MicroRNA-204-5p mediates sevoflurane-induced cytotoxicity in HT22 cells by targeting brain-derived neurotrophic factor. Histol Histopathol. 2020 Oct 02;:18266 Authors: Liu H, Wang J, Yan R, Jin S, Wan Z, Cheng J, Li N, Chen L, Yue C Abstract BACKGROUND: Sevoflurane is widely used as an inhalational anesthetic in clinical practice. However, sevoflurane can cause cytotoxicity and induce learning capacity decline in patients. A previous publication...
Sat Oct 03, 2020 13:04
Aldh2 gene reduces oxidative stress in the bladder by regulating the NF-κB pathway in a mouse model of ketamine-induced cystitis. Exp Ther Med. 2020 Nov;20(5):111 Authors: Xi XJ, Chen SH, Mi H Abstract Aldehyde dehydrogenase 2 (aldh2) serves an important role in the development of organ injury. Therefore, the present study investigated the effects of aldh2 on the oxidative stress response in a mouse model of ketamine-induced cystitis (KIC)....
Sat Oct 03, 2020 13:04
Role of TLR4/MyD88/NF-κB signaling in the contrast-induced injury of renal tubular epithelial cells.
Role of TLR4/MyD88/NF-κB signaling in the contrast-induced injury of renal tubular epithelial cells. Exp Ther Med. 2020 Nov;20(5):115 Authors: Wang X, Zhou J, Yang J, Wang S, Yang L Abstract The aim of the present study was to explore the role of toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MyD88)/nuclear factor (NF)-κB signaling in the contrast-induced injury of renal tubular epithelial cells, and to investigate...
Sat Oct 03, 2020 13:04
Brilliant blue G attenuates neuro-inflammation via regulating MAPKs and NF-κB signaling pathways in lipopolysaccharide-induced BV2 microglia cells. Exp Ther Med. 2020 Nov;20(5):116 Authors: Wang W, Huang F, Jiang W, Wang W, Xiang J Abstract Previous studies have demonstrated that the P2X purinoceptor 7 (P2X7) receptor (P2X7R) serves a critical role in regulating the inflammatory response of various diseases in the central nervous system. The...
Sat Oct 03, 2020 13:04
Irbesartan ameliorates myocardial fibrosis in diabetic cardiomyopathy rats by inhibiting the TGFβ1/Smad2/3 pathway. Exp Ther Med. 2020 Nov;20(5):117 Authors: Zong M, Zhao H, Li Q, Li Y, Zhang J Abstract Myocardial fibrosis (MF) is an important pathological change in diabetic cardiomyopathy. The aim of the present study was to investigate whether irbesartan serves a role in improving MF in a diabetic rat model. Fasting blood glucose (FBG), total...
Sat Oct 03, 2020 13:04
Primary carnitine deficiency in two sisters with intractable epilepsy and reversible metabolic cardiomyopathy: Two case reports. Exp Ther Med. 2020 Nov;20(5):118 Authors: Yang XF, Liu GS, Yi B Abstract Primary carnitine deficiency (PCD) is a disorder of the carnitine cycle that results in defective fatty acid oxidation. When carnitine cannot be transported into the cells, fatty acid oxidation is impaired, resulting a variety of symptoms, such...
Sat Oct 03, 2020 13:04
Association between α1-antitrypsin and acute coronary syndrome. Exp Ther Med. 2020 Nov;20(5):119 Authors: Liu Y, Huang D, Li B, Liu W, Sooranna SR, Pan X, Huang Z, Guo J Abstract α1-antitrypsin (AAT) is a protein released as part of the anti-inflammatory response. It regulates the activity of serine proteinases and has a crucial role in the pathogenesis of acute coronary syndrome (ACS). The present study aimed to examine its role in patients...
Sat Oct 03, 2020 13:04
Clinical investigation of acute myocardial infarction according to age subsets. Exp Ther Med. 2020 Nov;20(5):120 Authors: Wang J, Li L, Ma N, Zhang X, Qiao Y, Fang G, Li G, Zhong T Abstract A growing number of 'Young' patients less than 40 years of age are being hospitalized with a diagnosis of acute myocardial infarction (AMI) due to increased prevalence of risk factors for atherosclerosis. The aim of this study was to compare clinical characteristics...
Sat Oct 03, 2020 13:04
Enhanced expression of synoviolin in peripheral blood from obese/overweight donors. Exp Ther Med. 2020 Nov;20(5):121 Authors: Fujita H, Aratani S, Mizoguchi I, Yagishita N, Nakajima T Abstract Obesity is currently a major medical and societal issue. Synoviolin (SYVN1) is an E3 ubiquitin ligase involved in endoplasmic reticulum (ER) stress. Overexpression of Syvn1 has been found in genetically obese mice (ob/ob and db/db), and treatment with...
Sat Oct 03, 2020 13:04
GSK-3β mediates the effects of HNF-1β overexpression in ovarian clear cell carcinoma. Exp Ther Med. 2020 Nov;20(5):122 Authors: Kawahara N, Mizutani A, Matsubara S, Takeda Y, Kobayashi H Abstract Deubiquitinase USP28 is a target gene of the transcription factor HNF1 homeobox β (HNF-1β), which promotes the survival of ovarian clear cell carcinoma (OCCC) cell lines. However, the pharmacological inhibition of HNF-1β can cause several adverse effects...
Sat Oct 03, 2020 13:04
The c-Jun signaling pathway has a protective effect on nucleus pulposus cells in patients with intervertebral disc degeneration. Exp Ther Med. 2020 Nov;20(5):123 Authors: Lei M, Wang K, Li S, Zhao K, Hua W, Wu X, Yang C Abstract Among a range of diverse clinical symptoms, intervertebral disc degeneration (IDD) contributes mostly to the onset of lower back pain. The present study aimed to investigate the effects of c-Jun on nucleus pulposus...
Sat Oct 03, 2020 13:04
Roles of klotho and stem cells in mediating vascular calcification (Review). Exp Ther Med. 2020 Dec;20(6):124 Authors: Yu L, Li M Abstract Vascular calcification, characterized by the active deposition of calcium phosphate in the vascular walls, is commonly observed in aging, diabetes mellitus and chronic kidney disease. This process is mediated by different cell types, including vascular stem/progenitor cells. The anti-aging protein klotho...
Sat Oct 03, 2020 13:04
MicroRNA-142 protects MC3T3-E1 cells against high glucose-induced apoptosis by targeting β-catenin. Exp Ther Med. 2020 Dec;20(6):125 Authors: Zheng T, Ji G, Chen J, Lai J, Liu T, Mo J, Jin Q Abstract Osteoporosis, characterized by decreased mineral density and bone mass, is triggered by various detrimental factors and often causes further complications, including fractures. Aberrant expression of microRNAs (miRs) has been associated with the...
Sat Oct 03, 2020 13:04
The combination of PLLA/PLGA/PCL composite scaffolds integrated with BMP-2-loaded microspheres and low-intensity pulsed ultrasound alleviates steroid-induced osteonecrosis of the femoral head. Exp Ther Med. 2020 Dec;20(6):126 Authors: Zhu H, Shi Z, Cai X, Yang X, Zhou C Abstract Low-intensity pulsed ultrasound (LIPUS), which has been previously reported to promote bone repair, is proposed to be a noninvasive form of therapy for the treatment...
Sat Oct 03, 2020 13:04
Spinal anesthesia in a designated block bay for total joint arthroplasty: improving operating room efficiency. Reg Anesth Pain Med. 2020 Oct 01;: Authors: Kagan R, Zhao S, Stone A, Johnson AJ, Huff T, Schabel K, Woodworth GE, Ivie RM Abstract BACKGROUND: Creating highly efficient operating room (OR) protocols for total joint arthroplasty (TJA) is a challenging and multifactorial process. We evaluated whether spinal anesthesia in a designated...
Sat Oct 03, 2020 13:06
Variation in pediatric local anesthetic dosing for peripheral nerve blocks: an analysis from the Pediatric Regional Anesthesia Network (PRAN). Reg Anesth Pain Med. 2020 Oct 01;: Authors: Taenzer AH, Herrick M, Hoyt M, Ramamurthi RJ, Walker B, Flack SH, Bosenberg A, Franklin A, Polaner DM, PRAN investigators, PRAN investigator Abstract BACKGROUND: Variation of local anesthetic dosing has been reported for adult peripheral nerve blocks (PNBs)...
Sat Oct 03, 2020 13:06
Ilioinguinal/Iliohypogastric versus quadratus lumborum nerve blockade for elective open inguinal herniorrhaphy: a prospective, randomized, double-blinded, equivalency trial. Reg Anesth Pain Med. 2020 Oct 01;: Authors: Edwards CJ, Weller RS, Turner JD, Dobson SW, Jaffe JD, Reynolds JW, Russell G, Henshaw DS Abstract BACKGROUND: Open inguinal herniorrhaphy (OIH) is a commonly performed surgical procedure with expected postoperative pain....
Sat Oct 03, 2020 13:06
Further investigation of explant rates of electrical neuromodulation devices. Reg Anesth Pain Med. 2020 Oct 01;: Authors: Mukhdomi T, Harris M PMID: 33004655 [PubMed - as supplied by publisher]
Sat Oct 03, 2020 13:06
Dose-response relationship between local anesthetic volume and hemidiaphragmatic paresis following ultrasound-guided supraclavicular brachial plexus blockade. Reg Anesth Pain Med. 2020 Oct 01;: Authors: Tedore TR, Lin HX, Pryor KO, Tangel VE, Pak DJ, Akerman M, Wellman DS, Oden-Brunson H Abstract BACKGROUND: There is no consensus regarding what volume of local anesthetic should be used to achieve successful supraclavicular block while...
Sat Oct 03, 2020 13:06
Oral immunotherapy for peanut allergy: The pro argument. World Allergy Organ J. 2020 Aug;13(8):100455 Authors: Chinthrajah RS, Cao S, Dunham T, Sampath V, Chandra S, Chen M, Sindher S, Nadeau K Abstract Food allergy (FA) is a growing public health problem with personal, social, nutritional, and economic consequences. In the United States, it is estimated that 8% of children and 10.8% of adults have food allergies. Allergies to peanuts...
Sat Oct 03, 2020 13:06
Related Articles Successful Management of Ketogenic Parenteral Nutrition: A Pediatric Case Study. JPEN J Parenter Enteral Nutr. 2019 08;43(6):815-818 Authors: Lowe H, Segal S, Mouzaki M, Langos V, Dlamini N PMID: 30570167 [PubMed - indexed for MEDLINE]
Sat Oct 03, 2020 13:06
Mens Sana in Corpore Sano: Does the Glycemic Index Have a Role to Play? Nutrients. 2020 Sep 29;12(10): Authors: Carneiro L, Leloup C Abstract Although diet interventions are mostly related to metabolic disorders, nowadays they are used in a wide variety of pathologies. From diabetes and obesity to cardiovascular diseases, to cancer or neurological disorders and stroke, nutritional recommendations are applied to almost all diseases. Among such...
Sat Oct 03, 2020 13:06
Genetic Etiologies of Neonatal Seizures. Neoreviews. 2020 Oct;21(10):e663-e672 Authors: Kaur S, Pappas K Abstract Neonates presenting with seizures are frequently assessed and managed by neonatologists in the NICU. Although hypoxic-ischemic encephalopathy and infection are common underlying causes of neonatal seizures, many patients with neonatal epilepsy will have an identifiable genetic etiology. Often these cases will be evaluated in collaboration...
Sat Oct 03, 2020 13:06
Seizures elevate gliovascular unit Ca2+ and cause sustained vasoconstriction. JCI Insight. 2020 Oct 02;5(19): Authors: Tran CHT, George AG, Teskey GC, Gordon GR Abstract Seizures can result in a severe hypoperfusion/hypoxic attack that causes postictal memory and behavioral impairments. However, neither postictal changes to microvasculature nor Ca2+ changes in key cell types controlling blood perfusion have been visualized in vivo, leaving...
