Antioxidants, Vol. 9, Pages 94: Cellular Aging Characteristics and Their Association with Age-Related Disorders Antioxidants doi: 10.3390/antiox9020094 Authors: Rudzińska Parodi Balakireva Chepikova Venanzi Zamyatnin Different molecular signaling pathways, biological processes, and intercellular communication mechanisms control longevity and are affected during cellular senescence. Recent data have suggested that organelle communication, as well as genomic and metabolic...
Antioxidants, Vol. 9, Pages 93: Phytochemical Profile and Antioxidant Capacity of Coffee Plant Organs Compared to Green and Roasted Coffee Beans Antioxidants doi: 10.3390/antiox9020093 Authors: Acidri Sawai Sugimoto Handa Sasagawa Masunaga Yamamoto Nishihara The current study investigates the phytochemical composition of coffee plant organs and their corresponding antioxidant capacities compared to green and roasted coffee beans. HPLC analysis indicated that...
Antioxidants, Vol. 9, Pages 91: Insights on the Effects of Resveratrol and Some of Its Derivatives in Cancer and Autoimmunity: A Molecule with a Dual Activity Antioxidants doi: 10.3390/antiox9020091 Authors: Gianchecchi Fierabracci In recent years, the interest in natural compounds exerting immunoregulatory effects has enormously increased. Among these, the polyphenol resveratrol, found in a variety of foods and beverages, including red grapes and red wine, has been demonstrated...
Antioxidants, Vol. 9, Pages 92: Compared Phenolic Compound Contents of 22 Commercial Fruit and Vegetable Juices: Relationship to ex-vivo Vascular Reactivity and Potential in vivo Projection Antioxidants doi: 10.3390/antiox9020092 Authors: Matute Tabart Cheramy-Bien Pirotte Kevers Auger Schini-Kerth Dommes Defraigne Pincemail The real impact of polyphenol-rich vegetable and fruit juice intake on cardiovascular health remains a matter of controversy....
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Atmosphere, Vol. 11, Pages 125: The Early Days of Personal Solar Ultraviolet Dosimetry Atmosphere doi: 10.3390/atmos11020125 Authors: Diffey In the early 1970s, environmental conservationists were becoming concerned that a reduction in the thickness of the atmospheric ozone layer would lead to increased levels of ultraviolet (UV) radiation at ground level, resulting in higher population exposure to UV and subsequent harm, especially a rise in skin cancer. At the time, no measurements...
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Behavioral Sciences, Vol. 10, Pages 40: If People Are Attached to Plants, Do They Love Other People? Case of the Russian Youth Behavioral Sciences doi: 10.3390/bs10020040 Authors: Nartova-Bochaver Muhortova People’s attachment to the plant world makes a great contribution to the maintenance of psychological well-being. At the same time, little is known regarding the contribution of attitudes to plants to people’s morality; the current study is aimed at filling...
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Biomolecules, Vol. 10, Pages 172: Sperm Lipid Composition in Early Diverged Fish Species: Internal vs. External Mode of Fertilization Biomolecules doi: 10.3390/biom10020172 Authors: Engel Dzyuba Ninhaus-Silveira Veríssimo-Silveira Dannenberger Schiller Steinbach Dzyuba The lipid composition of sperm membranes is crucial for fertilization and differs among species. As the evolution of internal fertilization modes in fishes is not understood, a comparative...
Biomolecules, Vol. 10, Pages 169: Cymbopogon Citratus Functionalized Green Synthesis of CuO-Nanoparticles: Novel Prospects as Antibacterial and Antibiofilm Agents Biomolecules doi: 10.3390/biom10020169 Authors: Cherian Ali Saquib Faisal Wahab Musarrat Chemically synthesized copper oxide nanoparticles (CuONPs) involve the generation of toxic products, which narrowed its biological application. Hence, we have developed a one-pot, green method for CuONP production employing...
Biomolecules, Vol. 10, Pages 171: The Contribution of IgG Glycosylation to Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Complement-Dependent Cytotoxicity (CDC) in Hashimoto’s Thyroiditis: An in Vitro Model of Thyroid Autoimmunity Biomolecules doi: 10.3390/biom10020171 Authors: Ząbczyńska Polak Kozłowska Sokołowski Pocheć Antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) are involved in destruction of thyroid...
Biomolecules, Vol. 10, Pages 170: Tautomerism of Guanine Analogues Biomolecules doi: 10.3390/biom10020170 Authors: Štoček Dračínský Tautomerism of nucleic acid (NA) bases is a crucial factor for the maintenance and translation of genetic information in organisms. Only canonical tautomers of NA bases can form hydrogen-bonded complexes with their natural counterparts. On the other hand, rare tautomers of nucleobases have been proposed to be involved in processes catalysed by NA enzymes....
Biomolecules, Vol. 10, Pages 168: Hybrid Imaging of Aspergillus fumigatus Pulmonary Infection with Fluorescent, 68Ga-Labelled Siderophores Biomolecules doi: 10.3390/biom10020168 Authors: Pfister Summer Petrik Khoylou Lichius Kaeopookum Kochinke Orasch Haas Decristoforo Aspergillus fumigatus (A. fumigatus) is a human pathogen causing severe invasive fungal infections, lacking sensitive and selective diagnostic tools. A. fumigatus secretes the siderophore...
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Cancers, Vol. 12, Pages 275: Pancreatic Enzyme Replacement Therapy in Pancreatic Cancer Cancers doi: 10.3390/cancers12020275 Authors: Pezzilli Caccialanza Capurso Brunetti Milella Falconi Pancreatic cancer is an aggressive malignancy and the seventh leading cause of global cancer deaths in industrialised countries. More than 80% of patients suffer from significant weight loss at diagnosis and over time tend to develop severe cachexia. A major cause of weight loss...
