IJMS, Vol. 20, Pages 3700: Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis of Neuroblastoma Cells International Journal of Molecular Sciences doi: 10.3390/ijms20153700 Authors: Kiyohiro Ando Yohko Nakamura Hiroki Nagase Akira Nakagawara Tsugumichi Koshinaga Satoshi Wada Makoto Makishima Checkpoint kinase 1 (CHK1) is a central mediator of the DNA damage response (DDR) at the S and G2/M cell cycle checkpoints, and plays a crucial role in preserving...
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IJMS, Vol. 20, Pages 3698: Fluorescence Enhancement Effect of TiO2 Nanoparticles and Application for Photodynamic Diagnosis International Journal of Molecular Sciences doi: 10.3390/ijms20153698 Authors: Koki Kanehira Yukiko Yano Hisashi Hasumi Hideo Fukuhara Keiji Inoue Kazuhiro Hanazaki Masahiro Yao Photodynamic diagnosis (PDD) can improve diagnostic accuracy by using PDD agents such as 5-aminolevulinic acid (ALA). However, the weakness and photobleaching of fluorescence...
Sun Jul 28, 2019 03:00
IJMS, Vol. 20, Pages 3697: Large Aberration Correction by Magnetic Fluid Deformable Mirror with Model-Based Wavefront Sensorless Control Algorithm International Journal of Molecular Sciences doi: 10.3390/ijms20153697 Authors: Xiang Wei Yuanyuan Wang Zhan Cao Dziki Mbemba Azhar Iqbal Zhizheng Wu Magnetic fluid is a stable colloidal suspension of nano-sized, single-domain ferri/ferromagnetic particles dispersed in a liquid carrier. The liquid can be magnetized by the ferromagnetic...
Sun Jul 28, 2019 03:00
IJMS, Vol. 20, Pages 3699: Cell Autonomous Dysfunction and Insulin Resistance in Pancreatic α Cells International Journal of Molecular Sciences doi: 10.3390/ijms20153699 Authors: Norikiyo Honzawa Kei Fujimoto Tadahiro Kitamura To date, type 2 diabetes is considered to be a “bi-hormonal disorder” rather than an “insulin-centric disorder,” suggesting that glucagon is as important as insulin. Although glucagon increases hepatic glucose production...
Sun Jul 28, 2019 03:00
IJMS, Vol. 20, Pages 3693: A Novel CreA-Mediated Regulation Mechanism of Cellulase Expression in the Thermophilic Fungus Humicola insolens International Journal of Molecular Sciences doi: 10.3390/ijms20153693 Authors: Xinxin Xu Chao Fan Liya Song Jinyang Li Yuan Chen Yuhong Zhang Bo Liu Wei Zhang The thermophilic fungus Humicola insolens produces cellulolytic enzymes that are of great scientific and commercial interest; however, few reports have focused on its cellulase...
Sun Jul 28, 2019 03:00
IJMS, Vol. 20, Pages 3696: Downregulation of STAT3, β-Catenin, and Notch-1 by Single and Combinations of siRNA Treatment Enhance Chemosensitivity of Wild Type and Doxorubicin Resistant MCF7 Breast Cancer Cells to Doxorubicin International Journal of Molecular Sciences doi: 10.3390/ijms20153696 Authors: Walhan Alshaer Dana A. Alqudah Suha Wehaibi Duaa Abuarqoub Malek Zihlif Ma’mon M. Hatmal Abdalla Awidi Combinatorial therapeutic strategies using siRNA and small molecules...
Sun Jul 28, 2019 03:00
IJMS, Vol. 20, Pages 3694: The Role of Sodium Hydrogen Exchanger 1 in Dysregulation of Proton Dynamics and Reprogramming of Cancer Metabolism as a Sequalae International Journal of Molecular Sciences doi: 10.3390/ijms20153694 Authors: Rosa Angela Cardone Khalid Omer Alfarouk Robert L. Elliott Saad Saaed Alqahtani Samrein B. M. Ahmed Ahmed N. Aljarbou Maria Raffaella Greco Stefania Cannone Stephan Joel Reshkin Cancer cells have an unusual regulation of hydrogen...
Sun Jul 28, 2019 03:00
IJMS, Vol. 20, Pages 3695: Role of the Monocyte–Macrophage System in Normal Pregnancy and Preeclampsia International Journal of Molecular Sciences doi: 10.3390/ijms20153695 Authors: Polina Vishnyakova Andrey Elchaninov Timur Fatkhudinov Gennady Sukhikh The proper functioning of the monocyte–macrophage system, an important unit of innate immunity, ensures the normal course of pregnancy. In this review, we present the current data on the origin of the monocyte–macrophage...
