Experimental Brain Research

Correction to: The disengagement of visual attention in the gap paradigm across adolescence In the manuscript, we write that saccadic reaction time was determined as the time between the offset of the last fixation on the central stimulus and the onset of the peripheral stimulus (the target).

Superconditioning TMS for examining upper motor neuron function in MND Abstract We used transcranial magnetic stimulation (TMS) of motor cortex, including a novel four-pulse superconditioning (TMSsc) paradigm, in repeated examinations of motor-evoked potentials (MEPs) in eight subjects with motor neuron disease (MND), including seven with amyotrophic lateral sclerosis (ALS). The goals were: (1) to look for evidence of cortical hyperexcitability, including a reduction in short-interval intracortical inhibition (SICI); and (2) to examine the utility of using TMSsc for quantifying upper motor neuron function during MND progression. Testing of abductor pollicis brevis (APB) and tibialis anterior (TA) muscles bilaterally was carried out every 3 months in MND subjects for up to 2 years; results were compared to those from a cohort of 15 control subjects. Measures of SICI were not significantly different between control and MND subjects for either APB or TA muscles. Other measures of cortical excitability, including TMS threshold and MEP amplitude, were consistent with lowered cortical excitability in MND subjects. Certain combinations of superconditioning TMS were capable of causing stronger inhibition or facilitation of MEPs compared to dual-pulse TMS, for both APB and TA target muscles. Moreover, there were multiple cases in which target muscles unresponsive to strong single-pulse TMS, whether at rest or when tested with an active contraction, showed an MEP in response to TMSsc optimized for facilitation. Our findings suggest that a multi-faceted neurophysiologic protocol for examining upper motor neuron function in MND subjects might benefit from inclusion of TMSsc testing.

Auditory pitch glides influence time-to-contact judgements of visual stimuli Abstract A common experimental task used to study the accuracy of estimating when a moving object arrives at a designated location is the time-to-contact (TTC) task. The previous studies have shown evidence that sound motion cues influence TTC estimates of a visual moving object. However, the extent to which sound can influence TTC of visual targets still remains unclear. Some studies on the crossmodal correspondence between pitch and speed suggest that descending pitch sounds are associated with faster speeds compared to ascending pitch sounds due to an internal model of gravity. Other studies have shown an opposite pitch-speed mapping (i.e., ascending pitch associated with faster speeds) and no influence of gravity heuristics. Here, we explored whether auditory pitch glides, a continuous pure tone sound either ascending or descending in pitch, influence TTC estimates of a vertically moving visual target and if any observed effects are consistent with a gravity-centered or gravity-unrelated pitch-speed mapping. Subjects estimated when a disc moving either upward or downward at a constant speed reached a visual landmark after the disc disappeared behind an occluder under three conditions: with an accompanying ascending pitch glide, with a descending pitch glide, or with no sound. Overall, subjects underestimated TTC with ascending pitch glides and overestimated TTC with descending pitch glides, compared to the no-sound condition. These biases in TTC were consistent in both disc motion directions. These results suggest that subjects adopted a gravity-unrelated pitch-speed mapping where ascending pitch is associated with faster speeds and descending pitch associated with slower speeds.

The effects of conditioning startling acoustic stimulation (SAS) on the corticospinal motor system: a SAS–TMS study Abstract A startling acoustic stimulus (SAS) could cause transient effects on the primary motor cortex and its descending tracts after habituation of reflex responses. In the literature, there is evidence that the effects of SAS depend on the status of M1 excitability and delivery time of SAS. In this study, we aimed to comprehensively investigate the effects of SAS on the excitability of primary motor cortex. Eleven healthy subjects participated in this study. Transcranial magnetic stimulation (TMS) was delivered to the hot spot for left biceps at rest and during isometric right elbow flexion (10, 30, and 60% of their maximum voluntary contraction, MVC). There were three SAS conditions: (1) No SAS; (2) SAS was delivered 50 ms prior to TMS (SAS50); (3) SAS 90 ms prior to TMS (SAS90). For each subject, the induced MEP amplitude was normalized to the largest response at rest with No SAS. Two-way ANOVAs (4 force levels × 3 SAS conditions) with repeated measures were used to determine the differences under different conditions. For the MEP amplitude, there were significant force level effect and FORCE LEVEL × SAS interactions. Specifically, the MEP amplitude increased with force level. Furthermore, post hoc analysis showed that the MEP amplitude reduced during SAS50 and SAS90 compared to No SAS only at rest. Our results provide evidence that a conditioning SAS causes a transient suppression of the corticospinal excitability at rest when it is delivered 50 ms and 90 ms prior to TMS. However, a conditioning SAS has no effect when the corticospinal excitability is already elevated with an external visual target.