Sat Oct 03, 2020 13:06
Altered Static and Dynamic Spontaneous Neural Activity in Drug-Naïve and Drug-Receiving Benign Childhood Epilepsy With Centrotemporal Spikes. Front Hum Neurosci. 2020;14:361 Authors: Jiang S, Luo C, Huang Y, Li Z, Chen Y, Li X, Pei H, Wang P, Wang X, Yao D Abstract The present study aims to investigate intrinsic abnormalities of brain and the effect of antiepileptic treatment on brain activity in Benign childhood epilepsy with centrotemporal...
Sat Oct 03, 2020 13:06
Primary carnitine deficiency in two sisters with intractable epilepsy and reversible metabolic cardiomyopathy: Two case reports. Exp Ther Med. 2020 Nov;20(5):118 Authors: Yang XF, Liu GS, Yi B Abstract Primary carnitine deficiency (PCD) is a disorder of the carnitine cycle that results in defective fatty acid oxidation. When carnitine cannot be transported into the cells, fatty acid oxidation is impaired, resulting a variety of symptoms, such...
Sat Oct 03, 2020 13:06
Coffin-Siris syndrome and epilepsy. Neurol Sci. 2020 Oct 02;: Authors: Curcio MR, Ferranti S, Lotti F, Grosso S Abstract Coffin-Siris syndrome is a rare genetic disorder defined by the presence of particular facial traits, congenital malformations, intellectual disability, and speech impairment. Epilepsy in Coffin-Siris syndrome has only occasionally been reported, and its features are poorly defined. We provide a detailed description of the...
Sat Oct 03, 2020 13:06
Carbamazepine Versus levetiracetam in epilepsy due to neurocysticercosis. Acta Neurol Scand. 2020 Oct 02;: Authors: Santhosh AP, Goyal MK, Modi M, Kharbanda PS, Ahuja CK, Tandyala N, Prabhat N, Singh R, Mehta S, Mahesh KV Abstract BACKGROUND: The choice of antiepileptic drug (AED) in newly diagnosed neurocysticercosis (NCC) patients with epilepsy continues to be arbitrary. We compared efficacy and side effect profile of Levetiracetam (LEV)...
Sat Oct 03, 2020 13:06
Valeriana officinalis extract and 7-Nitroindozole ameliorated seizure behaviours, and 7-Nitroindozole reduced blood pressure and ECG parameters in pentylenetetrazole-kindled rats. Pol J Vet Sci. 2020 Sep;23(3):349-357 Authors: Kapucu A, Ustunova S, Akgun-Dar K Abstract Nitric oxide (NO) is known to be a neuromodulator with dual proconvulsive and anticonvul- sive action. Valeriana officinalis (VAL) was previously believed to be antiepileptic,...
Sat Oct 03, 2020 13:06
Publication date: Available online 2 October 2020Source: Dental MaterialsAuthor(s): Ririko Tsuboi, Haruaki Kitagawa, Satoshi Imazato
Sat Oct 03, 2020 13:07
Publication date: Available online 3 October 2020Source: Dental MaterialsAuthor(s): Dan L Romanyk, Yilan Guo, Nyssa Rae, Sydney Veldhuis, Slobodan Sirovica, Garry JP Fleming, Owen Addison
Sat Oct 03, 2020 13:07
Distinguishing Intrapulmonary Immune Cells from Intravascular Immune Cell Populations: the Intrajugular Approach. J Vis Exp. 2020 Sep 22;(163): Authors: Issah Y, Naik A, Tang SY, Forrest K, Theken KN, Sengupta S Abstract Circadian rhythms refer to oscillations in various biological process that occur with a 24 h period. At the molecular level, such rhythms are comprised of a web of transcriptional-translational feedback loops (TTFL) of...
Sat Oct 03, 2020 13:15
Nanoparticle-Based Chemotherapy Formulations for Head and Neck Cancer: A Systematic Review and Perspectives. Nanomaterials (Basel). 2020 Sep 29;10(10): Authors: de Lima JM, Bonan PR, da Cruz Perez DE, Hier M, Alaoui-Jamali MA, da Silva SD Abstract Head and neck cancer (HNC) is a complex and heterogeneous disease associated with high mortality and morbidity worldwide. Standard therapeutic management of advanced HNC, which is based on radiotherapy...
Sat Oct 03, 2020 13:17
Systemic Treatment for Advanced and Metastatic Malignant Peripheral Nerve Sheath Tumors-A Sarcoma Reference Center Experience. J Clin Med. 2020 Sep 29;9(10): Authors: Sobczuk P, Teterycz P, Czarnecka AM, Świtaj T, Koseła-Paterczyk H, Kozak K, Falkowski S, Rutkowski P Abstract Malignant peripheral nerve sheath tumor (MPNST) is a rare type of soft tissue sarcomas. The localized disease is usually treated with surgery along with perioperative...
Sat Oct 03, 2020 13:17
Views of advanced cancer patients, families, and oncologists on initiating and engaging in advance care planning: a qualitative study. BMC Palliat Care. 2020 Oct 01;19(1):150 Authors: Toguri JT, Grant-Nunn L, Urquhart R Abstract BACKGROUND: Advance care planning (ACP) is a process by which patients reflect upon their goals, values and beliefs to allow them to make decisions about their future medical treatment that align with their goals and...
Sat Oct 03, 2020 13:17
Low doses of ionizing radiation activate endothelial cells and induce angiogenesis in peritumoral tissues. Radiother Oncol. 2020 Sep 28;: Authors: Gil Marques F, Poli E, Malaquias J, Carvalho T, Portêlo A, Ramires A, Aldeia F, Ribeiro RM, Vitorino E, Diegues I, Costa L, Coutinho J, Pina F, Mareel M, Constantino Rosa Santos S Abstract PURPOSE: During radiotherapy the peritumoral tissues are daily exposed to subtherapeutic doses of ionizing radiation....
Sat Oct 03, 2020 13:17
Genome-wide noninvasive prenatal diagnosis of monogenic disorders: Current and future trends. Comput Struct Biotechnol J. 2020;18:2463-2470 Authors: Rabinowitz T, Shomron N Abstract Noninvasive prenatal diagnosis (NIPD) is a risk-free alternative to invasive methods for prenatal diagnosis, e.g. amniocentesis. NIPD is based on the presence of fetal DNA within the mother's plasma cell-free DNA (cfDNA). Though currently available for various monogenic...
