Deoxycholic acid, also known as cholanoic acid, Kybella, Celluform Plus, Belkyra, and 3α,12α-dihydroxy-5β-cholan-24-oic acid, is a bile acid. Deoxycholic acid is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. Wikipedia
Molar mass: 392.572 g/mol
Formula: C24H40O4
Solubility in water: 0.024%
Melting point: 174–176 °C (345–349 °F; 447–449 K)
Acidity (pKa): 6.58
ATC code: D11AX24 (WHO)
Deoxycholic acid Side Effects Medically reviewed by Drugs.com. Last updated on Feb 21, 2019. OverviewSide EffectsDosageProfessionalInteractionsPregnancyMore Consumer Professional Managing Side Effects For the Consumer Applies to deoxycholic acid: subcutaneous solution Along with its needed effects, deoxycholic acid may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur while taking deoxycholic acid: Less Common Headache muscle weakness in the face pain in the mouth or throat pounding in the ears slow or fast heartbeat trouble swallowing uneven smile Incidence Not Known Blue-green to black skin discoloration cracking of the skin fainting neck pain pain, redness, or sloughing of the skin at the injection site swollen, painful, or tender lymph glands in the neck Some side effects of deoxycholic acid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More Common Bleeding, blistering, bruising, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, rash, scarring, soreness, stinging, swelling, tenderness, tightness of the skin, tingling, or warmth at the injection site Less Common Nausea Incidence Not Known Hair loss at the injection site For Healthcare Professionals Applies to deoxycholic acid: subcutaneous solution Gastrointestinal Common (1% to 10%): Oropharyngeal pain, nausea, dysphagia[Ref] Local Very common (10% or more): Injection site reactions (96%): edema/swelling (87%), hematoma/bruising (72%), pain (70%), numbness (66%), erythema (27%), induration (23%), paresthesia (14%), nodule (13%), pruritus (12%), Common (1% to 10%): Injection site reactions: skin tightness, site warmth, marginal mandibular nerve injury Frequency not reported: Injection site reactions: hemorrhage, discoloration, urticaria[Ref] Cardiovascular Common (1% to 10%): Hypertension[Ref] Hematologic Frequency not reported: Lymphadenopathy[Ref] Musculoskeletal Frequency not reported: Neck pain[Ref] Nervous system Common (1% to 10%): Headache Frequency not reported: Pre-syncope/syncope[Ref] References 1. "Product Information. Kybella (deoxycholic acid)." Kythera Biopharmaceuticals, Inc., Westlake Village, CA. Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Some side effects may not be reported. You may report them to the FDA.
Deoxycholic acid Generic Name: deoxycholic acid (dee OX i KOE lik AS id) Brand Name: Kybella Medically reviewed by Drugs.com on Jun 20, 2018 – Written by Cerner Multum OverviewSide EffectsDosageProfessionalInteractionsPregnancyMore What is deoxycholic acid? Deoxycholic acid is a manmade form of a substance your body makes that helps to absorb fats. Deoxycholic acid works by destroying fat cells where it is injected into the body. Deoxycholic acid is used to help decrease the appearance of fat that hangs below the chin, sometimes called a double-chin. Deoxycholic acid has not been tested for safe use on other areas of the body. Deoxycholic acid may also be used for purposes not listed in this medication guide. Important Information Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Before taking this medicine You should not be treated with deoxycholic acid if you are allergic to it, or if you have: an infection in or around the area to be treated. Tell your doctor if you have ever had: surgery or other cosmetic treatments on your neck, chin, or face (or if you plan to have surgery on any of these areas); trouble swallowing; a thyroid disorder; swollen lymph glands in your neck; or a bleeding or blood clotting disorder such as hemophilia. It is not known whether deoxycholic acid will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk. Deoxycholic acid is not approved for use by anyone younger than 18 years old. How is deoxycholic acid given? Deoxycholic acid is injected under the skin directly into the area beneath your chin. A healthcare provider will give you this injection. You may be treated with a topical numbing medicine or an ice pack to ease pain and make you comfortable during the injections. Deoxycholic acid must be given in a series of up to 6 treatment sessions in order to be effective. You may receive up to 50 injections at each session. Each treatment session should be spaced no less than 1 month apart. Many people have had visible results after 2 to 4 sessions. Your doctor will determine the right number of injections and how many sessions you need, depending on the results you want. What happens if I miss a dose? Call your doctor for instructions if you miss an appointment for your deoxycholic acid injection. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid after receiving deoxycholic acid? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Deoxycholic acid side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: trouble swallowing; weak muscles in your face; a crooked smile; open skin sores or drainage around treated areas; or pain, burning, irritation, or skin changes where the injection was given. Common side effects may include: numbness or hardening of treated areas; hair loss around treated areas; or swelling, bruising, redness, or tenderness of treated areas. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. See also: Deoxycholic acid side effects (in more detail) Deoxycholic acid dosing information Usual Adult Dose for Submental Fat Reduction: Area-adjusted dose of 2 mg/cm2 injected subcutaneously into fat tissue in the submental area. Comments: -A single treatment consists of up to a maximum of 50 injections, 0.2 mL each (up to a total of 10 mL), spaced 1-cm apart. -Up to 6 single treatments may be administered at intervals no less than 1 month apart. -The number of injections and the number of treatments should be tailored to the individual patient's submental fat distribution and treatment goals. Use: Improvement in the appearance of moderate to severe convexity or fullness associated with submental fat. What other drugs will affect deoxycholic acid? Tell your doctor about all your other medicines, especially: a blood thinner--warfarin, Coumadin, Jantoven; or any other medicines to prevent blood clots. This list is not complete. Other drugs may affect deoxycholic acid, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here. See also: Deoxycholic acid drug interactions (in more detail) Further information Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Copyright 1996-2018 Cerner Multum, Inc. Version: 2.01.