Dynamic bimanual force control in chronic stroke: contribution of non-paretic and paretic hands Abstract Dynamic force modulation is critical for performing skilled bimanual tasks. Unilateral motor impairments after stroke contribute to asymmetric hand function. Here, we investigate the impact of stroke on dynamic bimanual force control and compare the contribution of each hand to a bimanual task. Thirteen chronic stroke and thirteen healthy control participants performed bimanual, isometric finger flexion during visually guided, force tracking of a trapezoidal trajectory with force increment and decrement phases. We quantified the accuracy and variability of total force from both hands. Individual hand contribution was quantified with the proportion of force contributed to total force and force variability of each hand. The total force output was 53.10% less accurate and 56% more variable in the stroke compared with the control group. The variability of total force was 91.10% greater in force decrement than increment phase. In stroke group, the proportion of force and force variability contributed by each hand differed across the two phases. During force decrement, the proportion of force contributed by the non-paretic hand reduced and force variability of the non-paretic hand increased, compared with the increment phase. The control group showed no differences in each hand’s contribution across the two force phases. In conclusion, dynamic bimanual force modulation is impaired after stroke, with greater deficits in force decrement than force increment. The non-paretic and paretic hands adapt differentially to dynamic bimanual task constraints. During force decrement, the non-paretic hand preferentially assumes force modulation, while the paretic hand produces steady force to meet the force requirements.

Diffusion modeling of interference and decay in auditory short-term memory Abstract Decay and interference are two leading proposals for the cause of forgetting from working and/or short-term memory, and mathematical models of both processes exist. In the present study, we apply a computational model to data from a simple short-term memory task and demonstrate that decay and interference can co-occur in the same experimental paradigm, and that neither decay nor interference alone can account for all cases of forgetting.

Neural entrainment is associated with subjective groove and complexity for performed but not mechanical musical rhythms Abstract Both movement and neural activity in humans can be entrained by the regularities of an external stimulus, such as the beat of musical rhythms. Neural entrainment to auditory rhythms supports temporal perception, and is enhanced by selective attention and by hierarchical temporal structure imposed on rhythms. However, it is not known how neural entrainment to rhythms is related to the subjective experience of groove (the desire to move along with music or rhythm), the perception of a regular beat, the perception of complexity, and the experience of pleasure. In two experiments, we used musical rhythms (from Steve Reich’s Clapping Music) to investigate whether rhythms that are performed by humans (with naturally variable timing) and rhythms that are mechanical (with precise timing), elicit differences in (1) neural entrainment, as measured by inter-trial phase coherence, and (2) subjective ratings of the complexity, preference, groove, and beat strength of rhythms. We also combined results from the two experiments to investigate relationships between neural entrainment and subjective perception of musical rhythms. We found that mechanical rhythms elicited a greater degree of neural entrainment than performed rhythms, likely due to the greater temporal precision in the stimulus, and the two types only elicited different ratings for some individual rhythms. Neural entrainment to performed rhythms, but not to mechanical ones, correlated with subjective desire to move and subjective complexity. These data, therefore, suggest multiple interacting influences on neural entrainment to rhythms, from low-level stimulus properties to high-level cognition and perception.