Sat Oct 03, 2020 13:17
Future perspectives of surgical treatment of breast cancer. Ann Med Surg (Lond). 2020 Nov;59:93-95 Authors: Riis M Abstract Breast cancer is a heterogenous disease which requires updates on scientific research to offer patients the best possible and personalized treatment. Modern surgical treatment of breast cancer is recently been reviewed and it is clearly a field of continuous change and improvement. The change in treatment strategies is...
Sat Oct 03, 2020 13:17
Poly(ADP-Ribose) Glycohydrolase (PARG) vs. Poly(ADP-Ribose) Polymerase (PARP) - Function in Genome Maintenance and Relevance of Inhibitors for Anti-cancer Therapy. Front Mol Biosci. 2020;7:191 Authors: Harrision D, Gravells P, Thompson R, Bryant HE Abstract Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that catalyze the addition of poly(ADP-ribose) (PAR) subunits onto themselves and other acceptor proteins. PARPs are known to...
Sat Oct 03, 2020 13:17
Auto-segmentations by convolutional neural network in cervical and anorectal cancer with clinical structure sets as the ground truth. Clin Transl Radiat Oncol. 2020 Nov;25:37-45 Authors: Sartor H, Minarik D, Enqvist O, Ulén J, Wittrup A, Bjurberg M, Trägårdh E Abstract Background: It is time-consuming for oncologists to delineate volumes for radiotherapy treatment in computer tomography (CT) images. Automatic delineation based on image processing...
Sat Oct 03, 2020 13:17
The Toronto Sarcoma Flap Score: A Validated Wound Complication Classification System for Extremity Soft Tissue Sarcoma Flap Reconstruction. Ann Surg Oncol. 2020 Oct 01;: Authors: O'Neill AC, Roy M, Boucher A, Fitzpatrick AM, Griffin AM, Tsoi K, Ferguson PC, Wunder JS, Hofer SOP Abstract BACKGROUND: Flap reconstruction plays an important role in limb preservation after wide resection of extremity soft tissue sarcoma (ESTS), but can be associated...
Sat Oct 03, 2020 13:17
Chemotherapy resistance and stromal targets in breast cancer treatment: a review. Mol Biol Rep. 2020 Oct 01;: Authors: van der Spek YM, Kroep JR, Tollenaar RAEM, Mesker WE Abstract Therapy resistance is a known problem in breast cancer and is associated with a variety of mechanisms. The role of the tumor microenvironment in cancer development and resistance mechanisms is becoming increasingly understood. Tumor-stroma is the main component of...
Sat Oct 03, 2020 13:17
The role of serum biomarkers in cancer patients receiving cardiotoxic cancer therapies: a position statement from the Cardio-Oncology Study Group of the Heart Failure Association and Cardio-Oncology Council of the European Society of Cardiology. Eur J Heart Fail. 2020 Oct 02;: Authors: Pudil R, Mueller C, Čelutkienė J, Henriksen PA, Lenihan D, Dent S, Barac A, Stanway S, Moslehi J, Suter TM, Ky B, Štěrba M, Cardinale D, Cohen-Solal A, Tocchetti CG, Farmakis...
Sat Oct 03, 2020 13:17
Changes in peripheral immune cells after intraoperative radiation therapy in low-risk breast cancer.
Changes in peripheral immune cells after intraoperative radiation therapy in low-risk breast cancer. J Radiat Res. 2020 Oct 02;: Authors: Linares-Galiana I, Berenguer-Frances MA, Cañas-Cortés R, Pujol-Canadell M, Comas-Antón S, Martínez E, Laplana M, Pérez-Montero H, Pla-Farnós MJ, Navarro-Martin A, Nuñez M, Both B, Guedea F Abstract A detailed understanding of the interactions and the best dose-fractionation scheme of radiation to maximize...
Sat Oct 03, 2020 13:17
Predictors and Effects of Usage of an Online Mindfulness Intervention for Distressed Cancer Patients: Usability Study. J Med Internet Res. 2020 Oct 02;22(10):e17526 Authors: Cillessen L, van de Ven MO, Compen FR, Bisseling EM, van der Lee ML, Speckens AE Abstract BACKGROUND: One in three cancer patients experience high psychological distress. Mindfulness-based interventions are effective in reducing psychological distress in this patient group....
Sat Oct 03, 2020 13:17
Leading by Design: Lessons for the Future From 25 Years of the Executive Leadership in Academic Medicine (ELAM) Program for Women. Acad Med. 2020 Oct;95(10):1479-1482 Authors: Jagsi R, Spector ND Abstract The Hedwig van Ameringen Executive Leadership in Academic Medicine (ELAM) Program for Women is designed to promote the careers of senior female leaders in academic health care in a way that ultimately seeks to transform culture and promote...
Sat Oct 03, 2020 13:17
Targeting the p53-MDM2 pathway for neuroblastoma therapy: Rays of hope. Cancer Lett. 2020 Sep 29;: Authors: Zafar A, Wang W, Liu G, Xian W, McKeon F, Zhou J, Zhang R Abstract Despite being the subject of extensive research and clinical trials, neuroblastoma remains a major therapeutic challenge in pediatric oncology. The p53 protein is a central safeguard that protects cells against genome instability and malignant transformation. Mutated TP53...
Sat Oct 03, 2020 13:17
Abstract The gamma‐1 isoform of casein kinase 1, the protein encoded by CSNK1G1, is involved in the growth and morphogenesis of cells. This protein is expressed ubiquitously among many tissue types, including the brain, where it regulates the phosphorylation of NMDA receptors and plays a role in synaptic transmission. One prior individual with a de novo variant in CSNK1G presenting with severe developmental delay and early‐onset epilepsy has been reported. Here we report an updated clinical...
Sat Oct 03, 2020 11:53
Acculturation Associated with Sleep Duration, Sleep Quality, and Sleep Disorders at the US-Mexico Border. Int J Environ Res Public Health. 2020 Sep 29;17(19): Authors: Ghani SB, Delgadillo ME, Granados K, Okuagu AC, Alfonso-Miller P, Buxton OM, Patel SR, Ruiz J, Parthasarathy S, Haynes PL, Molina P, Seixas A, Williams N, Jean-Louis G, Grandner MA Abstract Sleep disparities exist among Hispanics/Latinos, although little work has characterized...
