Antibiotics, Vol. 8, Pages 165: Stability of Biological Activity of Frozen β-lactams over Time as Assessed by Time-Lapsed Broth Microdilutions Antibiotics doi: 10.3390/antibiotics8040165 Authors: Gleice Leite Alexander Lawandi Matthew P. Cheng Todd Lee To evaluate the antimicrobial agent’s stability stored at −80 °C, six β-lactams (meropenem, ertapenem, imipenem, ceftriaxone, ceftazidime, and piperacillin-tazobactam) were studied using the...
Wed Sep 25, 2019 03:00
Antioxidants, Vol. 8, Pages 430: Formononetin Upregulates Nrf2/HO-1 Signaling and Prevents Oxidative Stress, Inflammation, and Kidney Injury in Methotrexate-Induced Rats Antioxidants doi: 10.3390/antiox8100430 Authors: Saleem H. Aladaileh Omnia E. Hussein Mohammad H. Abukhalil Sultan A. M. Saghir May Bin-Jumah Manal A. Alfwuaires Mousa O. Germoush Amer A. Almaiman Ayman M. Mahmoud Acute kidney injury (AKI) is a serious complication of methotrexate (MTX). This...
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Antioxidants, Vol. 8, Pages 429: A Comprehensive Review on Lipid Oxidation in Meat and Meat Products
Antioxidants, Vol. 8, Pages 429: A Comprehensive Review on Lipid Oxidation in Meat and Meat Products Antioxidants doi: 10.3390/antiox8100429 Authors: Rubén Domínguez Mirian Pateiro Mohammed Gagaoua Francisco J. Barba Wangang Zhang José M. Lorenzo Meat and meat products are a fundamental part of the human diet. The protein and vitamin content, as well as essential fatty acids, gives them an appropriate composition to complete the nutritional requirements. However, meat...
Wed Sep 25, 2019 03:00
Antioxidants, Vol. 8, Pages 428: Red-Osier Dogwood Extracts Prevent Inflammatory Responses in Caco-2 Cells and a Caco-2 BBe1/EA.hy926 Cell Co-Culture Model Antioxidants doi: 10.3390/antiox8100428 Authors: Qian Jiang Hua Zhang Runqiang Yang Qianru Hui Yuhuan Chen Lili Mats Rong Tsao Chengbo Yang Red-osier dogwood extracts (RDE) contain high levels of phenolic compounds which have been recognized as natural antioxidants. In this study, the potential of RDE to prevent...
Wed Sep 25, 2019 03:00
Antioxidants, Vol. 8, Pages 427: Larrea tridentata Extract Mitigates Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells Antioxidants doi: 10.3390/antiox8100427 Authors: Karla Morán-Santibañez Abimael H. Vasquez Armando Varela-Ramirez Veronica Henderson Janae Sweeney Valerie Odero-Marah Karine Fenelon Rachid Skouta Creosote bush (Larrea tridentata; LT) leaves extracts were tested for their potential efficacy to mitigate cellular oxidative stress...
Wed Sep 25, 2019 03:00
Arts, Vol. 8, Pages 125: Approaches in Intelligent Music Production Arts doi: 10.3390/arts8040125 Authors: David Moffat Mark B. Sandler Music production technology has made few advancements over the past few decades. State-of-the-art approaches are based on traditional studio paradigms with new developments primarily focusing on digital modelling of analog equipment. Intelligent music production (IMP) is the approach of introducing some level of artificial intelligence into the space...
Wed Sep 25, 2019 03:00
Atmosphere, Vol. 10, Pages 581: Estimation of CO2 Emissions from Wildfires Using OCO-2 Data Atmosphere doi: 10.3390/atmos10100581 Authors: Guo Li Wen Huang The biomass burning model (BBM) has been the most widely used method for estimation of trace gas emissions. Due to the difficulty and variability in obtaining various necessary parameters of BBM, a new method is needed to quickly and accurately calculate the trace gas emissions from wildfires. Here, we used satellite...
Wed Sep 25, 2019 03:00
Atmosphere, Vol. 10, Pages 580: Investigating the Behaviour of Human Thermal Indices under Divergent Atmospheric Conditions: A Sensitivity Analysis Approach Atmosphere doi: 10.3390/atmos10100580 Authors: Ioannis Charalampopoulos Andre Santos Nouri This paper aims to analyse and conclude about the behaviour of the most commonly used human thermal comfort indices under a variety of atmospheric conditions in order to provide further information about their appropriateness. Utilising...