Sun Jul 28, 2019 03:00
IJMS, Vol. 20, Pages 3692: Affinities of Terminal Inverted Repeats to DNA Binding Domain of Transposase Affect the Transposition Activity of Bamboo Ppmar2 Mariner-Like Element International Journal of Molecular Sciences doi: 10.3390/ijms20153692 Authors: Muthusamy Ramakrishnan Mingbing Zhou Chunfang Pan Heikki Hänninen Kim Yrjälä Kunnummal Kurungara Vinod Dingqin Tang Mariner-like elements (MLE) are a super-family of DNA transposons widespread in animal and plant genomes....
Sun Jul 28, 2019 03:00
IJMS, Vol. 20, Pages 3691: Extracellular Vesicle-Induced Differentiation of Neural Stem Progenitor Cells International Journal of Molecular Sciences doi: 10.3390/ijms20153691 Authors: Eleonora Stronati Roberta Conti Emanuele Cacci Silvia Cardarelli Stefano Biagioni Giancarlo Poiana Neural stem progenitor cells (NSPCs) from E13.5 mouse embryos can be maintained in culture under proliferating conditions. Upon growth-factor removal, they may differentiate toward either neuronal...
Sat Jul 27, 2019 03:00
IJMS, Vol. 20, Pages 3689: CRISPR/Cas Applications in Myotonic Dystrophy: Expanding Opportunities International Journal of Molecular Sciences doi: 10.3390/ijms20153689 Authors: Renée H.L. Raaijmakers Lise Ripken C. Rosanne M. Ausems Derick G. Wansink CRISPR/Cas technology holds promise for the development of therapies to treat inherited diseases. Myotonic dystrophy type 1 (DM1) is a severe neuromuscular disorder with a variable multisystemic character for which no cure is yet...
Sat Jul 27, 2019 03:00
IJMS, Vol. 20, Pages 3686: Design and Characterization of Chitosan Nanoformulations for the Delivery of Antifungal Agents International Journal of Molecular Sciences doi: 10.3390/ijms20153686 Authors: Natalia L. Calvo Sruthi Sreekumar Laura A. Svetaz María C. Lamas Bruno M. Moerschbacher Darío Leonardi Among different Candida species triggering vaginal candidiasis, Candida albicans is the most predominant yeast. It is commonly treated using azole drugs such as Tioconazole...
Sat Jul 27, 2019 03:00
IJMS, Vol. 20, Pages 3687: Activation of Adrenal Steroidogenesis and an Improvement of Mood Balance in Postmenopausal Females after Spa Treatment Based on Physical Activity International Journal of Molecular Sciences doi: 10.3390/ijms20153687 Authors: Pavla Honců Martin Hill Marie Bičíková Dobroslava Jandová Marta Velíková Jiří Kajzar Lucie Kolátorová Jiří Bešťák Ludmila Máčová Radmila Kancheva Milada Krejčí Jaroslav Novotný Ľuboslav Stárka Spa treatment...
Sat Jul 27, 2019 03:00
IJMS, Vol. 20, Pages 3688: Association between Lysosomal Dysfunction and Obesity-Related Pathology: A Key Knowledge to Prevent Metabolic Syndrome International Journal of Molecular Sciences doi: 10.3390/ijms20153688 Authors: Yuhei Mizunoe Masaki Kobayashi Ryoma Tagawa Yoshimi Nakagawa Hitoshi Shimano Yoshikazu Higami Obesity causes various health problems, such as type 2 diabetes, non-alcoholic fatty liver disease, and cardio- and cerebrovascular diseases. Metabolic organs,...
Sat Jul 27, 2019 03:00
IJMS, Vol. 20, Pages 3690: Gene–Environment Interactions on Body Fat Distribution International Journal of Molecular Sciences doi: 10.3390/ijms20153690 Authors: Xiang Li Lu Qi The prevalence of obesity has been increasing markedly in the U.S. and worldwide in the past decades; and notably, the obese populations are signified by not only the overall elevated adiposity but also particularly harmful accumulation of body fat in the central region of the body, namely, abdominal obesity....
Sat Jul 27, 2019 03:00
IJMS, Vol. 20, Pages 3685: Partial Failure of Proteostasis Systems Counteracting TDP-43 Aggregates in Neurodegenerative Diseases International Journal of Molecular Sciences doi: 10.3390/ijms20153685 Authors: Roberta Cascella Giulia Fani Alessandra Bigi Fabrizio Chiti Cristina Cecchi Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are progressive and fatal neurodegenerative disorders showing mislocalization and cytosolic accumulation of TDP-43...