Molar mass: 392.572 g/mol
Formula: C24H40O4
Solubility in water: 0.024%
Melting point: 174–176 °C (345–349 °F; 447–449 K)
Acidity (pKa): 6.58
ATC code: D11AX24 (WHO)
Deoxycholic acid Side Effects Medically reviewed by Drugs.com. Last updated on Feb 21, 2019. OverviewSide EffectsDosageProfessionalInteractionsPregnancyMore Consumer Professional Managing Side Effects For the Consumer Applies to deoxycholic acid: subcutaneous solution Along with its needed effects, deoxycholic acid may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur while taking deoxycholic acid: Less Common Headache muscle weakness in the face pain in the mouth or throat pounding in the ears slow or fast heartbeat trouble swallowing uneven smile Incidence Not Known Blue-green to black skin discoloration cracking of the skin fainting neck pain pain, redness, or sloughing of the skin at the injection site swollen, painful, or tender lymph glands in the neck Some side effects of deoxycholic acid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More Common Bleeding, blistering, bruising, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, rash, scarring, soreness, stinging, swelling, tenderness, tightness of the skin, tingling, or warmth at the injection site Less Common Nausea Incidence Not Known Hair loss at the injection site For Healthcare Professionals Applies to deoxycholic acid: subcutaneous solution Gastrointestinal Common (1% to 10%): Oropharyngeal pain, nausea, dysphagia[Ref] Local Very common (10% or more): Injection site reactions (96%): edema/swelling (87%), hematoma/bruising (72%), pain (70%), numbness (66%), erythema (27%), induration (23%), paresthesia (14%), nodule (13%), pruritus (12%), Common (1% to 10%): Injection site reactions: skin tightness, site warmth, marginal mandibular nerve injury Frequency not reported: Injection site reactions: hemorrhage, discoloration, urticaria[Ref] Cardiovascular Common (1% to 10%): Hypertension[Ref] Hematologic Frequency not reported: Lymphadenopathy[Ref] Musculoskeletal Frequency not reported: Neck pain[Ref] Nervous system Common (1% to 10%): Headache Frequency not reported: Pre-syncope/syncope[Ref] References 1. "Product Information. Kybella (deoxycholic acid)." Kythera Biopharmaceuticals, Inc., Westlake Village, CA. Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Some side effects may not be reported. You may report them to the FDA.
Deoxycholic acid Generic Name: deoxycholic acid (dee OX i KOE lik AS id) Brand Name: Kybella Medically reviewed by Drugs.com on Jun 20, 2018 – Written by Cerner Multum OverviewSide EffectsDosageProfessionalInteractionsPregnancyMore What is deoxycholic acid? Deoxycholic acid is a manmade form of a substance your body makes that helps to absorb fats. Deoxycholic acid works by destroying fat cells where it is injected into the body. Deoxycholic acid is used to help decrease the appearance of fat that hangs below the chin, sometimes called a double-chin. Deoxycholic acid has not been tested for safe use on other areas of the body. Deoxycholic acid may also be used for purposes not listed in this medication guide. Important Information Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Before taking this medicine You should not be treated with deoxycholic acid if you are allergic to it, or if you have: an infection in or around the area to be treated. Tell your doctor if you have ever had: surgery or other cosmetic treatments on your neck, chin, or face (or if you plan to have surgery on any of these areas); trouble swallowing; a thyroid disorder; swollen lymph glands in your neck; or a bleeding or blood clotting disorder such as hemophilia. It is not known whether deoxycholic acid will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk. Deoxycholic acid is not approved for use by anyone younger than 18 years old. How is deoxycholic acid given? Deoxycholic acid is injected under the skin directly into the area beneath your chin. A healthcare provider will give you this injection. You may be treated with a topical numbing medicine or an ice pack to ease pain and make you comfortable during the injections. Deoxycholic acid must be given in a series of up to 6 treatment sessions in order to be effective. You may receive up to 50 injections at each session. Each treatment session should be spaced no less than 1 month apart. Many people have had visible results after 2 to 4 sessions. Your doctor will determine the right number of injections and how many sessions you need, depending on the results you want. What happens if I miss a dose? Call your doctor for instructions if you miss an appointment for your deoxycholic acid injection. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid after receiving deoxycholic acid? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Deoxycholic acid side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: trouble swallowing; weak muscles in your face; a crooked smile; open skin sores or drainage around treated areas; or pain, burning, irritation, or skin changes where the injection was given. Common side effects may include: numbness or hardening of treated areas; hair loss around treated areas; or swelling, bruising, redness, or tenderness of treated areas. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. See also: Deoxycholic acid side effects (in more detail) Deoxycholic acid dosing information Usual Adult Dose for Submental Fat Reduction: Area-adjusted dose of 2 mg/cm2 injected subcutaneously into fat tissue in the submental area. Comments: -A single treatment consists of up to a maximum of 50 injections, 0.2 mL each (up to a total of 10 mL), spaced 1-cm apart. -Up to 6 single treatments may be administered at intervals no less than 1 month apart. -The number of injections and the number of treatments should be tailored to the individual patient's submental fat distribution and treatment goals. Use: Improvement in the appearance of moderate to severe convexity or fullness associated with submental fat. What other drugs will affect deoxycholic acid? Tell your doctor about all your other medicines, especially: a blood thinner--warfarin, Coumadin, Jantoven; or any other medicines to prevent blood clots. This list is not complete. Other drugs may affect deoxycholic acid, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here. See also: Deoxycholic acid drug interactions (in more detail) Further information Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Copyright 1996-2018 Cerner Multum, Inc. Version: 2.01.
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου