IJMS, Vol. 20, Pages 4769: Characterization and Activity Analyses of the FLOWERING LOCUS T Promoter in Gossypium Hirsutum International Journal of Molecular Sciences doi: 10.3390/ijms20194769 Authors: Na Sang Darun Cai Chao Li Yuqiang Sun Xianzhong Huang Flowering transition is a crucial development process in cotton (Gossypium hirsutum L.), and the flowering time is closely correlated with the timing of FLOWERING LOCUS T (FT) expression. However, the mechanism underlying...
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IJMS, Vol. 20, Pages 4768: Coordination of miR-192 and miR-22 in p53-Mediated Cell Fate Decision International Journal of Molecular Sciences doi: 10.3390/ijms20194768 Authors: Cheng-Yuan Sun Xiao-Peng Zhang Wei Wang p53-targeted microRNAs (miRNAs) markedly affect cellular response to DNA damage. These miRNAs may contribute to either cell cycle arrest or apoptosis induction. However, how these miRNAs coordinate to modulate the decision between cell survival and death remains less...
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IJMS, Vol. 20, Pages 4767: Ursolic Acid Suppresses Cholesterol Biosynthesis and Exerts Anti-Cancer Effects in Hepatocellular Carcinoma Cells International Journal of Molecular Sciences doi: 10.3390/ijms20194767 Authors: Geon-Hee Kim Sang-Yeon Kan Hyeji Kang Sujin Lee Hyun Myung Ko Ji Hyung Kim Ji-Hong Lim Abnormally upregulated cholesterol and lipid metabolism, observed commonly in multiple cancer types, contributes to cancer development and progression through the...
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IJMS, Vol. 20, Pages 4766: In Vitro Reconstruction of Xenopus Oocyte Ovulation International Journal of Molecular Sciences doi: 10.3390/ijms20194766 Authors: Alexander A. Tokmakov Yuta Matsumoto Takumi Isobe Ken-Ichi Sato Progesterone is widely used to induce maturation of isolated fully grown oocytes of the African clawed frog, Xenopus laevis. However, the hormone fails to release oocytes from the layer of surrounding follicle cells. Here, we report that maturation and follicle...
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IJMS, Vol. 20, Pages 4765: Corticosteroids in Acute Lung Injury: The Dilemma Continues International Journal of Molecular Sciences doi: 10.3390/ijms20194765 Authors: Mokra Mikolka Kosutova Mokry Acute lung injury (ALI) represents a serious heterogenous pulmonary disorder with high mortality. Despite improved understanding of the pathophysiology, the efficacy of standard therapies such as lung-protective mechanical ventilation, prone positioning and administration of neuromuscular...
Wed Sep 25, 2019 03:00
IJMS, Vol. 20, Pages 4763: Improved In Vivo Anti-Tumor and Anti-Metastatic Effect of GnRH-III-Daunorubicin Analogs on Colorectal and Breast Carcinoma Bearing Mice International Journal of Molecular Sciences doi: 10.3390/ijms20194763 Authors: Ranđelović Schuster Kapuvári Fossati Steinkühler Mező Tóvári Among various homing devices, gonadotropin-releasing hormone-III (GnRH-III) peptide represents a suitable targeting moiety for drug delivery systems. The anti-tumor...
Wed Sep 25, 2019 03:00
IJMS, Vol. 20, Pages 4764: Role of GOLPH3 and TPX2 in Neuroblastoma DNA Damage Response and Cell Resistance to Chemotherapy International Journal of Molecular Sciences doi: 10.3390/ijms20194764 Authors: Marzia Ognibene Marina Podestà Alberto Garaventa Annalisa Pezzolo Neuroblastoma (NB) is an aggressive, relapse-prone infancy tumor of the sympathetic nervous system and is the leading cause of death among preschool age diseases, so the search for novel therapeutic targets is...
Wed Sep 25, 2019 03:00
IJMS, Vol. 20, Pages 4762: Overexpression of Magnaporthe Oryzae Systemic Defense Trigger 1 (MoSDT1) Confers Improved Rice Blast Resistance in Rice International Journal of Molecular Sciences doi: 10.3390/ijms20194762 Authors: Wang Li Duan Wang Zhang Yang The effector proteins secreted by a pathogen not only promote virulence and infection of the pathogen, but also trigger plant defense response. Therefore, these proteins could be used as important genetic resources...