Sat Jul 27, 2019 03:00
IJMS, Vol. 20, Pages 3684: Interrogating the Essential Bacterial Cell Division Protein FtsQ with Fragments Using Target Immobilized NMR Screening (TINS) International Journal of Molecular Sciences doi: 10.3390/ijms20153684 Authors: Marjolein Glas Eiso AB Johan Hollander Gregg Siegal Joen Luirink Iwan de Esch The divisome is a large protein complex that regulates bacterial cell division and therefore represents an attractive target for novel antibacterial drugs. In this...
Sat Jul 27, 2019 03:00
IJMS, Vol. 20, Pages 3683: Arachidonic Acid Metabolism and Kidney Inflammation International Journal of Molecular Sciences doi: 10.3390/ijms20153683 Authors: Tianqi Wang Xianjun Fu Qingfa Chen Jayanta Kumar Patra Dongdong Wang Zhenguo Wang Zhibo Gai As a major component of cell membrane lipids, Arachidonic acid (AA), being a major component of the cell membrane lipid content, is mainly metabolized by three kinds of enzymes: cyclooxygenase (COX), lipoxygenase (LOX),...
Sat Jul 27, 2019 03:00
IJMS, Vol. 20, Pages 3681: Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation International Journal of Molecular Sciences doi: 10.3390/ijms20153681 Authors: Bi-He Cai Chung-Faye Chao Hsiang-Chi Huang Hsueh-Yi Lee Reiji Kannagi Jang-Yi Chen The p53 canonical consensus sequence is a 10-bp repeat of PuPuPuC(A/T)(A/T)GPyPyPy, separated by a spacer with up to 13 bases. C(A/T)(A/T)G is the core sequence and purine (Pu) and pyrimidine...
Sat Jul 27, 2019 03:00
IJMS, Vol. 20, Pages 3682: LPS-Binding Protein Modulates Acute Renal Fibrosis by Inducing Pericyte-to-Myofibroblast Trans-Differentiation through TLR-4 Signaling International Journal of Molecular Sciences doi: 10.3390/ijms20153682 Authors: Giuseppe Castellano Alessandra Stasi Rossana Franzin Fabio Sallustio Chiara Divella Alessandra Spinelli Giuseppe Stefano Netti Enrico Fiaccadori Vincenzo Cantaluppi Antonio Crovace Francesco Staffieri Luca Lacitignola Giuseppe...
Sat Jul 27, 2019 03:00
IJMS, Vol. 20, Pages 3679: Overexpression of the Oral Mucosa-Specific microRNA-31 Promotes Skin Wound Closure International Journal of Molecular Sciences doi: 10.3390/ijms20153679 Authors: Lin Chen Alyne Simões Zujian Chen Yan Zhao Xinming Wu Yang Dai Luisa A. DiPietro Xiaofeng Zhou Wounds within the oral mucosa are known to heal more rapidly than skin wounds. Recent studies suggest that differences in the microRNAome profiles may underlie the exceptional healing...
Sat Jul 27, 2019 03:00
IJMS, Vol. 20, Pages 3680: The Latest Studies on Lotus (Nelumbo nucifera)-an Emerging Horticultural Model Plant International Journal of Molecular Sciences doi: 10.3390/ijms20153680 Authors: Zhongyuan Lin Cheng Zhang Dingding Cao Rebecca Njeri Damaris Pingfang Yang Lotus (Nelumbo nucifera) is a perennial aquatic basal eudicot belonging to a small family Nelumbonaceace, which contains only one genus with two species. It is an important horticultural plant, with its uses ranging...
Sat Jul 27, 2019 03:00
IJMS, Vol. 20, Pages 3677: Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP International Journal of Molecular Sciences doi: 10.3390/ijms20153677 Authors: Sammel Peters Lokau Scharfenberg Werny Linder Garbers Rose-John Becker-Pauly Interleukin-11 (IL-11) has been associated with inflammatory conditions, bone homeostasis, hematopoiesis, and fertility. So far, these functions have...