Sat Oct 03, 2020 13:22
The Impact of Empagliflozin on Obstructive Sleep Apnea, Cardiovascular, and Renal Outcomes: An Exploratory Analysis of the EMPA-REG OUTCOME Trial. Diabetes Care. 2020 Oct 01;: Authors: Neeland IJ, Eliasson B, Kasai T, Marx N, Zinman B, Inzucchi SE, Wanner C, Zwiener I, Wojeck BS, Yaggi HK, Johansen OE, EMPA-REG OUTCOME Investigators Abstract OBJECTIVE: To explore the effects of empagliflozin on the incidence of obstructive sleep apnea (OSA)...
Sat Oct 03, 2020 13:22
Self-reported sleepiness and not the apnoea hypopnoea index is the best predictor of sleepiness-related accidents in obstructive sleep apnoea. Sci Rep. 2020 Oct 01;10(1):16267 Authors: Philip P, Bailly S, Benmerad M, Micoulaud-Franchi JA, Grillet Y, Sapène M, Jullian-Desayes I, Joyeux-Faure M, Tamisier R, Pépin JL Abstract To evaluate the value of apnoea + hypopnoea index versus self-reported sleepiness at the wheel in anticipating the risk...
Sat Oct 03, 2020 13:22
Influence of multiple apolipoprotein A-I and B genetic variations on insulin resistance and metabolic syndrome in obstructive sleep apnea. Nutr Metab (Lond). 2020;17:83 Authors: Li X, Fu Z, Xu H, Zou J, Zhu H, Li Z, Su K, Huai, Yi H, Guan J, Yin S Abstract Background: The relationships between apolipoprotein A-I (APOA-I), apolipoprotein B (APOB) with insulin resistance, metabolic syndrome (MetS) are unclear in OSA. We aimed to evaluate whether...
Sat Oct 03, 2020 13:22
Hypertension and Alcohol: A Mechanistic Approach. Cureus. 2020 Aug 27;12(8):e10086 Authors: Okojie OM, Javed F, Chiwome L, Hamid P Abstract Hypertension is a global public health challenge and a major cause of morbidity and mortality. Alcohol is one of the most frequently abused substances around the world. The financial implications of treating hypertension are also significant. Developing successful strategies to prevent hypertension may...
Sat Oct 03, 2020 13:22
Serum matrix metalloproteinase-2 as a predictor of level of hypoxemia and severity of obstructive sleep apnea. Sleep Breath. 2020 Oct 01;: Authors: Franczak A, Skomro R, Sawicka J, Bil-Lula I, Nocon A, Fenton M, Lawson J, Sawicki G Abstract PURPOSE: Intermittent hypoxia in obstructive sleep apnea (OSA) resembles ischemia/reperfusion. Oxidative stress during ischemia/reperfusion increases matrix metalloproteinase-2 (MMP-2) activity and leads...
Sat Oct 03, 2020 13:22
Survival benefit of continuous positive airway pressure in Japanese patients with obstructive sleep apnea: a propensity-score matching analysis. J Clin Sleep Med. 2020 Oct 02;: Authors: Nakamura K, Nakamura H, Tohyama K, Takara C, Iseki C, Woodward M, Iseki K Abstract STUDY OBJECTIVES: Continuous positive airway pressure (CPAP) improves quality of life in patients with obstructive sleep apnea (OSA). However, the long-term benefit in all-cause...
Sat Oct 03, 2020 13:22
Diffuse midline glioma presenting with central sleep apnea and pulmonary hypertension in a four-year-old patient: a case report. J Clin Sleep Med. 2020 Oct 02;: Authors: Huang SW, Lee PL, Fan PC, Kuo MF, Chen CA, Chiu SN, Lin MT, Lu CW, Wang JK, Wu MH Abstract None: Central sleep apnea is a rare disorder in pediatric population with various initial presentations and is secondary to many underlining diseases. This is a four-year-old boy with...
Sat Oct 03, 2020 13:22
The sociodemographic and risk factors for keratoconus: Nationwide matched case-control study in Taiwan, 1998-2015. Am J Ophthalmol. 2020 Sep 29;: Authors: Lin KK, Lee JS, Hou CH, Chen WM, Hsiao CH, Chen YW, Yeh CT, See LC Abstract PURPOSE: The aim of this study was to determine the sociodemographic and risk factors for KC patients with a nationwide Asian data base. DESIGN: Population-based matched case-control study. METHODS:...
Sat Oct 03, 2020 13:22
Association between Obstructive Sleep Apnea and Exfoliation Syndrome: The Utah Project on Exfoliation Syndrome. Ophthalmol Glaucoma. 2020 Sep 29;: Authors: Shumway C, Curtin K, Taylor S, Sundar KM, Wirostko BM, Ritch R Abstract PURPOSE: Exfoliation syndrome (XFS), the most common recognizable cause of open-angle glaucoma worldwide, is a systemic disorder with genetic predisposition due to variations in lysyl oxidase-like 1 (LOXL1) function,...
Sat Oct 03, 2020 13:22
Obstructive sleep Apnea's association with the cervical spine abnormalities, posture, and pain: a systematic review. Sleep Med. 2020 Sep 10;75:468-476 Authors: Pham T, Lin CK, Leek D, Chandrashekhar R, Annaswamy TM Abstract OBJECTIVES: While obstructive sleep apnea (OSA) is associated with several chronic health conditions such as hypertension, obesity, and chronic hypoxia, there is limited information on its association with neuromuscular...
Sat Oct 03, 2020 13:22
SARS-CoV-2 samples may escape detection because of a single point mutation in the N gene. Euro Surveill. 2020 Oct;25(39): Authors: Ziegler K, Steininger P, Ziegler R, Steinmann J, Korn K, Ensser A Abstract We found that a single nucleotide polymorphism (SNP) in the nucleoprotein gene of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a patient interfered with detection in a widely used commercial assay. Some 0.2% of the isolates...