Wed Sep 25, 2019 03:00
IJMS, Vol. 20, Pages 4761: The Bactericidal Activity of Temporin Analogues Against Methicillin Resistant Staphylococcus aureus International Journal of Molecular Sciences doi: 10.3390/ijms20194761 Authors: Anna Golda Paulina Kosikowska-Adamus Aleksandra Kret Olena Babyak Kinga Wójcik Ewelina Dobosz Jan Potempa Adam Lesner Joanna Koziel Staphylococcus aureus is a major infectious agent responsible for a plethora of superficial skin infections and systemic diseases,...
Wed Sep 25, 2019 03:00
IJMS, Vol. 20, Pages 4760: Chirality-Dependent Adsorption between Amphipathic Peptide and POPC Membrane International Journal of Molecular Sciences doi: 10.3390/ijms20194760 Authors: Ke Chen Yuebiao Sheng Jun Wang Wei Wang The interactions between chiral molecules and cell membranes have attracted more and more attention in recent decades, due to their importance in molecular science and medical applications. It is observed that some peptides composed of different chiral amino...
Wed Sep 25, 2019 03:00
IJMS, Vol. 20, Pages 4759: Cellular Mechanisms of Angiogenesis in Neonatal Rat Models of Retinal Neurodegeneration International Journal of Molecular Sciences doi: 10.3390/ijms20194759 Authors: Daiki Asano Masaki Hokazono Shogo Hirano Akane Morita Tsutomu Nakahara Νeuronal and glial cells play an important role in the development of vasculature in the retina. In this study, we investigated whether re-vascularization occurs in retinal neurodegenerative injury models....
Wed Sep 25, 2019 03:00
IJMS, Vol. 20, Pages 4758: Epigenetic Alterations of Heat Shock Proteins (HSPs) in Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20194758 Authors: Hyun Seung Ban Tae-Su Han Keun Hur Hyun-Soo Cho Heat shock proteins (HSPs) are associated with various physiological processes (protein refolding and degradation) involved in the responses to cellular stress, such as cytotoxic agents, high temperature, and hypoxia. HSPs are overexpressed in cancer cells and play...
Wed Sep 25, 2019 03:00
IJMS, Vol. 20, Pages 4756: Relationship Between Intermittent Hypoxia and Type 2 Diabetes in Sleep Apnea Syndrome International Journal of Molecular Sciences doi: 10.3390/ijms20194756 Authors: Hiroyo Ota Yukio Fujita Motoo Yamauchi Shigeo Muro Hiroshi Kimura Shin Takasawa Sleep apnea syndrome (SAS) is a very common disease involving intermittent hypoxia (IH), recurrent symptoms of deoxygenation during sleep, strong daytime sleepiness, and significant loss of quality of...
Wed Sep 25, 2019 03:00
IJMS, Vol. 20, Pages 4755: Proteomic Biomarkers of Retinal Inflammation in Diabetic Retinopathy International Journal of Molecular Sciences doi: 10.3390/ijms20194755 Authors: Hannah Youngblood Rebekah Robinson Ashok Sharma Shruti Sharma Diabetic retinopathy (DR), a sight-threatening neurovasculopathy, is the leading cause of irreversible blindness in the developed world. DR arises as the result of prolonged hyperglycemia and is characterized by leaky retinal vasculature, retinal...
Wed Sep 25, 2019 03:00
IJMS, Vol. 20, Pages 4757: APP, PSEN1, and PSEN2 Mutations in Asian Patients with Early-Onset Alzheimer Disease International Journal of Molecular Sciences doi: 10.3390/ijms20194757 Authors: Vo Van Giau Eva Bagyinszky Young Chul Youn Seong Soo A. An SangYun Kim The number of patients with Alzheimer’s disease (AD) is rapidly increasing in Asia. Mutations in the amyloid protein precursor (APP), presenilin-1 (PSEN1), and presenilin-2 (PSEN2) genes can cause autosomal...
Wed Sep 25, 2019 03:00
IJMS, Vol. 20, Pages 4754: Autophagic Machinery of Plant Peroxisomes International Journal of Molecular Sciences doi: 10.3390/ijms20194754 Authors: Sławomir Borek Szymon Stefaniak Jan Śliwiński Małgorzata Garnczarska Małgorzata Pietrowska-Borek Peroxisomes are cell organelles that play an important role in plants in many physiological and developmental processes. The plant peroxisomes harbor enzymes of the β-oxidation of fatty acids and the glyoxylate cycle; photorespiration;...
