Acta Otorrinolaringologica English
- A long styloid process and Collet–Sicard syndromePublication date: September–October 2019Source: Acta Otorrinolaringologica (English Edition), Volume 70, Issue 5Author(s): João Simões, Sofia Paiva, Jorge Miguéis, António Miguéis
- Otopalatodigital syndrome type <span class="small-caps">I</span>: New temporal bone CT-scan sign in a case with a de novo novel mutationPublication date: September–October 2019Source: Acta Otorrinolaringologica (English Edition), Volume 70, Issue 5Author(s): Marta Martínez-López, Ana Navedo, Reyes López De Mesa, Francisco Javier Cervera-Paz
- Executive Summary of the SEORL CCC-SEEN Consensus Document on Post-thyroidectomy HypoparathyroidismPublication date: September–October 2019Source: Acta Otorrinolaringologica (English Edition), Volume 70, Issue 5Author(s): Alejandro Castro, Amelia Oleaga, Pablo Parente Arias, Miguel Paja, Elisa Gil Carcedo, Cristina Álvarez EscoláAbstractHypoparathyroidism is the most common complication after total or completion thyroidectomy. It is defined as the presence of hypocalcemia accompanied by low or inappropriately normal parathyroid hormone (PTH) l
- Update on consensus on diagnosis and treatment of idiopathic sudden sensorineural hearing lossPublication date: September–October 2019Source: Acta Otorrinolaringologica (English Edition), Volume 70, Issue 5Author(s): Mayte Herrera, José Ramón García Berrocal, Ana García Arumí, María José Lavilla, Guillermo Plaza, Grupo de Trabajo de la Comisión de Audiología de la SEORLAbstractIntroductionIdiopathic sudden sensorineural hearing loss (ISSNHL) is a sudden, unexplained unilateral hearing loss.ObjectivesTo update the Spanish Consensus on the
- Depression and anxiety levels in mothers of children with epistaxis: A controlled studyPublication date: September–October 2019Source: Acta Otorrinolaringologica (English Edition), Volume 70, Issue 5Author(s): Nurdoğan Ata, Tahir Bülbül, Cem Gökçen, Abdullah Demirkan, Mehmet Ali ÇiftçiAbstractIntroductionPediatric epistaxis is very common. A child's illness can lead to depression and anxiety in the parents. The association between pediatric epistaxis and mothers’ anxiety has not been well documented.ObjectiveThe present study is ai
- <strong>Juvenile Nasopharyngeal Angiofibroma Surgical Treatment in Paediatric Patients</strong>Publication date: September–October 2019Source: Acta Otorrinolaringologica (English Edition), Volume 70, Issue 5Author(s): Juan Francisco Oré Acevedo, Luis Martín La Torre Caballero, Rosmery Janet Urteaga QuirogaAbstractIntroductionThe juvenile nasopharyngeal angiofibroma is a highly vascularised benign neoplasm of complex treatment in its surgical preparation, surgery to be performed, risks and recurrences.ObjectiveThe aim of the study was to de
- <strong>Epidemiologic Characteristics of Squamous Head and Neck Carcinoma Patients. Results of a Hospital Register</strong>Publication date: September–October 2019Source: Acta Otorrinolaringologica (English Edition), Volume 70, Issue 5Author(s): Xavier León, Montserrat López, Jacinto García, Juan R. Montserrat, Juan R. Gras, Katarzyna A. Kolanczak, Miquel QuerAbstractIntroduction and objectivesThe epidemiological characteristics of patients with head and neck cancer squamous cell carcinoma (HNSCC) have changed over recent years. The increase in life expectancy of the
- Clinical Assessment of Eustachian Tube Dysfunction Through the Eustachian Tube Dysfunction Questionnaire (ETDQ-7) and TubomanometryPublication date: September–October 2019Source: Acta Otorrinolaringologica (English Edition), Volume 70, Issue 5Author(s): Mayte Herrera, Gustavo Eisenberg, Guillermo PlazaAbstractObjectiveEvaluation of the severity of Eustachian tube dysfunction using the Spanish validation of the Eustachian Tube Dysfunction Questionnaire-7 (ETDQ-7) and tubomanometry (TMM).Materials and methodsSpanish validation of the ETDQ-7. Patients: Prospective study with 12
- Search for normality criteria of auditory brain responses and auditory steady state response with free-field stimulationPublication date: September–October 2019Source: Acta Otorrinolaringologica (English Edition), Volume 70, Issue 5Author(s): Juan B. Calero del Castillo, Alberto J. Guillén Martínez, Francisco García-Purriños GarcíaAbstractObjectiveTo discover the thresholds of normality of the tests of ABR and ASSR in free-field stimulation compared with headphones.MethodsDescriptive study of a series of cases of children without hearing loss carried out between A