Sat Oct 03, 2020 13:23
Automated digital reporting of clinical laboratory information to national public health surveillance systems, results of a EU/EEA survey, 2018. Euro Surveill. 2020 Oct;25(39): Authors: Leitmeyer KC, Espinosa L, Broberg EK, Struelens MJ, ECDC National Focal Points laboratory e-reporting survey group members, ECDC National Focal Points laboratory e-reporting survey group Abstract BackgroundTimely reporting of microbiology test results is essential...
Sat Oct 03, 2020 13:23
Authors' correction for Euro Surveill. 2020;25(32). Euro Surveill. 2020 Oct;25(39): Authors: Eurosurveillance editorial team PMID: 33006302 [PubMed - in process]
Sat Oct 03, 2020 13:23
Capturing respiratory syncytial virus season in Belgium using the influenza severe acute respiratory infection surveillance network, season 2018/19. Euro Surveill. 2020 Oct;25(39): Authors: Subissi L, Bossuyt N, Reynders M, Gérard M, Dauby N, Bourgeois M, Delaere B, Quoilin S, Van Gucht S, Thomas I, Barbezange C Abstract BackgroundRespiratory syncytial virus (RSV) is a common cause of severe respiratory illness in young children (< 5 years...
Sat Oct 03, 2020 13:23
Resolved: Expression of concern for Euro Surveill. 2020;25(32). Euro Surveill. 2020 Oct;25(39): Authors: Eurosurveillance editorial team PMID: 33006304 [PubMed - in process]
Sat Oct 03, 2020 13:23
Autochthonous dengue in two Dutch tourists visiting Département Var, southern France, July 2020. Euro Surveill. 2020 Oct;25(39): Authors: Vermeulen TD, Reimerink J, Reusken C, Giron S, de Vries PJ Abstract We report dengue virus (DENV) infection in two Dutch tourists who visited Département Var, southern France, in July and August 2020. As some autochthonous dengue cases have occurred in Europe in recent years, awareness among physicians and...
Sat Oct 03, 2020 13:23
Activation of ventrolateral orbital cortex improves mouse neuropathic pain-induced anxiodepression. JCI Insight. 2020 Oct 02;5(19): Authors: Sheng HY, Lv SS, Cai YQ, Shi W, Lin W, Liu TT, Lv N, Cao H, Zhang L, Zhang YQ Abstract Depression and anxiety are frequently observed in patients suffering from neuropathic pain. The underlying mechanisms remained unclear. The ventrolateral orbital cortex (VLO) has attracted considerable interest in its...
Sat Oct 03, 2020 13:24
Corrigendum to: Age specific colorectal cancer incidence rate in the world. Jpn J Clin Oncol. 2020 Oct 02;: Authors: Saito E, Hori M PMID: 33005927 [PubMed - as supplied by publisher]
Sat Oct 03, 2020 13:25
27 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2020/10/03PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Oct 03, 2020 13:27
Aldh2 gene reduces oxidative stress in the bladder by regulating the NF-κB pathway in a mouse model of ketamine-induced cystitis. Exp Ther Med. 2020 Nov;20(5):111 Authors: Xi XJ, Chen SH, Mi H Abstract Aldehyde dehydrogenase 2 (aldh2) serves an important role in the development of organ injury. Therefore, the present study investigated the effects of aldh2 on the oxidative stress response in a mouse model of ketamine-induced cystitis (KIC)....
Sat Oct 03, 2020 13:31
Role of TLR4/MyD88/NF-κB signaling in the contrast-induced injury of renal tubular epithelial cells.
Role of TLR4/MyD88/NF-κB signaling in the contrast-induced injury of renal tubular epithelial cells. Exp Ther Med. 2020 Nov;20(5):115 Authors: Wang X, Zhou J, Yang J, Wang S, Yang L Abstract The aim of the present study was to explore the role of toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MyD88)/nuclear factor (NF)-κB signaling in the contrast-induced injury of renal tubular epithelial cells, and to investigate...
Sat Oct 03, 2020 13:31
Brilliant blue G attenuates neuro-inflammation via regulating MAPKs and NF-κB signaling pathways in lipopolysaccharide-induced BV2 microglia cells. Exp Ther Med. 2020 Nov;20(5):116 Authors: Wang W, Huang F, Jiang W, Wang W, Xiang J Abstract Previous studies have demonstrated that the P2X purinoceptor 7 (P2X7) receptor (P2X7R) serves a critical role in regulating the inflammatory response of various diseases in the central nervous system. The...
Sat Oct 03, 2020 13:31
Irbesartan ameliorates myocardial fibrosis in diabetic cardiomyopathy rats by inhibiting the TGFβ1/Smad2/3 pathway. Exp Ther Med. 2020 Nov;20(5):117 Authors: Zong M, Zhao H, Li Q, Li Y, Zhang J Abstract Myocardial fibrosis (MF) is an important pathological change in diabetic cardiomyopathy. The aim of the present study was to investigate whether irbesartan serves a role in improving MF in a diabetic rat model. Fasting blood glucose (FBG), total...
Sat Oct 03, 2020 13:31
Primary carnitine deficiency in two sisters with intractable epilepsy and reversible metabolic cardiomyopathy: Two case reports. Exp Ther Med. 2020 Nov;20(5):118 Authors: Yang XF, Liu GS, Yi B Abstract Primary carnitine deficiency (PCD) is a disorder of the carnitine cycle that results in defective fatty acid oxidation. When carnitine cannot be transported into the cells, fatty acid oxidation is impaired, resulting a variety of symptoms, such...
Sat Oct 03, 2020 13:31
Association between α1-antitrypsin and acute coronary syndrome. Exp Ther Med. 2020 Nov;20(5):119 Authors: Liu Y, Huang D, Li B, Liu W, Sooranna SR, Pan X, Huang Z, Guo J Abstract α1-antitrypsin (AAT) is a protein released as part of the anti-inflammatory response. It regulates the activity of serine proteinases and has a crucial role in the pathogenesis of acute coronary syndrome (ACS). The present study aimed to examine its role in patients...
