Filgotinib for Treatment-Resistant Rheumatoid Arthritis, Intensive vs Standard Glucose Management in Acute Stroke, Neuroimaging Finding in US Cuban Government Personnel, and more

ORIGINAL INVESTIGATION

Effect of Filgotinib vs Placebo on Clinical Response in Patients With Moderate to Severe Rheumatoid Arthritis Refractory to Disease-Modifying Antirheumatic Drug Therapy: The FINCH 2 Randomized Clinical Trial

Mark C. Genovese, MD; Kenneth Kalunian, MD; Jacques-Eric Gottenberg, MD, PhD; et al.

Earn CME credit

Editorial: Filgotinib, a JAK1 Inhibitor, for Treatment-Resistant Rheumatoid Arthritis; Jasvinder A. Singh, MBBS, MPH

Intensive vs Standard Treatment of Hyperglycemia and Functional Outcome in Patients With Acute Ischemic Stroke: The SHINE Randomized Clinical Trial

Karen C. Johnston, MD; Askiel Bruno, MD; Qi Pauls, MS; et al.

Neuroimaging Findings in US Government Personnel With Possible Exposure to Directional Phenomena in Havana, Cuba

Ragini Verma, PhD; Randel L. Swanson, DO, PhD; Drew Parker, BS; et al.

Editorial: Neurological Symptoms Among US Diplomats in Cuba; Christopher C. Muth, MD; Steven L. Lewis, MD

Editor's Note: Advanced Neuroimaging Findings in US Government Personnel With Possible Directional Phenomenon Exposure in Havana, Cuba; Christopher C. Muth, MD; Phil B. Fontanarosa, MD, MBA

Audio: Medical Findings In U.S. Government Personnel Reporting Symptoms After Exposure To Sensory Phenomena in Havana, Cuba

RESEARCH LETTER

Screening for Hepatitis B Infection in Pregnant Women: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

Jillian T. Henderson, PhD, MPH; Elizabeth M. Webber, MS; Sarah I. Bean, MPH

Audio Interview: Screening for Hepatitis B Virus Infection in Pregnant Women

Editorial: Hepatitis B Screening in Pregnant Women: A Perspective on the New USPSTF Recommendations; Neil S. Silverman, MD

Characteristics of Hospitals That Did and Did Not Join the Bundled Payments for Care Improvement–Advanced Program

Karen E. Joynt Maddox, MD, MPH; E. John Orav, PhD; Jie Zheng, PhD; et al.

US PREVENTIVE SERVICES TASK FORCE

Recommendation Statement

Screening for Hepatitis B Virus Infection in Pregnant Women: US Preventive Services Task Force Reaffirmation Recommendation Statement

US Preventive Services Task Force

Earn CME credit

Audio Interview: Screening for Hepatitis B Virus Infection in Pregnant Women

Editorial: Hepatitis B Screening in Pregnant Women: A Perspective on the New USPSTF Recommendations; Neil S. Silverman, MD

VIEWPOINT

Health Policy

Pharmacy Benefit Manager Reform: Lessons From Ohio

Trevor J. Royce, MD, MS, MPH; Sheetal Kircher, MD, MS; Rena M. Conti, PhD

A Practical Approach to Low-Dose Aspirin for Primary Prevention

Kim F. Chiang, MD; Shreya J. Shah, MD; Randall S. Stafford, MD, PhD

Audio Interview: A Practical Approach to Low-Dose Aspirin for Primary Prevention

Editorial: Aspirin for Primary Prevention: Clinical Considerations in 2019; J. Michael Gaziano, MD, MPH

Realignment of EMS Reimbursement Policy: New Hope for Patient-Centered Out-of-Hospital Care

Kevin G. Munjal, MD, MPH, MSCR; Gregg S. Margolis, PhD, NRP; Arthur L. Kellermann, MD, MPH

Incorporating Patient Preferences in Noninferiority Trials

Sergio A. Acuna, MD, PhD; Tyler R. Chesney, MD, MSc; Nancy N. Baxter, MD, PhD

A PIECE OF MY MIND

Comic Relief

Emily Silverman, MD

EDITORIAL

Filgotinib, a JAK1 Inhibitor, for Treatment-Resistant Rheumatoid Arthritis

Jasvinder A. Singh, MBBS, MPH

Hepatitis B Screening in Pregnant Women: A Perspective on the New USPSTF Recommendations