Wed Sep 25, 2019 03:00
IJMS, Vol. 20, Pages 4753: Clinical and Genetic Factors Associated with Resistance to Treatment in Patients with Schizophrenia: A Case-Control Study International Journal of Molecular Sciences doi: 10.3390/ijms20194753 Authors: Aline Hajj Sahar Obeid Saria Sahyoun Chadia Haddad Jocelyne Azar Lydia Rabbaa Khabbaz Souheil Hallit Objectives: To assess clinical and genetic factors affecting response to treatment in a sample of patients with schizophrenia (treatment-resistant...
Wed Sep 25, 2019 03:00
IJMS, Vol. 20, Pages 4752: NET4 Modulates the Compactness of Vacuoles in Arabidopsis thaliana International Journal of Molecular Sciences doi: 10.3390/ijms20194752 Authors: Sabrina Kaiser Ahmed Eisa Jürgen Kleine-Vehn David Scheuring The dimension of the plants largest organelle—the vacuole—plays a major role in defining cellular elongation rates. The morphology of the vacuole is controlled by the actin cytoskeleton, but molecular players remain largely unknown....
Wed Sep 25, 2019 03:00
IJMS, Vol. 20, Pages 4751: Eicosapentaenoic Acid (EPA) Modulates Glucose Metabolism by Targeting AMP-Activated Protein Kinase (AMPK) Pathway International Journal of Molecular Sciences doi: 10.3390/ijms20194751 Authors: Nami Kim Mi Sun Kang Miso Nam Shin Ae Kim Geum-Sook Hwang Hyeon Soo Kim EPA, an omega-3 polyunsaturated fatty acid, exerts beneficial effects on human health. However, the molecular mechanisms underlying EPA function are poorly understood. The object was...
Wed Sep 25, 2019 03:00
JCM, Vol. 8, Pages 1542: Dynamics of Phenotypic Heterogeneity during EMT and Stemness in Cancer Progression Journal of Clinical Medicine doi: 10.3390/jcm8101542 Authors: Jolly Celià-Terrassa Genetic and phenotypic heterogeneity contribute to the generation of diverse tumor cell populations, thus enhancing cancer aggressiveness and therapy resistance. Compared to genetic heterogeneity, a consequence of mutational events, phenotypic heterogeneity arises from dynamic, reversible cell...
Wed Sep 25, 2019 03:00
JCM, Vol. 8, Pages 1541: Heat Generation at the Implant–Bone Interface by Insertion of Ceramic and Titanium Implants Journal of Clinical Medicine doi: 10.3390/jcm8101541 Authors: Zipprich Weigl König Toderas Balaban Ratka Purpose: The aim of this study is to record material- and surface-dependent heat dissipation during the process of inserting implants into native animal bone. Materials and Methods: Implants made of titanium and zirconium that were identical in...
Wed Sep 25, 2019 03:00
JCM, Vol. 8, Pages 1539: High-Frequency Ultrasound for Assessment of Peri-Implant Bone Thickness Journal of Clinical Medicine doi: 10.3390/jcm8101539 Authors: Juliana Marotti Sarah Neuhaus Daniel Habor Lauren Bohner Stefan Heger Klaus Radermacher Stefan Wolfart Purpose: The aim of this study was to evaluate the accuracy of high-frequency ultrasound (HFUS) for measurement of bone thickness surrounding dental implants. Methods: Eight porcine bone samples containing dental...
Wed Sep 25, 2019 03:00
JCM, Vol. 8, Pages 1540: Ulnar Wrist Pain Revisited: Ultrasound Diagnosis and Guided Injection for Triangular Fibrocartilage Complex Injuries Journal of Clinical Medicine doi: 10.3390/jcm8101540 Authors: Wei-Ting Wu Ke-Vin Chang Kamal Mezian Ondřej Naňka Yi-Chiang Yang Yu-Chun Hsu Po-Cheng Hsu Levent Özçakar The triangular fibrocartilage complex (TFCC) serves as the major stabilizer of the wrist. Its injuries can result from trauma or degeneration, both of which...