- Vowel Production in Hearing Impaired Children: A Comparison Between Normal-hearing, Hearing-aided and Cochlear-implanted ChildrenPublication date: September–October 2019Source: Acta Otorrinolaringologica (English Edition), Volume 70, Issue 5Author(s): Faustino Núñez-Batalla, Gabriela Vasile, Noelia Cartón-Corona, Daniel Pedregal-Mallo, Marta Menéndez de Castro, Maite Guntín García, Justo Gómez-Martínez, Pilar Carro Fernández, Jose Luis Llorente-PendásAbstractIntroduction and objectivesInadequate auditory feedback in prelingually deaf children alters the articulation of con
- Transmastoid approach for surgical repair of superior canal dehiscence syndromePublication date: Available online 24 September 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Raphaelle A. Chemtob, Samuel R. Barber, Angela W. Zhu, Elliott D. Kozin, Daniel J. LeePatients with superior canal dehiscence syndrome may present with a myriad of auditory and/or vestibular complaints. Treatment of superior canal dehiscence syndrome depends on severity of symptoms and impact on quality of life. Surge
- Description and validation of the LocoWhisk system: Quantifying rodent exploratory, sensory and motor behavioursPublication date: Available online 24 September 2019Source: Journal of Neuroscience MethodsAuthor(s): David Gillespie, Moi Hoon Yap, Brett M. Hewitt, Heather Driscoll, Ugne Simanaviciute, Emma F. Hodson-Tole, Robyn A. GrantAbstractBackgroundPrevious studies have demonstrated that analysing whisker movements and locomotion allows us to quantify the behavioural consequences of sensory, motor and cognitive deficits in rodents. Independent whisker an
Allergy
- Social contributions to the foraging behavior of young wild golden lion tamarins (Leontopithecus rosalia): Age‐related changes and partner preferencesDuring the periods of most intensive care, golden lion tamarin parents ‐ especially mothers ‐ provision young with prey more frequently than do older siblings. Neither older sibling sex nor age significantly influence the rate at which they provide food to juveniles. Abstract In cooperatively breeding species, group members other than the parents contribute to the care of the young. The costs and benefits to caregiving may vary with the type
Cancers
- Cancers, Vol. 11, Pages 1433: Potent Activity of Composite Cyclin Dependent Kinase Inhibition against Hepatocellular CarcinomaCancers, Vol. 11, Pages 1433: Potent Activity of Composite Cyclin Dependent Kinase Inhibition against Hepatocellular Carcinoma Cancers doi: 10.3390/cancers11101433 Authors: Yu-Yun Shao Yong-Shi Li Hung-Wei Hsu Hang Lin Han-Yu Wang Rita Robin Wo Ann-Lii Cheng Chih-Hung Hsu Alterations in cell cycle regulators are common in hepatocellular carcinoma (HCC). We tested the efficacy of composite inhibition of CDKs 1, 2,
- Cancers, Vol. 11, Pages 1432: Potential Role of MSC/Cancer Cell Fusion and EMT for Breast Cancer Stem Cell FormationCancers, Vol. 11, Pages 1432: Potential Role of MSC/Cancer Cell Fusion and EMT for Breast Cancer Stem Cell Formation Cancers doi: 10.3390/cancers11101432 Authors: Ralf Hass Juliane von der Ohe Hendrik Ungefroren Solid tumors comprise of maturated cancer cells and self-renewing cancer stem-like cells (CSCs), which are associated with various other nontumorigenic cell populations in the tumor microenvironment. In addition to immu
- Cancers, Vol. 11, Pages 1431: Liquid Biopsy Testing Can Improve Selection of Advanced Non-Small-Cell Lung Cancer Patients to Rechallenge with GefitinibCancers, Vol. 11, Pages 1431: Liquid Biopsy Testing Can Improve Selection of Advanced Non-Small-Cell Lung Cancer Patients to Rechallenge with Gefitinib Cancers doi: 10.3390/cancers11101431 Authors: Riziero Esposito Abate Raffaella Pasquale Alessandra Sacco Maria Carmela Piccirillo Alessandro Morabito Paolo Bidoli Giovanna Finocchiaro Rita Chiari Luisa Foltran Roberta Buosi Marcello Tiseo Laura Giannetta
- Cancers, Vol. 11, Pages 1429: The Targeting of RNA Polymerase I Transcription Using CX-5461 in Combination with Radiation Enhances Tumour Cell Killing Effects in Human Solid CancersCancers, Vol. 11, Pages 1429: The Targeting of RNA Polymerase I Transcription Using CX-5461 in Combination with Radiation Enhances Tumour Cell Killing Effects in Human Solid Cancers Cancers doi: 10.3390/cancers11101429 Authors: Mohammed Ismael Roger Webb Mazhar Ajaz Karen J. Kirkby Helen M. Coley An increased rate of cellular proliferation is a hallmark of cancer and may be accompanied by an increase in ribosome biogenesi