Neil S. Silverman, MD

JAMA INSIGHTS

Clinical Update

Management of Hepatitis C in 2019

Kristen Marks, MD; Susanna Naggie, MD

JAMA CLINICAL CHALLENGE

Oral and Penile Lesions in a Young Man

Gordon T. Moffat, MD; Franco Falcone, MD

Earn CME credit

EDITOR'S NOTE

Advanced Neuroimaging Findings in US Government Personnel With Possible Directional Phenomenon Exposure in Havana, Cuba

Christopher C. Muth, MD; Phil B. Fontanarosa, MD, MBA

MEDICAL NEWS & PERSPECTIVES

Wide Interest in a Vitamin C Drug Cocktail for Sepsis Despite Lagging Evidence

Rita Rubin, MA

Audio: JAMA Medical News Summary for July 2019

Uncovering a Link Between the Appendix and Parkinson Disease Risk

Rita Rubin, MA

NEWS FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION

Surviving Cancer Costs

Bridget Kuehn, MSJ

Breast Milk for Preemies

Bridget Kuehn, MSJ

CLINICAL TRIALS UPDATE

Preventing Cardiotoxicity Associated With Breast Cancer Therapy

Anita Slomski, MA

Esketamine Nasal Spray Effective in Treatment-Resistant Depression

Anita Slomski, MA

Yoga for Anxiety and Depression Associated With Parkinson Disease

Anita Slomski, MA

Antibiotics Prevented Maternal Infections After Vaginal Delivery

Anita Slomski, MA

Progesterone and Early Pregnancy Bleeding

Anita Slomski, MA

HEALTH AGENCIES UPDATE

Task Force to Prevent Veteran Suicides

Rita Rubin, MA

Cancer Mortality Continues to Decline

Rita Rubin, MA

NIH Director Takes Stand Against “Manels”

Rita Rubin, MA

POETRY AND MEDICINE

Next of Kin

Pavlos Theodorou, MBBS

JAMA REVISITED

Smile and Say “Cheese”

JAMA PATIENT PAGE

Screening for Hepatitis B in Pregnant Women

Jill Jin, MD, MPH

Editorial: Hepatitis B Screening in Pregnant Women: A Perspective on the New USPSTF Recommendations; Neil S. Silverman, MD

AUDIO

Audio Summary

Filgotinib for Treatment-Resistant Rheumatoid Arthritis, Intensive vs Standard Glucose Management in Acute Stroke, Neuroimaging Finding in US Cuban Government Personnel, and more

Audio

Medical Findings In U.S. Government Personnel Reporting Symptoms After Exposure To Sensory Phenomena in Havana, Cuba

Audio Interview

Screening for Hepatitis B Virus Infection in Pregnant Women

Audio Interview

A Practical Approach to Low-Dose Aspirin for Primary Prevention

Audio

JAMA Medical News Summary for July 2019

COMMENT & RESPONSE

Improving Usability of Health Information Technology

Matthew E. Hirschtritt, MD, MPH; Deirdre B. Hirschtritt, MSI

Improving Usability of Health Information Technology—Reply

Raj M. Ratwani, PhD; Jacob Reider, MD; Hardeep Singh, MD, MPH

Multinutrient Supplementation for Prevention of Major Depressive Disorder in Overweight Adults

Julia J. Rucklidge, PhD; Alexandra J. Richardson, PhD

Multinutrient Supplementation for Prevention of Major Depressive Disorder in Overweight Adults—Reply

Ingeborg A. Brouwer, PhD; Brenda W. H. J. Penninx, PhD; Marjolein Visser, PhD

Collaborative Care for Adults With Obesity and Depression

Calum D. Moulton, MRCPsych; Thahesh Tharmaraja, BSc(Hons); Christopher W. P. Hopkins, MRCPsych

Collaborative Care for Adults With Obesity and Depression—Reply

Jun Ma, MD, PhD; Elizabeth M. Venditti, PhD; Mark B. Snowden, MD, MPH

CORRECTION

Data Errors and Incorrect Version of Clinical Prediction Tool Used

Unclear Statement

JAMA MASTHEAD

JAMA