Sat Oct 03, 2020 13:31
Clinical investigation of acute myocardial infarction according to age subsets. Exp Ther Med. 2020 Nov;20(5):120 Authors: Wang J, Li L, Ma N, Zhang X, Qiao Y, Fang G, Li G, Zhong T Abstract A growing number of 'Young' patients less than 40 years of age are being hospitalized with a diagnosis of acute myocardial infarction (AMI) due to increased prevalence of risk factors for atherosclerosis. The aim of this study was to compare clinical characteristics...
Sat Oct 03, 2020 13:31
Enhanced expression of synoviolin in peripheral blood from obese/overweight donors. Exp Ther Med. 2020 Nov;20(5):121 Authors: Fujita H, Aratani S, Mizoguchi I, Yagishita N, Nakajima T Abstract Obesity is currently a major medical and societal issue. Synoviolin (SYVN1) is an E3 ubiquitin ligase involved in endoplasmic reticulum (ER) stress. Overexpression of Syvn1 has been found in genetically obese mice (ob/ob and db/db), and treatment with...
Sat Oct 03, 2020 13:31
GSK-3β mediates the effects of HNF-1β overexpression in ovarian clear cell carcinoma. Exp Ther Med. 2020 Nov;20(5):122 Authors: Kawahara N, Mizutani A, Matsubara S, Takeda Y, Kobayashi H Abstract Deubiquitinase USP28 is a target gene of the transcription factor HNF1 homeobox β (HNF-1β), which promotes the survival of ovarian clear cell carcinoma (OCCC) cell lines. However, the pharmacological inhibition of HNF-1β can cause several adverse effects...
Sat Oct 03, 2020 13:31
The c-Jun signaling pathway has a protective effect on nucleus pulposus cells in patients with intervertebral disc degeneration. Exp Ther Med. 2020 Nov;20(5):123 Authors: Lei M, Wang K, Li S, Zhao K, Hua W, Wu X, Yang C Abstract Among a range of diverse clinical symptoms, intervertebral disc degeneration (IDD) contributes mostly to the onset of lower back pain. The present study aimed to investigate the effects of c-Jun on nucleus pulposus...
Sat Oct 03, 2020 13:31
Roles of klotho and stem cells in mediating vascular calcification (Review). Exp Ther Med. 2020 Dec;20(6):124 Authors: Yu L, Li M Abstract Vascular calcification, characterized by the active deposition of calcium phosphate in the vascular walls, is commonly observed in aging, diabetes mellitus and chronic kidney disease. This process is mediated by different cell types, including vascular stem/progenitor cells. The anti-aging protein klotho...
Sat Oct 03, 2020 13:31
MicroRNA-142 protects MC3T3-E1 cells against high glucose-induced apoptosis by targeting β-catenin. Exp Ther Med. 2020 Dec;20(6):125 Authors: Zheng T, Ji G, Chen J, Lai J, Liu T, Mo J, Jin Q Abstract Osteoporosis, characterized by decreased mineral density and bone mass, is triggered by various detrimental factors and often causes further complications, including fractures. Aberrant expression of microRNAs (miRs) has been associated with the...
Sat Oct 03, 2020 13:31
The combination of PLLA/PLGA/PCL composite scaffolds integrated with BMP-2-loaded microspheres and low-intensity pulsed ultrasound alleviates steroid-induced osteonecrosis of the femoral head. Exp Ther Med. 2020 Dec;20(6):126 Authors: Zhu H, Shi Z, Cai X, Yang X, Zhou C Abstract Low-intensity pulsed ultrasound (LIPUS), which has been previously reported to promote bone repair, is proposed to be a noninvasive form of therapy for the treatment...
Sat Oct 03, 2020 13:31
Volumetric Flow Changes in Extracranial Arteries in a Symptomatic Patient with Significant Bilateral Carotid Artery Stenosis: A Case Study and Literature Review. Am J Case Rep. 2020 Oct 02;21:e927202 Authors: Leszczyński J, Kaszczewski P, Elwertowski M, Stępkowski K, Maciąg R, Elwertowska A, Gałązka Z Abstract BACKGROUND Hemodynamically significant carotid artery stenoses are rarely diagnosed in people under 60 years of age, being mainly secondary...
Sat Oct 03, 2020 13:31
Isolated Superior Mesenteric Artery Dissection Mimicking Impending Rupture of Abdominal Aortic Aneurysm. Am J Case Rep. 2020 Oct 02;21:e925464 Authors: Kawahigashi T, Kawabe T, Iijima H, Takagi M, Noda T, Watanabe K Abstract BACKGROUND Isolated superior mesenteric artery dissection (SMAD) is a rare vascular disease that is difficult to diagnose. We report a case of SMAD in a patient with an abdominal aortic aneurysm (AAA) that mimicked an impending...
Sat Oct 03, 2020 13:31
Minimally invasive robotic-assisted harvest of the deep inferior epigastric perforator flap for autologous breast reconstruction. J Plast Reconstr Aesthet Surg. 2020 Sep 20;: Authors: Piper M, Ligh CA, Shakir S, Messa C, Soriano I, Kanchwala S PMID: 33004296 [PubMed - as supplied by publisher]
Sat Oct 03, 2020 13:35
Related Articles Dramatic progression of a chest wall desmoid-like fibromatosis. ANZ J Surg. 2019 11;89(11):E529-E530 Authors: Zizzo M, Castagnetti F, Valli R, Bellafiore S, Borrelli R, Di Stefano T, Lococo F PMID: 30239095 [PubMed - indexed for MEDLINE]
Sat Oct 03, 2020 13:40
Related Articles Primary anterior abdominal wall leiomyoma in a pregnant woman. ANZ J Surg. 2019 11;89(11):E527-E528 Authors: Mousa HM, Al-Salam SA, Abdullah A, Abu-Zidan FM PMID: 30239100 [PubMed - indexed for MEDLINE]
Sat Oct 03, 2020 13:40
Related Articles Laparoscopic resection of an urachal abscess caused by migration of a fish bone: a case report. ANZ J Surg. 2019 11;89(11):E536-E537 Authors: Okada M, Emoto S, Kaneko M, Yamada D, Nozawa H PMID: 30277300 [PubMed - indexed for MEDLINE]
Sat Oct 03, 2020 13:40
Related Articles Minimally invasive robotic-assisted excision of an aortopulmonary mediastinal paraganglioma. Eur J Cardiothorac Surg. 2019 May 01;55(5):1012-1014 Authors: Wasserman GA, Kent AJ, Lazzaro RS, Patton BD Abstract Aortopulmonary paragangliomas are rare, neural crest-derived tumours that arise in the aortopulmonary window and present a significant surgical challenge due to their proximity to major vessels. In the relatively few cases...