Cancers, Vol. 12, Pages 273: Animal Modeling of Pediatric Liver Cancer Cancers doi: 10.3390/cancers12020273 Authors: Whitlock Yang Vasudevan Woodfield Hepatoblastoma (HB) is the most common pediatric liver malignancy. Management of HB requires multidisciplinary efforts. The 5-year overall survival of this disease is about 80% in developed countries. Despite advances in the care of these patients, survival in recurrent or treatment-refractory disease is lower than 50%. This...
Cancers, Vol. 12, Pages 272: Diagnostic Agreement for High-Grade Urothelial Cell Carcinoma in Atypical Urine Cytology: A Nationwide Survey Reveals a Tendency for Overestimation in Specimens with an N/C Ratio Approaching 0.5 Cancers doi: 10.3390/cancers12020272 Authors: Wang Hang Wen Liao Lee Lai In the Paris System (TPS), standardized cytomorphological criteria and diagnostic categories were proposed for reporting urine cytology. To evaluate the diagnostic agreement...
Cancers, Vol. 12, Pages 271: Mutation Enrichment and Transcriptomic Activation Signatures of 419 Molecular Pathways in Cancer Cancers doi: 10.3390/cancers12020271 Authors: Zolotovskaia Tkachev Seryakov Kuzmin Kamashev Sorokin Roumiantsev Buzdin Carcinogenesis is linked with massive changes in regulation of gene networks. We used high throughput mutation and gene expression data to interrogate involvement of 278 signaling, 72 metabolic, 48 DNA repair and 47...
Cancers, Vol. 12, Pages 268: Phenethyl Isothiocyanate Suppresses Stemness in the Chemo- and Radio-Resistant Triple-Negative Breast Cancer Cell Line MDA-MB-231/IR Via Downregulation of Metadherin Cancers doi: 10.3390/cancers12020268 Authors: Nguyen Moon Ediriweera Cho Resistance to chemotherapy and radiation therapy is considered a major therapeutic barrier in breast cancer. Cancer stem cells (CSCs) play a prominent role in chemo and radiotherapy resistance. The established...
Cancers, Vol. 12, Pages 270: Multistate Markov Model to Predict the Prognosis of High-Risk Human Papillomavirus-Related Cervical Lesions Cancers doi: 10.3390/cancers12020270 Authors: Taguchi Hara Tomio Kawana Tanaka Baba Kawata Eguchi Tsuruga Mori Adachi Nagamatsu Oda Yasugi Osuga Fujii Cervical intraepithelial neoplasia (CIN) has a natural history of bidirectional transition between different states. Therefore, conventional...
Cancers, Vol. 12, Pages 269: Molecular Mechanisms of the Efficacy of Cold Atmospheric Pressure Plasma (CAP) in Cancer Treatment Cancers doi: 10.3390/cancers12020269 Authors: Semmler Bekeschus Schäfer Bernhardt Fischer Witzke Seebauer Rebl Grambow Vollmar Nebe Metelmann Woedtke Emmert Boeckmann Recently, the potential use of cold atmospheric pressure plasma (CAP) in cancer treatment has gained increasing interest. Especially the...
Cancers, Vol. 12, Pages 274: Cancer Stem Cell Marker DCLK1 Correlates with Tumorigenic Immune Infiltrates in the Colon and Gastric Adenocarcinoma Microenvironments Cancers doi: 10.3390/cancers12020274 Authors: Wu Qu Weygant Peng Houchen Immunotherapy that has proven efficacy in several solid cancers plays a partial role in improving clinical outcomes of advanced gastrointestinal (GI) cancers. There is an unmet need to find new immune-related therapeutic targets. Doublecortin-like...
Cancers, Vol. 12, Pages 266: Pre-Disease and Pre-Surgery BMI, Weight Loss and Sarcopenia Impact Survival of Resected Lung Cancer Independently of Tumor Stage Cancers doi: 10.3390/cancers12020266 Authors: Icard Schussler Loi Bobbio Lupo Wislez Iannelli Fournel Damotte Alifano Lower pre-surgery Body Mass Index (BMI) and low muscle mass impact negatively long-term survival of non-small cell lung cancer (NSCLC). We investigated their influence on survival...
Cancers, Vol. 12, Pages 267: Trans-Mucosal Efficacy of Non-Thermal Plasma Treatment on Cervical Cancer Tissue and Human Cervix Uteri by a Next Generation Electrosurgical Argon Plasma Device Cancers doi: 10.3390/cancers12020267 Authors: Wenzel Carvajal Berrio Reisenauer Layland Koch Wallwiener Brucker Schenke-Layland Brauchle Weiss Non-invasive physical plasma (NIPP) generated by non-thermally operated electrosurgical argon plasma sources is a promising...
Cancers, Vol. 12, Pages 265: Proteasome Inhibitors for the Treatment of Multiple Myeloma Cancers doi: 10.3390/cancers12020265 Authors: Ito Use of proteasome inhibitors (PIs) has been the therapeutic backbone of myeloma treatment over the past decade. Many PIs are being developed and evaluated in the preclinical and clinical setting. The first-in-class PI, bortezomib, was approved by the US food and drug administration in 2003. Carfilzomib is a next-generation PI, which selectively and...