Fri Jul 26, 2019 03:00
IJMS, Vol. 20, Pages 3676: GARP as an Immune Regulatory Molecule in the Tumor Microenvironment of Glioblastoma Multiforme International Journal of Molecular Sciences doi: 10.3390/ijms20153676 Authors: Zimmer Kim Sprang Leukel Khafaji Ringel Sommer Tuettenberg Tuettenberg Glycoprotein A repetition predominant (GARP), a specific surface molecule of activated regulatory T cells, has been demonstrated to significantly contribute to tolerance in humans by...
Fri Jul 26, 2019 03:00
IJMS, Vol. 20, Pages 3678: Poly(2,6-Dimethyl-1,4-Phenylene Oxide)-Based Hydroxide Exchange Separator Membranes for Zinc–Air Battery International Journal of Molecular Sciences doi: 10.3390/ijms20153678 Authors: Ali Abbasi Soraya Hosseini Anongnat Somwangthanaroj Ahmad Azmin Mohamad Soorathep Kheawhom Rechargeable zinc–air batteries are deemed as the most feasible alternative to replace lithium–ion batteries in various applications. Among battery components,...
Fri Jul 26, 2019 03:00
IJMS, Vol. 20, Pages 3674: Nitrogen Fertilizer Induced Alterations in The Root Proteome of Two Rice Cultivars International Journal of Molecular Sciences doi: 10.3390/ijms20153674 Authors: Tang Sun Chen Damaris Lu Hu Nitrogen (N) is an essential nutrient for plants and a key limiting factor of crop production. However, excessive application of N fertilizers and the low nitrogen use efficiency (NUE) have brought in severe damage to the environment. Therefore, improving...
Fri Jul 26, 2019 03:00
IJMS, Vol. 20, Pages 3675: Heme, Heme Oxygenase, and Endoplasmic Reticulum Stress—A New Insight into the Pathophysiology of Vascular Diseases International Journal of Molecular Sciences doi: 10.3390/ijms20153675 Authors: Gáll Balla Balla The prevalence of vascular disorders continues to rise worldwide. Parallel with that, new pathophysiological pathways have been discovered, providing possible remedies for prevention and therapy in vascular diseases. Growing evidence suggests...
Fri Jul 26, 2019 03:00
IJMS, Vol. 20, Pages 3672: Glutathione Metabolism in Renal Cell Carcinoma Progression and Implications for Therapies International Journal of Molecular Sciences doi: 10.3390/ijms20153672 Authors: Xiao Meierhofer A significantly increased level of the reactive oxygen species (ROS) scavenger glutathione (GSH) has been identified as a hallmark of renal cell carcinoma (RCC). The proposed mechanism for increased GSH levels is to counteract damaging ROS to sustain the viability and growth...
Fri Jul 26, 2019 03:00
IJMS, Vol. 20, Pages 3673: Peroxisomal Hydrogen Peroxide Metabolism and Signaling in Health and Disease International Journal of Molecular Sciences doi: 10.3390/ijms20153673 Authors: Lismont Revenco Fransen Hydrogen peroxide (H2O2), a non-radical reactive oxygen species generated during many (patho)physiological conditions, is currently universally recognized as an important mediator of redox-regulated processes. Depending on its spatiotemporal accumulation profile, this molecule...
Fri Jul 26, 2019 03:00
IJMS, Vol. 20, Pages 3671: Rapid or Slow Time to Brain Death? Impact on Kidney Graft Injuries in an Allotransplantation Porcine Model International Journal of Molecular Sciences doi: 10.3390/ijms20153671 Authors: Thomas Kerforne Sébastien Giraud Jérôme Danion Raphael Thuillier Pierre Couturier William Hebrard Olivier Mimoz Thierry Hauet The use of donors deceased after brain death (DBD) with extended criteria in response to the shortage of grafts leads to the removal...
Fri Jul 26, 2019 03:00
IJMS, Vol. 20, Pages 3669: Extracellular Vesicles Released by Colorectal Cancer Cell Lines Modulate Innate Immune Response in Zebrafish Model: The Possible Role of Human Endogenous Retroviruses International Journal of Molecular Sciences doi: 10.3390/ijms20153669 Authors: Luca Ferrari Marco Cafora Federica Rota Mirjam Hoxha Simona Iodice Letizia Tarantini Maria Dolci Serena Delbue Anna Pistocchi Valentina Bollati Extracellular vesicles (EVs) are important components...
Fri Jul 26, 2019 03:00
IJMS, Vol. 20, Pages 3670: Light Stress-Induced Increase of Sphingosine 1-Phosphate in Photoreceptors and Its Relevance to Retinal Degeneration International Journal of Molecular Sciences doi: 10.3390/ijms20153670 Authors: Ryo Terao Megumi Honjo Takashi Ueta Hideru Obinata Takashi Izumi Makoto Kurano Yutaka Yatomi Hideto Koso Sumiko Watanabe Makoto Aihara Sphingosine 1-phosphate (S1P) is a potent lipid mediator that modulates inflammation and angiogenesis....
Fri Jul 26, 2019 03:00
IJMS, Vol. 20, Pages 3667: Genome-Wide Association Study for Multiple Biotic Stress Resistance in Synthetic Hexaploid Wheat International Journal of Molecular Sciences doi: 10.3390/ijms20153667 Authors: Madhav Bhatta Alexey Morgounov Vikas Belamkar Stephen N. Wegulo Abdelfattah A. Dababat Gül Erginbas-Orakci Mustapha El Bouhssini Pravin Gautam Jesse Poland Nilüfer Akci Lütfü Demir Ruth Wanyera P. Stephen Baenziger Genetic resistance against biotic...
Fri Jul 26, 2019 03:00
IJMS, Vol. 20, Pages 3664: Arterial Stiffness Assessed by Cardio-Ankle Vascular Index International Journal of Molecular Sciences doi: 10.3390/ijms20153664 Authors: Takayuki Namba Nobuyuki Masaki Bonpei Takase Takeshi Adachi Arterial stiffness is an age-related disorder. In the medial layer of arteries, mechanical fracture due to fatigue failure for the pulsatile wall strain causes medial degeneration vascular remodeling. The alteration of extracellular matrix composition and...
Fri Jul 26, 2019 03:00
IJMS, Vol. 20, Pages 3668: Asymmetric (ADMA) and Symmetric (SDMA) Dimethylarginines in Chronic Kidney Disease: A Clinical Approach International Journal of Molecular Sciences doi: 10.3390/ijms20153668 Authors: Elena Oliva-Damaso Nestor Oliva-Damaso Francisco Rodriguez-Esparragon Juan Payan Eduardo Baamonde-Laborda Fayna Gonzalez-Cabrera Raquel Santana-Estupiñan Jose Carlos Rodriguez-Perez Asymmetric dimethylarginine (ADMA) and its enantiomer, Symmetric dimethylarginine...
Fri Jul 26, 2019 03:00
IJMS, Vol. 20, Pages 3665: Involvement of Lhcb6 and Lhcb5 in Photosynthesis Regulation in Physcomitrella patens Response to Abiotic Stress International Journal of Molecular Sciences doi: 10.3390/ijms20153665 Authors: Xingji Peng Xingguang Deng Xiaoya Tang Tinghong Tan Dawei Zhang Baohui Liu Honghui Lin There are a number of highly conserved photosystem II light-harvesting antenna proteins in moss whose functions are unclear. Here, we investigated the involvement of...
Fri Jul 26, 2019 03:00
IJMS, Vol. 20, Pages 3666: Melanocyte Activation Mechanisms and Rational Therapeutic Treatments of Solar Lentigos International Journal of Molecular Sciences doi: 10.3390/ijms20153666 Authors: Genji Imokawa To characterize the pathobiology of solar lentigos (SLs), analyses by semiquantitative RT-PCR, Western blotting, and immunohistochemistry revealed the upregulated expression of endothelin (EDN)-1/endothelin B receptors (EDNBRs), stem cell factor (SCF)/c-KIT, and tumor necrosis factor...
Fri Jul 26, 2019 03:00
IJMS, Vol. 20, Pages 3662: Cell-Free Nucleic Acids and their Emerging Role in the Pathogenesis and Clinical Management of Inflammatory Bowel Disease International Journal of Molecular Sciences doi: 10.3390/ijms20153662 Authors: Zuzana Kubiritova Jan Radvanszky Roman Gardlik Cell-free nucleic acids (cfNAs) are defined as any nucleic acids that are present outside the cell. They represent valuable biomarkers in various diagnostic protocols such as prenatal diagnostics, the detection...
Fri Jul 26, 2019 03:00
IJMS, Vol. 20, Pages 3661: Culture Dependent and Independent Analysis of Potential Probiotic Bacterial Genera and Species Present in the Phyllosphere of Raw Eaten Produce International Journal of Molecular Sciences doi: 10.3390/ijms20153661 Authors: Sascha Patz Katja Witzel Ann-Christin Scherwinski Silke Ruppel The plant phyllosphere is colonized by a complex ecosystem of microorganisms. Leaves of raw eaten vegetables and herbs are habitats for bacteria important not only to...
Fri Jul 26, 2019 03:00
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