Journal of Cutaneous Medicine and Surgery, Ahead of Print. Background:Punctate palmoplantar keratoderma type 1 (PPPK1) presents in late childhood to adulthood with multiple small discrete hyperkeratotic papules on palms and soles. PPPK1 is an autosomal dominant skin disease caused by AAGAB mutations. It has been suggested that PPPK1 may be associated with an increased predisposition to systemic malignancies.Objectives:To evaluate the presence of AAGAB mutations in Canadian families with PPPK1 and...
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Background The epidemiology of nickel allergy in occupational settings is not well understood. Objective The aim of the study was to characterize occupationally related nickel allergy (ORNA). Methods This is a retrospective cross-sectional analysis of 44,378 patients patch tested by the North American Contact Dermatitis Group from 1998 to 2016. Characteristics of individuals with ORNA were compared with those with non-ORNA (NORNA). Results A total of 7928 (18.2%) individuals were...
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Background Contact dermatitis is a prevalent condition that has a significant impact on quality of life (QoL). Although many generic dermatological QoL instruments exist, none were developed by and for patients with allergic contact dermatitis (ACD). Objective The aim of the study was to create and validate a reliable QoL instrument specific for the ACD population. Methods We identified QoL items specific to ACD through a series of qualitative interviews with ACD patients and experts....
Atopic dermatitis (AD) often requires combination treatment regimens. However, little is known about treatment combinations and polypharmacy in AD. We sought to characterize patterns of outpatient prescriptions and polypharmacy among US children and adults with AD. Data from the 1993–2015 National Ambulatory Medical Care Survey were analyzed, including 128,300 pediatric and 623,935 adult outpatient visits. Among AD visits, dermatologists prescribed more topical corticosteroids (TCSs, P = 0.01) than...
Background Cyanoacrylates are strong adhesives used for a variety of medical, industrial, and cosmetic applications and have been implicated as a cause of allergic contact dermatitis. Objective The aim of the study was to review our experience in patch testing with cyanoacrylates. Methods We reviewed patch test results of 38 patients with a clinical history of contact dermatitis due to a cyanoacrylate-containing adhesive (mostly Dermabond). Testing used cyanoacrylates of >99% purity...
Multiple etiologies contribute to sleep disturbance in atopic dermatitis (AD) patients, including learned scratching behavior and increased monoamines, cutaneous blood flow, inflammatory cell activities, and cytokines, as well as decreased melatonin, anti-inflammatory cytokines, and skin barrier function. Insomnia impairs cognitive development in children with AD, leading to behavioral problems and learning disabilities. Insomnia in adults with AD impedes work productivity. In this article, we discuss...
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Journal of International Medical Research, Ahead of Print.
Mon Sep 16, 2019 09:23
Journal of International Medical Research, Ahead of Print.
Mon Sep 16, 2019 12:12
Journal of International Medical Research, Ahead of Print.
Mon Sep 16, 2019 12:17
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Cancers, Vol. 11, Pages 1382: Radioiodine-Refractory Thyroid Cancer: Molecular Basis of Redifferentiation Therapies, Management, and Novel Therapies Cancers doi: 10.3390/cancers11091382 Authors: Mohamed Aashiq Deborah A. Silverman Shorook Na’ara Hideaki Takahashi Moran Amit Recurrent, metastatic disease represents the most frequent cause of death for patients with thyroid cancer, and radioactive iodine (RAI) remains a mainstay of therapy for these patients. Unfortunately,...
Cancers, Vol. 11, Pages 1379: Observations on Solitary Versus Multiple Isolated Pancreatic Metastases of Renal Cell Carcinoma: Another Indication of a Seed and Soil Mechanism? Cancers doi: 10.3390/cancers11091379 Authors: Franz Sellner Isolated pancreas metastases are a rare type of metastasis of renal cell carcinoma, characterized by the presence of pancreatic metastases, while all other organs remain unaffected. In a previous study, we determined arguments from the literature which...
Cancers, Vol. 11, Pages 1381: BRAF Mutations Classes I, II, and III in NSCLC Patients Included in the SLLIP Trial: The Need for a New Pre-Clinical Treatment Rationale Cancers doi: 10.3390/cancers11091381 Authors: Jillian Wilhelmina Paulina Bracht Niki Karachaliou Trever Bivona Richard B. Lanman Iris Faull Rebecca J. Nagy Ana Drozdowskyj Jordi Berenguer Manuel Fernandez-Bruno Miguel Angel Molina-Vila Rafael Rosell BRAF V600 mutations have been found in 1–2%...
Cancers, Vol. 11, Pages 1380: Age-Related Alterations in Immune Contexture Are Associated with Aggressiveness in Rhabdomyosarcoma Cancers doi: 10.3390/cancers11091380 Authors: Patrizia Gasparini Orazio Fortunato Loris De Cecco Michela Casanova Maria Federica Iannó Andrea Carenzo Giovanni Centonze Massimo Milione Paola Collini Mattia Boeri Matteo Dugo Chiara Gargiuli Mavis Mensah Miriam Segale Luca Bergamaschi Stefano Chiaravalli Maria Luisa Sensi...
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