Cancers, Vol. 12, Pages 263: Comment on: Malfitano, A.M. et al. “Virotherapy as a Potential Therapeutic Approach for the Treatment of Aggressive Thyroid Cancer” Cancers 2019, 11, 1532 Cancers doi: 10.3390/cancers12020263 Authors: Alberts I read with interest the recent review on virotherapy in thyroid cancer by Malfitano et al. [...]
Cancers, Vol. 12, Pages 264: Gastric Cancer in History: A Perspective Interdisciplinary Study Cancers doi: 10.3390/cancers12020264 Authors: Topi Santacroce Bottalico Ballini Inchingolo Dipalma Charitos Inchingolo Background: Gastric adenocarcinoma is the fourth most common type of cancer and the second leading cause of cancer death in the world. Despite abundant traces of an ancient history, the comprehension of its pathogenic mechanisms is rather recent...
Cancers, Vol. 12, Pages 262: Optimization of Predictive Performance for the Therapeutic Response Using Iodine Scan-Corrected Serum Thyroglobulin in Patients with Differentiated Thyroid Carcinoma Cancers doi: 10.3390/cancers12020262 Authors: Yoo Chowdhury Jeon Kang Cho Kim Lee Ryu Song Bom Min Kwon We investigated whether the performance of serum thyroglobulin (Tg) for response prediction could be improved based on the iodine uptake pattern...
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Cells, Vol. 9, Pages 274: Modulation of Cell–Cell Interactions in Drosophila Oocyte Development Cells doi: 10.3390/cells9020274 Authors: Antel Inaba The Drosophila ovary offers a suitable model system to study the mechanisms that orchestrate diverse cellular processes. Oogenesis starts from asymmetric stem cell division, proper differentiation and the production of fully patterned oocytes equipped with all the maternal information required for embryogenesis. Spatial and temporal...
Cells, Vol. 9, Pages 275: Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells Cells doi: 10.3390/cells9020275 Authors: Yue Wang Du Zhang Hamada Matsumoto Jin Zhou Mikoshiba Gill Han Wang Being the largest the Ca2+ store in mammalian cells, endoplasmic reticulum (ER)-mediated Ca2+ signalling often involves both Ca2+ release via inositol 1, 4, 5-trisphosphate...
Cells, Vol. 9, Pages 270: Nuclear Export of Cyclin B Mediated by the Nup62 Complex Is Required for Meiotic Initiation in Drosophila Males Cells doi: 10.3390/cells9020270 Authors: Okazaki Yamazoe Inoue Background: The central channel of the nuclear pore complex plays an important role in the selective transport of proteins between the nucleus and cytoplasm. Previous studies have demonstrated that the depletion of the Nup62 complex, constructing the nuclear pore channel in premeiotic...
Cells, Vol. 9, Pages 272: HSP90 Interacts with the Fibronectin N-terminal Domains and Increases Matrix Formation Cells doi: 10.3390/cells9020272 Authors: Chakraborty Boel Edkins Heat shock protein 90 (HSP90) is an evolutionarily conserved chaperone protein that controls the function and stability of a wide range of cellular client proteins. Fibronectin (FN) is an extracellular client protein of HSP90, and exogenous HSP90 or inhibitors of HSP90 alter the morphology of the extracellular...
Cells, Vol. 9, Pages 273: Biological Functions and Analytical Strategies of Sialic Acids in Tumor Cells doi: 10.3390/cells9020273 Authors: Zhou Yang Guan Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important roles in many physiological and pathological processes via carbohydrate-protein interactions, including cell–cell communication,...
Cells, Vol. 9, Pages 271: Cytokinesis in Eukaryotic Cells: The Furrow Complexity at a Glance Cells doi: 10.3390/cells9020271 Authors: Fraschini The duplication cycle is the fascinating process that, starting from a cell, results in the formation of two daughter cells and it is essential for life. Cytokinesis is the final step of the cell cycle, it is a very complex phase, and is a concert of forces, remodeling, trafficking, and cell signaling. All of the steps of cell division must...
Cells, Vol. 9, Pages 269: Long Noncoding RNA in Myeloid and Lymphoid Cell Differentiation, Polarization and Function Cells doi: 10.3390/cells9020269 Authors: Ahmad Valverde Ahmad Naqvi Long noncoding RNA (lncRNA) are a class of endogenous, non-protein coding RNAs that are increasingly being associated with various cellular functions and diseases. Yet, despite their ubiquity and abundance, only a minute fraction of these molecules has an assigned function. LncRNAs show tissue-,...
Cells, Vol. 9, Pages 268: Isoform Specific Effects of Mef2C during Direct Cardiac Reprogramming Cells doi: 10.3390/cells9020268 Authors: Wang Huang Near Ravi Xu Liu Qian Direct conversion of cardiac fibroblasts into induced cardiomyocytes (iCMs) by forced expression of defined factors holds great potential for regenerative medicine by offering an alternative strategy for treatment of heart disease. Successful iCM conversion can be achieved by minimally using...
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Challenges, Vol. 11, Pages 2: Acknowledgement to Reviewers of Challenges in 2019 Challenges doi: 10.3390/challe11010002 Authors: Challenges Editorial Office The editorial team greatly appreciates the reviewers who have dedicated their considerable time and expertise to the journal’s rigorous editorial process over the past 12 months, regardless of whether the papers are finally published or not [...]
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Climate, Vol. 8, Pages 18: Effects of Climate Change on Precipitation and the Maximum Daily Temperature (Tmax) at Two US Military Bases with Different Present-Day Climates Climate doi: 10.3390/cli8020018 Authors: Tadić Biraud In this study, the effects of climate change on precipitation and the maximum daily temperature (Tmax) at two USA locations that have different climates—the Travis Airforce Base (AFB) in California [38.27° N, 121.93° W] and Fort Bragg...
