Cancers, Vol. 11, Pages 1068: Nomogram for Predicting Survival in Patients Treated with Liposomal Irinotecan Plus Fluorouracil and Leucovorin in Metastatic Pancreatic Cancer Cancers doi: 10.3390/cancers11081068 Authors: Chen Macarulla Blanc Mirakhur Jong Belanger Bekaii-Saab Siveke NAPOLI-1 (NCT01494506) was a phase III study of liposomal irinotecan (nal-IRI) plus 5-fluorouracil/leucovorin (5-FU/LV) in patients with metastatic pancreatic ductal adenocarcinoma...
Sun Jul 28, 2019 03:00
Cancers, Vol. 11, Pages 1067: EP300 and SIRT1/6 Co-Regulate Lapatinib Sensitivity Via Modulating FOXO3-Acetylation and Activity in Breast Cancer Cancers doi: 10.3390/cancers11081067 Authors: Zimam Mahmud Ana R. Gomes Hee Jin Lee Sathid Aimjongjun Yannasittha Jiramongkol Shang Yao Stefania Zona Glowi Alasiri Gyungyub Gong Ernesto Yagüe Eric W.-F. Lam Forkhead Box O3 (FOXO3) is a tumor suppressor whose activity is fine-tuned by post-translational modifications...
Sun Jul 28, 2019 03:00
Cancers, Vol. 11, Pages 1066: Diminished Condensin Gene Expression Drives Chromosome Instability That May Contribute to Colorectal Cancer Pathogenesis Cancers doi: 10.3390/cancers11081066 Authors: Allison K. Baergen Lucile M. Jeusset Zelda Lichtensztejn Kirk J. McManus Chromosome instability (CIN), or constantly evolving chromosome complements, is a form of genome instability implicated in the development and progression of many cancer types, however, the molecular determinants...
Sun Jul 28, 2019 03:00
Cancers, Vol. 11, Pages 1065: Downregulation of SHIP2 by Hepatitis B Virus X Promotes the Metastasis and Chemoresistance of Hepatocellular Carcinoma through SKP2 Cancers doi: 10.3390/cancers11081065 Authors: Kuo-Jung Su Yung-Luen Yu Hepatitis B virus (HBV)-encoded X protein (HBx) plays an important role in the development of hepatocellular carcinoma (HCC). The protein SH2 domain containing inositol 5-phosphatase 2 (SHIP2) belongs to the family of enzymes that dephosphorylate the 5...
Sat Jul 27, 2019 03:00
Cancers, Vol. 11, Pages 1063: Persistent Organic Pollutants and Breast Cancer: A Systematic Review and Critical Appraisal of the Literature Cancers doi: 10.3390/cancers11081063 Authors: Kaoutar Ennour-Idrissi Pierre Ayotte Caroline Diorio Persistent organic pollutants (POPs) bioaccumulate in the food chain and have been detected in human blood and adipose tissue. Experimental studies demonstrated that POPs can cause and promote growth of breast cancer. However, inconsistent results...
Sat Jul 27, 2019 03:00
Cancers, Vol. 11, Pages 1064: Accuracy of Tumour-Associated Circulating Endothelial Cells as a Screening Biomarker for Clinically Significant Prostate Cancer Cancers doi: 10.3390/cancers11081064 Authors: Sebastian Chakrit Bhakdi Prapat Suriyaphol Ponpan Thaicharoen Sebastian Tobias Karl Grote Chulaluk Komoltri Bansithi Chaiyaprasithi Komgrid Charnkaew Even though more than 350,000 men die from prostate cancer every year, broad-based screening for the disease remains...
Sat Jul 27, 2019 03:00
Cancers, Vol. 11, Pages 1062: APOBEC3B Gene Expression in Ductal Carcinoma In Situ and Synchronous Invasive Breast Cancer Cancers doi: 10.3390/cancers11081062 Authors: Anieta M. Sieuwerts Shusma C. Doebar Vanja de Weerd Esther I. Verhoef Corine M. Beauford Marie C. Agahozo John W.M. Martens Carolien H.M. van Deurzen The underlying mechanism of the progression of ductal carcinoma in situ (DCIS), a non-obligate precursor of invasive breast cancer (IBC), has yet to...