Wed Sep 25, 2019 03:00
Atmosphere, Vol. 10, Pages 578: A Violently Tornadic Supercell Thunderstorm Simulation Spanning a Quarter-Trillion Grid Volumes: Computational Challenges, I/O Framework, and Visualizations of Tornadogenesis Atmosphere doi: 10.3390/atmos10100578 Authors: Leigh Orf Tornadoes remain an active subject of observational and numerical research due to the damage and fatalities they cause worldwide as well as poor understanding of their behavior, such as what processes result in their genesis...
Wed Sep 25, 2019 03:00
Atmosphere, Vol. 10, Pages 577: Past and Projected Weather Pattern Persistence with Associated Multi-Hazards in the British Isles Atmosphere doi: 10.3390/atmos10100577 Authors: Paolo De Luca Colin Harpham Robert L. Wilby John K. Hillier Christian L. E. Franzke Gregor C. Leckebusch Hazards such as heatwaves, droughts and floods are often associated with persistent weather patterns. Atmosphere-Ocean General Circulation Models (AOGCMs) are important tools for evaluating projected...
Wed Sep 25, 2019 03:00
Atmosphere, Vol. 10, Pages 579: Capturing Plume Rise and Dispersion with a Coupled Large-Eddy Simulation: Case Study of a Prescribed Burn Atmosphere doi: 10.3390/atmos10100579 Authors: Nadya Moisseeva Roland Stull Current understanding of the buoyant rise and subsequent dispersion of smoke due to wildfires has been limited by the complexity of interactions between fire behavior and atmospheric conditions, as well as the uncertainty in model evaluation data. To assess the feasibility...
Wed Sep 25, 2019 03:00
Bioengineering, Vol. 6, Pages 88: Towards Bioengineered Liver Stem Cell Transplantation Studies in a Preclinical Dog Model for Inherited Copper Toxicosis Bioengineering doi: 10.3390/bioengineering6040088 Authors: Hedwig S. Kruitwagen Hille Fieten Louis C. Penning Wilson Disease is a rare autosomal recessive liver disorder in humans. Although its clinical presentation and age of onset are highly variable, hallmarks include signs of liver disease, neurological features and so-called...
Wed Sep 25, 2019 03:00
Biomolecules, Vol. 9, Pages 533: The Effects of Laparoscopic Sleeve Gastrectomy on the Parameters of Leptin Resistance in Obesity Biomolecules doi: 10.3390/biom9100533 Authors: Mazahreh Alfaqih Saadeh Al-Zoubi Hatamleh Alqudah Aleshawi Alzoubi Obesity is a growing public health problem worldwide. Bariatric surgical procedures achieve the most sustainable and efficacious outcomes in the treatment of morbid obesity. However, little is known about the underlying...
Wed Sep 25, 2019 03:00
Biomolecules, Vol. 9, Pages 532: Ice Nucleation Properties of Ice-binding Proteins from Snow Fleas Biomolecules doi: 10.3390/biom9100532 Authors: Akalabya Bissoyi Naama Reicher Michael Chasnitsky Sivan Arad Thomas Koop Yinon Rudich Ido Braslavsky Ice-binding proteins (IBPs) are found in many organisms, such as fish and hexapods, plants, and bacteria that need to cope with low temperatures. Ice nucleation and thermal hysteresis are two attributes of IBPs. While ice nucleation...
Wed Sep 25, 2019 03:00
Biomolecules, Vol. 9, Pages 530: Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems
Biomolecules, Vol. 9, Pages 530: Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems Biomolecules doi: 10.3390/biom9100530 Authors: Tavakol Ashrafizadeh Deng Azarian Abdoli Motavaf Poormoghadam Khanbabaei Afshar Mandegary Pardakhty Yap Mohammadinejad Kumar Autophagy modulation is considered to be a promising programmed cell death mechanism to prevent and cure a great number of disorders and diseases. The crucial step...
Wed Sep 25, 2019 03:00
Biomolecules, Vol. 9, Pages 529: A Design of Experiments Strategy to Enhance the Recovery of Polyphenolic Compounds from Vitis vinifera By-Products through Heat Reflux Extraction Biomolecules doi: 10.3390/biom9100529 Authors: Moldovan Iurian Puscas Silaghi-Dumitrescu Hanganu Bogdan Vlase Oniga Benedec The aim of the present study was to establish the best experimental conditions that lead to the extracts richest in polyphenolic compounds obtained from...