- Cancers, Vol. 11, Pages 1430: Macrophage Migration Inhibitory Factor Is a Molecular Determinant of the Anti-EGFR Monoclonal Antibody Cetuximab Resistance in Human Colorectal Cancer CellsCancers, Vol. 11, Pages 1430: Macrophage Migration Inhibitory Factor Is a Molecular Determinant of the Anti-EGFR Monoclonal Antibody Cetuximab Resistance in Human Colorectal Cancer Cells Cancers doi: 10.3390/cancers11101430 Authors: Rosita Russo Nunzia Matrone Valentina Belli Davide Ciardiello Mariangela Valletta Sabrina Esposito Paolo Vincenzo Pedone Fortunato Ciardiello Teresa Troiani Angela Chambery Back
- Cancers, Vol. 11, Pages 1427: FOXO1 Confers Maintenance of the Dark Zone Proliferation and Survival Program and Can Be Pharmacologically Targeted in Burkitt LymphomaCancers, Vol. 11, Pages 1427: FOXO1 Confers Maintenance of the Dark Zone Proliferation and Survival Program and Can Be Pharmacologically Targeted in Burkitt Lymphoma Cancers doi: 10.3390/cancers11101427 Authors: Franziska Gehringer Stephanie Weissinger Lotteke Swier Peter Möller Thomas Wirth Alexey Ushmorov The FOXO1 transcription factor plays a central role in the proliferation and survival of B cells at several stage
- Cancers, Vol. 11, Pages 1428: STAT3 and STAT5 Activation in Solid CancersCancers, Vol. 11, Pages 1428: STAT3 and STAT5 Activation in Solid Cancers Cancers doi: 10.3390/cancers11101428 Authors: Sebastian Igelmann Heidi A. Neubauer Gerardo Ferbeyre The Signal Transducer and Activator of Transcription (STAT)3 and 5 proteins are activated by many cytokine receptors to regulate specific gene expression and mitochondrial functions. Their role in cancer is largely context-dependent as they can both act as
- Cancers, Vol. 11, Pages 1426: Evaluation and Validation of Plasma Proteins Using Two Different Protein Detection Methods for Early Detection of Colorectal CancerCancers, Vol. 11, Pages 1426: Evaluation and Validation of Plasma Proteins Using Two Different Protein Detection Methods for Early Detection of Colorectal Cancer Cancers doi: 10.3390/cancers11101426 Authors: Megha Bhardwaj Anton Gies Korbinian Weigl Kaja Tikk Axel Benner Petra Schrotz-King Christoph H. Borchers Hermann Brenner Objective: Plasma protein biomarkers could be an efficient alternative for population-b
- Cancers, Vol. 11, Pages 1425: ErbB3 Phosphorylation as Central Event in Adaptive Resistance to Targeted Therapy in Metastatic Melanoma: Early Detection in CTCs during Therapy and Insights into Regulation by Autocrine NeuregulinCancers, Vol. 11, Pages 1425: ErbB3 Phosphorylation as Central Event in Adaptive Resistance to Targeted Therapy in Metastatic Melanoma: Early Detection in CTCs during Therapy and Insights into Regulation by Autocrine Neuregulin Cancers doi: 10.3390/cancers11101425 Authors: Ciro Francesco Ruggiero Debora Malpicci Luigi Fattore Gabriele Madonna Vito Vanella Domenico Mallardo Domenico Liguoro Valentina Salvati Mariaele
Clinical and translational oncology
- Network indirect comparison of 3 BRAF + MEK inhibitors for the treatment of advanced BRAF mutated melanomaAbstract Backgroud Synergistic combinations between BRAF and MEK inhibitors, such as dabrafenib plus trametinib, vemurafenib plus cobimetinib or encorafenib plus binimetinib, represent the current standard of care in metastatic or locally advanced BRAF V600 mutated malignant melanomas (MM). However, no studies explored the direct head-to-head comparison between the three different comb
- Miyazaki Syndrome: cervical myelo/radiculopathy caused by overshunting. A systematic reviewPublication date: Available online 24 September 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Gábor Czigléczki, Balázs Markia, Gábor Nagy, Éva Osztie, Anna Szűcs, János Vajda, Dusan Vitanovics, Péter Várallyay, Zoltán NagyABSTRACTObjectivesMiyazaki syndrome is a cervical myelopathy or radiculopathy caused by cervical epidural venous congestion, due to cerebrospinal fluid over-drainage by an implanted ventricular shunt. The complex pat
G3: .Genes, Genomes, Genetics Mission - Online First Articles