Sat Jul 27, 2019 03:00
Cancers, Vol. 11, Pages 1061: Molecular Characteristics of Uveal Melanoma: Insights from the Cancer Genome Atlas (TCGA) Project Cancers doi: 10.3390/cancers11081061 Authors: Mathieu F. Bakhoum Bita Esmaeli The Cancer Genome Atlas (TCGA) uveal melanoma project was a comprehensive multi-platform deep molecular investigation of 80 uveal melanoma primary tissue samples supported by the National Cancer Institute. In addition to identification of important mutations for the first time,...
Sat Jul 27, 2019 03:00
Cancers, Vol. 11, Pages 1060: High FREM2 Gene and Protein Expression Are Associated with Favorable Prognosis of IDH-WT Glioblastomas Cancers doi: 10.3390/cancers11081060 Authors: Ivana Jovčevska Alja Zottel Neja Šamec Jernej Mlakar Maxim Sorokin Daniil Nikitin Anton A. Buzdin Radovan Komel World Health Organization grade IV diffuse gliomas, known as glioblastomas, are the most common malignant brain tumors, and they show poor prognosis. Multimodal treatment of surgery...
Sat Jul 27, 2019 03:00
Cancers, Vol. 11, Pages 1058: Pivotal Role of AKT2 during Dynamic Phenotypic Change of Breast Cancer Stem Cells Cancers doi: 10.3390/cancers11081058 Authors: Gener Rafael Seras-Franzoso Perez Pindado Casas Arango Fernández Díaz-Riascos Abasolo Schwartz Therapeutic resistance seen in aggressive forms of breast cancer remains challenging for current treatments. More than half of the patients suffer from a disease relapse, most of them with distant...
Fri Jul 26, 2019 03:00
Cancers, Vol. 11, Pages 1057: Mining of Self-Organizing Map Gene-Expression Portraits Reveals Prognostic Stratification of HPV-Positive Head and Neck Squamous Cell Carcinoma Cancers doi: 10.3390/cancers11081057 Authors: Locati Serafini Iannò Carenzo Orlandi Resteghin Cavalieri Bossi Canevari Licitra De Cecco Patients (pts) with head and neck squamous cell carcinoma (HNSCC) have different epidemiologic, clinical, and outcome behaviors in relation...
Fri Jul 26, 2019 03:00
Cancers, Vol. 11, Pages 1059: Increased Soluble CMG2 Serum Protein Concentration is Associated with the Progression of Prostate Carcinoma Cancers doi: 10.3390/cancers11081059 Authors: Greither Marcou Fornara Behre Prostate carcinoma (PCa) is one of the leading causes of cancer-related death in males, but biomarkers for the prognosis are rare. Capillary morphogenesis gene 2 (CMG2) is a modulator of extracellular matrix remodeling during angiogenesis. Four isoforms of CMG2...
Fri Jul 26, 2019 03:00
Cancers, Vol. 11, Pages 1055: Immunological Backbone of Uveal Melanoma: Is There a Rationale for Immunotherapy? Cancers doi: 10.3390/cancers11081055 Authors: Ernesto Rossi Giovanni Schinzari Ilaria Grazia Zizzari Brigida Anna Maiorano Monica Maria Pagliara Maria Grazia Sammarco Vincenzo Fiorentino Gianluigi Petrone Alessandra Cassano Guido Rindi Emilio Bria Maria Antonietta Blasi Marianna Nuti Giampaolo Tortora No standard treatment has been established...
Fri Jul 26, 2019 03:00
Cancers, Vol. 11, Pages 1056: Infectious Knockdown of CREB and HIF-1 for the Treatment of Metastatic Uveal Melanoma Cancers doi: 10.3390/cancers11081056 Authors: Hanna Voropaev Maria Gimmelshein Vatkin Dudi Shneor Shahar Luski Alik Honigman Shahar Frenkel Uveal melanoma (UM) is the most prevalent primary intraocular cancer in adults. Up to half the patients develop metastases that are currently incurable, and most patients die within two years following the diagnosis of...
Fri Jul 26, 2019 03:00
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