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Diagnostics, Vol. 10, Pages 61: Active MMP-8 (aMMP-8) as a Grading and Staging Biomarker in the Periodontitis Classification Diagnostics doi: 10.3390/diagnostics10020061 Authors: Sorsa Alassiri Grigoriadis Räisänen Pärnänen Nwhator Gieselmann Sakellari The aim of this study was to investigate the utility of incorporating active matrix metalloproteinase-8 (aMMP-8) as a biomarker into the new periodontitis classification system (stage/grade) presented in 2018....
Diagnostics, Vol. 10, Pages 60: Diagnostic, Prognostic, and Therapeutic Value of Non-Coding RNA Expression Profiles in Renal Transplantation Diagnostics doi: 10.3390/diagnostics10020060 Authors: Franco-Acevedo Melo Echavarria End-stage renal disease is a public health problem responsible for millions of deaths worldwide each year. Although transplantation is the preferred treatment for patients in need of renal replacement therapy, long-term allograft survival remains challenging....
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Environments, Vol. 7, Pages 10: Ultraviolet Radiation Exposure: Some Observations and Considerations, Focusing on Some Italian Experiences, on Cancer Risk, and Primary Prevention Environments doi: 10.3390/environments7020010 Authors: Miligi Solar ultraviolet radiation may cause acute and chronic health effects on the skin, eyes, and also on the immune system. Actinic keratosis, non-melanoma skin cancers, and malignant melanoma are the main long-term adverse skin effects. In the white...
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Foods, Vol. 9, Pages 119: Growth Behavior of Listeria monocytogenes in a Traditional Norwegian Fermented Fish Product (Rakfisk), and Its Inhibition through Bacteriophage Addition Foods doi: 10.3390/foods9020119 Authors: Axelsson Bjerke McLeod Berget Holck Listeria monocytogenes may persist in food production environments and cause listeriosis. In Norway, a product of concern is the traditional and popular fermented fish product “rakfisk”, which is...
Foods, Vol. 9, Pages 118: Effects of Salt Stimulation on Lunasin Accumulation and Activity during Soybean Germination Foods doi: 10.3390/foods9020118 Authors: Zhang Hao Teng Fan Yang Liu Ren Tan Lunasin, a bioactive peptide, was originally found in soybeans, and it has exhibited multiple biological functions. On the basis of previous studies, salt stress was found able to induce changes in many polypeptides and translatable mRNA levels in plants. Salt stress...
Foods, Vol. 9, Pages 117: Metabolic Profiling-Based Evaluation of the Fermentative Behavior of Aspergillus oryzae and Bacillus subtilis for Soybean Residues Treated at Different Temperatures Foods doi: 10.3390/foods9020117 Authors: Hyeon Min Moon Cha Gupta Park Kim Kim Soybean processing, e.g., by soaking, heating, and fermentation, typically results in diverse metabolic changes. Herein, multivariate analysis-based metabolic profiling was employed to investigate...
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Humanities, Vol. 9, Pages 12: Acknowledgement to Reviewers of Humanities in 2019 Humanities doi: 10.3390/h9010012 Authors: Humanities Editorial Office The editorial team greatly appreciates the reviewers who have dedicated their considerable time and expertise to the journal’s rigorous editorial process over the past 12 months, regardless of whether the papers are finally published or not[...]
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IJERPH, Vol. 17, Pages 729: Maturity Related Differences in Body Composition Assessed by Classic and Specific Bioimpedance Vector Analysis among Male Elite Youth Soccer Players International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030729 Authors: Toselli Marini Maietta Latessa Benedetti Campa The aim of this study was to analyze the efficiency of classic and specific bioelectrical impedance vector analysis (BIVA) in the assessment of...
IJERPH, Vol. 17, Pages 728: Relationship between Shift Type and Voluntary Exercise Training in South Korean Firefighters International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030728 Authors: Park Kwon Noh Lee Song Park Lee Seo Kang Ahn Background: According to the National Fire Agency, 69% of South Korean firefighters prefer the three circuit system. Since the three circuit system involves working for 24 h consecutively,...
IJERPH, Vol. 17, Pages 726: What Affects the Diffusion of New Energy Vehicles Financial Subsidy Policy? Evidence from Chinese Cities International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030726 Authors: Liu Yi Designing and implementing effective new energy vehicle (NEV) policy are policy priorities for policymakers and energy policy scholars. However, the formulation, adoption, and diffusion of the NEV policies have not been fully examined in the...
IJERPH, Vol. 17, Pages 718: Effects of A Personalized Intervention Program on the Biochemical and Hematological Profile in Community Dwelling Old Adults—The AGA@4life Intervention Model International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030718 Authors: Caseiro Rocha Silva Ferreira Silva Clemente Cipriano Saraiva Barreira Azenha Loureiro Martins Pereira Aging is a social and economic challenge of the...
IJERPH, Vol. 17, Pages 725: Green Spaces, Land Cover, Street Trees and Hypertension in the Megacity of São Paulo International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030725 Authors: Moreira Polizel Santos Filho Bensenor Lotufo Mauad Proximity to green spaces has been shown to be beneficial to several cardiovascular outcomes in urban spaces. Few studies, however, have analyzed the relationship between these outcomes and green...
