involvement of the integument been described.
What does this study add?
- A closer description of the cutaneous phenotype of MALT1 deficiency in a patient with two novel MALT1 mutations.
- Immune mapping of follicular epidermis shows lympho‐epithelial Kazal‐type‐related inhibitor is reduced in MALT1 deficiency and absent on interfollicular staining.
- Clinically, MALT1 deficiency mimics Netherton syndrome and Omenn syndrome, and should be considered a differential diagnosis
Research Letters
Clinical outcomes of patients with pemphigus treated by the same physicians in a public safety net healthcare system vs. a private healthcare system
Version of Record online: 21 July 2019
Translational Research
Keratin 6a mutations lead to impaired mitochondrial quality control
Version of Record online: 21 July 2019
What's already known about this topic?
What does this study add?
What is the translational message?
Respond to this article
- Terminal epidermal differentiation is a multistep process that includes the elimination of cellular components by autophagy.
- Autophagy‐impaired keratinocytes have been shown to result in thickening of epidermal layers.
- Hyperkeratosis also occurs in pachyonychia congenita (PC), a rare skin disease caused by mutations in keratins 6, 16 and 17.
What does this study add?
- Keratins contribute to mitochondrial quality control as well as maintenance of mitochondria–endoplasmic reticulum contact sites.
- Keratins influence autolysosomal maturation or reformation.
What is the translational message?
- Overaged mitochondria and autolysosomes accumulate in PC.
- Mutations in keratin 6a lead to severely impaired mitophagy, which might contribute to PC pathogenesis.
Respond to this article
Research Letters
Dermatological manifestations of hereditary fibrosing poikiloderma with tendon contractures, myopathy and pulmonary fibrosis (POIKTMP): a case series of 28 patients
Version of Record online: 10 April 2019
| British Journal of Dermatology Accepted Articles
Accepted, unedited articles published online and citable. The final edited and typeset Version of Record will appear in the future.
|
Original Articles
Ivermectin safety in infants and children under 15 kg treated for scabies: A multicentric Observational study
First Published: 25 July 2019
Original Articles
Itch induction by audiovisual stimuli and histamine iontophoresis: a randomised, controlled non‐inferiority study
First Published: 25 July 2019
Original Articles
Dysfunctional coping is related to impaired skin‐related QoL and psychological distress in Neurofibromatosis type 1 patients with major skin involvement
First Published: 22 July 2019
Original Articles
Basement membrane zone IgE deposition is associated with bullous pemphigoid disease severity and treatment results
First Published: 22 July 2019
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου