Association Between Pulmonary Function and Asthma Symptoms Publication date: September–October 2019 Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 7 Author(s): Patrick W. Sullivan, Vahram H. Ghushchyan, Jessica Marvel, Yu Chen Barrett, Anne L. Fuhlbrigge Background FEV1 as a percentage of predicted (FEV1%pred) is commonly measured in asthma clinical studies; however, reports vary on its association with asthma control instruments evaluating symptoms. Objective Assess the association between FEV1%pred and Asthma Control Questionnaire (ACQ) scores in a managed-care population with persistent asthma. Methods Retrospective analysis of survey responses and spirometry results of patients (aged ≥12 years) with persistent asthma from the Observational Study of Asthma Control and Outcomes was done. Eligible patients received 4 identical surveys including the 5-item ACQ (ACQ-5)/6-item ACQ (ACQ-6) and completed spirometry in parallel. Longitudinal analyses, comparisons of change over time, and fixed- and random-effects regression analyses were conducted, with/without adjustment for covariates. Results There were 1748 survey responses with valid spirometry results. In unadjusted models, coefficients for ACQ-5/ACQ-6 scores were not statistically significant and coefficient of determination (R2) was low (0.03). When adjusted for covariates, ACQ-5 and ACQ-6 scores were significantly associated with FEV1%pred (P < .001) and R2 increased to 0.11 and 0.12, respectively. In adjusted models, every 1-point increase in ACQ-5 and ACQ-6 scores was associated with a 1.7% and 1.9% decrease, respectively, in FEV1%pred. Change in FEV1%pred and change in ACQ-5/ACQ-6 scores were not significantly associated in regressions with/without covariates. Conclusions The weak and statistically insignificant association between FEV1%pred and ACQ-5/ACQ-6 scores in unadjusted models suggests a high degree of unexplained variation between these measures. Results support the use of both symptoms and pulmonary function, rather than relying on one measure alone, to assess asthma control in clinical care and outcomes studies.

Polyethylene glycols and polysorbates: Two still neglected ingredients causing true IgE-mediated reactions Publication date: September–October 2019 Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 7 Author(s): Gianfranco Calogiuri, Caterina Foti, Eustachio Nettis, Elisabetta Di Leo, Luigi Macchia, Angelo Vacca

SCIT Adherence: Making IT Happen! Publication date: September–October 2019 Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 7 Author(s): Hannah G. Russell, Mike S. Tankersley

The Clinical Utility of Epicutaneous Immunotherapy for Peanut Allergy Publication date: September–October 2019 Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 7 Author(s): Miriam Samstein, Punita Ponda

CME Exam: Food Allergy: Challenges with the New Guidelines Publication date: September–October 2019 Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 7 Author(s):

Food Allergy: Challenges with the New Guidelines Publication date: September–October 2019 Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 7 Author(s): Moira Breslin, Gideon Lack

Blood Eosinophilia May Not Adequately Estimate Lung Fluid Eosinophilia in Childhood Asthma Publication date: September–October 2019 Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 7 Author(s): W. Gerald Teague

Children with severe persistent asthma have disparate peripheral blood and lower airway eosinophil levels Publication date: September–October 2019 Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 7 Author(s): Victoria Ribeiro, Jade Andrade, Samantha Rose, Chantal Spencer, Alfin Vicencio, Supinda Bunyavanich

Epinephrine drug degradation in autoinjector products Publication date: September–October 2019 Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 7 Author(s): Lynn Kassel, Caroline Jones, Abebe Mengesha

Impact of omalizumab on patient-reported outcomes in chronic idiopathic urticaria: Results from a randomized study (XTEND-CIU) Publication date: September–October 2019 Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 7 Author(s): Thomas B. Casale, Thomas R. Murphy, Michael Holden, Yamina Rajput, Bongin Yoo, Jonathan A. Bernstein