IJERPH, Vol. 17, Pages 724: Environmental Exposure of Arsenic in Groundwater Associated to Carcinogenic Risk in Underweight Children Exposed to Fluorides International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030724 Authors: Molina-Frechero Nevarez-Rascón Tremillo-Maldonado Vergara-Onofre Gutiérrez-Tolentino Gaona Castañeda Jarquin-Yañez Bologna-Molina Background: The purpose of this study was to determine the concentration...
IJERPH, Vol. 17, Pages 716: Price Competition and Product Differentiation Based on the Subjective and Social Effect of Consumers’ Environmental Awareness International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030716 Authors: Dayi He Ximing Deng Consumer environmental awareness (CEA) can affect green consumption decisions in different and confusing ways. In order to explain the reasons for these divergences, this study divides CEA into two main components:...
IJERPH, Vol. 17, Pages 723: “All Weather Friends”: How China Transformed Zimbabwe’s Tobacco Sector International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030723 Authors: Fang De Souza Smith Lee Recent research documents the globalization strategy of the Chinese tobacco industry since the early 2000s and risks posed to global health. There are limited analyses to date of how this strategy is playing out in specific countries. This paper analyses...
IJERPH, Vol. 17, Pages 717: Reducing Sedentary Time among Older Adults in Assisted Living: Perceptions, Barriers, and Motivators International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030717 Authors: Voss Pope Copeland Older adults accumulate more sedentary time (ST) than any other age group, especially those in assisted living residences (ALRs). Reducing prolonged ST could help maintain function among older adults. However, to develop effective...
IJERPH, Vol. 17, Pages 722: Occurrence of Diarrhea and Feeding Practices among Children below Two Years of Age in Southwestern Saudi Arabia International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030722 Authors: Shati Khalil Asiri Alshehri Deajim Al-Amer Alshehri Alshehri Alqahtani Growing evidence suggests that feeding practices in early childhood play a major role in the occurrence of childhood diarrhea. However, there...
IJERPH, Vol. 17, Pages 721: The Correlation between Leader–Member Exchange and Organisational Commitment among Spanish Registered Nurses: The Moderating Role of Sex and Hospital Size International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030721 Authors: López-Ibort Gónzalez-de la Cuesta Antoñanzas-Lombarte Gascón-Catalán The role of the supervisor in hospitals is to oversee and encourage the active work participation of registered nurses....
IJERPH, Vol. 17, Pages 720: Primary Health Care for Aboriginal Australian Women in Remote Communities after a Pregnancy with Hyperglycaemia International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030720 Authors: Wood MacKay Fitzsimmons Derkenne Kirkham Boyle Connors Whitbread Welsh Brown Shaw Maple-Brown Background: Hyperglycaemia in pregnancy contributes to adverse outcomes for women and their children. The...
IJERPH, Vol. 17, Pages 719: Organizational Downsizing, Work Conditions, and Employee Outcomes: Identifying Targets for Workplace Intervention among Survivors International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030719 Authors: Frone Blais This study broadly assesses the association of organizational downsizing to deleterious work conditions and employee outcomes, and the extent to which work conditions mediate the association of downsizing to employee...
IJERPH, Vol. 17, Pages 727: Job Burnout Among Primary Healthcare Workers in Rural China: A Multilevel Analysis International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030727 Authors: Xu Pan Li Lu Zhang The health workers in rural primary care systems are at the increasing risk of job burnout. To explore the prevalence and associated factors of the job burnout among the primary healthcare worker in rural China, a cross-sectional survey was...
IJERPH, Vol. 17, Pages 715: Determinants of Vitamin D Supplementation among Individuals with Type 1 Diabetes International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030715 Authors: Kamiński Molenda Banaś Uruska Zozulińska-Ziółkiewicz Half of the individuals with type 1 diabetes (T1DM) may present Vitamin D (VD) deficiency. There is little known about factors determining a decision on VD supplementation. The study aimed to determine the...
IJERPH, Vol. 17, Pages 713: Will the Economic Recession Inhibit the Out-of-Pocket Payment Willingness for Health Care? International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030713 Authors: Zheng Huang Jiang We used an individual regression and panel data regression method to analyze the samples of 60 countries from 2000 to 2016 to study the impact of the economic recession on residents’ out-of-pocket payment willingness for health care....
IJERPH, Vol. 17, Pages 714: An Expanded Agenda for the Primary Prevention of Breast Cancer: Charting a Course for the Future International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030714 Authors: White Kavanaugh-Lynch Davis-Patterson Buermeyer Advances in breast cancer science, early detection, and treatment have resulted in improvements in breast cancer survival but not in breast cancer incidence. After skin cancer, breast cancer is the most...
IJERPH, Vol. 17, Pages 711: Horticultural Therapy Program for People with Mental Illness: A Mixed-Method Evaluation International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030711 Authors: Siu Kam Mok Background. Horticultural therapy (HT) has long been used in the rehabilitation of people with mental illness, but many HT programs are not standardized, and there have been few evaluation studies. Aims. This study evaluated the process and outcomes...
IJERPH, Vol. 17, Pages 712: Association between Uranium Exposure and Thyroid Health: A National Health and Nutrition Examination Survey Analysis and Ecological Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030712 Authors: van Gerwen Alpert Lieberman-Cribbin Cooke Ziadkhanpour Liu Genden : Besides specific, incidental radiation exposure, which has been associated with increased thyroid cancer risk, the effects of...
IJERPH, Vol. 17, Pages 709: Effect of Frequency of Exercise on Cognitive Function in Older Adults: Serial Mediation of Depression and Quality of Sleep International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030709 Authors: Yuan Fu Liu Fang Background: Sleep quality and depression are two reciprocal causation socioemotional factors and their roles in the relationship between physical exercise and cognition are still unclear. Methods: A face-to-face...
IJERPH, Vol. 17, Pages 708: T1ρ-Mapping for Musculoskeletal Pain Diagnosis: Case Series of Variation of Water Bound Glycosaminoglycans Quantification before and after Fascial Manipulation® in Subjects with Elbow Pain International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030708 Authors: Menon Oswald Raghavan Regatte Stecco Diagnosis and management of musculoskeletal pain is a major clinical challenge. Following this need, the first aim...
IJERPH, Vol. 17, Pages 707: Coincidence Analysis of the Cropland Distribution of Multi-Sets of Global Land Cover Products International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030707 Authors: Zhang Ye Fang Li Zheng Modern global cropland products have been widely used to assess the impact of land use and cover change (LUCC) on carbon budgets, climate change, terrestrial ecosystems, etc. However, each product has its own uncertainty, and...
IJERPH, Vol. 17, Pages 710: Bidirectional Associations between Objective Physical Activity and Sleep Patterns in Spanish School Children International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030710 Authors: Ávila-García Femia-Marzo Huertas-Delgado Tercedor Physical activity (PA) and sleep contribute to better children’s health. Nonetheless, the bidirectional relationship between both of these health-related factors is unclear when...
IJERPH, Vol. 17, Pages 705: Neonatal Transport in the Practice of the Crews of the Polish Medical Air Rescue: A Retrospective Analysis International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030705 Authors: Rzońca Świeżewski Gałązkowski Bień Kosowski Leszczyński Rzońca The aim of the study was to present characteristics of patients transported in incubators by crews of Helicopter Emergency Medical Service (HEMS) and Emergency Medical...
IJERPH, Vol. 17, Pages 706: Factors Associated with Seasonal Food Insecurity among Small-Scale Subsistence Farming Households in Rural Honduras International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030706 Authors: Dodd Gómez Cerna Orellana Humphries Sadoine Zombré Zinszer Kipp Cole In the context of climate change, a nutritional transition, and increased pressures to migrate internally and internationally, this study examined...
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IJMS, Vol. 21, Pages 736: Placental Hofbauer Cell Polarization Resists Inflammatory Cues In Vitro International Journal of Molecular Sciences doi: 10.3390/ijms21030736 Authors: Schliefsteiner Ibesich Wadsack Feto-placental Hofbauer cells (HBCs) are macrophages residing in placental stroma. They are generally described as anti-inflammatory M2 polarized cells, promoting tolerance and tissue remodeling. In certain pathologies, however, a possible phenotypical switch towards pro-inflammatory...
IJMS, Vol. 21, Pages 737: The Gene and Protein Expression of the Main Components of the Lipolytic System in Human Myocardium and Heart Perivascular Adipose Tissue. Effect of Coronary Atherosclerosis International Journal of Molecular Sciences doi: 10.3390/ijms21030737 Authors: Knapp Górski Lewkowicz Lisowska Gil Wójcik Hirnle Chabowski Mikłosz The aim of our study was to examine the regulation of triacylglycerols (TG) metabolism in myocardium and heart...
IJMS, Vol. 21, Pages 734: Elucidating the H+ Coupled Zn2+ Transport Mechanism of ZIP4; Implications in Acrodermatitis Enteropathica International Journal of Molecular Sciences doi: 10.3390/ijms21030734 Authors: Hoch Levy Hershfinkel Sekler Cellular Zn2+ homeostasis is tightly regulated and primarily mediated by designated Zn2+ transport proteins, namely zinc transporters (ZnTs; SLC30) that shuttle Zn2+ efflux, and ZRT-IRT-like proteins (ZIPs; SLC39) that mediate Zn2+ influx....
IJMS, Vol. 21, Pages 733: Genome Editing for the Understanding and Treatment of Inherited Cardiomyopathies International Journal of Molecular Sciences doi: 10.3390/ijms21030733 Authors: Nguyen Lim Yokota Cardiomyopathies are diseases of heart muscle, a significant percentage of which are genetic in origin. Cardiomyopathies can be classified as dilated, hypertrophic, restrictive, arrhythmogenic right ventricular or left ventricular non-compaction, although mixed morphologies...
IJMS, Vol. 21, Pages 735: Disparate Phenotypes Resulting from Mutations of a Single Histidine in Switch II of Geobacillus stearothermophilus Translation Initiation Factor IF2 International Journal of Molecular Sciences doi: 10.3390/ijms21030735 Authors: Tomsic Smorlesi Caserta Giuliodori Pon Gualerzi The conserved Histidine 301 in switch II of Geobacillus stearothermophilus IF2 G2 domain was substituted with Ser, Gln, Arg, Leu and Tyr to generate mutants displaying...
IJMS, Vol. 21, Pages 731: Love at First Taste: Induction of Larval Settlement by Marine Microbes International Journal of Molecular Sciences doi: 10.3390/ijms21030731 Authors: Dobretsov Rittschof Marine biofilms are composed of many species of bacteria, unicellular algae, and protozoa. Biofilms can induce, inhibit, or have no effect on settlement of larvae and spores of algae. In this review, we focus on induction of larval settlement by marine bacteria and unicellular eukaryotes...
IJMS, Vol. 21, Pages 732: Advances in HDL: Much More than Lipid Transporters International Journal of Molecular Sciences doi: 10.3390/ijms21030732 Authors: Ben-Aicha Badimon Vilahur High Density Lipoprotein (HDL) particles, beyond serving as lipid transporters and playing a key role in reverse cholesterol transport, carry a highly variable number of proteins, micro-RNAs, vitamins, and hormones, which endow them with the ability to mediate a plethora of cellular and molecular...
IJMS, Vol. 21, Pages 730: miRNAs and lncRNAs in Echinococcus and Echinococcosis International Journal of Molecular Sciences doi: 10.3390/ijms21030730 Authors: He Yan Yuan Yang Yang Echinococcosis are considered to be potentially lethal zoonotic diseases that cause serious damage to hosts. The metacestode of Echinococcus multilocularis and E. granulosus can result in causing the alveolar and cystic echinococcoses, respectively. Recent studies have shown that non-coding...
IJMS, Vol. 21, Pages 720: The Role of Dermal Fibroblasts in Nevoid Basal Cell Carcinoma Syndrome Patients: An Overview International Journal of Molecular Sciences doi: 10.3390/ijms21030720 Authors: Bellei Caputo Carbone Silipo Papaccio Picardo Eibenschutz Nevoid basal cell carcinoma syndrome (NBCCS), also named Gorlin syndrome, is a rare multisystem genetic disorder characterized by marked predisposition to basal cell carcinomas (BCCs), childhood medulloblastomas,...
IJMS, Vol. 21, Pages 728: Chromium-Induced Reactive Oxygen Species Accumulation by Altering the Enzymatic Antioxidant System and Associated Cytotoxic, Genotoxic, Ultrastructural, and Photosynthetic Changes in Plants International Journal of Molecular Sciences doi: 10.3390/ijms21030728 Authors: Wakeel Xu Gan Chromium (Cr) is one of the top seven toxic heavy metals, being ranked 21st among the abundantly found metals in the earth’s crust. A huge amount of Cr releases...
IJMS, Vol. 21, Pages 721: In-silico Analysis of NF1 Missense Variants in ClinVar: Translating Variant Predictions into Variant Interpretation and Classification International Journal of Molecular Sciences doi: 10.3390/ijms21030721 Authors: Accetturo Bartolomeo Stella Background: With the advent of next-generation sequencing in genetic testing, predicting the pathogenicity of missense variants represents a major challenge potentially leading to misdiagnoses in the clinical setting....
IJMS, Vol. 21, Pages 722: Analysis of the Effect of Increased α2,3-Sialylation on RTK Activation in MKN45 Gastric Cancer Spheroids Treated with Crizotinib International Journal of Molecular Sciences doi: 10.3390/ijms21030722 Authors: Balmaña Diniz Feijão Barrias Mereiter Reis In the scenario of personalized medicine, targeted therapies are currently the focus of cancer drug development. These drugs can block the growth and spread of tumor cells by interfering with...
IJMS, Vol. 21, Pages 723: Phytocannabinoids in Neurological Diseases: Could They Restore a Physiological GABAergic Transmission? International Journal of Molecular Sciences doi: 10.3390/ijms21030723 Authors: Cifelli Ruffolo De Felice Alfano van Vliet Aronica Palma γ-Aminobutyric acid type A receptors (GABAARs) are the main inhibitory mediators in the central nervous system (CNS). GABAARs are pentameric ligand gated ion channels, and the main subunit...
IJMS, Vol. 21, Pages 729: DUX4 Signalling in the Pathogenesis of Facioscapulohumeral Muscular Dystrophy International Journal of Molecular Sciences doi: 10.3390/ijms21030729 Authors: Lim Nguyen Yokota Facioscapulohumeral muscular dystrophy (FSHD) is a disabling inherited muscular disorder characterized by asymmetric, progressive muscle weakness and degeneration. Patients display widely variable disease onset and severity, and sometimes present with extra-muscular symptoms....
IJMS, Vol. 21, Pages 724: Global Transcriptomic Analysis of Zebrafish Glucagon Receptor Mutant Reveals Its Regulated Metabolic Network International Journal of Molecular Sciences doi: 10.3390/ijms21030724 Authors: Kang Hu Jia Bai Liu Wu Chen Li The glucagon receptor (GCGR) is a G-protein-coupled receptor (GPCR) that mediates the activity of glucagon. Disruption of GCGR results in many metabolic alterations, including increased glucose tolerance, decreased...
IJMS, Vol. 21, Pages 725: The Influence of Inflammation on Anemia in CKD Patients International Journal of Molecular Sciences doi: 10.3390/ijms21030725 Authors: Gluba-Brzózka Franczyk Olszewski Rysz : Anemia is frequently observed in the course of chronic kidney disease (CKD) and it is associated with diminishing the quality of a patient's life. It also enhances morbidity and mortality and hastens the CKD progression rate. Patients with CKD frequently suffer from a chronic...
IJMS, Vol. 21, Pages 726: Effects of Dietary Anaplerotic and Ketogenic Energy Sources on Renal Fatty Acid Oxidation Induced by Clofibrate in Suckling Neonatal Pigs International Journal of Molecular Sciences doi: 10.3390/ijms21030726 Authors: Lin Pike Zhao Fan Zhu Zhang Wang Odle Maintaining an active fatty acid metabolism is important for renal growth, development, and health. We evaluated the effects of anaplerotic and ketogenic energy sources on fatty...
IJMS, Vol. 21, Pages 727: Current Knowledge and Future Perspectives on Mesenchymal Stem Cell-Derived Exosomes as a New Therapeutic Agent International Journal of Molecular Sciences doi: 10.3390/ijms21030727 Authors: Joo Suh Lee Bang Lee Mesenchymal stem cells (MSCs) are on the cusp of regenerative medicine due to their differentiation capacity, favorable culture conditions, ability to be manipulated in vitro, and strong immunomodulatory activity. Recent studies indicate...