Wed Sep 25, 2019 03:00
Biomolecules, Vol. 9, Pages 531: Physicochemical Characterization and Antioxidant Activity Evaluation of Idebenone/Hydroxypropyl-β-Cyclodextrin Inclusion Complex † Biomolecules doi: 10.3390/biom9100531 Authors: Valentina Venuti Vincenza Crupi Barbara Fazio Domenico Majolino Giuseppe Acri Barbara Testagrossa Rosanna Stancanelli Federica De Gaetano Agnese Gagliardi Donatella Paolino Giuseppe Floresta Venerando Pistarà Antonio Rescifina Cinzia A. Ventura...
Wed Sep 25, 2019 03:00
Biomolecules, Vol. 9, Pages 527: Studies on the Interaction of Alyteserin 1c Peptide and Its Cationic Analogue with Model Membranes Imitating Mammalian and Bacterial Membranes Biomolecules doi: 10.3390/biom9100527 Authors: Alberto Aragón-Muriel Alessio Ausili Kevin Sánchez Oscar E. Rojas A. Juan Londoño Mosquera Dorian Polo-Cerón Jose Oñate-Garzón Antimicrobial peptides (AMPs) are effector molecules of the innate immune system and have been isolated from multiple organisms....
Wed Sep 25, 2019 03:00
Biomolecules, Vol. 9, Pages 528: Mesoporous Silica Nanoparticles Trigger Liver and Kidney Injury and Fibrosis Via Altering TLR4/NF-κB, JAK2/STAT3 and Nrf2/HO-1 Signaling in Rats Biomolecules doi: 10.3390/biom9100528 Authors: Ayman M. Mahmoud Ekram M. Desouky Walaa G. Hozayen May Bin-Jumah El-Shaymaa El-Nahass Hanan A. Soliman Ahmed A. Farghali Mesoporous silica nanoparticles (MSNs) represent a promising inorganic platform for multiple biomedical applications. Previous...
Wed Sep 25, 2019 03:00
Biomolecules, Vol. 9, Pages 526: Two Auxin Response Elements Fine-Tune PINOID Expression During Gynoecium Development in Arabidopsis thaliana Biomolecules doi: 10.3390/biom9100526 Authors: André Kuhn Bethany Runciman William Tasker-Brown Lars Østergaard The plant hormone auxin controls almost all aspects of plant development through the gene regulatory properties of auxin response factors (ARFs) which bind so-called auxin responsive elements (AuxREs) in regulatory regions of...
Wed Sep 25, 2019 03:00
Brain Sciences, Vol. 9, Pages 253: Serum Levels of Tumor Necrosis Factor-α and Loudness Dependence of Auditory Evoked Potentials at Pretreatment and Posttreatment in Patients with Major Depressive Disorder Brain Sciences doi: 10.3390/brainsci9100253 Authors: Bun-Hee Lee Young-Min Park Seung-Hwan Lee Miseon Shim Background: Proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), are associated with the pathophysiology of major depressive disorder (MDD)....
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Brain Sciences, Vol. 9, Pages 252: Improvement of Cognitive Function after Continuous Positive Airway Pressure Treatment for Subacute Stroke Patients with Obstructive Sleep Apnea: A Randomized Controlled Trial Brain Sciences doi: 10.3390/brainsci9100252 Authors: Kim Im Park Kim Sohn Jee Background: Obstructive sleep apnea (OSA) is common after stroke. Various studies on continuous positive airway pressure (CPAP) therapy for OSA after stroke have been published. However,...
Wed Sep 25, 2019 03:00
Brain Sciences, Vol. 9, Pages 251: Does Video Gaming Have Impacts on the Brain: Evidence from a Systematic Review Brain Sciences doi: 10.3390/brainsci9100251 Authors: Denilson Brilliant T. Rui Nouchi Ryuta Kawashima Video gaming, the experience of playing electronic games, has shown several benefits for human health. Recently, numerous video gaming studies showed beneficial effects on cognition and the brain. A systematic review of video gaming has been published. However, the...
Wed Sep 25, 2019 03:00
Brain Sciences, Vol. 9, Pages 250: Exercise-Induced Fatigue in One Leg Does Not Impair the Neuromuscular Performance in the Contralateral Leg but Improves the Excitability of the Ipsilateral Corticospinal Pathway Brain Sciences doi: 10.3390/brainsci9100250 Authors: Saied Jalal Aboodarda Cindy Xin Yu Zhang Ruva Sharara Madeleine Cline Guillaume Y Millet To investigate the influence of pre-induced fatigue in one leg on neuromuscular performance and corticospinal responses of...