Wed Sep 25, 2019 03:00
JCM, Vol. 8, Pages 1538: Diabetic Foot Infection Presenting Systemic Inflammatory Response Syndrome: A Unique Disorder of Systemic Reaction from Infection of the Most Distal Body Journal of Clinical Medicine doi: 10.3390/jcm8101538 Authors: Cheng-Wei Lin Shih-Yuan Hung Chung-Huei Huang Jiun-Ting Yeh Yu-Yao Huang Diabetic foot infection (DFI) is a major complication of diabetic foot that lead to nontraumatic lower-extremity amputation (LEA). Such distal infection of the body...
Wed Sep 25, 2019 03:00
Medicina, Vol. 55, Pages 642: IL28B Genetic Variations in Patients with Recurrent Herpes Simplex Keratitis Medicina doi: 10.3390/medicina55100642 Authors: Savić Borivoje Stanojlović Svetlana Hadži-Milić Milan Đonović Nela Milošević-Đorđević Olivera Milisavljević Filip Stojković Milenko Pajić Srbislav Background and objectives: Recurrent herpes simplex keratitis (HSK) is the most common cause of corneal blindness in the developed world. A relationship between host...
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Medicina, Vol. 55, Pages 640: Antrodia Cinnamomea Prolongs Survival in a Patient with Small Cell Lung Cancer Medicina doi: 10.3390/medicina55100640 Authors: Huei Long Chi-Tan Hu Ching-Feng Weng Introduction: Antrodia cinnamomea (AC) is an extremely rare medicinal fungus native to forested regions of Taiwan. It possesses numerous biological activities, especially anti-tumor effects shown in various in vitro cancer cells and in vivo animal models. However, there are few clinical...
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Medicina, Vol. 55, Pages 641: Pollen-Food Allergy Syndrome: A not so Rare Disease in Childhood Medicina doi: 10.3390/medicina55100641 Authors: Carla Mastrorilli Fabio Cardinale Arianna Giannetti Carlo Caffarelli Seasonal allergic rhinoconjunctivitis (SAR) affects millions of people worldwide, particularly in childhood and adolescence. Pollen food allergy syndrome (PFAS) is a common adverse reaction occurring few minutes after the consumption of vegetable foods in patients with...
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Medicina, Vol. 55, Pages 639: Structural, Dermal and Ungual Characteristics of the Foot in Patients with Type II Diabetes Medicina doi: 10.3390/medicina55100639 Authors: Gonzalez-Martin Pertega-Diaz Seoane-Pillado Balboa-Barreiro Soto-Gonzalez Veiga-Seijo Background and Objectives: Diabetes is a chronic and metabolic disease, considered as an important public health problem. The objective of this study was to determine the prevalence of podiatric pathology in type...
Wed Sep 25, 2019 03:00
Medicina, Vol. 55, Pages 638: Formaldehyde Exposure and Acute Myeloid Leukemia: A Review of the Literature Medicina doi: 10.3390/medicina55100638 Authors: Allegra Spatari Mattioli Curti Innao Ettari Allegra Giorgianni Gangemi Musolino Background and objective: The aim of the present study was to evaluate associations between cumulative and peak formaldehyde exposure and occurrence of acute myeloid leukemia. Material and Methods: A comprehensive search...
Wed Sep 25, 2019 03:00
Medicina, Vol. 55, Pages 637: Epidemiology, Risk Factors and Measures for Preventing Drowning in Africa: A Systematic Review Medicina doi: 10.3390/medicina55100637 Authors: Miller Alele Emeto Franklin : Background: Drowning is a leading cause of unintentional injury related mortality worldwide, and accounts for roughly 320,000 deaths yearly. Over 90% of these deaths occur in low- and middle-income countries with inadequate prevention measures. The highest rates of drowning...
Wed Sep 25, 2019 03:00
Medicina, Vol. 55, Pages 636: Tools for the Quality Control of Pharmaceutical Heparin Medicina doi: 10.3390/medicina55100636 Authors: Anthony Devlin Courtney Mycroft-West Patricia Procter Lynsay Cooper Scott Guimond Marcelo Lima Edwin Yates Mark Skidmore Heparin is a vital pharmaceutical anticoagulant drug and remains one of the few naturally sourced pharmaceutical agents used clinically. Heparin possesses a structural order with up to four levels of complexity....
Wed Sep 25, 2019 03:00
Medicina, Vol. 55, Pages 635: Physical Activity and Body Composition in Children and Their Mothers According to Mother’s Gestational Diabetes Risk: A Seven-Year Follow-Up Study Medicina doi: 10.3390/medicina55100635 Authors: Marja H Leppänen Jani Raitanen Pauliina Husu Urho M Kujala Pipsa PA Tuominen Henri Vähä-Ypyä Riitta Luoto Background and Objectives: There is lack of knowledge on whether mothers’ gestational diabetes (GDM) risk is related to their physical...