Sat Oct 03, 2020 13:40
Related Articles Fungal granuloma: a case report of a rare cause for isolated adrenal incidentaloma. ANZ J Surg. 2019 11;89(11):E525-E526 Authors: Bender K, Waldie AM, Asogan M, Figtree MC, Sywak MS PMID: 30347491 [PubMed - indexed for MEDLINE]
Sat Oct 03, 2020 13:40
Related Articles Venous Gas Embolism during Hysteroscopic Endometrial Ablation: Report of 5 Cases and Review of the Literature. J Minim Invasive Gynecol. 2020 Mar - Apr;27(3):748-754 Authors: Vilos GA, Hutson JR, Singh IS, Giannakopoulos F, Rafea BA, Vilos AG Abstract STUDY OBJECTIVE: To highlight the circumstances, presentation, and treatment of venous gas embolism (VGE) and provide guidance and propose potential changes in surgical practice...
Sat Oct 03, 2020 13:40
Related Articles TGF-β receptor inhibitor LY2109761 enhances the radiosensitivity of gastric cancer by inactivating the TGF-β/SMAD4 signaling pathway. Aging (Albany NY). 2019 10 19;11(20):8892-8910 Authors: Yang T, Huang T, Zhang D, Wang M, Wu B, Shang Y, Sattar S, Ding L, Liu Y, Jiang H, Liang Y, Zhou F, Wei Y Abstract Radiotherapy is used to treat gastric cancer (GC); however, radioresistance challenges the clinical outcomes of GC, and the...
Sat Oct 03, 2020 13:40
Related Articles Metastatic pheochromocytoma to the pancreas diagnosed by endoscopic ultrasound-guided fine needle aspiration: A case report and review of literature. Diagn Cytopathol. 2020 Mar;48(3):217-221 Authors: Yang SX, Dogra VS, Kothari TH, Reyes MCD Abstract Pancreatic pheochromocytomas are rare and typically diagnosed by local resection. We present the first reported case of metastatic pheochromocytoma to the pancreas diagnosed by...
Sat Oct 03, 2020 13:40
Related Articles Pseudoglandular schwannoma mimicking alveolar rhabdomyosarcoma: A diagnostic challenge on fine-needle cytology. Diagn Cytopathol. 2020 Mar;48(3):228-233 Authors: Yaprak Bayrak B, Vural Ç, Paksoy N Abstract Pseudoglandular schwannoma (PGS) is a rare morphological variant of benign schwannoma. PGS is quite distinct from the somewhat better characterized glandular schwannoma variant. PGS is characterized by the presence of gland-like...
Sat Oct 03, 2020 13:40
Related Articles Cytological diagnosis of amyloidosis presenting as a supraclavicular swelling. Diagn Cytopathol. 2020 Mar;48(3):234-238 Authors: Rakheja G, Handa U, Tahlan A, Lehl SS Abstract Amyloidosis is a well-recognized entity, that can present as a systemic disease, or, uncommonly, as a localized mass. We report here, a rare presentation of amyloidosis presenting as a supraclavicular swelling, diagnosed on fine-needle aspiration cytology....
Sat Oct 03, 2020 13:40
Related Articles Excretion of Ascaris lumbricoides following reduced-intensity allogeneic hematopoietic stem cell transplantation and consecutive treatment with mebendazole. Transpl Infect Dis. 2020 Feb;22(1):e13224 Authors: Luber V, Lutz M, Abele-Horn M, Einsele H, Grigoleit GU, Mielke S Abstract Here, we present the unique case of a 51-year-old German patient with multiple myeloma excreting Ascaris lumbricoides in his stool five weeks after...
Sat Oct 03, 2020 13:40
Related Articles Psammoma Bodies in a Large Myoepithelioma. J Craniofac Surg. 2020 Jun;31(4):e326-e329 Authors: Melo MP, Silva DFB, Ribeiro RA, Peixoto TS, Gomes DQC, Alves PM, Nonaka CFW, Monteiro BVB Abstract Myoepithelioma is a rare benign tumor of the salivary glands, in which the vast majority of neoplastic cells are myoepithelial. A rare microscopic finding in salivary gland tumors, including myoepitheliomas, is the presence of psammoma...
Sat Oct 03, 2020 13:40
Related Articles The Upper Lip Squamous Cell Carcinoma the Role of Wedge Excision. J Craniofac Surg. 2020 Jun;31(4):e332-e333 Authors: Obradovic B Abstract Lip cancer is the most common malignant lesion of the oral cavity. Most of the tumors have been presented in the lower lip as a SCC, whereas the upper lip SCC is rare. Surgical excision with negative margins is the mainstay of treatment for lip SCC. The author presents a patient with the...
Sat Oct 03, 2020 13:40
Related Articles Pseudomyogenic Hemangioendothelioma: A Rare Vascular Tumor of the Oral Cavity. J Craniofac Surg. 2020 Jun;31(4):e333-e334 Authors: Ramos-Fuentes H, Ortiz-Diaz C, Sifuentes-Cervantes S, Castro-Núñez J Abstract Pseudomyogenic hemangioendothelioma is a vascular neoplasm that presents a borderline biological behavior, intermediate between entirely benign hemangiomas and highly malignant angiosarcomas. Up to date, only 1 case of...
Sat Oct 03, 2020 13:40
Related Articles Recent advances in understanding and managing chordomas: an update. F1000Res. 2020;9: Authors: Connors SW, Aoun SG, Shi C, Peinado-Reyes V, Hall K, Bagley CA Abstract Chordomas are rare and difficult-to-treat tumors arising from the embryonic notochord. While surgery is the mainstay of treatment, and despite new techniques aimed at maximizing total tumoral resection, recurrence remains high and the probability of disease-free...
Sat Oct 03, 2020 13:40
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