Wed Sep 25, 2019 03:00
Cancers, Vol. 11, Pages 1433: Potent Activity of Composite Cyclin Dependent Kinase Inhibition against Hepatocellular Carcinoma Cancers doi: 10.3390/cancers11101433 Authors: Yu-Yun Shao Yong-Shi Li Hung-Wei Hsu Hang Lin Han-Yu Wang Rita Robin Wo Ann-Lii Cheng Chih-Hung Hsu Alterations in cell cycle regulators are common in hepatocellular carcinoma (HCC). We tested the efficacy of composite inhibition of CDKs 1, 2, 5, and 9 through dinaciclib on HCC. In vitro, dinaciclib...
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Cancers, Vol. 11, Pages 1432: Potential Role of MSC/Cancer Cell Fusion and EMT for Breast Cancer Stem Cell Formation Cancers doi: 10.3390/cancers11101432 Authors: Ralf Hass Juliane von der Ohe Hendrik Ungefroren Solid tumors comprise of maturated cancer cells and self-renewing cancer stem-like cells (CSCs), which are associated with various other nontumorigenic cell populations in the tumor microenvironment. In addition to immune cells, endothelial cells, fibroblasts, and further...
Wed Sep 25, 2019 03:00
Cancers, Vol. 11, Pages 1431: Liquid Biopsy Testing Can Improve Selection of Advanced Non-Small-Cell Lung Cancer Patients to Rechallenge with Gefitinib Cancers doi: 10.3390/cancers11101431 Authors: Riziero Esposito Abate Raffaella Pasquale Alessandra Sacco Maria Carmela Piccirillo Alessandro Morabito Paolo Bidoli Giovanna Finocchiaro Rita Chiari Luisa Foltran Roberta Buosi Marcello Tiseo Laura Giannetta Ciro Battiloro Gianpiero Fasola Gianpiero Romano...
Wed Sep 25, 2019 03:00
Cancers, Vol. 11, Pages 1429: The Targeting of RNA Polymerase I Transcription Using CX-5461 in Combination with Radiation Enhances Tumour Cell Killing Effects in Human Solid Cancers Cancers doi: 10.3390/cancers11101429 Authors: Mohammed Ismael Roger Webb Mazhar Ajaz Karen J. Kirkby Helen M. Coley An increased rate of cellular proliferation is a hallmark of cancer and may be accompanied by an increase in ribosome biogenesis and dysregulation in rRNA synthesis. In this regard,...
Wed Sep 25, 2019 03:00
Cancers, Vol. 11, Pages 1430: Macrophage Migration Inhibitory Factor Is a Molecular Determinant of the Anti-EGFR Monoclonal Antibody Cetuximab Resistance in Human Colorectal Cancer Cells Cancers doi: 10.3390/cancers11101430 Authors: Rosita Russo Nunzia Matrone Valentina Belli Davide Ciardiello Mariangela Valletta Sabrina Esposito Paolo Vincenzo Pedone Fortunato Ciardiello Teresa Troiani Angela Chambery Background: The clinical impact of the monoclonal antibody...
Wed Sep 25, 2019 03:00
Cancers, Vol. 11, Pages 1427: FOXO1 Confers Maintenance of the Dark Zone Proliferation and Survival Program and Can Be Pharmacologically Targeted in Burkitt Lymphoma Cancers doi: 10.3390/cancers11101427 Authors: Franziska Gehringer Stephanie Weissinger Lotteke Swier Peter Möller Thomas Wirth Alexey Ushmorov The FOXO1 transcription factor plays a central role in the proliferation and survival of B cells at several stages of differentiation. B cell malignancies, with exception...
Wed Sep 25, 2019 03:00
Cancers, Vol. 11, Pages 1428: STAT3 and STAT5 Activation in Solid Cancers Cancers doi: 10.3390/cancers11101428 Authors: Sebastian Igelmann Heidi A. Neubauer Gerardo Ferbeyre The Signal Transducer and Activator of Transcription (STAT)3 and 5 proteins are activated by many cytokine receptors to regulate specific gene expression and mitochondrial functions. Their role in cancer is largely context-dependent as they can both act as oncogenes and tumor suppressors. We review here the...