Corticospinal excitability changes following downhill and uphill walking Abstract Locomotor exercise may induce corticospinal excitability and/or cortical inhibition change in the knee extensors. This study investigated whether the mode of muscle contraction involved during a locomotor exercise modulates corticospinal and intracortical responsiveness. Eleven subjects performed two 45-min treadmill walking exercises in an uphill (+ 15%) or a downhill (− 15%) condition matched for speed. Maximal voluntary isometric torque (MVIC), voluntary activation level (VAL), doublet (Dt) twitch torque, and M-wave area of the knee extensors were assessed before and after exercise. At the same time-points, motor-evoked potential (MEP), cortical silent period (CSP), and short-interval cortical inhibition (SICI) were recorded in the vastus lateralis (VL) and rectus femoris (RF) muscles. After exercise, uphill and downhill conditions induced a similar loss in MVIC torque (− 9%; p < 0.001), reduction in VAL (− 7%; p < 0.001), and in M-wave area in the VL muscle (− 8%; p < 0.001). Dt twitch torque decreased only after the downhill exercise (− 11%; p < 0.001). MEP area of the VL muscle increased after the downhill condition (p = 0.007), with no change after the uphill condition. MEP area of the RF muscle remained stable after exercises. CSP and SICI did not change in the two conditions for both muscles. Downhill walking induces an increase in MEP area of the VL muscle, with no change of the CSP duration or SICI ratio. The eccentric mode of muscle contraction during a locomotor exercise can modulate specifically corticospinal excitability in the knee extensors.

Spatial and temporal influences on discrimination of vibrotactile stimuli on the arm Abstract Body–machine interfaces (BMIs) provide a non-invasive way to control devices. Vibrotactile stimulation has been used by BMIs to provide performance feedback to the user, thereby reducing visual demands. To advance the goal of developing a compact, multivariate vibrotactile display for BMIs, we performed two psychophysical experiments to determine the acuity of vibrotactile perception across the arm. The first experiment assessed vibration intensity discrimination of sequentially presented stimuli within four dermatomes of the arm (C5, C7, C8, and T1) and on the ulnar head. The second experiment compared vibration intensity discrimination when pairs of vibrotactile stimuli were presented simultaneously vs. sequentially within and across dermatomes. The first experiment found a small but statistically significant difference between dermatomes C7 and T1, but discrimination thresholds at the other three locations did not differ. Thus, while all tested dermatomes of the arm and hand could serve as viable sites of vibrotactile stimulation for a practical BMI, ideal implementations should account for small differences in perceptual acuity across dermatomes. The second experiment found that sequential delivery of vibrotactile stimuli resulted in better intensity discrimination than simultaneous delivery, independent of whether the pairs were located within the same dermatome or across dermatomes. Taken together, our results suggest that the arm may be a viable site to transfer multivariate information via vibrotactile feedback for body–machine interfaces. However, user training may be needed to overcome the perceptual disadvantage of simultaneous vs. sequentially presented stimuli.

Critical thinking and regional gray matter volume interact to predict representation connection in scientific problem solving Abstract Representation connection (RC) is a stable ability that significantly predicts the accuracy of scientific innovation problem solving while critical thinking has been strongly related to problem solving. However, the neural mechanisms underlying this relationship have not been assessed. Using voxel-based morphometry (VBM) and scientific innovation problem solving materials, we investigated the correlation between RC and regional gray matter volume (rGMV) in healthy young participants. We found that RC was positively correlated with rGMV in the right superior temporal gyrus (STG) and in a cluster in the left medial frontal gyrus (MFG). These results indicate that increased rGMV in the right STG may lead to the ability to overcome misdirection more easily, which may result in better semantic integration of the “certain construction” of heuristic prototypes. Increased rGMV in the left MFG may be associated with forming novel associations and retrieving matched unsolved technical problems from memory. Further analysis revealed that the interaction between critical thinking and rGMV predicted RC in insightful problem solving, and found that higher rGMV was correlated with higher RC in participants with lower cognitive maturity, but not in participants with higher cognitive maturity. These findings suggest that rGMV could interact with cognitive maturity to modulate RC in insightful problem solving.