IJMS, Vol. 21, Pages 716: Methyl Jasmonate Induced Oxidative Stress and Accumulation of Secondary Metabolites in Plant Cell and Organ Cultures International Journal of Molecular Sciences doi: 10.3390/ijms21030716 Authors: Ho Murthy Park Recently, plant secondary metabolites are considered as important sources of pharmaceuticals, food additives, flavours, cosmetics, and other industrial products. The accumulation of secondary metabolites in plant cell and organ cultures often...
IJMS, Vol. 21, Pages 717: High Mobility Group A (HMGA): Chromatin Nodes Controlled by a Knotty miRNA Network International Journal of Molecular Sciences doi: 10.3390/ijms21030717 Authors: Sgarra Pegoraro D’Angelo Ros Zanin Sgubin Petrosino Battista Manfioletti High mobility group A (HMGA) proteins are oncofoetal chromatin architectural factors that are widely involved in regulating gene expression. These proteins are unique, because they are highly expressed...
IJMS, Vol. 21, Pages 718: Validation of a New Multicistronic Plasmid for the Efficient and Stable Expression of Transgenes in Microalgae International Journal of Molecular Sciences doi: 10.3390/ijms21030718 Authors: Molina-Márquez Vila Rengel Fernández García-Maroto Vigara León Low stability of transgenes and high variability of their expression levels among the obtained transformants are still pending challenges in the nuclear genetic transformation of microalgae....
IJMS, Vol. 21, Pages 715: Carbonic Anhydrase XII Expression Is Modulated during Epithelial Mesenchymal Transition and Regulated through Protein Kinase C Signaling International Journal of Molecular Sciences doi: 10.3390/ijms21030715 Authors: Vergara Ravaioli Fonzi Adamo Damato Bravaccini Pirini Gaballo Barbano Pasculli Franck Fournier Salzet Maffia Members of the carbonic anhydrase family are functionally involved in the regulation...
IJMS, Vol. 21, Pages 719: Combined Effects of Diatom-Derived Oxylipins on the Sea Urchin Paracentrotus lividus International Journal of Molecular Sciences doi: 10.3390/ijms21030719 Authors: Esposito Ruocco Albarano Ianora Manfra Libralato Costantini Oxylipins are diatom-derived secondary metabolites, deriving from the oxidation of polyunsatured fatty acids that are released from cell membranes after cell damage or senescence of these single-celled algae. Previous...
IJMS, Vol. 21, Pages 714: Osteoporosis: From Molecular Mechanisms to Therapies International Journal of Molecular Sciences doi: 10.3390/ijms21030714 Authors: Tang Osteoporosis is a common skeletal disorder, occurring as a result of an imbalance between bone resorption and bone formation, with bone breakdown exceeding bone building. Bone resorption inhibitors, e.g., bisphosphonates, have been designed to treat osteoporosis, while anabolic agents such as teriparatide stimulate bone formation...
IJMS, Vol. 21, Pages 713: Flexible Data Trimming Improves Performance of Global Machine Learning Methods in Omics-Based Personalized Oncology International Journal of Molecular Sciences doi: 10.3390/ijms21030713 Authors: Tkachev Sorokin Borisov Garazha Buzdin Borisov (1) Background: Machine learning (ML) methods are rarely used for an omics-based prescription of cancer drugs, due to shortage of case histories with clinical outcome supplemented by high-throughput...
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JCM, Vol. 9, Pages 314: Plasma Krebs Cycle Intermediates in Nonalcoholic Fatty Liver Disease Journal of Clinical Medicine doi: 10.3390/jcm9020314 Authors: Sandlers Shah Pearce Dasarathy McCullough Dasarathy Nonalcoholic liver disease (NAFLD) is manifested with a wide spectrum of clinical symptoms and is closely associated with the metabolic syndrome, inflammation, and mitochondrial dysfunction. Although the mechanism of mitochondrial dysfunction in NAFLD is still...
JCM, Vol. 9, Pages 317: Role of Arginase 2 in Murine Retinopathy Associated with Western Diet-Induced Obesity Journal of Clinical Medicine doi: 10.3390/jcm9020317 Authors: Atawia Bunch Fouda Lemtalsi Eldahshan Xu Saul Elmasry Al-Shabrawey Caldwell Caldwell Western diet-induced obesity is linked to the development of metabolic dysfunctions, including type 2 diabetes and complications that include retinopathy, a leading cause of blindness. Aberrant...
JCM, Vol. 9, Pages 316: Simultaneously Improved Pulmonary and Cardiovascular Autonomic Function and Short-Term Functional Outcomes in Patients with Parkinson’s Disease after Respiratory Muscle Training Journal of Clinical Medicine doi: 10.3390/jcm9020316 Authors: Huang Lai Wu Kuo Tsai Cheng Tsai Lu Both pulmonary function and autonomic function are impaired in patients with Parkinson's diseases (PD). This study tested the hypothesis that respiratory muscle...
JCM, Vol. 9, Pages 313: Impact of Grape Products on Lipid Profile: A Meta-Analysis of Randomized Controlled Studies Journal of Clinical Medicine doi: 10.3390/jcm9020313 Authors: Lupoli Ciciola Costabile Giacco Minno Capaldo Background: Growing evidence shows that grape polyphenols can improve cardiovascular risk factors. Although there are clear data supporting a beneficial effect of grape supplementation on blood pressure and glucose metabolism, the effects of grape...
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