Wed Sep 25, 2019 03:00
Cancers, Vol. 11, Pages 1426: Evaluation and Validation of Plasma Proteins Using Two Different Protein Detection Methods for Early Detection of Colorectal Cancer Cancers doi: 10.3390/cancers11101426 Authors: Megha Bhardwaj Anton Gies Korbinian Weigl Kaja Tikk Axel Benner Petra Schrotz-King Christoph H. Borchers Hermann Brenner Objective: Plasma protein biomarkers could be an efficient alternative for population-based screening for early detection of colorectal cancer...
Wed Sep 25, 2019 03:00
Cancers, Vol. 11, Pages 1425: ErbB3 Phosphorylation as Central Event in Adaptive Resistance to Targeted Therapy in Metastatic Melanoma: Early Detection in CTCs during Therapy and Insights into Regulation by Autocrine Neuregulin Cancers doi: 10.3390/cancers11101425 Authors: Ciro Francesco Ruggiero Debora Malpicci Luigi Fattore Gabriele Madonna Vito Vanella Domenico Mallardo Domenico Liguoro Valentina Salvati Mariaelena Capone Barbara Bedogni Paolo Antonio Ascierto...
Wed Sep 25, 2019 03:00
Cells, Vol. 8, Pages 1149: Mutations in NDUFS1 Cause Metabolic Reprogramming and Disruption of the Electron Transfer Cells doi: 10.3390/cells8101149 Authors: Ni Hagras Konstantopoulou Mayr Stuchebrukhov Meierhofer Complex I (CI) is the first enzyme of the mitochondrial respiratory chain and couples the electron transfer with proton pumping. Mutations in genes encoding CI subunits can frequently cause inborn metabolic errors. We applied proteome and metabolome profiling...
Wed Sep 25, 2019 03:00
Cells, Vol. 8, Pages 1148: Intracellular Signals Activated by Canonical Wnt Ligands Independent of GSK3 Inhibition and β-Catenin Stabilization Cells doi: 10.3390/cells8101148 Authors: Antonio García de Herreros Mireia Duñach In contrast to non-canonical ligands, canonical Wnts promote the stabilization of β-catenin, which is a prerequisite for formation of the TCF4/β-catenin transcriptional complex and activation of its target genes. This pathway is initiated by...
Wed Sep 25, 2019 03:00
Cells, Vol. 8, Pages 1147: Mesenchymal WNT-5A/5B Signaling Represses Lung Alveolar Epithelial Progenitors Cells doi: 10.3390/cells8101147 Authors: Wu van Dijk Ng-Blichfeldt Bos Ciminieri Königshoff Kistemaker Gosens Chronic obstructive pulmonary disease (COPD) represents a worldwide concern with high morbidity and mortality, and is believed to be associated with accelerated ageing of the lung. Alveolar abnormalities leading to emphysema are a key characteristic...
Wed Sep 25, 2019 03:00
Cells, Vol. 8, Pages 1146: Tubulin-Dependent Transport of Connexin-36 Potentiates the Size and Strength of Electrical Synapses Cells doi: 10.3390/cells8101146 Authors: Brown del Corsso Zoidl Donaldson Spray Zoidl Connexin-36 (Cx36) electrical synapses strengthen transmission in a calcium/calmodulin (CaM)/calmodulin-dependent kinase II (CaMKII)-dependent manner similar to a mechanism whereby the N-methyl-D-aspartate (NMDA) receptor subunit NR2B facilitates chemical...
Wed Sep 25, 2019 03:00
Cells, Vol. 8, Pages 1145: CTC-Derived Models: A Window into the Seeding Capacity of Circulating Tumor Cells (CTCs) Cells doi: 10.3390/cells8101145 Authors: Tayoun Faugeroux Oulhen Aberlenc Pawlikowska Farace Metastasis is the main cause of cancer-related death owing to the blood-borne dissemination of circulating tumor cells (CTCs) early in the process. A rare fraction of CTCs harboring a stem cell profile and tumor initiation capacities is thought to possess the...
Wed Sep 25, 2019 03:00
Cells, Vol. 8, Pages 1144: The Role of Two-Pore Channels in Norepinephrine-Induced [Ca2+]i Rise in Rat Aortic Smooth Muscle Cells and Aorta Contraction Cells doi: 10.3390/cells8101144 Authors: Sergei K. Trufanov Elena Yu. Rybakova Piotr P. Avdonin Alexandra A. Tsitrina Irina L. Zharkikh Nikolay V. Goncharov Richard O. Jenkins Pavel V. Avdonin Second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) triggers Ca2+ release via two-pore channels (TPCs)...
Wed Sep 25, 2019 03:00
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