Wed Sep 25, 2019 03:00
Microorganisms, Vol. 7, Pages 392: Mediterranean Native Leguminous Plants: A Reservoir of Endophytic Bacteria with Potential to Enhance Chickpea Growth under Stress Conditions Microorganisms doi: 10.3390/microorganisms7100392 Authors: Clarisse Brígido Esther Menéndez Ana Paço Bernard R. Glick Anabela Belo Maria R. Félix Solange Oliveira Mário Carvalho Bacterial endophytes, a subset of a plant’s microbiota, can facilitate plant growth by a number of different mechanisms....
Wed Sep 25, 2019 03:00
Molecules, Vol. 24, Pages 3483: Root Bark of Paeonia suffruticosa Extract and Its Component Methyl Gallate Possess Peroxynitrite Scavenging Activity and Anti-inflammatory Properties through NF-κB Inhibition in LPS-treated Mice Molecules doi: 10.3390/molecules24193483 Authors: Park Jung Park Yokozawa Jeong A peroxynitrite (ONOO–)-generating system induced by 3-morpholinosydnonimine, was used to evaluate the ONOO– scavenging properties of plants that...
Wed Sep 25, 2019 03:00
Molecules, Vol. 24, Pages 3482: Enzymatic Cascades for Tailored 13C6 and 15N Enriched Human Milk Oligosaccharides Molecules doi: 10.3390/molecules24193482 Authors: Fischöder Cajic Grote Heinzler Reichl Franzreb Rapp Elling Several health benefits, associated with human milk oligosaccharides (HMOS), have been revealed in the last decades. Further progress, however, requires not only the establishment of a simple "routine" method for absolute quantification...
Wed Sep 25, 2019 03:00
Molecules, Vol. 24, Pages 3480: Substituted 1,3,5-Triazine Hexacarboxylates as Potential Linkers for MOFs Molecules doi: 10.3390/molecules24193480 Authors: Arne Klinkebiel Ole Beyer Ulrich Lüning Hexacarboxylates are promising linkers for MOFs such as NU-109 or NU-110, which possess large values for surfaces and pore volumina. Starting from 2,4,6-tris(bromoaryl)-1,3,5-triazines, palladium-catalyzed cross coupling reactions (Suzuki-Miyaura, Sonogashira-Hagihara) form elongated hexacarboxylate...
Wed Sep 25, 2019 03:00
Molecules, Vol. 24, Pages 3479: Inuloxin E, a New Seco-Eudesmanolide Isolated from Dittrichia viscosa, Stimulating Orobanche cumana Seed Germination Molecules doi: 10.3390/molecules24193479 Authors: Marco Masi Mónica Fernández-Aparicio Roukia Zatout Angela Boari Alessio Cimmino Antonio Evidente A new sesquiterpenoid belonging to the subgroup seco-eudesmanolides and named inuloxin E was isolated from Dittrichia viscosa, together with the already known sesquiterpenoids inuloxins...
Wed Sep 25, 2019 03:00
Molecules, Vol. 24, Pages 3481: Eco-Friendly Extraction and Characterisation of Nutraceuticals from Olive Leaves Molecules doi: 10.3390/molecules24193481 Authors: Cinzia Benincasa Ilaria Santoro Monica Nardi Alfredo Cassano Giovanni Sindona Olive tree (Olea europaea L.) leaf, a waste by-product of the olive oil industry, is an inexpensive and abundant source of biophenols of great interest for various industrial applications in the food supplement, cosmetic, and pharmaceutical...
Wed Sep 25, 2019 03:00
Molecules, Vol. 24, Pages 3477: Chemoenzymatic Total Synthesis of (+)-10-Keto-Oxycodone from Phenethyl Acetate Molecules doi: 10.3390/molecules24193477 Authors: Mary Ann Endoma-Arias Helen Dela Paz Tomas Hudlicky The total synthesis of (+)-10-keto-oxycodone was attained from phenethyl acetate in a stereoselective manner. Absolute stereochemistry was established via enzymatic dihydroxylation of phenethyl acetate with the recombinant strain JM109 (pDTG601A) that furnished the corresponding...
Wed Sep 25, 2019 03:00
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