- A Mouse Mutation That Dysregulates Neighboring Galnt17 and Auts2 Genes Is Associated with Phenotypes Related to the Human AUTS2 SyndromeAUTS2 was originally discovered as the gene disrupted by a translocation in human twins with Autism spectrum disorder, intellectual disability, and epilepsy. Since that initial finding, AUTS2-linked mutations and variants have been associated with a very broad array of neuropsychiatric disorders, suggesting that AUTS2 is required for fundamental steps of neurodevelopment. However, genotype-phenotype correlations in this region are complicated, be
- Genome Improvement and Genetic Map Construction for Aethionema arabicum, the First Divergent Branch in the Brassicaceae FamilyThe genus Aethionema is a sister-group to the core-group of the Brassicaceae family that includes Arabidopsis thaliana and the Brassica crops. Thus, Aethionema is phylogenetically well-placed for the investigation and understanding of genome and trait evolution across the family. We aimed to improve the quality of the reference genome draft version of the annual species Aethionema arabicum. Secondly, we constructed the first Ae. arabicum genetic
- Comparing Model Performance in Characterizing the PK/PD of the Anti‐Myostatin Antibody DomagrozumabAbstract Modeling and simulation provides quantitative information on target coverage for dose selection. Optimal model selection often relies on fit criteria and is not necessarily mechanistically driven. One such case is discussed where healthy volunteer data of an anti‐myostatin monoclonal antibody domagrozumab was used to develop different target‐mediated drug disposition models; a quasi steady‐state rapid binding approximation (QSS) model,
- Prognostic significance of preoperative systemic cellular inflammatory markers in gliomas: a systematic review and meta‐analysisAbstractGlioma is the most common malignant brain tumor and has high lethality. This tumor generated a robust inflammatory response results in the deterioration of the disease. However, the prognostic role of systemic cellular inflammatory indicators in gliomas remains controversial. This meta‐analysis aimed to assess the prognostic significance of preoperative neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyt
Clinical Ophthalmology
- Near‐Infrared Photoimmunotherapy through BoneAbstract NIR‐PIT is a molecularly‐targeted cancer photo‐therapy that is based on injecting a conjugate of a silicon‐phthalocyanine derivative, IRdye700DX (IR700), and a monoclonal antibody (mAb) that targets an expressed antigen on the cancer cell surface. Subsequent local exposure to NIR light results in the rapid and highly selective immunogenic cell death (ICD) of targeted cancer cells. Because many cancers grow in bones through which light d
- Driver gene alterations and activated signaling pathways toward malignant progression of gastrointestinal stromal tumorsAbstract Mutually exclusive KIT and PDGFRA mutations are considered to be the earliest events in gastrointestinal stromal tumors (GISTs), but insufficient for their malignant progression. Here, we explored to identify driver genes and signaling pathways relevant to GIST progression. We investigated genetic profiles of 707 driver genes, including mutations, gene fusions, copy number gain or loss, and gene expression for 65 clinical specimens of s
- DIF‐1 suppresses cyclin D1‐induced cell proliferation of MCF‐7 breast cancer cells by inhibiting S6K‐mediated STAT3 synthesisAbstract Differentiation‐inducing factor‐1 (DIF‐1) has been reported to inhibit the proliferation of various mammalian cells by unknown means, although some possible mechanisms of its action have been proposed including the activation of glycogen synthase kinase‐3 (GSK‐3). Here, we report an alternative mechanism underlying the action of DIF‐1 in human breast cancer cell line MCF‐7, on which the effects of DIF‐1 have not been examined previously
OEM Online First
- Changes in the gut microbiota during and after commercial helium-oxygen saturation diving in ChinaObjectivesThe influence of commercial helium–oxygen saturation diving on divers’ gut microbiotas was assessed to provide dietary suggestion.MethodsFaecal samples of 47 divers working offshore were collected before (T1), during (T2) and after (T3) saturation diving. Their living and excursion depths were 55–134 metres underwater with a saturation duration of 12–31 days and PaO2 of 38–65 kPa. The faecal samples were examined through 16S ribosomal D
Τετάρτη 25 Σεπτεμβρίου 2019
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